Oxytocin and rejection sensitivity: a comparative biomarker study in women with borderline personality and eating disorders.

0 PSYCHIATRY
Francisco Ruiz-Guerrero, Andrés Gómez Del Barrio, Alejandro de la Torre-Luque, Karina MacDowell, Luis Beato-Fernández, Leticia Castro Fuentes, Wala Ayad-Ahmed, Pablo Mola, Álvaro Carrasco-Díaz, José Manuel Villatoro, Juan C Leza, José Luis Carrasco, Marina Diaz-Marsa
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Abstract

Background: Emotional dysregulation is a hallmark feature of borderline personality disorder (BPD) and eating disorders (ED), which impacts the individuals' well-being and functioning. Oxytocin dysregulation has been involved in social cognition deficits associated with these disorders.

Methods: We conducted a study including a total 108 women categorized into 3 groups: 50 with eating disorders (ED), 35 with borderline personality disorder (BPD), and 23 healthy controls. Psychopathological profiles were assessed using the Bulimic Investigatory Test Edinburgh (BITE), the Eating Attitude Test 40 (EAT-40), the Barratt Impulsiveness Scale (BIS-11), and the Rejection Sensitivity Questionnaire (RSQ). Plasma oxytocin levels and oxytocin receptor expression were measured as well.

Results: BPD patients exhibited significantly lower plasma oxytocin levels vs ED patients and healthy controls. However, oxytocin receptor expression did not differ significantly across the groups. Oxytocin levels were positively associated with rejection sensitivity, particularly in BPD patients.

Conclusions: Our findings suggest a potential role of oxytocin dysregulation in emotional dysregulation and rejection sensitivity, particularly in BPD. Higher oxytocin levels in ED patients may serve as a compensatory mechanism to mitigate challenges in interpersonal relationships. These results highlight the importance of personalized therapeutic interventions targeting oxytocin dysregulation in the management of ED and BPD.

催产素和排斥敏感性:一项边缘型人格和饮食失调女性的比较生物标志物研究。
背景:情绪失调是边缘型人格障碍(BPD)和饮食障碍(ED)的显著特征,影响着个体的健康和功能。催产素失调与这些疾病相关的社会认知缺陷有关。方法:我们对108名女性进行了一项研究,将其分为3组:50名饮食失调(ED)患者,35名边缘型人格障碍(BPD)患者和23名健康对照组。采用爱丁堡暴食调查测试(BITE)、饮食态度测试40 (EAT-40)、Barratt冲动性量表(BIS-11)和排斥敏感性问卷(RSQ)对精神病理特征进行评估。同时测定血浆催产素水平和催产素受体表达。结果:BPD患者血浆催产素水平明显低于ED患者和健康对照组。然而,催产素受体的表达在两组之间并没有显著差异。催产素水平与排斥敏感性呈正相关,尤其是在BPD患者中。结论:我们的研究结果表明,催产素失调在情绪失调和排斥敏感性中具有潜在的作用,特别是在BPD中。ED患者较高的催产素水平可能是缓解人际关系挑战的代偿机制。这些结果强调了针对催产素失调的个性化治疗干预在ED和BPD管理中的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
9.50
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