New insights into the effects of serotonin on Parkinson's disease and depression through its role in the gastrointestinal tract.

0 PSYCHIATRY

Spanish Journal of Psychiatry and Mental Health Pub Date : 2024-07-09 DOI:10.1016/j.sjpmh.2024.07.002

María Sancho-Alonso, Unai Sarriés-Serrano, Lluis Miquel-Rio, Claudia Yanes Castilla, Verónica Paz, José Javier Meana, Mario Perello, Analia Bortolozzi

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Abstract

Neuropsychiatric and neurodegenerative disorders are frequently associated with gastrointestinal (GI) co-pathologies. Although the central and enteric nervous systems (CNS and ENS, respectively) have been studied separately, there is increasing interest in factors that may contribute to conditions affecting both systems. There is compelling evidence that serotonin (5-HT) may play an important role in several gut-brain disorders. It is well known that 5-HT is essential for the development and functioning of the CNS. However, most of the body's 5-HT is produced in the GI tract. A deeper understanding of the specific effects of enteric 5-HT on gut-brain disorders may provide the basis for the development of new therapeutic targets. This review summarizes current data focusing on the important role of 5-HT in ENS development and motility, with particular emphasis on novel aspects of 5-HT signaling in conditions where CNS and ENS comorbidities are common, such as Parkinson's disease and depressive disorders.

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通过血清素在胃肠道中的作用，深入了解血清素对帕金森病和抑郁症的影响。

神经精神疾病和神经退行性疾病经常与胃肠（GI）并发病症有关。尽管中枢神经系统和肠道神经系统（分别为 CNS 和 ENS）已被分开研究，但人们对可能导致影响这两个系统的病症的因素的兴趣与日俱增。有令人信服的证据表明，5-羟色胺（5-HT）可能在多种肠脑疾病中扮演重要角色。众所周知，5-羟色胺对中枢神经系统的发育和功能至关重要。然而，人体的大部分 5-HT 是在消化道中产生的。深入了解肠道 5-HT 对肠道-大脑疾病的具体影响，可为开发新的治疗靶点奠定基础。这篇综述总结了当前的数据，重点关注 5-HT 在 ENS 发育和运动中的重要作用，并特别强调了 5-HT 信号在中枢神经系统和 ENS 常见合并症（如帕金森病和抑郁症）中的新作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Spanish Journal of Psychiatry and Mental Health

CiteScore

9.50

自引率

0.00%

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