Spanish Journal of Psychiatry and Mental Health最新文献

{"title":"Role of inflammatory genes in antidepressant-induced sexual dysfunction.","authors":"Carlo Alemany, Maria Jesús Arranz, Ángel Luis Montejo, Núria Cullell, Alexandre Serra-Llovich, Santiago Duran-Sindreu, Rosa Sauras, Mar Carceller-Sindreu, Juliana Salazar, Dolors Puigdemont, Narcís Cardoner, Maria Jesus Portella, Javier de Diego-Adeliño","doi":"10.1016/j.sjpmh.2026.08.002","DOIUrl":"10.1016/j.sjpmh.2026.08.002","url":null,"abstract":"<p><strong>Introduction: </strong>Sexual dysfunction (SD) is a frequent adverse effect of antidepressants, affecting 20-70% of patients. Although some studies have examined serotonergic, dopaminergic, and glutamatergic gene variants, results remain inconclusive. Given the role of inflammatory cytokines in antidepressant response, their genetic variants may also influence SD. The aim of this study is to investigate associations between inflammatory cytokine gene variants and antidepressant-induced SD.</p><p><strong>Materials and methods: </strong>A total of 99 Caucasian patients (51 women, 48 men) in remission or with mild depressive or anxiety symptoms and receiving stable SSRI or SNRI monotherapy were recruited. Participants completed a semistructured interview, clinical assessments, and the Psychotropic-Related Sexual Dysfunction Questionnaire (PRSexDQ-SALSEX). DNA samples were genotyped for 61 single nucleotide polymorphisms (SNPs) in 9 cytokine-related genes (IL-1β, IL-2, IL-6, IL-6R, IL-8, IL-10, IL-18, TNF-α, IFN-γ). Analyses included linear and logistic regression, adjusting for age, sex, antidepressant type, dose, and treatment duration. Primary endpoints included the presence and severity of SD, with secondary outcomes focusing on associations between specific SNPs and SD subdomains.</p><p><strong>Results: </strong>SD was reported by 78.8% of participants, and 57.6% experienced moderate-to-severe impairment; 60.8% did not report symptoms spontaneously. Significant associations were found between SD and polymorphisms in TNF-α, IL-2, IL-1β, IL-6, and IL-18. The TNF-α rs1799724-T allele was associated with a lower risk of SD, particularly delayed orgasm and absence of orgasm, whereas rs1799964-C was associated with an increased risk. The rs361525-A variant showed a protective effect against decreased libido. A TNF-α haplotype (rs1799724-T, rs1799964-T, rs1800629-G, rs3093664-A, rs361525-G) was inversely related to SD scores. IL-2 rs3136534-G increased SD risk, whereas rs1479923-A was protective. IL-1β haplotypes were associated with reduced sexual desire and dysfunction.</p><p><strong>Conclusions: </strong>This study provides novel evidence linking inflammatory cytokine gene variants, especially TNF-α, to antidepressant-induced SD. These findings support further research into immune-genetic mechanisms underlying antidepressant-associated sexual adverse effects.</p>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149129767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific effects of the rs9896243 single nucleotide polymorphism on verbal memory in first episode psychosis: A family-based approach.","authors":"Rosa Ayesa-Arriola, Noelia Rodríguez-Pérez, Daniel Herrera-Escartín, Covadonga García-San Nicolás, Sergi Papiol, Mar Fatjó-Vilas","doi":"10.1016/j.sjpmh.2026.08.001","DOIUrl":"10.1016/j.sjpmh.2026.08.001","url":null,"abstract":"<p><strong>Background: </strong>Sex differences in verbal memory (VM) are well documented in schizophrenia spectrum disorders, with women typically outperforming men, especially in early illness stages. A previous genome-wide association study identified the SNP rs9896243 in the NSF gene as linked to VM performance in the general population. Here, we investigate its role in a family-based first-episode psychosis (FEP) cohort, focusing on interactions with sex and diagnostic status.</p><p><strong>Methods: </strong>A total of 486 participants completed the Spanish version of Rey Auditory Verbal Learning Test (RAVLT). Mixed-effects models assessed associations between rs9896243 genotypes and VM outcomes, testing interactions by sex and clinical status. Variant functional annotation was carried out using the Variant Effect Predictor, with integrated eQTL and sQTL information derived from the Genotype-Tissue Expression (GTEx) project and gene enrichment analysis.</p><p><strong>Results: </strong>Female C-allele carriers in the control and sibling groups showed significantly higher scores in immediate, short-delay, and long-delay recall tasks compared to males. However, this female advantage was not observed in FEP patients. Notably, male FEP patients carrying the C allele demonstrated the most pronounced recognition deficits. Functional annotation data implicated brain-region-specific regulation of ARL17A, MAPT, CRHR1, and KANSL1, genes involved in memory-related pathways.</p><p><strong>Conclusions: </strong>Our findings extend previous genomic data identifying the role of NSF gene in VM performance by showing a sex-specific genetic influence of rs9896243 that differs between FEP patients and unaffected individuals, with female C-allele carriers outside the FEP group showing a better cognitive performance Although the functional annotations are exploratory and should be considered hypothesis-generating, they suggest that rs9896243 plays a role in brain regulatory networks essential for cognitive function, with potential implications for sex-informed early detection strategies in psychosis.</p>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149129772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mentally passive, but not mentally active, sedentary behavior is associated with depressive symptoms: A dose-response analysis.","authors":"Adriana Assunção, Alexandre Silva Martins, Felipe Barreto Schuch, Brendon Stubbs, Lucas Melo Neves, Paula da S Queiroz, Carolina Nunes França, Bruno Gualano, Hamilton Roschel, Saulo Gil","doi":"10.1016/j.sjpmh.2026.07.005","DOIUrl":"10.1016/j.sjpmh.2026.07.005","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149129792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health impact of COVID-19 among Spanish health care workers: A 3-year longitudinal study (MINDCOVID).","authors":"J Alonso, G Vilagut, F Amigo, M Ruiz-Rivera, M Ferrer, A Aragón-Peña, E Aragonès, M Campos, I Del Cura-González, I Urreta, M J Forjaz, A González Pinto, J M Haro, N López Fresneña, A Martínez de Salázar, J D Molina, R M Ortí Lucas, M Parellada, J M Pelayo-Terán, A Pérez Zapata, M N Plana, T Puig, C Rius, C Rodriguez-Blazquez, F Sanz, C Serra, R C Kessler, R Bruffaerts, E Vieta, V Pérez-Solá, P Mortier","doi":"10.1016/j.sjpmh.2026.06.006","DOIUrl":"10.1016/j.sjpmh.2026.06.006","url":null,"abstract":"<p><strong>Aims: </strong>We assessed the trajectory of adverse mental health outcomes of Spanish healthcare workers (HCWs) during three years after the COVID-19 pandemic initiation, and their association with distal and proximal risk factors.</p><p><strong>Methods: </strong>A prospective cohort of HCWs from 18 Spanish institutions was assessed seven times between May 2020 and June 2023 through institutional web-based surveys. Outcomes included: (1) any probable mental disorder (MDx)-depression (PHQ-8 ≥10), anxiety (GAD-7 ≥10), panic attack, post-traumatic stress disorder (PCL-5 ≥7), or substance use disorder (CAGE-AID ≥2); and (2) any suicidal thoughts or behaviors (STB, CSSRS). Risk factors comprised 11 distal (sociodemographic, professional, health-related) and 13 proximal (COVID-19 infection, work, health, financial, and family stressors) variables. Latent class growth analysis identified trajectories.</p><p><strong>Results: </strong>Four thousand eight hundred nine were followed. Most were women (77.3%), hospital workers (57.6%), and nurses/nurse assistants (44.4%). Prevalence of any MDx declined from 45.5% (May-September 2020) to 31.2% (April-June 2023), while STB increased slightly from 8.4% to 9.4% (not significant). Common risk factors for MDx and STB were previous mental disorders, female gender, nurse assistant role, foreign-born status, primary care work, and physical comorbidities. Four trajectory classes were identified for both MDx and STB: persistent high (19.4%, 5.0%), decreasing from high prevalence (28.5%, 5.2%), increasing from low (5.9%, 4.2%), and persistent low (46.2%, 85.5%). Persistent high classes were associated with interpersonal stress, loved ones' health, lack of preparedness/protective equipment, and ethically challenging care decisions.</p><p><strong>Conclusions: </strong>Adverse mental health outcomes remained substantial among Spanish HCWs during three years of follow-up, about one in five showing persistently high burden. Continued monitoring and support are warranted.</p>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148946408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond repetitive behaviours: Recognising and treating OCD in autistic individuals.","authors":"David Mataix-Cols, Helene Ringberg, Ailsa Russell","doi":"10.1016/j.sjpmh.2026.07.004","DOIUrl":"10.1016/j.sjpmh.2026.07.004","url":null,"abstract":"<p><p>Obsessive-compulsive disorder (OCD) is one of the most common and impairing co-occurring conditions in autistic individuals, yet it is frequently under-recognised and undertreated. This clinical perspective examines the challenges of recognising, diagnosing, and managing OCD in autism. We discuss the overlap and important distinctions between autistic repetitive behaviours and OCD compulsions, highlighting the need for careful differential diagnosis to ensure that treatable OCD is identified without pathologising core autistic characteristics. We review the limited clinical trial evidence on autism-adapted cognitive behavioural therapy (CBT) for OCD, arguing that the scarcity of treatment trials is likely to reflect a lack of research rather than a lack of efficacy. We also consider barriers to accessing specialist care and discuss the potential of therapist-supported internet-delivered CBT to expand access to evidence-based treatment. Finally, we outline priorities for clinical practice and research, including improving recognition of OCD in autistic people, increasing their inclusion in treatment trials, and developing accessible, autism-adapted interventions.</p>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148908457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cumulative early adverse stress and age at depression onset in adult outpatients.","authors":"Sergio Gloger, Dante Diez de Medina, Paul A Vöhringer, Pablo Israel, Carolina Santis, Pablo Martínez","doi":"10.1016/j.sjpmh.2026.07.002","DOIUrl":"10.1016/j.sjpmh.2026.07.002","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148908479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Kanner saw but did not name: Sensory atypicalities in autism from 1943 to today.","authors":"Antonio Narzisi, Rosy Muccio, Pamela Fantozzi, Elena Valente, Greta Tolomei, Stefano Berloffa, Valentina Viglione, Annarita Milone, Gabriele Masi","doi":"10.1016/j.sjpmh.2026.07.003","DOIUrl":"10.1016/j.sjpmh.2026.07.003","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148908496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interventional psychiatry and neuromodulation in Spain: State of the art and a call to action.","authors":"Sergi López-Rodríguez, Iván Echeverria, Joan A Camprodon","doi":"10.1016/j.sjpmh.2026.06.005","DOIUrl":"10.1016/j.sjpmh.2026.06.005","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of the October 2024 flood in Valencia on subjects with psychotic spectrum disorders: A follow-up study.","authors":"Antonio Jovani, Pablo Navalón, Asier Adriasola, Belén Almansa, Alberto Domínguez, Luisa Luna, Pilar Benavent, Ana Catalán, Pilar Sierra, Ana García-Blanco","doi":"10.1016/j.sjpmh.2026.05.001","DOIUrl":"10.1016/j.sjpmh.2026.05.001","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Validation of the Adult Attachment Questionnaire-Revised (CAA-r)\" [Span J Psychiatry Ment Health. 17 (2024) 81-87].","authors":"Remedios Melero, María José Cantero","doi":"10.1016/j.sjpmh.2026.07.001","DOIUrl":"10.1016/j.sjpmh.2026.07.001","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148475527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}