Spanish Journal of Psychiatry and Mental Health最新文献

{"title":"Impact of the SARS-CoV-2 pandemic on pediatric suicide attempts in an emergency department.","authors":"Mar Sabater-Garcia, Jessica Acosta-Cabello, Anna Borja-Lloret, Sandra Ortigosa-Gómez, Amaia Bilbao-Garitagoitia, López-Vílchez, Mª Ángeles","doi":"10.1016/j.sjpmh.2025.04.003","DOIUrl":"10.1016/j.sjpmh.2025.04.003","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144639182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive performance as a health indicator: Lessons from the Spanish version of the mini-mental.","authors":"Antonio Lobo","doi":"10.1016/j.sjpmh.2025.04.001","DOIUrl":"10.1016/j.sjpmh.2025.04.001","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxytocin and rejection sensitivity: A comparative biomarker study in women with borderline personality and eating disorders.","authors":"Francisco Ruiz-Guerrero, Andrés Gomez Del Barrio, Alejandro de la Torre-Luque, Karina MacDowell, Luis Beato-Fernández, Leticia Castro Fuentes, Wala Ayad-Ahmed, Pablo Mola, Álvaro Carrasco-Díaz, José Manuel Lopez-Villatoro, Juan C Leza, José Luis Carrasco, Marina Diaz-Marsa","doi":"10.1016/j.sjpmh.2025.04.002","DOIUrl":"10.1016/j.sjpmh.2025.04.002","url":null,"abstract":"<p><strong>Background: </strong>Emotional dysregulation is a hallmark feature of borderline personality disorder (BPD) and eating disorders (ED), which impacts the individuals' well-being and functioning. Oxytocin dysregulation has been involved in social cognition deficits associated with these disorders.</p><p><strong>Methods: </strong>We conducted a study including a total 108 women categorized into 3 groups: 50 with eating disorders (ED), 35 with borderline personality disorder (BPD), and 23 healthy controls. Psychopathological profiles were assessed using the Bulimic Investigatory Test Edinburgh (BITE), the Eating Attitude Test 40 (EAT-40), the Barratt Impulsiveness Scale (BIS-11), and the Rejection Sensitivity Questionnaire (RSQ). Plasma oxytocin levels and oxytocin receptor expression were measured as well.</p><p><strong>Results: </strong>BPD patients exhibited significantly lower plasma oxytocin levels vs ED patients and healthy controls. However, oxytocin receptor expression did not differ significantly across the groups. Oxytocin levels were positively associated with rejection sensitivity, particularly in BPD patients.</p><p><strong>Conclusions: </strong>Our findings suggest a potential role of oxytocin dysregulation in emotional dysregulation and rejection sensitivity, particularly in BPD. Higher oxytocin levels in ED patients may serve as a compensatory mechanism to mitigate challenges in interpersonal relationships. These results highlight the importance of personalized therapeutic interventions targeting oxytocin dysregulation in the management of ED and BPD.</p>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are patients with depression exposed to less light than healthy controls?","authors":"Aida Martín-Reina, Anna Riera-Gimeno, José Angel Rubiño, Maria Cristina Nicolau, Francesca Canellas","doi":"10.1016/j.sjpmh.2025.03.002","DOIUrl":"10.1016/j.sjpmh.2025.03.002","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic and epigenetic changes to the glucocorticoid receptor gene (NR3C1) and cognition in major depressive disorder.","authors":"Alex Ferrer, Javier Labad, Neus Salvat-Pujol, Mikel Urretavizcaya, Roser Obrador-Font, José M Menchón, Diego Palao, Carles Soriano-Mas, Javier Costas, Marta Barrachina, Ángel Carracedo, Virginia Soria","doi":"10.1016/j.sjpmh.2024.12.002","DOIUrl":"10.1016/j.sjpmh.2024.12.002","url":null,"abstract":"<p><strong>Introduction: </strong>Many studies have found that hypothalamic-pituitary-adrenal (HPA) axis abnormalities are related to the pathophysiology of major depressive disorder (MDD) and cognitive functioning. Our aim was to assess the influence of genetic polymorphisms and methylation levels in three different promoter regions throughout the glucocorticoid receptor (GR) gene NR3C1 on cognitive performance in MDD. Plausible interactions with childhood adversity and mediation relationships between genetic and epigenetic variables were explored.</p><p><strong>Materials and methods: </strong>The sample included a total of 64 MDD patients and 82 healthy controls. Child maltreatment and neurocognitive performance were assessed in all participants. HPA negative feedback was analyzed using the dexamethasone suppression test after the administration of 0.25mg of dexamethasone. A total of 23 single-nucleotide polymorphisms were genotyped, and methylation levels at several CpGs in exons 1D, 1F and 1H of the GR gene were measured.</p><p><strong>Results: </strong>Results show that, beyond the influence of other covariables, NR3C1 single-nucleotide polymorphisms and methylation levels predicted performance in executive functioning and working memory tasks. No significant interactions or mediation relationships were detected.</p><p><strong>Conclusions: </strong>Results suggest that genetic variations and epigenetic regulation of the GR gene are relevant factors influencing cognitive performance in MDD and could emerge as significant biomarkers and therapeutic targets in mood disorders and other stress-related disorders.</p>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic pathways and mortality across psychotic disorders: Evidence from Catalonia integrated health records.","authors":"Santiago Madero, Gerard Anmella, Michele De Prisco, Vincenzo Oliva, Clàudia Valenzuela-Pascual, Ariadna Mas, Giovanna Fico, Andrea Murru, Marc Valentí, Jordi Blanch, Clemente Garcia-Rizo, Vicent Llorca-Bofí, Silvia Amoretti, Norma Verdolini, Miquel Bioque, Eduard Parellada, Eduard Vieta, Diego Hidalgo-Mazzei","doi":"10.1016/j.sjpmh.2025.02.001","DOIUrl":"10.1016/j.sjpmh.2025.02.001","url":null,"abstract":"<p><strong>Introduction: </strong>Although psychotic disorders are associated with significant morbidity and mortality, the diagnostic trajectories and mortality risks across the spectrum of these disorders remain poorly understood. This study aimed to characterize diagnostic pathways and compare mortality outcomes across psychotic disorders in Catalonia.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study using electronic health records of 357,007 adults accessing mental health services in Catalonia from 2015 through 2019. Diagnostic categories included schizophrenia, bipolar disorder, schizoaffective disorder, delusional disorder, other non-organic psychoses, unipolar psychotic depression, and other mental health diagnoses. Cox proportional hazards models assessed mortality risk, adjusting for sociodemographic factors and comorbidities.</p><p><strong>Results: </strong>About one-third of the sample received their first psychotic disorder diagnosis in specialized care. All psychotic disorders showed elevated mortality risk vs other mental health conditions. Schizophrenia had the highest risk (HR, 2.63; 95%CI, 2.46-2.81, p<0.001 followed by schizoaffective (HR, 1.99; 95%CI, 1.77-2.24, p<0.001) and delusional disorders (HR, 1.92; 95%CI, 1.66-2.21, p<0.001). Low socioeconomic status (HR, 3.69; 95%CI, 3.48-3.92, p<0.001) and comorbidities (HR, 1.82 per comorbidity; 95%CI, 1.81-1.83, p<0.001) were significant predictors of mortality across diagnoses. Gradient boosting machine modeling identified comorbidities (56.07%) and diagnostic category (24.51%) as top predictors of mortality risk.</p><p><strong>Conclusions: </strong>This study demonstrates significantly elevated mortality risk across the spectrum of psychotic disorders in a Southern European context, with socioeconomic factors and medical comorbidities emerging as critical determinants. These findings underscore the need for integrated care approaches addressing both mental and physical health needs in psychotic disorders.</p>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient's determinants of subjective and objective burden in caregivers of people with first episode psychosis","authors":"Imke Dachs ,&nbsp;Marcia Irazabal ,&nbsp;Helena García-Mieres ,&nbsp;Nuria Del Cacho ,&nbsp;Judith Usall ,&nbsp;Ana Barajas ,&nbsp;Montserrat Dolz ,&nbsp;Bernardo Sánchez ,&nbsp;Iris Baños ,&nbsp;Elena Huerta-Ramos ,&nbsp;Silvia Marco-García ,&nbsp;Janina Carlson ,&nbsp;Marta Coromina ,&nbsp;GENIPE GROUP and Susana Ochoa","doi":"10.1016/j.rpsm.2022.04.003","DOIUrl":"10.1016/j.rpsm.2022.04.003","url":null,"abstract":"<div><h3>Background</h3><div>Understanding if there are differential determinants of objective and subjective burdening in caregivers of first episode psychosis (FEP) patients would be essential to optimize current early support programs. Our aim was to elucidate the clinical and sociodemographic characteristics of FEP patients that influence the objective and subjective burdening of their informal caregivers.</div></div><div><h3>Materials and methods</h3><div>75 participants with FEP were assessed in social functioning and psychotic symptoms. Their caregivers were assessed with an instrument of objective and subjective family burden. Objective burdening was assessed in terms of time spent. Subjective burden was assessed in terms of worry experienced.</div></div><div><h3>Results</h3><div><span>Regression analyses<span> showed that impaired social functioning of the patient was the major determinant of family burdening, in assisting in daily activities and containing disrupted behavior. Excitative symptoms were more determinant than </span></span>positive symptoms in explaining burdening when containing disrupted behavior. A younger age of the patient specifically determined higher subjective but not objective burdening. Economic incomes had little contribution to family burdening.</div></div><div><h3>Conclusions</h3><div>Our results suggest that there may not be differential determinants of objective and subjective burdening on domains of family burdening in FEP. Current multicomponent early interventions may consider social functioning and excitative symptoms the factors that may focus on to reduce both objective and subjective family burdening. Caregivers of youngest patients may need additional psychological support as they care of patients with higher dependency level and involving more subjective burdening.</div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"18 2","pages":"Pages 72-79"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72947179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individualized pretest risk estimates to guide treatment decisions in patients with clinical high risk for psychotic disorders","authors":"Elodie Sprüngli-Toffel ,&nbsp;Erich Studerus ,&nbsp;Logos Curtis ,&nbsp;Caroline Conchon ,&nbsp;Luis Alameda ,&nbsp;Barbara Bailey ,&nbsp;Camille Caron ,&nbsp;Carmina Haase ,&nbsp;Julia Gros ,&nbsp;Evelyn Herbrecht ,&nbsp;Christian G. Huber ,&nbsp;Anita Riecher-Rössler ,&nbsp;Philippe Conus ,&nbsp;Alessandra Solida ,&nbsp;Marco Armando ,&nbsp;Afroditi Kapsaridi ,&nbsp;Mathieu Mercapide Ducommun ,&nbsp;Paul Klauser ,&nbsp;Kerstin Jessica Plessen ,&nbsp;Sébastien Urben ,&nbsp;Christina Andreou","doi":"10.1016/j.sjpmh.2024.09.001","DOIUrl":"10.1016/j.sjpmh.2024.09.001","url":null,"abstract":"<div><h3>Introduction</h3><div>Clinical high risk for psychosis (CHR) states are associated with an increased risk of transition to psychosis. However, the predictive value of CHR screening interviews is dependent on pretest risk enrichment in referred patients. This poses a major obstacle to CHR outreach campaigns since they invariably lead to risk dilution through enhanced awareness. A potential compensatory strategy is to use estimates of individual pretest risk as a ‘gatekeeper’ for specialized assessment. We aimed to test a risk stratification model previously developed in London, UK (OASIS) and to train a new predictive model for the Swiss population.</div></div><div><h3>Method</h3><div>The sample was composed of 513 individuals referred for CHR assessment from six Swiss early psychosis detection services. Sociodemographic variables available at referral were used as predictors whereas the outcome variable was transition to psychosis.</div></div><div><h3>Results</h3><div>Replication of the risk stratification model developed in OASIS resulted in poor performance (Harrel's <em>c</em> <!-->=<!--> <!-->0.51). Retraining resulted in moderate discrimination (Harrel's <em>c</em> <!-->=<!--> <!-->0.67) which significantly differentiated between different risk groups. The lowest risk group had a cumulative transition incidence of 6.4% (CI: 0–23.1%) over two years.</div></div><div><h3>Conclusion</h3><div>Failure to replicate the OASIS risk stratification model might reflect differences in the public health care systems and referral structures between Switzerland and London. Retraining resulted in a model with adequate discrimination performance. The developed model in combination with CHR assessment result, might be useful for identifying individuals with high pretest risk, who might benefit most from specialized intervention.</div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"18 2","pages":"Pages 133-140"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternity in women with schizophrenia and schizoaffective disorder","authors":"Gemma Safont ,&nbsp;Marina Garriga ,&nbsp;Alexandre González-Rodríguez ,&nbsp;Silvia Amoretti ,&nbsp;Olga Simón ,&nbsp;Eva Solè ,&nbsp;Clemente Garcia-Rizo ,&nbsp;Belén Arranz ,&nbsp;Eduard Vieta ,&nbsp;Miquel Bernardo","doi":"10.1016/j.sjpmh.2023.04.002","DOIUrl":"10.1016/j.sjpmh.2023.04.002","url":null,"abstract":"<div><h3>Purpose</h3><div><span>Maternity rates in women with schizophrenia have tripled in the past decades, with a current percentage similar to the general population (50–60%). However, mothers with schizophrenia present higher rates of single marital status, and social dysfunction than the general population. In addition, the incidence of </span>unplanned pregnancy<span>, abortions, miscarriages and obstetric complications is higher.</span></div><div>This study aimed to describe variables related to maternity in this population.</div></div><div><h3>Methods</h3><div><span>One-hundred and ninety-two outpatient women diagnosed with schizophrenia and schizoaffective disorders were included (DSM-IV-TR criteria) in a two-site study. Psychosocial risk factors, demographic variables and </span>clinical features were recorded in the same visit. Non-parametric tests were used in order to describe variables for likelihood offspring in psychotic women.</div></div><div><h3>Results</h3><div>One-hundred and forty-seven (76.6%) women suffered from schizophrenia and 45 (23.4%) schizoaffective disorder. Psychotic mothers used to be married/having a partner and presented a later onset of the illness (over 36 years old) compared to non-mothers. In addition, mothers generally presented pregnancy before the onset of illness. Regarding obstetric complications, around the 80% of the sample presented at least one obstetric complication. Although desire or wish of pregnancy was reported in 66.3% of the mothers, rates of planned pregnancy were 25% and only the 47.9% were currently taking care of their children with their husband/partner.</div></div><div><h3>Conclusion</h3><div><span>Maternity rate is high in this population. This study highlights the need to promote reproductive health care for women with </span>mental disorders and to consider their reproductive life plan.</div><div>Later onset of disease and being married are potential predictors of maternity in our sample of women with a schizophrenia and schizoaffective disorders while only the half were caring their children at the moment of the evaluation.</div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"18 2","pages":"Pages 106-110"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135890038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting first-episode psychosis and schizophrenia through a multidimensional and longitudinal lens","authors":"Benedicto Crespo-Facorro ,&nbsp;Emilio Fernandez-Egea","doi":"10.1016/j.sjpmh.2025.06.001","DOIUrl":"10.1016/j.sjpmh.2025.06.001","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"18 2","pages":"Pages 65-66"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144489502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}