Spanish Journal of Psychiatry and Mental Health最新文献

{"title":"Genetic and epigenetic variations of the glucocorticoid receptor gene (NR3C1) and cognition in major depressive disorder.","authors":"Alex Ferrer, Javier Labad, Neus Salvat-Pujol, Mikel Urretavizcaya, Roser Obrador-Font, José M Menchón, Diego Palao, Carles Soriano-Mas, Javier Costas, Marta Barrachina, Ángel Carracedo, Virginia Soria","doi":"10.1016/j.sjpmh.2024.12.002","DOIUrl":"https://doi.org/10.1016/j.sjpmh.2024.12.002","url":null,"abstract":"<p><strong>Introduction: </strong>Many studies have found that hypothalamic‒pituitary‒adrenal (HPA) axis abnormalities are related to the pathophysiology of major depressive disorder (MDD) and cognitive functioning. Our aim was to assess the influence of genetic polymorphisms and methylation levels in three different promoter regions throughout the glucocorticoid receptor (GR) gene NR3C1 on cognitive performance in MDD. Plausible interactions with childhood adversity and mediation relationships between genetic and epigenetic variables were explored.</p><p><strong>Materials and methods: </strong>The sample included 64 MDD patients and 82 healthy controls. Childhood maltreatment and neurocognitive performance were assessed in all participants. HPA negative feedback was analysed using the dexamethasone suppression test after the administration of 0.25 mg of dexamethasone. Twenty-three single-nucleotide polymorphisms were genotyped, and methylation levels at several CpGs in exons 1D, 1F and 1H of the GR gene were measured.</p><p><strong>Results: </strong>The results show that, beyond the influence of other covariables, NR3C1 single-nucleotide polymorphisms and methylation levels predicted performance in executive functioning and working memory tasks. No significant interactions or mediation relationships were detected.</p><p><strong>Conclusions: </strong>The results suggest that genetic variations and epigenetic regulation of the GR gene are relevant factors influencing cognitive performance in MDD and could emerge as significant biomarkers and therapeutic targets in mood disorders and other stress-related disorders.</p>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic pathways and mortality across psychotic disorders: evidence from Catalonia integrated health records.","authors":"Santiago Madero, Gerard Anmella, Michele De Prisco, Vincenzo Oliva, Clàudia Valenzuela-Pascual, Ariadna Mas, Giovanna Fico, Andrea Murru, Marc Valentí, Jordi Blanch, Clemente Garcia-Rizo, Vicent Llorca-Bofí, Silvia Amoretti, Norma Verdolini, Miquel Bioque, Eduard Parellada, Eduard Vieta, Diego Hidalgo-Mazzei","doi":"10.1016/j.sjpmh.2025.02.001","DOIUrl":"https://doi.org/10.1016/j.sjpmh.2025.02.001","url":null,"abstract":"<p><strong>Introduction: </strong>Although pychotic disorders are associated with significant morbidity and mortality, the diagnostic trajectories and mortality risks across the spectrum of these disorders remain poorly understood. This study aimed to characterize diagnostic pathways and compare mortality outcomes across psychotic disorders in Catalonia.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study using electronic health records of 357,007 adults accessing mental health services in Catalonia from 2015 through 2019. Diagnostic categories included schizophrenia, bipolar disorder, schizoaffective disorder, delusional disorder, other non-organic psychoses, unipolar psychotic depression, and other mental health diagnoses. Cox proportional hazards models assessed mortality risk, adjusting for sociodemographic factors and comorbidities.</p><p><strong>Results: </strong>About one-third of the sample received their first psychotic disorder diagnosis in specialized care. All psychotic disorders showed elevated mortality risk vs other mental health conditions. Schizophrenia had the highest risk (HR, 2.63; 95%CI, 2.46-2.81, p < 0.001 followed by schizoaffective (HR, 1.99; 95%CI, 1.77-2.24, p < 0.001) and delusional disorders (HR, 1.92; 95%CI, 1.66-2.21, p < 0.001). Low socioeconomic status (HR, 3.69; 95%CI, 3.48-3.92, p < 0.001) and comorbidities (HR, 1.82 per comorbidity; 95%CI, 1.81-1.83, p < 0.001) were significant predictors of mortality across diagnoses. Gradient boosting machine modeling identified comorbidities (56.07%) and diagnostic category (24.51%) as top predictors of mortality risk.</p><p><strong>Conclusions: </strong>This study demonstrates significantly elevated mortality risk across the spectrum of psychotic disorders in a Southern European context, with socioeconomic factors and medical comorbidities emerging as critical determinants. These findings underscore the need for integrated care approaches addressing both mental and physical health needs in psychotic disorders.</p>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal thickness: A window into cognitive impairment in bipolar disorder.","authors":"Juan Pablo Chart-Pascual, Guillermo Cano-Escalera, Manuel Graña, Iñaki Zorrilla, Purificacion Lopez-Peña, Carmen Martin Requena, Andrea Flores Ceballos, Irene Perez Landaluce, Haritz Urcola, Miguel Angel Alvarez-Mon, Hilary P Blumberg, Joaquim Radua, Ana Gonzalez-Pinto","doi":"10.1016/j.sjpmh.2025.01.001","DOIUrl":"10.1016/j.sjpmh.2025.01.001","url":null,"abstract":"<p><strong>Introduction: </strong>Cognitive impairment (CI) in bipolar disorder (BD) significantly impacts overall functioning and quality of life. A better understanding of the neurobiological mechanisms associated with CI is needed. Studies on neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, have revealed promising findings related to retinal thickness alterations using optical coherence tomography (OCT). Similarly, retinal differences between healthy controls and individuals with BD or schizophrenia have been described. This study explores the utility of OCT in discerning retinal changes possibly associated with CI in BD to enhance our understanding of the biological markers of BD and provide additional information to neuropsychological testing.</p><p><strong>Material and methods: </strong>Optical coherence tomography (OCT) was employed to measure retinal thickness in the macular ganglion cell layer (GCL), inner plexiform layer (IPL), retinal nerve fiber layer (RNFL), and peripapillary RNFL (pRNFL) in 50 individuals with bipolar disorder (BD). Associations with cognitive impairments were analyzed using cross-validated Random Forest models.</p><p><strong>Results: </strong>The analysis revealed significant associations between retinal thinning in various segments of the macular GCL, IPL, and RNFL and cognitive impairment (CI) in BD, with particular relevance to executive function deficits (AUC>0.8).</p><p><strong>Conclusions: </strong>Thinning of the GCL, IPL, and RNFL was significantly associated with worse cognitive performance in individuals with BD. Similar patterns have been observed in schizophrenia, highlighting an innovative and promising field for research and clinical application.</p>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability and validity of proxy reports of impulsivity and aggression: An evidence-based assessment approach to psychological autopsy methods","authors":"Sergio Sanz-Gómez ,&nbsp;Adrían Alacreu-Crespo ,&nbsp;Julio Antonio Guija ,&nbsp;Lucas Giner","doi":"10.1016/j.sjpmh.2023.10.003","DOIUrl":"10.1016/j.sjpmh.2023.10.003","url":null,"abstract":"<div><h3>Introduction</h3><div>Psychological autopsy methods often include measures of impulsivity and aggression. The aim is to assess their reliability and validity in a Spanish sample.</div></div><div><h3>Methods</h3><div>Cross-sectional web-based survey was fulfilled by 184 proband and proxy pairs. Data was collected on sociodemographic characteristics, impulsivity through Barratt Impulsiveness Scale (BIS-11), aggression through Buss–Perry Aggression Questionnaire (BPAQ), and history of suicide ideation. Proxies filled out BIS-11, BPAQ and suicide ideation with the responses they would expect from the probands. Reliability was assessed using intraclass correlation coefficients (ICC) between proband and proxies. Logistic regression analysis was performed to assess the predictive validity of proxy reports in predicting probands’ suicide ideation.</div></div><div><h3>Results</h3><div>Bivariate analysis showed differences in BPAQ (Median 68 vs. 62; <em>p</em> <!-->=<!--> <!-->0.001), but not in BIS-11 (<em>p</em> <!-->&gt;<!--> <!-->.050). BIS-11 showed good concordance (ICC<!--> <!-->=<!--> <!-->0.754; CI 95% 0.671–0.816) and BPAQ acceptable (ICC<!--> <!-->=<!--> <!-->0.592; CI 95% 0.442–0.699). In the probands regression model BPAQ predicted suicide ideation (OR 1.038; CI 95% 1.016–1.061) but not BIS-11 (OR 0.991; CI 95% 0.958–1.025). In the proxy-report model BPAQ also predicted probands’ suicide ideation (OR 1.036; CI 95% 1.014–1.058) but not BIS-11 (OR 0.973; CI 95% 0.942–1.004).</div></div><div><h3>Conclusion</h3><div>Used as proxy-reported assessment tools, BIS-11 showed better reliability than the BPAQ. However, both showed validity in Spanish population and could be included in psychological autopsy protocols.</div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"18 1","pages":"Pages 28-33"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138049125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in clinical response to deep brain stimulation in resistant obsessive-compulsive disorder","authors":"Lorea Mar-Barrutia ,&nbsp;Oliver Ibarrondo ,&nbsp;Javier Mar ,&nbsp;Eva Real ,&nbsp;Cinto Segalàs ,&nbsp;Sara Bertolín ,&nbsp;Marco Alberto Aparicio ,&nbsp;Gerard Plans ,&nbsp;José Manuel Menchón ,&nbsp;Pino Alonso","doi":"10.1016/j.sjpmh.2024.01.006","DOIUrl":"10.1016/j.sjpmh.2024.01.006","url":null,"abstract":"<div><h3>Introduction</h3><div>Deep brain stimulation (DBS) is an effective alternative to treat severe refractory obsessive-compulsive disorder (OCD), although little is known on factors predicting response. The objective of this study was to explore potential sex differences in the pattern of response to DBS in OCD patients.</div></div><div><h3>Methods</h3><div>We conducted a prospective observational study in 25 patients with severe resistant OCD. Response to treatment was defined as a ≥35% reduction in Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score. Logistic regression models were calculated to measure the likelihood of response at short and long-term follow-up by sex as measured by Y-BOCS score. Similar analyses were carried out to study changes in depressive symptomatology assessed with the Hamilton Depression Rating Scale (HDRS). Additionally, effect sizes were calculated to assess clinical significance.</div></div><div><h3>Results</h3><div>We did not observe significant clinical differences between men and women prior to DBS implantation, nor in the response after one year of stimulation. At long-term follow-up, 76.9% of men could be considered responders to DBS versus only 33.3% of women. The final response odds ratio in men was 10.05 with significant confidence intervals (88.90–1.14). No other predictors of response were identified. The sex difference in Y-BOCS reduction was clinically significant, with an effect size of 3.2. The main limitation was the small sample size.</div></div><div><h3>Conclusions</h3><div>Our results suggest that gender could influence the long-term response to DBS in OCD, a finding that needs to be confirmed in new studies given the paucity of results on predictors of response to DBS.</div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"18 1","pages":"Pages 34-41"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and fMRI-based response predictors to mindfulness-based cognitive therapy in obsessive-compulsive disorder: Study protocol for a randomised clinical trial","authors":"Neus Miquel-Giner ,&nbsp;Muriel Vicent-Gil ,&nbsp;Ignacio Martínez-Zalacaín ,&nbsp;Daniel Porta-Casteras ,&nbsp;Lorea Mar ,&nbsp;Marina López-Solà ,&nbsp;Jessica R. Andrews-Hanna ,&nbsp;Carles Soriano-Mas ,&nbsp;José Manuel Menchón ,&nbsp;Narcís Cardoner ,&nbsp;Pino Alonso ,&nbsp;Maria Serra-Blasco ,&nbsp;Clara López-Solà","doi":"10.1016/j.rpsm.2022.11.002","DOIUrl":"10.1016/j.rpsm.2022.11.002","url":null,"abstract":"<div><h3>Background</h3><div>Around 40–50% of patients with obsessive-compulsive disorder (OCD) suffer from obsessions and compulsions after receiving first-line treatments. Mindfulness-based cognitive therapy (MBCT) has been proposed as a reasonable augmentation strategy for OCD. MBCT trains to decentre from distressful thoughts and emotions by focusing on them voluntarily and with consciousness. This practice develops alternative ways to deal with obsessions, which could increase non-reactivity behaviours and, in turn, reduce compulsions. This study aims to investigate the efficacy of MBCT to improve OCD symptoms. Secondly, it pursues to investigate which socio-demographic, clinical, and neurobiological characteristics mediate or moderate the MBCT response; and identify potential biomarkers of positive/negative response.</div></div><div><h3>Methods</h3><div>This study is a randomised clinical trial (RCT) of 60 OCD patients who do not respond to first-line treatments. Participants will be randomised to either an MBCT program or treatment as usual. The MBCT group will undergo 10 weekly sessions of 120<!--> <!-->min. <em>Principal outcome</em>: change in OCD severity symptoms using clinician and self-reported measures. Also, participants will undergo a comprehensive evaluation assessing comorbid clinical variables, neuropsychological functioning and thought content. Finally, a comprehensive neuroimaging protocol using structural and functional magnetic resonance imaging will be acquired in a 3T scanner. All data will be obtained at baseline and post-intervention.</div></div><div><h3>Discussion</h3><div>This study will assess the efficacy of mindfulness in OCD patients who do not achieve clinical recovery after usual treatment. It is the first RCT in this subject examining clinical, neuropsychological and neuroimaging variables to examine the neural patterns associated with the MBCT response.</div><div>Clinical trials registration: <span><span>NCT03128749</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"18 1","pages":"Pages 6-12"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41238294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Koro-like syndrome in Huntington's disease","authors":"Saul Martinez-Horta ,&nbsp;Jesus Perez-Perez ,&nbsp;Jaime Kulisevsky","doi":"10.1016/j.rpsm.2023.01.006","DOIUrl":"10.1016/j.rpsm.2023.01.006","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"18 1","pages":"Pages 58-59"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49681819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obsessive–compulsive symptoms and disorder in clozapine-treated schizophrenia","authors":"Jonathan Gerard Hsueh Ching Seow ,&nbsp;Deborah Hui Yi Tan ,&nbsp;Yuen Mei See ,&nbsp;Jie Yin Yee ,&nbsp;Boon Tat Ng ,&nbsp;Charmaine Tang ,&nbsp;Jimmy Lee","doi":"10.1016/j.sjpmh.2023.10.001","DOIUrl":"10.1016/j.sjpmh.2023.10.001","url":null,"abstract":"<div><h3>Background</h3><div>Obsessive–compulsive symptoms (OCS) and obsessive–compulsive disorder (OCD) are commonly reported in patients with schizophrenia. Furthermore, the use of clozapine in treatment-resistant schizophrenia has been thought to induce or aggravate these disorders. To date, there is a paucity of research regarding the prevalence and associated factors. Hence, this study aims to report the prevalence of OCS and OCD, and examine potential risk factors, in clozapine-treated schizophrenia.</div></div><div><h3>Methods</h3><div>This is a cross-sectional study conducted in the only tertiary hospital for psychiatric patients in Singapore. In total, 162 patients on a stable dose of clozapine were recruited for this study; 159 patients with a diagnosis of schizophrenia or schizoaffective disorder were included in the current analysis. Sociodemographic, clinical and treatment factors were analysed to identify factors associated with OCS and OCD.</div></div><div><h3>Results</h3><div>The prevalence of OCS and OCD is 21.4% and 12.6% respectively. Factors associated with OCS include younger age (OR:0.96, <em>p</em> <!-->=<!--> <!-->0.033) and younger age of onset of psychosis (OR:0.92, <em>p</em> <!-->=<!--> <!-->0.017). There were no significant factors associated with OCD. However, in an analysis of both OCS and/or OCD, factors associated include younger age (OR:0.96, <em>p</em> <!-->=<!--> <!-->0.027) and younger age of onset of psychosis (OR:0.91, <em>p</em> <!-->=<!--> <!-->0.016). Severity of psychotic illness and Clozapine dose were not associated with OCS or OCD in clozapine-treated schizophrenia.</div></div><div><h3>Discussion &amp; conclusions</h3><div>Our results suggest a high prevalence of OCS and OCD in clozapine-treated schizophrenia which clinicians should routinely screen for. Further research is warranted to establish the link between the factors identified in this study and OCS/OCD in clozapine-treated schizophrenia.</div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"18 1","pages":"Pages 17-20"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71430790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New insights into prediction of OCD treatment response, DBS for treatment resistant schizophrenia and bipolar disorder, consensus for the practical management of depression and pain, and coping behaviours in times of crisis","authors":"David Mataix-Cols","doi":"10.1016/j.sjpmh.2025.03.001","DOIUrl":"10.1016/j.sjpmh.2025.03.001","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"18 1","pages":"Pages 1-2"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of pharmacological response in OCD using machine learning techniques and clinical and neuropsychological variables","authors":"Maria Tubío-Fungueiriño ,&nbsp;Eva Cernadas ,&nbsp;Manuel Fernández-Delgado ,&nbsp;Manuel Arrojo ,&nbsp;Sara Bertolin ,&nbsp;Eva Real ,&nbsp;José Manuel Menchon ,&nbsp;Angel Carracedo ,&nbsp;Pino Alonso ,&nbsp;Montse Fernández-Prieto ,&nbsp;Cinto Segalàs","doi":"10.1016/j.sjpmh.2024.11.001","DOIUrl":"10.1016/j.sjpmh.2024.11.001","url":null,"abstract":"<div><h3>Introduction</h3><div>Obsessive compulsive disorder is associated with affected executive functioning, including memory, cognitive flexibility, and organizational strategies. As it was reported in previous studies, patients with preserved executive functions respond better to pharmacological treatment, while others need to keep trying different pharmacological strategies.</div></div><div><h3>Material and methods</h3><div>In this work we used machine learning techniques to predict pharmacological response (OCD patients’ symptomatology reduction) based on executive functioning and clinical variables. Among those variables we used anxiety, depression and obsessive-compulsive symptoms scores by applying <em>State-Trait Anxiety Inventory</em>, <em>Hamilton Depression Rating Scale</em> and <em>Yale-Brown Obsessive Compulsive Scale</em> respectively, while <em>Rey-Osterrieth Complex Figure Test</em> was used to assess organisation skills and non-verbal memory; Digits’ subtests from <em>Wechsler Adult Intelligence Scale-IV</em> were used to assess short-term memory and working memory; and <em>Raven's Progressive Matrices</em> were applied to assess problem solving and abstract reasoning.</div></div><div><h3>Results</h3><div>As a result of our analyses, we created a reliable algorithm that predicts Y-BOCS score after 12 weeks based on patients’ clinical characteristics (sex at birth, age, pharmacological strategy, depressive and obsessive-compulsive symptoms, years passed since diagnostic and <em>Raven's Progressive Matrices</em> score) and Digits’ scores. A high correlation (0.846) was achieved in predicted and true values.</div></div><div><h3>Conclusions</h3><div>The present study proves the viability to predict if a patient would respond or not to a certain pharmacological strategy with high reliability based on sociodemographics, clinical variables and cognitive functions as short-term memory and working memory. These results are promising to develop future prediction models to help clinical decision making.</div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"18 1","pages":"Pages 51-57"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142650098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}