Spanish Journal of Psychiatry and Mental Health最新文献

{"title":"Depression and suicide: Untangling the web from epidemiology to mechanisms","authors":"Benedicto Crespo-Facorro , Gin S. Malhi","doi":"10.1016/j.sjpmh.2025.09.001","DOIUrl":"10.1016/j.sjpmh.2025.09.001","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"18 3","pages":"Pages 153-154"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortalidad por suicidio en España (1984-2018): análisis edad-período-cohorte","authors":"Lucia Cayuela ,&nbsp;Agustín Sánchez Gayango ,&nbsp;Paula Antona Sánchez-Trincado ,&nbsp;Susana Rodríguez-Domínguez ,&nbsp;Antonio Andrés Velasco Quiles ,&nbsp;Aurelio Cayuela","doi":"10.1016/j.rpsm.2020.05.010","DOIUrl":"10.1016/j.rpsm.2020.05.010","url":null,"abstract":"<div><h3>Objetivo</h3><div>Evaluar los efectos de la edad, período y cohorte sobre la tendencia de la mortalidad por suicidio en España (1984-2018).</div></div><div><h3>Métodos</h3><div>Los datos de mortalidad y población se obtuvieron del Instituto Nacional de Estadísticas. El análisis del efecto de la edad, el período de muerte y la cohorte de nacimiento sobre la evolución de la mortalidad por suicidio en el período 1984-2018 se realizó utilizando una herramienta web para el análisis edad-período-cohorte proporcionada por la División de Epidemiología y Genética del Cáncer del Instituto Nacional del Cáncer de EE. UU.</div></div><div><h3>Resultados</h3><div>Las tasas aumentan en función de la edad (efecto edad) en ambos sexos. El efecto período muestra, en los hombres, un aumento durante el período 1984-1998 seguido de un descenso significativo hasta 2018. En las mujeres, las tasas permanecen estables durante el período 1987-2002, descienden durante 2007-2012 (p &lt; 0,05) y se estabilizan al final. Tanto en hombres como en mujeres el riesgo disminuyó en cada cohorte de nacimiento sucesiva nacida entre 1904 y 1939. Posteriormente, los riesgos aumentaron hasta la cohorte de nacidos durante el período 1964-1974 a partir de los que el riesgo disminuye en los hombres y permanece estable en las mujeres.</div></div><div><h3>Conclusión</h3><div>Una mejor comprensión de los efectos de la cohorte de nacimiento podría abrir nuevas puertas a la prevención del suicidio.</div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"18 3","pages":"Pages 163-168"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38163481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective connectivity of the locus coeruleus in patients with late-life Major Depressive Disorder or mild cognitive impairment","authors":"Pablo Maturana-Quijada ,&nbsp;Pamela Chavarría-Elizondo ,&nbsp;Inés del Cerro ,&nbsp;Ignacio Martínez-Zalacaín ,&nbsp;Asier Juaneda-Seguí ,&nbsp;Andrés Guinea-Izquierdo ,&nbsp;Jordi Gascón-Bayarri ,&nbsp;Ramón Reñé ,&nbsp;Mikel Urretavizcaya ,&nbsp;José M. Menchón ,&nbsp;Isidre Ferrer ,&nbsp;Virginia Soria ,&nbsp;Carles Soriano-Mas","doi":"10.1016/j.sjpmh.2024.02.002","DOIUrl":"10.1016/j.sjpmh.2024.02.002","url":null,"abstract":"<div><h3>Introduction</h3><div>We compared effective connectivity from the locus coeruleus (LC) during the resting-state in patients with late-life Major Depressive Disorder (MDD), individuals with amnestic Mild Cognitive Impairment (aMCI), and Healthy Controls (HCs).</div></div><div><h3>Participants</h3><div>23 patients with late-life MDD, 22 patients with aMCI, and 28 HCs.</div></div><div><h3>Material and methods</h3><div>Participants were assessed in two time-points, 2 years apart. They underwent a resting-state functional magnetic resonance imaging and a high-resolution anatomical acquisition, as well as clinical assessments. Functional imaging data were analyzed with dynamic causal modeling, and parametric empirical Bayes model was used to map effective connectivity between 7 distinct nodes: 4 from the locus coeruleus and 3 regions displaying gray matter decreases during the two-year follow-up period.</div></div><div><h3>Results</h3><div>Longitudinal analysis of structural data identified three clusters of larger over-time gray matter volume reduction in patients (MDD<!--> <!-->+<!--> <!-->aMCI vs. HCs): the right precuneus, and the visual association and parahippocampal cortices. aMCI patients showed decreased effective connectivity from the left rostral to caudal portions of the LC, while connectivity from the left rostral LC to the parahippocampal cortex increased. In MDD, there was a decline in effective connectivity across LC caudal seeds, and increased connectivity from the left rostral to the left caudal LC seed over time. Connectivity alterations with cortical regions involved cross-hemisphere increases and same-hemisphere decreases.</div></div><div><h3>Conclusions</h3><div>Our discoveries provide insight into the dynamic changes in effective connectivity in individuals with late-life MDD and aMCI, also shedding light on the mechanisms potentially contributing to the onset of neurodegenerative disorders.</div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"18 3","pages":"Pages 199-207"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140061691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidepressants overuse in primary care: Prescription trends between 2010 and 2019 in Catalonia","authors":"Gerard Anmella ,&nbsp;Miriam Sanabra ,&nbsp;Mireia Primé-Tous ,&nbsp;Xavier Segú ,&nbsp;Aleix Solanes ,&nbsp;Victoria Ruíz ,&nbsp;Ivette Morilla ,&nbsp;Antonieta Also Fontanet ,&nbsp;Elisenda Sant ,&nbsp;Sandra Murgui ,&nbsp;Mireia Sans-Corrales ,&nbsp;Anabel Martínez-Aran ,&nbsp;Giovanna Fico ,&nbsp;Michele De Prisco ,&nbsp;Vincenzo Oliva ,&nbsp;Andrea Murru ,&nbsp;Roland Zahn ,&nbsp;Allan H. Young ,&nbsp;Victor Vicens ,&nbsp;Clara Viñas-Bardolet ,&nbsp;Diego Hidalgo-Mazzei","doi":"10.1016/j.rpsm.2022.12.001","DOIUrl":"10.1016/j.rpsm.2022.12.001","url":null,"abstract":"<div><h3>Introduction</h3><div>There has been an increase in the prescription of antidepressants (AD) in primary care (PC). However, it is unclear whether this was explained by a rise in diagnoses with an indication for AD. We investigated the changes in frequency and the variables associated with AD prescription in Catalonia, Spain.</div></div><div><h3>Methods</h3><div><span>We retrieved AD prescription, sociodemographic, and health-related data using individual electronic health records from a population-representative sample (</span><em>N</em> <!-->=<!--> <!-->947.698) attending PC between 2010 and 2019. Prescription of AD was calculated using DHD (Defined Daily Doses per 1000 inhabitants/day). We compared cumulative changes in DHD with cumulative changes in diagnoses with an indication for AD during the study period. We used Poisson regression to examine sociodemographic and health-related variables associated with AD prescription.</div></div><div><h3>Results</h3><div>Both AD prescription and mental health diagnoses with an indication for AD gradually increased. At the end of the study period, DHD of AD prescriptions and mental health diagnoses with an indication for AD reached cumulative increases of 404% and 49% respectively. Female sex (incidence rate ratio (IRR)<!--> <!-->=<!--> <!-->2.83), older age (IRR<!--> <!-->=<!--> <!-->25.43), and lower socio-economic status (IRR<!--> <!-->=<!--> <!-->1.35) were significantly associated with increased risk of being prescribed an AD.</div></div><div><h3>Conclusions</h3><div>Our results from a large and representative cohort of patients confirm a steady increase of AD prescriptions that is not explained by a parallel increase in mental health diagnoses with an indication for AD. A trend on AD off-label and over-prescriptions in the PC system in Catalonia can be inferred from this dissociation.</div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"18 3","pages":"Pages 174-181"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41133176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical predictors and psychosocial risk factors of suicide attempt severity","authors":"Itxaso González-Ortega ,&nbsp;Marina Diaz-Marsa ,&nbsp;Purificación López-Peña ,&nbsp;Jessica Fernández-Sevillano ,&nbsp;Jorge Andreo-Jover ,&nbsp;Julio Bobes ,&nbsp;María Fe Bravo-Ortiz ,&nbsp;Ana Isabel Cebria ,&nbsp;Benedicto Crespo-Facorro ,&nbsp;Alejandro de la Torre-Luque ,&nbsp;Matilde Elices ,&nbsp;Verónica Fernández-Rodrigues ,&nbsp;Nathalia Garrido-Torres ,&nbsp;Iria Grande ,&nbsp;Ángela Palao-Tarrero ,&nbsp;Andrés Pemau ,&nbsp;Natalia Roberto ,&nbsp;Miguel Ruiz-Veguilla ,&nbsp;Elisa Seijo-Zazo ,&nbsp;Susana Alberich ,&nbsp;Iñaki Zorrilla","doi":"10.1016/j.sjpmh.2023.07.002","DOIUrl":"10.1016/j.sjpmh.2023.07.002","url":null,"abstract":"<div><h3>Background</h3><div>Suicide attempts are an important predictor of completed suicide and may differ in terms of severity of medical consequences or medical lethality. There is little evidence on serious suicide attempt (SSA) and very few studies have compared SSA with non-SSA.</div></div><div><h3>Objective</h3><div>The aim of this multisite, coordinated, cohort study was to analyze the role of clinical variables and the sociodemographic and psychological risk factors of SSA.</div></div><div><h3>Method</h3><div>In this multisite, coordinated, cohort study, 684 participants (222 for the mild suicide attempt group, 371 for the moderate suicide attempt group and 91 for the SSA group) were included in the study. Ordinal regression models were performed to analyze the predictor variables of SSA.</div></div><div><h3>Results</h3><div>Early physical abuse (OR<!--> <!-->=<!--> <!-->1.231) and impulsivity (OR<!--> <!-->=<!--> <!-->1.036) were predictors of SSA, while depressive symptoms were associated with a lower risk of SSA.</div></div><div><h3>Conclusion</h3><div>Environmental and psychological factors as physical abuse and impulsivity are related with severe suicide severity. These findings will help to develop strategies to prevent suicide and may be considered for the treatment and management of suicide.</div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"18 3","pages":"Pages 182-190"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135588290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upward trends in eating disorders, self-harm, and suicide attempt emergency admissions in female adolescents after COVID-19 lockdown","authors":"Adriana Fortea ,&nbsp;Lydia Fortea ,&nbsp;Marta Gómez-Ramiro ,&nbsp;Giovanna Fico ,&nbsp;Anna Giménez-Palomo ,&nbsp;Maria Sagué-Vilavella ,&nbsp;Maria Teresa Pons ,&nbsp;Mireia Vázquez ,&nbsp;Nuria Baldaquí ,&nbsp;Lluc Colomer ,&nbsp;Tábatha Maria Fernández ,&nbsp;Felipe Gutiérrez-Arango ,&nbsp;Maria Llobet ,&nbsp;Ester Pujal ,&nbsp;Luisa Lázaro ,&nbsp;Eduard Vieta ,&nbsp;Joaquim Radua ,&nbsp;Inmaculada Baeza","doi":"10.1016/j.sjpmh.2023.09.003","DOIUrl":"10.1016/j.sjpmh.2023.09.003","url":null,"abstract":"<div><h3>Introduction</h3><div>Increased mental health problems have been reported in children and adolescents related to the COVID-19 lockdown and its immediate aftermath, especially among adolescent females. However, the longer-term impact of persistent quarantine measures and social restrictions on this population is yet to be further explored.</div></div><div><h3>Materials and methods</h3><div>We compared the number of children/adolescents admissions to the psychiatric emergency<span> department (ED) of Hospital Clínic de Barcelona during the COVID-19 lockdown and the following year with the numbers of admissions the year before lockdown, adjusting for variations in the population. We also conducted separate analyses by gender, age group, and diagnostic categories. Finally, we also repeated the analyses considering the cumulated deficit/excess since the start of the lockdown. Statistical significance was estimated using binomial tests with Bonferroni correction.</span></div></div><div><h3>Results</h3><div>A total of 2425 admissions were recorded. Globally, admission rates decreased during the lockdown (46%) and progressively increased during the one-year aftermath (43% by spring 2021). This increase was particularly high in adolescent females (85%) while unclear in children and/or males. The main diagnostic categories involved were anxiety, depressive, and eating disorders, as well as self-harm behavior, suicidal ideation, and suicide attempts. The increase in eating disorders, self-harm behavior, and suicide attempts admissions in female adolescents remained statistically significant when considering the cumulated deficit/excess.</div></div><div><h3>Conclusions</h3><div>We found increased ED admissions during the aftermath of the COVID-19 lockdown among adolescent females. We recommend strengthening the attention to this population to provide adequate specialized care and prevention strategies.</div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"18 3","pages":"Pages 158-162"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134978155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New insights into the effects of serotonin on Parkinson's disease and depression through its role in the gastrointestinal tract","authors":"María Sancho-Alonso ,&nbsp;Unai Sarriés-Serrano ,&nbsp;Lluis Miquel-Rio ,&nbsp;Claudia Yanes Castilla ,&nbsp;Verónica Paz ,&nbsp;José Javier Meana ,&nbsp;Mario Perello ,&nbsp;Analia Bortolozzi","doi":"10.1016/j.sjpmh.2024.07.002","DOIUrl":"10.1016/j.sjpmh.2024.07.002","url":null,"abstract":"<div><div>Neuropsychiatric and neurodegenerative disorders are frequently associated with gastrointestinal (GI) co-pathologies. Although the central and enteric nervous systems (CNS and ENS, respectively) have been studied separately, there is increasing interest in factors that may contribute to conditions affecting both systems. There is compelling evidence that serotonin (5-HT) may play an important role in several gut–brain disorders. It is well known that 5-HT is essential for the development and functioning of the CNS. However, most of the body's 5-HT is produced in the GI tract. A deeper understanding of the specific effects of enteric 5-HT on gut–brain disorders may provide the basis for the development of new therapeutic targets. This review summarizes current data focusing on the important role of 5-HT in ENS development and motility, with particular emphasis on novel aspects of 5-HT signaling in conditions where CNS and ENS comorbidities are common, such as Parkinson's disease and depressive disorders.</div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"18 3","pages":"Pages 216-227"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141592545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive performance as a health indicator: Lessons from the Spanish version of the mini-mental.","authors":"Antonio Lobo","doi":"10.1016/j.sjpmh.2025.04.001","DOIUrl":"10.1016/j.sjpmh.2025.04.001","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxytocin and rejection sensitivity: A comparative biomarker study in women with borderline personality and eating disorders.","authors":"Francisco Ruiz-Guerrero, Andrés Gomez Del Barrio, Alejandro de la Torre-Luque, Karina MacDowell, Luis Beato-Fernández, Leticia Castro Fuentes, Wala Ayad-Ahmed, Pablo Mola, Álvaro Carrasco-Díaz, José Manuel Lopez-Villatoro, Juan C Leza, José Luis Carrasco, Marina Diaz-Marsa","doi":"10.1016/j.sjpmh.2025.04.002","DOIUrl":"10.1016/j.sjpmh.2025.04.002","url":null,"abstract":"<p><strong>Background: </strong>Emotional dysregulation is a hallmark feature of borderline personality disorder (BPD) and eating disorders (ED), which impacts the individuals' well-being and functioning. Oxytocin dysregulation has been involved in social cognition deficits associated with these disorders.</p><p><strong>Methods: </strong>We conducted a study including a total 108 women categorized into 3 groups: 50 with eating disorders (ED), 35 with borderline personality disorder (BPD), and 23 healthy controls. Psychopathological profiles were assessed using the Bulimic Investigatory Test Edinburgh (BITE), the Eating Attitude Test 40 (EAT-40), the Barratt Impulsiveness Scale (BIS-11), and the Rejection Sensitivity Questionnaire (RSQ). Plasma oxytocin levels and oxytocin receptor expression were measured as well.</p><p><strong>Results: </strong>BPD patients exhibited significantly lower plasma oxytocin levels vs ED patients and healthy controls. However, oxytocin receptor expression did not differ significantly across the groups. Oxytocin levels were positively associated with rejection sensitivity, particularly in BPD patients.</p><p><strong>Conclusions: </strong>Our findings suggest a potential role of oxytocin dysregulation in emotional dysregulation and rejection sensitivity, particularly in BPD. Higher oxytocin levels in ED patients may serve as a compensatory mechanism to mitigate challenges in interpersonal relationships. These results highlight the importance of personalized therapeutic interventions targeting oxytocin dysregulation in the management of ED and BPD.</p>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are patients with depression exposed to less light than healthy controls?","authors":"Aida Martín-Reina, Anna Riera-Gimeno, José Angel Rubiño, Maria Cristina Nicolau, Francesca Canellas","doi":"10.1016/j.sjpmh.2025.03.002","DOIUrl":"10.1016/j.sjpmh.2025.03.002","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}