Spanish Journal of Psychiatry and Mental Health最新文献

{"title":"Postpartum suicide beyond 42 days: A missing signal in maternal mortality surveillance.","authors":"I Dewa Ayu Eka Purba Dharma Tari, Kadek Suhardita, Erfan Ramadhani, Rikas Saputra, Rizky Andana Pohan, Andika Ari Saputra, Triyono","doi":"10.1016/j.sjpmh.2026.06.004","DOIUrl":"10.1016/j.sjpmh.2026.06.004","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simple coping behaviors and their role in mitigating anxiety and depression: A call for further research","authors":"Khairul Bariyyah, Laily Tiarani Soejanto, Aji Septiaji, Royyan Hafizi, Uswatun Hasanah, Dita Rosyalita, Muhammad Rizki Perdana, Afdhal Ilahi, Erfan Ramadhani","doi":"10.1016/j.sjpmh.2025.07.005","DOIUrl":"10.1016/j.sjpmh.2025.07.005","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"19 3","pages":"Pages 186-187"},"PeriodicalIF":2.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145331553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A critical review of “Effective connectivity of the locus coeruleus in late-life major depressive disorder and mild cognitive impairment”","authors":"Achmad Fauzi, Seno Andri, Muchid, Febri Yuliani, Adianto, Meyzi Heriyanto","doi":"10.1016/j.sjpmh.2025.12.002","DOIUrl":"10.1016/j.sjpmh.2025.12.002","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"19 3","pages":"Page 190"},"PeriodicalIF":2.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145852004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are patients with depression exposed to less light than healthy controls?","authors":"Aida Martín-Reina, Anna Riera-Gimeno, José Angel Rubiño, Maria Cristina Nicolau, Francesca Canellas","doi":"10.1016/j.sjpmh.2025.03.002","DOIUrl":"10.1016/j.sjpmh.2025.03.002","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"19 3","pages":"Pages 179-181"},"PeriodicalIF":2.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic and epigenetic changes to the glucocorticoid receptor gene (NR3C1) and cognition in major depressive disorder","authors":"Alex Ferrer,&nbsp;Javier Labad,&nbsp;Neus Salvat-Pujol,&nbsp;Mikel Urretavizcaya,&nbsp;Roser Obrador-Font,&nbsp;José M. Menchón,&nbsp;Diego Palao,&nbsp;Carles Soriano-Mas,&nbsp;Javier Costas,&nbsp;Marta Barrachina,&nbsp;Ángel Carracedo,&nbsp;Virginia Soria","doi":"10.1016/j.sjpmh.2024.12.002","DOIUrl":"10.1016/j.sjpmh.2024.12.002","url":null,"abstract":"<div><h3>Introduction</h3><div><span><span>Many studies have found that hypothalamic–pituitary–adrenal (HPA) axis abnormalities are related to the pathophysiology of major depressive disorder (MDD) and cognitive functioning. Our aim was to assess the influence of </span>genetic<span> polymorphisms and methylation<span><span> levels in three different promoter regions throughout the </span>glucocorticoid receptor (GR) gene </span></span></span><em>NR3C1</em> on cognitive performance in MDD. Plausible interactions with childhood adversity and mediation relationships between genetic and epigenetic variables were explored.</div></div><div><h3>Materials and methods</h3><div><span>The sample included a total of 64 MDD patients and 82 healthy controls. Child maltreatment and neurocognitive performance were assessed in all participants. HPA negative feedback was analyzed using the dexamethasone suppression test after the administration of 0.25</span> <span>mg of dexamethasone<span>. A total of 23 single-nucleotide polymorphisms were genotyped, and methylation levels at several CpGs in exons 1D, 1F and 1H of the GR gene were measured.</span></span></div></div><div><h3>Results</h3><div>Results show that, beyond the influence of other covariables, <em>NR3C1</em> single-nucleotide polymorphisms and methylation levels predicted performance in executive functioning and working memory tasks. No significant interactions or mediation relationships were detected.</div></div><div><h3>Conclusions</h3><div>Results suggest that genetic variations and epigenetic regulation of the GR gene are relevant factors influencing cognitive performance in MDD and could emerge as significant biomarkers and therapeutic targets in mood disorders and other stress-related disorders.</div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"19 3","pages":"Pages 169-178"},"PeriodicalIF":2.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cajal's arrows","authors":"José M. Delgado-García","doi":"10.1016/j.sjpmh.2026.06.002","DOIUrl":"10.1016/j.sjpmh.2026.06.002","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"19 3","pages":"Pages 140-141"},"PeriodicalIF":2.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148285015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxytocin and rejection sensitivity: A comparative biomarker study in women with borderline personality and eating disorders","authors":"Francisco Ruiz-Guerrero,&nbsp;Andrés Gomez del Barrio,&nbsp;Alejandro de la Torre-Luque,&nbsp;Karina MacDowell,&nbsp;Luis Beato-Fernández,&nbsp;Leticia Castro Fuentes,&nbsp;Wala Ayad-Ahmed,&nbsp;Pablo Mola,&nbsp;Álvaro Carrasco-Díaz,&nbsp;José Manuel Lopez-Villatoro,&nbsp;Juan C. Leza,&nbsp;José Luis Carrasco,&nbsp;Marina Diaz-Marsa","doi":"10.1016/j.sjpmh.2025.04.002","DOIUrl":"10.1016/j.sjpmh.2025.04.002","url":null,"abstract":"<div><h3>Background</h3><div>Emotional dysregulation<span> is a hallmark feature of borderline personality disorder (BPD) and eating disorders (ED), which impacts the individuals’ well-being and functioning. Oxytocin dysregulation has been involved in social cognition deficits associated with these disorders.</span></div></div><div><h3>Methods</h3><div>We conducted a study including a total 108 women categorized into 3 groups: 50 with eating disorders (ED), 35 with borderline personality disorder (BPD), and 23 healthy controls. Psychopathological profiles were assessed using the Bulimic Investigatory Test Edinburgh (BITE), the Eating Attitude Test 40 (EAT-40), the Barratt Impulsiveness Scale<span> (BIS-11), and the Rejection Sensitivity Questionnaire (RSQ). Plasma oxytocin levels and oxytocin receptor expression were measured as well.</span></div></div><div><h3>Results</h3><div>BPD patients exhibited significantly lower plasma oxytocin levels vs ED patients and healthy controls. However, oxytocin receptor expression did not differ significantly across the groups. Oxytocin levels were positively associated with rejection sensitivity, particularly in BPD patients.</div></div><div><h3>Conclusions</h3><div>Our findings suggest a potential role of oxytocin dysregulation in emotional dysregulation and rejection sensitivity, particularly in BPD. Higher oxytocin levels in ED patients may serve as a compensatory mechanism to mitigate challenges in interpersonal relationships. These results highlight the importance of personalized therapeutic interventions targeting oxytocin dysregulation in the management of ED and BPD.</div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"19 3","pages":"Pages 154-159"},"PeriodicalIF":2.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The locus coeruleus and cognitive–emotional resilience in late-life depression and cognitive disorders","authors":"Dony Darma Sagita,&nbsp;Mutiara Felicita Amsal","doi":"10.1016/j.sjpmh.2025.11.003","DOIUrl":"10.1016/j.sjpmh.2025.11.003","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"19 3","pages":"Pages 188-189"},"PeriodicalIF":2.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145812665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of depressive symptoms with all-cause, cardiovascular, and cancer mortality: A population-based study in Spain","authors":"Teresa López-Cuadrado,&nbsp;Cristina Ortiz,&nbsp;Roberto Pastor-Barriuso,&nbsp;Iñaki Galán","doi":"10.1016/j.sjpmh.2026.02.002","DOIUrl":"10.1016/j.sjpmh.2026.02.002","url":null,"abstract":"<div><h3>Introduction</h3><div>Depression affects 4.4% of the global population and is associated with an increased risk of disability and premature mortality. Below we evaluate the association between depression and mortality in the adult population of Spain.</div></div><div><h3>Material and methods</h3><div>We conducted a longitudinal study using data from the 2014 European Health Interview Survey for Spain, including participants aged ≥15 years (<em>N</em> <!-->=<!--> <!-->22,652), associated with the national mortality registry up to December 2023. Depression was self-reported using the 8-item Patient Health Questionnaire (PHQ-8) and measured once at baseline, with a score ≥10 being indicative of moderate-to-severe depressive symptoms. We explored the effect of a prior physician-diagnosis of depression and antidepressant treatment received within the previous two weeks. Age-standardized rate ratios (SRR) and differences (SRD) for all-cause, cardiovascular, and cancer mortality were estimated using Poisson regression.</div></div><div><h3>Results</h3><div>Compared with individuals with no or mild depressive symptoms, those with a PHQ-8 score ≥10 had an SRR of 1.33 (95%CI, 1.16, 1.54), with an estimated SRD of 3.94 per 1000 person-years (95%CI, 1.78, 6.11). For cardiovascular and cancer mortality, the SRR was 1.30 (95%CI, 1.00, 1.67) and 1.09 (95%CI, 0.79, 1.50), respectively. Among individuals with PHQ-8 ≥10, those with a prior diagnosis had an SRR for all-cause mortality of 1.18 (95%CI, 0.92, 1.50) vs 1.60 (95%CI, 1.31, 1.95) in those with no prior diagnosis (<em>P</em> <!-->=<!--> <!-->.006). Similarly, participants with PHQ-8 ≥10 who had received pharmacotherapy showed lower mortality risk than untreated individuals (<em>P</em> <!-->=<!--> <!-->.044).</div></div><div><h3>Conclusions</h3><div>Individuals with moderate-to-severe depressive symptoms, particularly those undiagnosed and/or not receiving treatment, have an increased risk of all-cause and cardiovascular mortality.</div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"19 3","pages":"Pages 147-153"},"PeriodicalIF":2.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147367938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond clinical remission: The foundations and rationale of palliative psychiatry","authors":"Marc Peraire,&nbsp;Iván Echeverria","doi":"10.1016/j.sjpmh.2025.10.002","DOIUrl":"10.1016/j.sjpmh.2025.10.002","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"19 3","pages":"Pages 138-139"},"PeriodicalIF":2.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145558716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}