Spanish Journal of Psychiatry and Mental Health最新文献

{"title":"The urgent need for suicide prevention tools in Spain","authors":"Lucas Giner, Enrique Baca-Garcia, Pilar A. Saiz","doi":"10.1016/j.sjpmh.2023.02.002","DOIUrl":"https://doi.org/10.1016/j.sjpmh.2023.02.002","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135200194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet and white blood-cell-based ratios: Differential inflammatory markers of severe mental disorders?","authors":"Gonzalo Paniagua, Leticia González Blanco, Pilar A Sáiz, Carlota Moya Lacasa, Laura Gutiérrez, Patricia Martínez Botía, Francesco Dal Santo, Luis Jiménez Treviño, María Paz García-Portilla, Julio Bobes","doi":"10.1016/j.sjpmh.2023.03.002","DOIUrl":"https://doi.org/10.1016/j.sjpmh.2023.03.002","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"88 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135298482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of enhancing cognitive reserve in children, adolescents and young adults at genetic risk for psychosis: Study protocol for a randomized controlled trial","authors":"Elena de la Serna ,&nbsp;Laura Montejo ,&nbsp;Brisa Solé ,&nbsp;Josefina Castro-Fornieles ,&nbsp;Patricia Camprodon-Boadas ,&nbsp;Gisela Sugranyes ,&nbsp;Mireia Rosa-Justicia ,&nbsp;Anabel Martinez-Aran ,&nbsp;Eduard Vieta ,&nbsp;Muriel Vicent-Gil ,&nbsp;Maria Serra-Blasco ,&nbsp;Narcís Cardoner ,&nbsp;Carla Torrent","doi":"10.1016/j.rpsm.2021.02.003","DOIUrl":"10.1016/j.rpsm.2021.02.003","url":null,"abstract":"<div><h3>Background</h3><p>Offspring of patients diagnosed with bipolar disorder and schizophrenia (Off-BDSZ) have a high genetic risk of developing a mental illness. The aim of this project is to develop and investigate the efficacy of an intervention aimed at this population, based on the concept of cognitive reserve.</p></div><div><h3>Methods</h3><p>This is a multicenter randomized trial with an experimental test–retest design study with control group. Two groups will be included: a community comparison group (CC) and a Off-BDSZ group. A total of 108 Off-BDSZ and 65 CC aged between 6 and 25 years will be recruited. Off-BDSZ participants will be randomized to receive either Cognitive Reserve EnhAncement ThErapy (CREATE) (<em>n</em> <!-->=<!--> <!-->54), or a supportive approach (<em>n</em> <!-->=<!--> <span>54). The CC group will be assessed at baseline. The duration of the intervention will be 3 months, with 12 weekly group sessions. The primary outcome will be the improvement in CR measured according to change in the Cognitive Reserve Assessment Scale in Health (CRASH) and Cognitive Reserve scale for Adolescents (CORE-A). All participants will be blindly evaluated using clinical, cognitive and neuroimaging measures at baseline, at three months (after the psychological intervention), and at twelve-month follow-up after treatment completion.</span></p></div><div><h3>Discussion</h3><p>The results will provide insight into whether the CREATE-Offspring version may enhance cognitive reserve (CR) in child, adolescent and young adult Off-BDSZ as well as advance knowledge about changes in clinical manifestations, neuropsychological performance and brain structure and function associated with improving CR. This novel and cost-effective intervention represents an advance in the framework of preventive interventions in mental health.</p></div><div><h3>Trial registration</h3><p>Clinicaltrials.gov, <span>NCT03722082</span><svg><path></path></svg>. Registered on 26 October 2018.</p></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"16 3","pages":"Pages 184-191"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25405332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying risk factors for predominant negative symptoms from early stages in schizophrenia: A longitudinal and sex-specific study in first-episode schizophrenia patients","authors":"Gisela Mezquida ,&nbsp;Silvia Amoretti ,&nbsp;Miquel Bioque ,&nbsp;Clemente García-Rizo ,&nbsp;Ana M. Sánchez-Torres ,&nbsp;Laura Pina-Camacho ,&nbsp;Purificación Lopez-Pena ,&nbsp;Anna Mané ,&nbsp;Roberto Rodriguez-Jimenez ,&nbsp;Iluminada Corripio ,&nbsp;Salvador Sarró ,&nbsp;Angela Ibañez ,&nbsp;Judith Usall ,&nbsp;María Paz García-Portilla ,&nbsp;Eduard Vieta ,&nbsp;Sergi Mas ,&nbsp;Manuel J. Cuesta ,&nbsp;Mara Parellada ,&nbsp;Ana González-Pinto ,&nbsp;Esther Berrocoso ,&nbsp;Miguel Bernardo","doi":"10.1016/j.rpsm.2023.01.004","DOIUrl":"10.1016/j.rpsm.2023.01.004","url":null,"abstract":"<div><h3>Background</h3><p>People with schizophrenia and predominant negative symptoms (PNS) present a different clinical and functional profile from those without such symptomatology. Few studies have examined the risk factors and the incidence of PNS in first-episode schizophrenia patients (FES) and differentiating by sex. This study aims to assess prevalence, demographic and clinical characteristics related to PNS from early stages and to study if there are sex-specific features in terms of developing PNS.</p></div><div><h3>Methods</h3><p>In a sample of 121 FES patients derived from a multicentre and naturalistic study, those who developed PNS at 12-months were identified. Environmental, clinical, functional, and cognitive ratings were examined longitudinally. Binary logistic regressions were applied to detect baseline risk factors for developing PNS at one-year follow-up.</p></div><div><h3>Results</h3><p>In the present FES cohort, 24.8% of the patients (<em>n</em> <!-->=<!--> <!-->30) developed PNS (20% of the women, 27.6% of the men). Compared to non-PNS (75.2%, <em>n</em> <!-->=<!--> <!-->91), at baseline, PNS group had more negative (<em>t</em> <!-->=<!--> <!-->−6.347; <em>p</em> <!-->&lt;<!--> <!-->0.001) and depressive symptoms (<em>t</em> <!-->=<!--> <!-->−5.026; <em>p</em> <!-->&lt;<!--> <!-->0.001), poorer premorbid adjustment (<em>t</em> <!-->=<!--> <!-->−2.791; <em>p</em> <!-->=<!--> <!-->0.006) and functional outcome (<em>t</em> <!-->=<!--> <!-->−2.649; <em>p</em> <!-->&lt;<!--> <!-->0.001), more amotivation (<em>t</em> <!-->=<!--> <!-->−7.333; <em>p</em> <!-->&lt;<!--> <!-->0.001), more expressivity alterations (<em>t</em> <!-->=<!--> <!-->−4.417; <em>p</em> <!-->&lt;<!--> <!-->0.001), worse cognitive reserve (<em>t</em> <!-->=<!--> <!-->2.581; <em>p</em> <!-->&lt;<!--> <!-->0.011), a lower estimated intelligent quotient (<em>t</em> <!-->=<!--> <!-->2.417; <em>p</em> <!-->=<!--> <!-->0.017), worse verbal memory (<em>t</em> <!-->=<!--> <!-->2.608; <em>p</em> <!-->=<!--> <!-->0.011), and worse fluency (<em>t</em> <!-->=<!--> <!-->2.614; <em>p</em> <!-->=<!--> <!-->0.010). Regressions showed that the premorbid adjustment was the main predictor of PNS in females (<em>p</em> <!-->=<!--> <!-->0.007; Exp(<em>B</em>)<!--> <!-->=<!--> <!-->1.106) while in males were a worse verbal memory performance (<em>p</em> <!-->=<!--> <!-->0.031; Exp(<em>B</em>)<!--> <!-->=<!--> <!-->0.989) and more alterations in the motivation domain (<em>p</em> <!-->=<!--> <!-->0.001; Exp(<em>B</em>)<!--> <!-->=<!--> <!-->1.607).</p></div><div><h3>Conclusions</h3><p>A different baseline clinical profile and notable risk factors differences in the development of PNS between males and females were found. Results suggest that sex may be an important confounder in studies comparing schizophrenia patients with predominant and non-predominant negative symptomatology.</p></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"16 3","pages":"Pages 159-168"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10272479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic syndrome and related factors in a large sample of antipsychotic naïve patients with first-episode psychosis: 3 years follow-up results from the PAFIP cohort","authors":"Nathalia Garrido-Torres ,&nbsp;Miguel Ruiz-Veguilla ,&nbsp;Júlia Olivé Mas ,&nbsp;Aurora Rodríguez Gangoso ,&nbsp;Manuel Canal-Rivero ,&nbsp;María Juncal-Ruiz ,&nbsp;Marcos Gómez-Revuelta ,&nbsp;Rosa Ayesa-Arriola ,&nbsp;Benedicto Crespo-Facorro ,&nbsp;Javier Vázquez-Bourgon","doi":"10.1016/j.rpsm.2022.05.003","DOIUrl":"10.1016/j.rpsm.2022.05.003","url":null,"abstract":"<div><h3>Background</h3><p>Latest studies in patients<span> with first episode psychosis (FEP) have shown alterations in cardiovascular, immune and endocrinological systems. These findings could indicate a systemic onset alteration in the metabolic disease as opposed to justifying these findings exclusively by antipsychotics’ side effects and long-term lifestyle consequences. In any case, this population is considered at higher risk for developing cardiometabolic disorders than their age-matched peers.</span></p></div><div><h3>Methods</h3><p>This is a prospective longitudinal study. Metabolic syndrome<span> (MetS) prevalence between 244 subjects with FEP and 166 controls at 3 years was compared. Additionally, we explored whether baseline differences in any of the MetS components according to Adult Treatment Panel III definition and prescribed antipsychotic could help to predict the MetS development at 3 years.</span></p></div><div><h3>Results</h3><p>Patients with FEP present a similar baseline prevalence of MetS (<em>6.6% vs 5.4%, p</em> <!-->=<!--> <em>0.320</em>), according to ATP-III criteria. but with a higher prevalence of metabolic alterations than controls before the start of antipsychotic treatment. At 3-years follow-up the MetS prevalence had increased from 6.6% to 18.3% in the FEP group, while only from 5.4% to 8.1% in the control group. The multivariate model showed that, before antipsychotic exposure, a baseline altered waist circumference WC <em>(OR</em> <!-->=<!--> <em>1.1, p</em> <!-->=<!--> <em>0.011),</em><span> triglycerides </span><em>(OR</em> <!-->=<!--> <em>1.1, p</em> <!-->=<!--> <em>0.043)</em> and high-density lipoprotein HDL <em>(OR</em> <!-->=<!--> <em>0.9, p</em> <!-->=<!--> <em>0.008)</em> significantly predicted the presence of MetS at 3-years. We propose a predictive model of MetS at 3 years in 244 drug-naïve FEP patients.</p></div><div><h3>Conclusion</h3><p>We found that altered WC, HDL and triglycerides at baseline predicted the presence of full MetS after 3-years of initiating antipsychotic treatment. Our findings support the need for interventions to improve factors related to the physical health of FEP individuals.</p></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"16 3","pages":"Pages 175-183"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87373762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First-episode psychosis: Current research and future developments","authors":"Manuel J. Cuesta","doi":"10.1016/j.sjpmh.2023.11.002","DOIUrl":"https://doi.org/10.1016/j.sjpmh.2023.11.002","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"16 3","pages":"Pages 133-134"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138436629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clonidine reduces the need for antipsychotics in conduct disorders associated with intellectual disability and mental illness: A case series","authors":"Milton Merizalde Torres ,&nbsp;Ester Castan Campanera ,&nbsp;Josep Pifarré Paredero","doi":"10.1016/j.rpsm.2022.09.004","DOIUrl":"10.1016/j.rpsm.2022.09.004","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"16 3","pages":"Pages 204-205"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10635744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social cognition in first-episode schizophrenia/schizoaffective disorder patients","authors":"Judit Joseph Fortuny ,&nbsp;Guillem Navarra-Ventura ,&nbsp;Sol Fernández-Gonzalo ,&nbsp;Esther Pousa Tomàs ,&nbsp;Josep Maria Crosas Armengol ,&nbsp;Diego Palao Vidal ,&nbsp;Mercè Jodar Vicente","doi":"10.1016/j.rpsm.2020.04.006","DOIUrl":"10.1016/j.rpsm.2020.04.006","url":null,"abstract":"<div><h3>Introduction</h3><p><span>People with schizophrenia have neurocognitive as well as social cognition deficits. Numerous studies have shown impairment in these domains </span>in patients with chronic schizophrenia. However, these disturbances during the early phase of the disease have been less studied.</p></div><div><h3>Objective</h3><p>The aim of the study is to explore the theory of mind (ToM) and emotional processing in first-episode patients, compared to healthy subjects.</p></div><div><h3>Method</h3><p>Forty patients with a first psychotic episode of less than 5 years’ duration, and 40 healthy control subjects matched by age and years of schooling were assessed. The measures of social cognition included four stories of false belief, the Reading the Mind in the Eyes Test (RMET) and the Pictures Of Facial Affect (POFA) series.</p></div><div><h3>Results</h3><p>The patients with a first psychotic episode performed significantly worse in all tasks of social cognition, compared to the healthy controls. The second-order ToM was impaired whereas the first-order ToM was preserved in the patients. Happiness was the emotion most easily identified by both patients and controls. Fear was most difficult for the patients, while for the controls it was disgust.</p></div><div><h3>Conclusions</h3><p>Deficits in ToM and emotional processing are present in patients with a first psychotic episode.</p></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"16 3","pages":"Pages 169-174"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38010947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metacognition in psychosis: What and how do we assess it?","authors":"Luciana Díaz-Cutraro ,&nbsp;Helena García-Mieres ,&nbsp;Giancarlo Dimaggio ,&nbsp;Paul Lysaker ,&nbsp;Steffen Moritz ,&nbsp;Susana Ochoa","doi":"10.1016/j.rpsm.2022.09.003","DOIUrl":"10.1016/j.rpsm.2022.09.003","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"16 3","pages":"Pages 206-207"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10272478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute effects of a session of electroconvulsive therapy on brain-derived neurotrophic factor plasma levels","authors":"Miquel Bioque ,&nbsp;Karina S. Mac-Dowell ,&nbsp;Cristina Font ,&nbsp;Ana Meseguer ,&nbsp;Elisabet Macau ,&nbsp;Marta Garcia-Orellana ,&nbsp;Marc Valentí ,&nbsp;Juan C. Leza ,&nbsp;Miquel Bernardo","doi":"10.1016/j.rpsm.2020.05.011","DOIUrl":"10.1016/j.rpsm.2020.05.011","url":null,"abstract":"<div><p>Brain-derived neurotrophic factor (BDNF) and nerve growth factor<span><span><span> (NGF) are neurotrophins that play critical roles in brain neuronal function. Previous studies have established the association between BDNF and NGF signaling and severe </span>mental disorders, but changes in BDNF plasma levels and </span>electroconvulsive therapy (ECT) response are controversial. The aim of his study was to explore the acute effects of a single session of ECT on these neurotrophins signaling.</span></p><p>Plasma levels of BDNF and NGF and their tyrosine kinase-type receptors expression<span> in peripheral blood mononuclear cells (PBMCs) were determined before and two hours after a single ECT session in 30 subjects with a severe mental disorder.</span></p><p>Two hours after an ECT session we found a statistically significant decrease of BDNF plasma levels (<em>p</em> <!-->=<!--> <!-->0.007). We did not find significant acute effects on NGF plasma levels or receptors expression in PBMCs. We found a significant inverse correlation between the time of convulsion and BDNF plasma levels decrease (<em>r</em> <!-->=<!--> <!-->−0.041, <em>p</em> <!-->=<!--> <!-->0.024).</p><p>We have identified a decrease in BDNF plasma levels after 2<!--> <!-->h of a single ECT session. These results indicate the interest for future research in the role of neurotrophins in the response and safety of ECT.</p></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"16 3","pages":"Pages 137-142"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38163479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}