中国中西医结合杂志最新文献

{"title":"[Efficacy of Chinese Medicine Combined with Fixed Quadruple Therapy on Hp Positive Chronic Gastritis].","authors":"Nan Wang,&nbsp;Chui-Jie Wang,&nbsp;Yu-Feng Li","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To study the efficacy of Chinese medicine combined with fixed \"quadruple therapy\" on Hp positive chronic gastritis. Methods Totally 375 patients with Hp positive chronic gastritis were assigned to the control group (group A) , syndrome differentiation group (group B) and Kangyou Mixture group (group C). All the patients received quadruple therapy; patients in group B took TCM Decoction; patients in group C took Kangyou Mixture . The treatment lasted for 14 days intotal. The symptom scores were observed before and after treatment. The positive rate of Hp was reviewed at 1 month after treatment. Results The eradication rates of Hp in group B and C were increased compared with group A (P <0. 01 , P <0. 05). The symptom scores of each group were decreased after treatment (P <0. 01). Compared with group A, the improvement rate of symptom scores were increased in both Group B and Group C after treatment(P <0. 05). Conclusion Chinese medicine combined with fixed \"quadruple thera- py\" could improve the eradication rate of Hp.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"37 4","pages":"406-409"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36859078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of Modified Dachengqi Decoction on Recovery of Gastrointestinal Function after Surgery in Patients with Rectal Cancer].","authors":"Ji-Ping Yu,&nbsp;Yue-Min Yuan,&nbsp;Jian-Ming Qiu,&nbsp;Kan Xu,&nbsp;Dong Wang,&nbsp;Guo-Zhen Xu,&nbsp;Fang-Fang Xu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To observe the effect of Modified Dachengqi Decoction on recovery of gastrointestinal function after closure of protective ileostomy of rectal cancer. Methods Seventy pa- tients with rectal cancer, scheduled to receive protective ileostomy were enrolled and randomized into treatment group (35 cases) and control group (35 cases). The treatment group was subjected to ante-grade enema with Modified Dachengqi Decoction (500 mL) once a day before ileostomy, the therapeutic course was 2 weeks ,and the control group received ileostomy alone. The oral feeding time, anal exhaust time, ileus rate and length of hospital stay were observed. Results Compared with the control group, the oral feeding time(h,22 ±6 vs.41 ±8), anal exhaust time(h,27 ±5 vs.48 ±8), ileus rate(2. 85% vs. 14. 29%) and length of hospital stay ( d,5. 5 ± 1. 0 vs.7. 6 ± 1. 2) were decreased in the treatment group (P <0. 01 , P <0. 05).Conclusion Modified Dachengqi Decoction could promote the recovery of gastroin- testinal function after surgery in patients with rectal cancer.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"37 4","pages":"419-421"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36913611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Metabonomics of Syndrome Markers in Infantile Bronchial Asthma Episode].","authors":"Jia-Leil Tao,&nbsp;Shou-Chuan Wang,&nbsp;Man Tian,&nbsp;Huif Liang,&nbsp;Tong Xie,&nbsp;Li-Li Lin,&nbsp;Qi-Gang Dai","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To analyze urinary metabolites of bronchial asthma children patients with phlegm-heat obstructing Fei syndrome (PHOFS) and non-PHOFS using gas chromatography-mass spec- trometry/mass spectrometer ( GC-MS/MS) , thus performing research on syndrome markers. Methods Totally 44 bronchial asthma children patients with PHOFS and non-PHOFS in onset of asthma were recrui- ted. Another 29 healthy children were also recruited. Their urine samples were analyzed by GC-MS/MS. The profiles were analyzed using orthogonal partial least squares-discriminant analysis (OPLS-DA) , vari- able importance in the projection (VIP) , and non-parametric test to determine intergroup differential metabolites. Abnormal metabolic pathways were determined by Metaboanalyst. Results Compared with the health control group, contents of fourteen substances like inositol, uric acid, stearic acid, and so on de- creased, and mino-malonic acid content increased in asthma episode children (P <0. 05). The process was mainly involved in 5 metabolic pathways such as lysine degradation and biosynthesis, pyruvate me- tabolism, and so on. Compared with the non-PHOFS group in bronchial asthma episode, contents of nine substances like oxalic acid, L-threonine, pyrimidine, and so on decreased in the PHOFS group (P < 0. 05). The process was mainly involved in 5 metabolic pathways such as pentose phosphate pathway, inositol phosphate metabolism, and so on. Conclusions Urinary metabolites are different in infantile bronchial asthma episode and healthy children. Metabolic biomarkers and pathways exist in different syn- dromes in bronchial asthma episode.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"37 3","pages":"319-325"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36912899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of Jianpi Shengxue Granule on Fertility and Early Embryo Development Toxicity of Rats].","authors":"Wen Qu,&nbsp;Zhi-Chun Jin,&nbsp;Gang Zhao,&nbsp;Qi-Zhi Yu,&nbsp;Yan-Hua Zheng,&nbsp;Qin-Qi Liu,&nbsp;Huang Zhi-Jun","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To assess the effects of Jianpi Shengxue Granule (JSG) on the fertility and early embryo development in rats. Methods Totally 176 SD rats were stratified by sex, and divided into 4 groups, i.e., the control group, low, medium, high dose JSG treatment groups. Rats in the 3 JSG treatment groups were administered with JSG at 0, 1. 16, 3. 48, 5. 80 g/kg per day by gastrogavage, re- spectively. After 2 weeks of administration for females and 4 weeks of administration for males, males and females were caged in the ratio of 1:1. Females were administered to the gestation day 7. Males were administered for 59 -63 days until the day before anatomy. All parental generations were anatomized to observe signs and morphologies. Pathological examination was performed. General toxicity was detected. The testis and epididymis were weighed. Spermatozoa number was counted from epididymis, and repro- duction toxicity of sperm motility was checked. The numbers of corpus luteum, live fetus, dead fetus, and absorbed fetus were counted. The implantation number was calculated to observe early embryo de- velopment toxicity. Results (1) General toxicity: The body weight growth slowed down in male rats of the high dose JSG treatment group. No abnormality was found in low and medium dose JSG treatment groups. (2)Fertility toxicity: There was no obvious toxic effect on testis, epididymis, and spermatozoa number from epididymis sperm in all JSG treatment groups. (3) Early embryo development toxicity: No significant effect on the formation of early embryos was found in all JSG treatment groups. Conclusions Certain gastrointestinal toxicity of JSG might exist to some extent. The dose for non-adverse effect of JSG on fertility and early embryo development was 3. 38 g/kg per day. No obvious fertility or early embryo development toxicity occurred in each JSG treatment group.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"37 3","pages":"356-359"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36859079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of Shenmai Injection on Vascular Endothelial Dependence Diastolic Function in Coronary Heart Disease Patients].","authors":"Yan Zhou,&nbsp;Hang-Yuan Guo,&nbsp;Fang Pneg","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To observe the effect of Shenmai Injection (SI) on vascular endothelial dependent diastolic function in coronary heart disease (CHD) patients. Methods Totally 100 recruited CHD patients were assigned to the SI group and the control group by random digit table, 50 in each group. All patients received conventional drugs for CHD, 50 in each group. Patients in the SI group were intrave- nously injected with SI, 50 mL each time, once per day for 10 days. Changes of brachial artery diameter at hyperemia and sublingual nitroglycerin were measured in all patients before treatment and at day 10 after treatment by intravascular ultrasound. Serum NO level, plasma levels of endothelin (ET) , thromboxane B₂ (TXB₂), 6-keto-PGF₁α , superoxide dismutase (SOD) were measured using biochemical assay and ELISA. Thirty non-CHD patients confirmed with coronary CT or coronary angiogram were recruited as the non-CHD group. Results Changed value of brachial artery diameter at hyperemia and after sublingual nitroglycerin were more obviously reduced in the CHD group than in the non-CHD group (P <0. 05, P <0. 01). Besides, levels of NO, 6-keto-PGF1α were lowered, levels of ET and TXB₂ were elevated (P < 0. 01). Compared with the control group, congestion of brachial artery was significantly improved, levels of NO and 6-keto-PGF₁α increased, SOD concentration was obviously elevated, plasma levels of ET and TXB₂ decreased in the SI group (all P <0. 05). Conclusion SI could directly up-regulate levels of NO and 6-keto-PGF₁α , increase SOD activity, decrease levels of ET and TXB₂ , and improve vascular endothelial dependent vasodilation.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"37 3","pages":"302-305"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36860143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A Systematic Review on Safety Evaluation of Treating Cardiovascular Diseases by Shuxuening In- jection].","authors":"Hong-Yu Chen,&nbsp;Yan-Ming Xie,&nbsp;Xing Liao,&nbsp;Yuan-Yuan Chen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To systematically evaluate the safety of Shuxuening Injection ( SI) for treating cardiovascular disease in line with indications. Methods Ten databases such as Cochrane Li- brary, Medline, EMBase, Web of Science, Clinical Trials, CBM, CNKI, VIP, Wangfang Data, and Chinese Clinical Trial Registry Database were retrieved in October 2015 for collecting literatures on use of SI. Data were screened by inclusion and exclusion criteria. Literatures retrieved included randomized controlled trials, non-randomized controlled trials, observational research (case control, cohort studies, case series, case reports, and so on) , and were methodologically evaluated by Cochrane Systematic Risk of Bias Manual, TREND, and SUMARI. Results A total of 185 literatures were retrieved in this systematic review. Of them, 155 randomized controlled trials( RCT) , 6 non-randomized controlled trials, 11 case series, and 13 case reports were finally identified. Among the 13 case reports, adverse drug reactions (ADRs) occurred in 15 cases. Of the 155 RCT studies, XI was used in 8 553 patients, with ADRs in 162 cases and adverse events (AEs) in 4 cases. The outcomes of ADRs mainly covered the gastrointestinal system damage, central/peripheral nervous system damage, skin and appendages injury, and so on. The degree of damage was mostly mild. It is difficult to get a clear judgment on the relationship be- tween the occurrence of these ADRs and drug dosage, drug administration, drug solvents, and combina- tion medications. Conclusions The general safety of using XI for treating cardiovascular diseases was acceptable in this systematic review. Although Xl was systematically analyzed to be safely used in case reports, mechanism studies or large sample observational studies are lack.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"37 3","pages":"283-290"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36860149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Dynamic Visible Microcirculation and Activating Blood Removing Stasis Research].","authors":"Na Kou,&nbsp;Mei Xue,&nbsp;Ming-Ming Wang,&nbsp;Da-Zhuo Shi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The technology of dynamic visualization microcirculation is to observe changes of mi- crocirculation by using visualization technology, combined with fluorescence labeling, high-speed video, electronic microscopy and other methods, converting rest images into dynamic visual graphics. In the past ten years, domestic researchers used this technology, and carried out researches on the heart, piamater/mesenteric microcirculation, dynamically observed effects of activating blood removing stasis (ABRS) research monomer, single herb and compound on arteriole/venula diameter, and the velocity of red blood cell, white blood cell adhesion, platelet aggregation, microvascular permeability, superoxide production, and plasma albumin leakage, etc. Microcirculation detection technologies were further opti- mized. Exerting direct advantages of dynamic visualization microcirculation, systematically evaluating ac- tion mechanism of Chinese herbs (multi-sites and multi-targets) , and interaction mechonism between Chinese herbs and Western drugs are important directions for future researches on microcirculation.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"37 3","pages":"371-376"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36869667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effects of Electroacupuncture on Gastrointestinal Motility and Expressions of VIP and CGRP in Functional Dyspepsia Model Rats].","authors":"Pai-di Xu,&nbsp;Hong-Xing Zhang,&nbsp;Yun Yang,&nbsp;Yu Xin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To observe the effects of electroacupuncture (EA) on vasoactive intesti- nal peptide (VIP) , calcitonin gene-related peptide (CGRP) expression, gastric emptying, and small in- testine advance rate in functional dyspepsia (FD) rats. Methods Totally 48 SD rats were randomly di- vided into three groups, the blank group, the model group, and the EA group, 16 in each group. Except rats in the blank group, FD model was established by tail clamped stimulation plus irregular diet, and ice physiological saline gastrogavage for 14 successive days. After successful modeling EA at Zusanli (ST36) and Taichong (LR3) were performed, once per day for 28 days. Rats were intervened by gastro- gavage at the end of the treatment. Gastric tissue and small intestinal tissue were sampled after anatomy. The rates of gastric emptying and small intestinal transit were determined. Pathological changes of gastric antrum and jejunum tissue were observed by HE staining. mRNA expression levels of VIP and CGRP in gastric antrum and jejunum tissue were determined by Real-time PCR. Results No organic change oc- curred in tissues of the 3 groups. No gastric or intestinal ulcers , inflammatory infiltration, or glandular ep- ithelial lesion occurred in the 3 groups. Compared with the blank group, gastric residual rate obviously in- creased, small intestinal transit rate was lowered, mRNA expression levels of VIP and CGRP in gastric antrum and jejunum tissue were obviously elevated in the model group (P <0. 01, P <0. 05). Compared with the model group, gastric residual rate was obviously reduced, small intestinal transit was obviously elevated, mRNA expression levels of VIP and CGRP in gastric antrum and jejunum tissue were obviously decreased (P <0. 05, P <0. 01). Conclusions EA could significantly decrease mRNA expressions of VIP and CGRP in gastrointestinal tract, accelerate gastric emptying rate and small intestinal transit rate. EA's improving the gastrointestinal motility might be related to decreasing mRNA expressions of VIP and CGRP in gastrointestinal tract, indicating that abnormal secretion braingut peptide might be one of important mechanisms for FD.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"37 3","pages":"360-364"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36913614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of Water Extract of Ginseng on Biological Bechaviors of Lung Cancer A549 Cells and the Expression of F-actin in Co-culture System of TAMs and A549 Cells].","authors":"Jing Gao,&nbsp;Lei Bi,&nbsp;Yu-Cui Jiang,&nbsp;Ye Yang,&nbsp;Bian-Ying Li,&nbsp;Wei-Ping Chen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To study the effect of Water Extract of Ginseng (WEG) on the prolifera- tion/metastasis of lung cancer A549 cells and the expression of F-actin in co-culture system of tumor as- sociated macrophages (TAMs) and A549 cells. Methods Human acute leukemia mononuclear strain THP-1 was induced to become TAMs using Phorbol-12-myristate-13-acetate (PMA) combined IL-4 and IL- 13. The supernant of TAMs and A549 cells were co-cultured. A co-culture model was set up by simulating microenvironment of lung cancer. Then cells were divided into the blank control group (A549) , the co- culture group (A549 +TAMs) , high, middle, and low dose WEG groups (TAMs +A549 + high, middle, and low dose WEG). The effects of WEG on the proliferation/metastasis of lung cancer A549 cells and the expression of F-actin under various conditions were detected using MTT method, Real time cell analysis (RTCA) , and high content screening (HCS). Results Compared with the blank control group, the pro- liferation of A549 cells was obviously increased, cell migration was obviously elevated, and the area of cell skeleton was markedly enlarged in the TAMs + A549 group, with statistical difference (P <0. 05). Compared with the TAMs +A549 group, the proliferation and migration of A549 cells were inhibited, the area of cell skeleton and the number of microfilaments were reduced dose-dependently (P <0. 05). Conclusion WEG could effectively inhibit the proliferation and migration of A549 cells, which might be a- chieved by adjusting immunoactivities of TAMs, and further it affected biological behaviors of tumor cells.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"37 3","pages":"345-350"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36859076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Treating Moderately Severe Acute Pancreatitis with Raw Rhubarbs by Intranasal Jejuna Injection: a Randomized Clinical Analysis].","authors":"Li-Xin Yang,&nbsp;Jing Liu,&nbsp;Yun Xing,&nbsp;Li-Chuan Du,&nbsp;Jing Chen,&nbsp;Jian-Yu Hao","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To observe clinical efficacy of raw rhubarbs (by intranasal jejuna injection) for moderately severe acute pancreatitis (MSAP) , and its effects on gastrointestinal tract and coagulation fibrinolysis. Methods Totally 84 MSAP patients were randomly assigned to the control group and the treatment group by random number table, 42 in each group. All patients received routine medica- tion. Enteral nutrition by intranasal jejuna injection was input under the endoscope within 48 h of onset. Pa- tients in the treatment group additionally used raw rhubarbs (by intranasal jejuna injection) , 100 mL each time, twice per day, with the treatment duration for 3 -7 days. The recovery of gastrointestinal tract func- tion (passage of gas by anus, recovery time of bowel sound, distension disappearance time, abdominal pain disappearance time) was observed, prothrombin time (PT) , activated partial thromboplastin time (APTT), thrombin time (TT) , fibrinogen (Fib) content, platelet (PLT) count, D-dimer (DD), protein C were determined. Clinical efficacy was assessed as well. Results Compared with the control group, time for gas passage by anus, recovery time of bowel sound, distension disappearance time, and ab- dominal pain disappearance time were shortened, PT, APTT, Fib content, thrombin time, and DD decreased, and protein C increased in the treatment group (P <0. 05). The incidence rate of complications was lower in the treatment group than in the control group (P <0. 05). The cure rate was elevated (P < 0. 05). There was no statistical difference in the total effective rate between the two groups (P >0. 05). Conclusion Intranasal jejuna injection of raw rhubarbs in treating moderately severe acute pancreatitis could improve symptoms of gastrointestinal tract and coagulation fibrinolysis.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"37 3","pages":"306-309"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36860144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}