Claudio Tamarit, Maria Pellicer-Roca, María Alias-Ferrí, Carlos Roncero, Javier Didia-Attas, Francina Fonseca, Julián Andrés Mateus, Joan I MestrePintó, Marta Torrens
{"title":"Sex differences and substance use in the onset of psychosis: Implications for early intervention.","authors":"Esther Hesline Palandi, Amândio de Araújo Sarmento, Muhammad Iqbal Fajri, Asep Setiawan, Gilbert Rely, Ardi Azhar Nampira, Yurika, Zeth Parinding, Erfan Ramadhani","doi":"10.1016/j.sjpmh.2025.07.003","DOIUrl":"10.1016/j.sjpmh.2025.07.003","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145025028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francisco Ferre, Marisol Roncero, Nestor Szerman, Ignacio Basurte-Villamor, Pablo Vega, Nicolas Nieves, Ignacio Civeira, Celso Arango
{"title":"A population-based screening program provides insights into the characteristics and behaviors of individuals who self-refer for gambling disorder.","authors":"Francisco Ferre, Marisol Roncero, Nestor Szerman, Ignacio Basurte-Villamor, Pablo Vega, Nicolas Nieves, Ignacio Civeira, Celso Arango","doi":"10.1016/j.sjpmh.2025.07.002","DOIUrl":"10.1016/j.sjpmh.2025.07.002","url":null,"abstract":"<p><strong>Introduction: </strong>Since only around 10% of people with gambling disorder (GD) seek professional treatment or attend self-help groups, multiple strategies are needed to improve this rate. The proposal of the Behavioral Addictions Center 'Adcom' (Madrid, Spain) is one such strategy, a pioneering and innovative program aimed at the general population to identify people with addictions such as GD, in an attempt to offer them appropriate evidence-based treatments.</p><p><strong>Materials and methods: </strong>We analyzed information obtained from the first 305 adults who voluntarily sought attention at Adcom for self-referred gambling, and conducted a descriptive, cross-sectional and observational study of this population.</p><p><strong>Results: </strong>A total of 265 of these 305 individuals were tagged as GD and were eventually included in the study, 87.2% of whom were men. The mean age of this sample was 36.9 years old and while 49.8% were treated for self-referred offline gambling addiction, the remaining 50.2% self-referred to online gambling addiction. Other psychopathological symptoms were evident in 57.4% of the participants, with a Global Severity Index T-score of 62.6 (± 12.2). Based on the SCL-90, depression (63.6%), psychoticism (62.6%), anxiety (66.7%) and obsession/compulsion (59.3%) were present in more than half of our participants, while 37.4% were diagnosed with ADHD. A multivariate regression analysis revealed that being born in Spain and excessive Internet use were independent predictors of online gambling addiction.</p><p><strong>Conclusions: </strong>This study of problem gamblers recruited in a non-clinical, self-referred setting confirms that GD is associated with an elevated presence of other mental disorders, identifying predictors of online and offline gambling addiction.</p>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145017049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muriel Vicent-Gil, Maria Serra-Blasco, Joan Trujols, Guillem Navarra-Ventura, Javier de Diego-Adeliño, Dolors Puigdemont, Carlo Alemany, Josefina Pérez, Maria J Portella, Narcís Cardoner
{"title":"Cognitive discrepancy patterns and their association with psychosocial functioning across affective disorders.","authors":"Muriel Vicent-Gil, Maria Serra-Blasco, Joan Trujols, Guillem Navarra-Ventura, Javier de Diego-Adeliño, Dolors Puigdemont, Carlo Alemany, Josefina Pérez, Maria J Portella, Narcís Cardoner","doi":"10.1016/j.sjpmh.2025.05.001","DOIUrl":"10.1016/j.sjpmh.2025.05.001","url":null,"abstract":"<p><strong>Introduction: </strong>Individuals with major depressive disorder (MDD) and bipolar disorder (BD) frequently exhibit a disagreement between self-reported and objectively measured cognitive performance. Research suggests that these cognitive discrepancies may vary across disorders and are not exclusive to a specific diagnosis, potentially being influenced by clinical and sociodemographic factors. Overestimating cognitive abilities is associated with better psychosocial functioning in depression, whereas heightened sensitivity to cognitive deficits correlates with worse functioning. However, these phenomena remain underexplored in both depression and bipolar disorder.</p><p><strong>Materials and methods: </strong>We conducted a cross-sectional study of 200 participants, including 160 patients in full or partial clinical remission (94 with MDD and 66 with BD) and 40 healthy controls. Sociodemographic, clinical, and functional variables were collected, along with both subjective and objective cognitive measures. We conducted a multivariate binary logistic regression to identify factors associated with cognitive discrepancy patterns (under- vs overestimation). Finally, a two-way ANOVA tested the interaction between diagnosis and cognitive discrepancy patterns on psychosocial functioning.</p><p><strong>Results: </strong>Patients with MDD tend to underestimate their cognitive abilities, while bipolar patients often overestimate theirs. Patients with higher depressive symptoms (B=-.045, p=.040) and higher intellectual level (B=-.241, p=<.001) report more subjective cognitive disturbances. Worse psychosocial functioning is not associated with underestimation but rather with the diagnosis itself (F=.63, p=.431), with bipolar disorder patients experiencing the most significant impact on daily functioning.</p><p><strong>Conclusions: </strong>Personalized cognitive assessments, integrating both objective and subjective measures, are of paramount importance to avoid generalizations and to accurately evaluate cognitive symptoms in patients with affective disorders.</p>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144985218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Potential duplicate cases in the official suicide statistics reported by the Spanish National Statistics Institute (INE).","authors":"Sergio Sanz Gómez, Julio A Guija, Lucas Giner","doi":"10.1016/j.sjpmh.2025.07.001","DOIUrl":"10.1016/j.sjpmh.2025.07.001","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144985139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mar Sabater-Garcia, Jessica Acosta-Cabello, Anna Borja-Lloret, Sandra Ortigosa-Gómez, Amaia Bilbao-Garitagoitia, Mª Ángeles López-Vílchez
{"title":"Impact of the SARS-CoV-2 pandemic on pediatric suicide attempts in an emergency department.","authors":"Mar Sabater-Garcia, Jessica Acosta-Cabello, Anna Borja-Lloret, Sandra Ortigosa-Gómez, Amaia Bilbao-Garitagoitia, Mª Ángeles López-Vílchez","doi":"10.1016/j.sjpmh.2025.04.003","DOIUrl":"10.1016/j.sjpmh.2025.04.003","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144639182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pablo L. Martino , Matias M. Pulopulos , Celia Del Canto , María L. Dupanlou , Stella M. Rubio , José L. Bonet
{"title":"High levels of TNF-α are associated with symptoms of depression in health professionals at a hospital","authors":"Pablo L. Martino , Matias M. Pulopulos , Celia Del Canto , María L. Dupanlou , Stella M. Rubio , José L. Bonet","doi":"10.1016/j.rpsm.2021.10.002","DOIUrl":"10.1016/j.rpsm.2021.10.002","url":null,"abstract":"<div><h3>Objective</h3><div>The current evidence indicates that inflammation is highly related to depression but not to anxiety in clinical samples. However, less understood is the relationship between inflammation and symptoms of depression and anxiety in a nonclinical sample. The aim of this study was to investigate the association between three inflammation markers and symptoms of depression and anxiety in a healthy sample without a history of psychiatric disorders.</div></div><div><h3>Methods</h3><div>Symptoms of depression and anxiety were evaluated in 74 healthy adults (mean age<!--> <!-->=<!--> <!-->42.3; SD<!--> <!-->=<!--> <span>11.8) using the Hospital Anxiety and Depression Scale<span><span>. We assessed proinflammatory cytokines (TNF-α, IL-1β, and CRP), and morning </span>cortisol levels using blood samples.</span></span></div></div><div><h3>Results</h3><div>TNF-α correlates positively with depressive symptoms, but there were no significant relationships between anxiety scores and inflammation markers. Importantly, TNF-α relates to symptoms of depression independently of anxiety scores, age, body mass index<span>, cortisol, and sex.</span></div></div><div><h3>Conclusions</h3><div>Our results indicate that TNF-α is associated with depressive symptoms, independently of anxiety, age, body mass index<span>, cortisol, and sex, even in a sample of hospital health professionals without diagnosis or psychiatric history.</span></div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"18 3","pages":"Pages 169-173"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74959091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Associations between unhealthy lifestyle and depression: Cross-sectional results from the Spanish National Health Survey","authors":"Guillem Navarra-Ventura , Victoria Coronado-Simsic , Pau Riera-Serra , Adoración Castro , Mauro García-Toro , Miquel Roca , Margalida Gili","doi":"10.1016/j.sjpmh.2023.08.001","DOIUrl":"10.1016/j.sjpmh.2023.08.001","url":null,"abstract":"<div><h3>Introduction</h3><div>Depression usually worsens lifestyle habits, but previous evidence also suggests that an unhealthy lifestyle (UL) increases the risk of depression. Many studies have analyzed the association between lifestyle and depression in several nationally representative samples, but none have done so in the Spanish adult population. Our aim was to examine the associations between UL habits and depression in Spain.</div></div><div><h3>Materials and methods</h3><div>Analysis of cross-sectional data from the latest National Health Survey published in 2018 (<em>N</em> <!-->=<!--> <!-->23,089). Data on depression and 4 lifestyle factors (diet, physical exercise, smoking, and alcohol consumption) were used. These factors were combined into an UL index ranging from 0 (healthiest lifestyle) to 4 (unhealthiest lifestyle). The prevalence of depression at different levels of the UL index, and the association between depression and both the cumulative UL index and the 4 UL factors was analyzed using parametric and non-parametric tests.</div></div><div><h3>Results</h3><div>Sedentarism was the most prevalent UL factor, followed by unhealthy diet, smoking and high-risk alcohol consumption. Having ≥1 UL factors was associated with a higher prevalence of depression compared to having 0 UL factors (2.5% vs. ≥5.2%), regardless of the cumulative number UL factors (1, 2, 3 or 4). Being physically inactive (OR<!--> <!-->=<!--> <!-->1.6) and a smoker (OR<!--> <!-->=<!--> <!-->1.3) increased the likelihood of depression. Being a high-risk wine drinker (OR<!--> <!-->=<!--> <!-->0.26) decreased the likelihood of depression. Dietary intake was not significant.</div></div><div><h3>Conclusions</h3><div>The prevalence of depression changes depending on several modifiable lifestyle factors. Policy makers should therefore spare no resources in promoting strategies to encourage healthy lifestyles and prevent the acquisition of UL habits.</div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"18 3","pages":"Pages 191-198"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134937291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ricardo Corral , Enrique Bojórquez , Marcelo Cetkovich-Bakmas , Rodrigo Córdoba , Julio Chestaro , Clarissa Gama , Gerardo García Bonetto , Carlos López Jaramillo , Ricardo Alberto Moreno , Bernardo Ng , Edilberto Pena de Leon , Luis Risco , Hernán Silva , Gustavo Vazquez
{"title":"Latin American consensus recommendations for the management and treatment of patients with treatment-resistant depression (TRD)","authors":"Ricardo Corral , Enrique Bojórquez , Marcelo Cetkovich-Bakmas , Rodrigo Córdoba , Julio Chestaro , Clarissa Gama , Gerardo García Bonetto , Carlos López Jaramillo , Ricardo Alberto Moreno , Bernardo Ng , Edilberto Pena de Leon , Luis Risco , Hernán Silva , Gustavo Vazquez","doi":"10.1016/j.sjpmh.2023.06.001","DOIUrl":"10.1016/j.sjpmh.2023.06.001","url":null,"abstract":"<div><div>Despite the abundance of literature on treatment-resistant depression (TRD), there is no universally accepted definition of TRD, and available treatment pathways for the management of TRD vary across the Latin American region, highlighting the need for a uniform definition and treatment principles to optimize the management of TRD in Latin America.</div></div><div><h3>Methods</h3><div>Following a thematic literature review and pre-meeting survey, a Latin America expert panel comprising 14 psychiatrists with clinical experience in managing patients with TRD convened and utilized the RAND/UCLA appropriateness method to develop consensus-based recommendations on the appropriate definition of TRD and principles for its management.</div></div><div><h3>Results</h3><div><span>The expert panel agreed that ‘treatment-resistant depression’ (TRD) is defined as ‘failure of two drug treatments of adequate doses, for 4–8 weeks duration with adequate adherence, during a major depressive episode’. A stepwise treatment approach should be employed for the management of TRD – treatment strategies can include maximizing dose, switching to a different class, and augmenting or combining treatments. Nonpharmacological treatments, such as </span>electroconvulsive therapy, are also appropriate options for patients with TRD.</div></div><div><h3>Conclusion</h3><div>These consensus recommendations on the operational definition of TRD and approved treatments for its management can be adapted to local contexts in the Latin American countries but should not replace clinical judgement. Individual circumstances and benefit–risk balance should be carefully considered while determining the most appropriate treatment option for patients with TRD.</div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"18 3","pages":"Pages 208-215"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135429468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A psychiatrist in the court of Philip II of Spain: Mental medicine in the work of Francisco Valles (1524–1592)","authors":"David Fraguas","doi":"10.1016/j.sjpmh.2024.08.001","DOIUrl":"10.1016/j.sjpmh.2024.08.001","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"18 3","pages":"Pages 155-157"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}