Relationship between the Gensini Score of Blood-Stasis Syndrome in Coronary Heart Disease and VEGF

Abstract

This work aimed to discuss the relationship between the Gensini score of blood-stasis syndrome (BSS) in coronary heart disease (CHD) and vascular endothelial growth factor (VEGF) levels. Ninety-six patients with BSS in CHD were divided into 48 cases with qi deficiency and blood-stasis pattern and 48 cases of intermingled phlegm and blood-stasis pattern, based on traditional Chinese medicine (TCM) syndrome differentiation. Coronary angiography was carried out, and VEGF level was determined. Simultaneously, the extent of blood stasis was assessed with the blood-stasis score. Furthermore, the result of coronary angiography was assessed with the Gensini score system. The result showed that the blood-stasis score and coronary artery stenosis in the group with qi deficiency and blood stasis were higher than those in the intermingled phlegm and blood-stasis group. The levels of serum VEGF and endothelin1 increased with the increase of the blood-stasis and Gensini scores, whereas the level of insulin-like growth factor-1 decreased with the increase of the blood-stasis and Gensini scores. Thus, the coronary Gensini score is in correlation with the VEGF level and blood-stasis score.