Spanish Journal of Psychiatry and Mental Health最新文献

{"title":"Meta-analysis of the effects of adjuvant drugs in co-occurring bipolar and substance use disorder","authors":"Joaquim Radua ,&nbsp;Lydia Fortea ,&nbsp;José Manuel Goikolea ,&nbsp;Iñaki Zorrilla ,&nbsp;Miquel Bernardo ,&nbsp;Manuel Arrojo ,&nbsp;Ruth Cunill ,&nbsp;Xavi Castells ,&nbsp;Elisardo Becoña ,&nbsp;Ana López-Durán ,&nbsp;Marta Torrens ,&nbsp;Judit Tirado-Muñoz ,&nbsp;Francina Fonseca ,&nbsp;Belén Arranz ,&nbsp;Marina Garriga ,&nbsp;Pilar A. Sáiz ,&nbsp;Gerardo Flórez ,&nbsp;Luis San ,&nbsp;Ana González-Pinto","doi":"10.1016/j.rpsm.2023.01.005","DOIUrl":"10.1016/j.rpsm.2023.01.005","url":null,"abstract":"<div><h3>Background</h3><div>Individuals with bipolar disorder<span> (BD) often have co-occurring substance use disorders (SUDs), which substantially impoverish the course of illness. Despite the importance of this dual diagnosis, the evidence of the efficacy and safety of adjuvant treatments is mostly unknown.</span></div></div><div><h3>Objective</h3><div>To perform a meta-analysis to evaluate the efficacy and safety of adjuvant drugs in patients with co-occurring BD and SUD.</div></div><div><h3>Methods</h3><div>We searched PubMed, Scopus, and Web of Knowledge until 30th April 2022 for randomized clinical trials<span> (RCT) evaluating the efficacy and safety of adjuvant drugs compared to placebo in patients with a dual diagnosis of BD and SUD. We meta-analyzed the effect of adjuvant drugs on general outcomes (illness severity, mania, depression, anxiety, abstinence, substance craving, substance use, gamma-GT, adherence, and adverse events) and used the results to objectively assess the quality of the evidence according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. For completeness, we also report the specific effects of specific adjuvant drugs in patients with specific substance disorders.</span></div></div><div><h3>Results</h3><div>We included 15 RCT studies (9 alcohol, 3 cocaine, 2 nicotine, and 1 cannabis) comprising 628 patients allocated to treatment and 622 to placebo. There was low-quality evidence that adjuvant drugs may reduce illness severity (<em>g</em> <!-->=<!--> <!-->−0.25, 95% CI: −0.44, −0.06), and very-low quality evidence that they may decrease substance use (<em>g</em> <!-->=<!--> <!-->−0.23, 95% CI: −0.44, −0.02) and increase substance abstinence (<em>g</em> <!-->=<!--> <!-->0.21, 95% CI: 0.04, 0.38).</div></div><div><h3>Discussion</h3><div>There is low-quality evidence that adjuvant drugs may help reduce illness severity, probably via facilitating abstinence and lower substance use. However, the evidence is weak; thus, these results should be considered cautiously until better evidence exists.</div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"17 4","pages":"Pages 239-250"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10181957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Remediation for Older Adults with Bipolar Disorder (FROA-BD): Study protocol for a randomized controlled trial","authors":"Laura Montejo ,&nbsp;Esther Jiménez ,&nbsp;Carla Torrent ,&nbsp;Caterina del Mar Bonnín ,&nbsp;Brisa Solé ,&nbsp;Anabel Martínez-Arán ,&nbsp;Eduard Vieta ,&nbsp;Jose Sánchez Moreno","doi":"10.1016/j.rpsm.2022.01.004","DOIUrl":"10.1016/j.rpsm.2022.01.004","url":null,"abstract":"<div><h3>Background</h3><div>Older Adults with Bipolar Disorder (OABD) show cognitive impairments with a negative impact on psychosocial functioning and quality of life. However, to date any intervention for the improvement of functioning has been developed for OABD. The current project aims to demonstrate the efficacy of the Functional Remediation program (FR) specifically adapted to OABD, over 60 years old, for improving functional outcome.</div></div><div><h3>Methods</h3><div>This is an experimental, randomized-controlled trial. Two groups will be included: the experimental group (<em>n</em> <!-->=<!--> <!-->42) will receive a 4-month intervention consisting of 32 sessions of treatment and the control group which will receive treatment as usual (TAU) (<em>n</em> <!-->=<!--> <!-->42). The intervention will result from the adaptation of the Functional Remediation program for OABD (FROA-BD), that has already proven its efficacy at improving psychosocial functioning in patients with bipolar disorder. Clinical, neuropsychological and functional evaluations will be carried out at baseline, post-intervention and follow-up (one year after baseline evaluation). We hypothesized that patients who have undergone the intervention FROA-BD will improve their psychosocial functioning, cognitive performance, quality of life and well-being. We also hypothesized that all these changes will remain stable after eight month follow-up.</div></div><div><h3>Conclusions</h3><div>The results will provide evidence of the efficacy in improving psychosocial functioning, cognitive performance and quality of life applying the FROA-BD. This project consists in the first attempt to adapt the FR program to OABD population who needs specific needs and approaches. The novelty of this contribution represents an advance in the framework of psychological treatment in later-life bipolar disorder.</div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"17 4","pages":"Pages 181-189"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91349231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empowering the future of psychiatry: The development of the young psychiatrists section of the Spanish Society of Psychiatry and Mental Health.","authors":"Gonzalo Salazar de Pablo, Claudia Aymerich, Justo Pinzón-Espinosa","doi":"10.1016/j.sjpmh.2024.09.003","DOIUrl":"10.1016/j.sjpmh.2024.09.003","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Luis Martín-Santos: A multidimensional psychiatrist.","authors":"José Lázaro","doi":"10.1016/j.sjpmh.2024.09.002","DOIUrl":"10.1016/j.sjpmh.2024.09.002","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individualized pretest risk estimates to guide treatment decisions in patients with clinical high risk for psychotic disorders.","authors":"Elodie Sprüngli-Toffel, Erich Studerus, Logos Curtis, Caroline Conchon, Luis Alameda, Barbara Bailey, Camille Caron, Carmina Haase, Julia Gros, Evelyn Herbrecht, Christian G Huber, Anita Riecher-Rössler, Philippe Conus, Alessandra Solida, Marco Armando, Afroditi Kapsaridi, Mathieu Mercapide Ducommun, Paul Klauser, Kerstin Jessica Plessen, Sébastien Urben, Anne Edan, Nathalie Nanzer, Ana Liso Navarro, Maude Schneider, Davina Genoud, Chantal Michel, Jochen Kindler, Michael Kaess, Dominic Oliver, Paolo Fusar-Poli, Stefan Borgwardt, Christina Andreou","doi":"10.1016/j.sjpmh.2024.09.001","DOIUrl":"10.1016/j.sjpmh.2024.09.001","url":null,"abstract":"<p><strong>Introduction: </strong>Clinical high risk for psychosis (CHR) states are associated with an increased risk of transition to psychosis. However, the predictive value of CHR screening interviews is dependent on pretest risk enrichment in referred patients. This poses a major obstacle to CHR outreach campaigns since they invariably lead to risk dilution through enhanced awareness. A potential compensatory strategy is to use estimates of individual pretest risk as a 'gatekeeper' for specialized assessment. We aimed to test a risk stratification model previously developed in London, UK (OASIS) and to train a new predictive model for the Swiss population.</p><p><strong>Method: </strong>The sample was composed of 513 individuals referred for CHR assessment from six Swiss early psychosis detection services. Sociodemographic variables available at referral were used as predictors whereas the outcome variable was transition to psychosis.</p><p><strong>Results: </strong>Replication of the risk stratification model developed in OASIS resulted in poor performance (Harrel's c=0.51). Retraining resulted in moderate discrimination (Harrel's c=0.67) which significantly differentiated between different risk groups. The lowest risk group had a cumulative transition incidence of 6.4% (CI: 0-23.1%) over two years.</p><p><strong>Conclusion: </strong>Failure to replicate the OASIS risk stratification model might reflect differences in the public health care systems and referral structures between Switzerland and London. Retraining resulted in a model with adequate discrimination performance. The developed model in combination with CHR assessment result, might be useful for identifying individuals with high pretest risk, who might benefit most from specialized intervention.</p>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coping behaviors to reduce anxiety and depressive symptoms: A prospective repeated assessment study.","authors":"Lydia Fortea, Aleix Solanes, Edith Pomarol-Clotet, Maria Angeles Garcia-Leon, Adriana Fortea, Carla Torrent, Cristina Varo, Caterina Del Mar Bonnin, Laura Montejo, Jordi Alonso, Susana Carmona, Pau Soldevila-Matías, Irene Alustiza, Daniel Arbós, Diego Hidalgo-Mazzei, Iria Grande, Eduard Vieta, Miquel Àngel Fullana, Joaquim Radua","doi":"10.1016/j.sjpmh.2024.08.003","DOIUrl":"10.1016/j.sjpmh.2024.08.003","url":null,"abstract":"<p><strong>Introduction: </strong>Health institutions provide general recommendations to cope with global crises such as pandemics or geopolitical tensions. However, these recommendations are mainly based on cross-sectional evidence. The preregistered Repeated Assessment of Behaviors and Symptoms in the Population (RABSYPO) study sought to establish prospective longitudinal evidence from a cohort with a demographic distribution similar to that of the Spanish population to provide evidence for developing solid universal recommendations to reduce anxiety and depressive symptoms during times of uncertainty.</p><p><strong>Material and methods: </strong>We first recruited via social networks a pool of Spanish individuals willing to participate and then randomly selected some within each stratum of age×gender×region×urbanicity to conduct a one-year-long bi-weekly online follow-up about the frequency of ten simple potential coping behaviors as well as anxiety (GAD-7) and depressive symptoms (PHQ-9). Mixed-effects autoregressive moving average models were used to analyze the relationship between past behaviors' frequency and subsequent symptom changes across the twenty-seven time points.</p><p><strong>Results: </strong>Among the 1049 who started the follow-up, 942 completed it and were included in the analyses. Avoiding excessive exposure to distressing news and maintaining a healthy/balanced diet, followed by spending time outdoors and physical exercise, were the coping behaviors most strongly associated with short and long-term reductions of anxiety and depressive symptoms. Engaging in relaxing activities and drinking water to hydrate were only associated with short-term symptom reductions. Socializing was associated with symptom reductions in the long term.</p><p><strong>Conclusions: </strong>This study provides compelling prospective evidence that adopting a set of simple coping behaviors is associated with small but significant reductions in anxiety and depressive symptoms during times of uncertainty. It also includes a layman's summary of this evidence to help develop general recommendations that serve as universal tools for enhancing mental health and well-being.</p>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A psychiatrist in the court of Philip II of Spain: Mental medicine in the work of Francisco Valles (1524-1592).","authors":"David Fraguas","doi":"10.1016/j.sjpmh.2024.08.001","DOIUrl":"10.1016/j.sjpmh.2024.08.001","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in the impact of suicide compared to other external causes of death: From 1995 to 2020.","authors":"Jimena María Merayo-Cano, Alejandro Porras-Segovia, Santiago Ovejero-Garcia, Enrique Baca-García","doi":"10.1016/j.sjpmh.2024.07.004","DOIUrl":"10.1016/j.sjpmh.2024.07.004","url":null,"abstract":"<p><strong>Background: </strong>Suicide is one of the world's greatest public health problems. More than 700,000 people lose their lives to suicide every year. While funding for mental health waits to be increased, thousands of suicides occur every day.</p><p><strong>Material and methods: </strong>This study aims to quantify the global impact of suicide compared to other external causes of death in terms of years of potential life lost (YPLL), and how this will change between 1995 and 2020. Our source of information is the World Health Organization (WHO) mortality database. We then use YPLL, a standard measure of premature mortality and burden of disease that brings precision to the assessment of the impact of different causes of death. This, combined with the compound annual growth rate (CAGR) as a way of expressing increase, gives us a better understanding of the real situation and trends of suicide compared to other external causes of death in different countries worldwide.</p><p><strong>Results: </strong>Based on the available sources of information and the selection criteria, we obtained a sample of 69 countries. The CAGR for all causes per capita decreased over the observed period in 65 countries, and it increases in 4 countries. In contrast, the CAGR specifically for suicide decreased in 49 countries, while an increase was observed in 20 countries.</p><p><strong>Conclusions: </strong>Prevention of most external causes of mortality shows promising data in most countries. However, this is not the case for suicide. Thus, YPLL due to suicide have decreased to a comparatively lesser extent and have even increased in some countries, a very worrying situation that poses many clinical and epidemiological challenges.</p>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141768419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cibersam: A change in the paradigm of mental health research in Spain.","authors":"Celso Arango, Eduard Vieta","doi":"10.1016/j.sjpmh.2024.07.003","DOIUrl":"10.1016/j.sjpmh.2024.07.003","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141763926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered activation of the dorsal anterior cingulate cortex during oddball performance in individuals at risk for Alzheimer's disease.","authors":"Pamela Chavarría-Elizondo, Carla Del Río-Torné, Pablo Maturana-Quijada, Ignacio Martínez-Zalacaín, Asier Juaneda, Inés Del Cerro, Andrés Guinea-Izquierdo, Jordi Gascón-Bayarri, Ramón Reñé-Ramírez, Mikel Urretavizcaya, Isidre Ferrer, José M Menchón, Virginia Soria, Carles Soriano-Mas","doi":"10.1016/j.sjpmh.2024.07.001","DOIUrl":"10.1016/j.sjpmh.2024.07.001","url":null,"abstract":"<p><strong>Introduction: </strong>The neural mechanisms underlying neurodegenerative disorders in the elderly remain elusive, despite extensive neuroimaging research in recent decades. Amnestic type mild cognitive impairment (aMCI) and late-life major depressive disorder (MDD) are two such conditions characterized by intersecting cognitive and affective symptomatology, and they are at a higher risk for Alzheimer's disease.</p><p><strong>Materials and methods: </strong>This study analyzed the neural underpinnings of cognitive and depressive symptoms in a cohort comprising 12 aMCI subjects, 24 late-life MDD patients, and 26 healthy controls (HCs). Participants underwent a detailed neuropsychological assessment and completed a visual attentional oddball task during functional magnetic resonance imaging (fMRI), with evaluations at baseline and at 2-year follow-up.</p><p><strong>Results: </strong>Initial findings showed that aMCI subjects had reduced dACC activation during oddball (target) stimulus detection, a pattern that persisted in longitudinal analyses and correlated with cognitive functioning measures. For HCs, subsequent dACC activation was linked to depression scores. Furthermore, in the affective-cognitive altered groups, later dACC activation correlated with oddball and memory performance.</p><p><strong>Conclusions: </strong>These findings enhance our comprehension of the neurobiological basis of cognitive and depressive disturbances in aging, indicating that dACC activation in response to a visual attentional oddball task could serve as a neural marker for assessing cognitive impairment and depression in conditions predisposing to Alzheimer's disease.</p>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141592544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}