中国中西医结合杂志最新文献

{"title":"[Correlation Research between Syndrome Elements of Chinese Medicine and KRAS, BRAF, NRAS Gene Mutations in Advanced Colorectal Cancer Patients].","authors":"Zhong-Ning Xu,&nbsp;Yu-Fei Yang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To study the correlation between syndrome elements of Chinese medicine (CM) and KRAS, BRAF, NRAS gene mutations in advanced colorectal cancer patients. Methods Syn- drome elements of CM, KRAS, BRAF, NRAS gene mutations (mutation \" +\" & wild type/non-mutation \" --\") were collected in 33 advanced colorectal cancer patients. The correlation between gene mutations and syndrome elements of CM was analyzed using binary Logistic regression. Results Wild type KRAS (KRAS-) was negatively correlated with Gan depression syndrome (P =0. 043, P <0. 05), while KRAS mutation (KRAS + ) was positively correlated with Gan depression syndrome (P =0. 043, P <0. 05). KRAS-and KRAS + had no significant relation with Pi deficiency, Fei deficiency, Shen deficiency, yang deficiency, yin deficiency, qi deficiency, blood deficiency, phlegm turbidity, qi stagnation, and blood sta- sis (P>0. 05). BRAF-and NRAS-had no significant relation with Gan stagnation, Pi deficiency, Fei defi- ciency, Shen deficiency, yang deficiency, yin deficiency, qi deficiency, blood deficiency, phlegm turbidi- ty, qi stagnation, and blood stasis (P >0. 05). Positive BRAF and NRAS were seldom found in this study, so they were not statistically analyzed. Conclusions There existed correlations between gene mutations and Gan stagnation. KRAS-was negatively correlated with Gan depression, while KRAS+ was positively correlated with Gan depression. Whether there exists mutation of BRAF or NRAS was not correlated with syndrome elements of CM.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"36 12","pages":"1445-1448"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36869201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Treatment of Olanzapine-induced Hyperprolactinemia by Shaoyao Gancao Decoction].","authors":"Pei Gu,&nbsp;Xiu Jin,&nbsp;Xue Li,&nbsp;Yan-Qing Wu,&nbsp;Fu-Qiang Mao","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To observe the efficacy and safety of Shaoyao Gancao Decoction (SGD) in treating olanzapine induced hyperprolactinemia. Methods Totally 120 schizophrenia patients who took Olanzapine Tablet (OT) were assigned to the treatment group and the control group by random number table, 60 in each group. All patients took OT. Those in the treatment group additionally took SGD. The ther- apeutic course for all was 8 weeks. Serum levels of prolactin were measured before treatment and at the end of week 2, 4, and 8 after treatment. The spiritual symptoms of patients were assessed by Positive and Negative Syndrome Scale (PANSS) before treatment and at the end of week 8 after treatment. Adverse reactions were assessed using Treatment Emergent Symptom Scale (TESS) before treatment and at the end of week 8 after treatment. Results Compared with before treatment in the same group, ser- um levels of prolactin were significantly reduced in the treatment group at the end of week 4 and 8 after treatment (P <0. 05). There was no statistical difference in serum levels of prolactin in the control group among each time points (P > 0. 05). Compared with the control group, serum levels of prolactin de- creased significantly in the treatment group at the end of week 4 and 8 after treatment (P <0. 01). There was no statistical difference in PANSS between the two groups at the end of week 8 after treatment (P> 0. 05). Adverse reactions occurred in 5 cases (943%) of the treatment group and 4 cases (7. 14%) in the control group. They were manifested as insomnia, headache, constipation, and incapability of sitting quietly. There was no statistical difference in adverse reaction between the two groups (P'>0. 05). Con- clusions SGD could effectively improve olanzapine-induced hyperprolactinemia, and had no obvious effect on psychotic symptoms. It showed no obvious adverse reactions.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"36 12","pages":"1456-1459"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36869203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Acupuncture Regulated the Expressions of Hsp84 and Hsp86 and Postponed Brain Aging in SAMP8].","authors":"Yu-Jie Jia,&nbsp;Kun Nie,&nbsp;Xue-Zhu Zhang,&nbsp;Jing Li,&nbsp;Lin Guo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To observe the correlations between heat shock protein 84 ( Hsp84)/ Hsp86 and brain aging in senescence accelerated mouse prone 8 (SAMP8) and the regulation effects of acupuncture. Methods Ten senescence accelerated mouse resistant 1 (SAMR1) were recruited as a normal control group. Another 30 SAMP8 mice were divided into the blank control group, the acupuncture group, and the non-acupoint group by random digit table, 10 in each group. Mice in the acupuncture group received treatment with \"Sanjiao\" acupuncture method. Mice in the non-acupoint group were needled at two fixed non-acupoints located at bilateral hypochondrium of the body. Catching stimulus at equal volume was given to mice in the rest two groups. All intervention was performed once per day for 15 successive days. Neuromuscular coordination of mice was evaluated. Levels of oxidative stress and protein carbonyl were determined. mRNA and protein expression levels of Hsp84 and Hsp86 in the hippocampus of mice and Neuro-2a cells were detected using Real-time PCR and Western blot. Results Compared with the normal control group, the success rate of tight rope experiment was lowered (P <0. 01) , levels of super- oxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the hippocampus were reduced (P < 0. 01) , the levels of superoxide anion and protein carbonyl increased (P <0. 01, P <0. 05), mRNA and protein expression levels of Hsp84 and Hsp86 in the hippocampus decreased (P <0. 01) in the blank con- trol group. Compared with the blank control group and the non-acupoint group, the success rate of tight rope experiment was elevated (P <0. 05) , levels of SOD and GSH-Px were increased (P <0. 05, P < 0. 01) , the levels of superoxide anion and protein carbonyl decreased (P <0. 01 , P <0. 05), and expres- sion levels of Hsp84 and Hsp86 in the hippocampus increased (P <0. 01) in the acupuncture group. mR- NA expression levels of Hsp84 and Hsp86 were decreased in Neuro-2a cells after treated with AP21-35 (P <0. 01). Conclusions Increased oxidative damage of protein and decreased expression levels of Hsp84 and Hsp86 might be partial reasons for resulting in accumulation of denatured protein and brain aging in SAMP8. Acupuncture could delay brain aging by regulating the expressions of Hsp84 and Hsp86.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"36 12","pages":"1474-1479"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36912870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of Xinfeng Capsule in Improving Blood Stasis State of OA Patients].","authors":"Bing Tan,&nbsp;Jian Liu,&nbsp;Ping-Heng Zhang,&nbsp;Li Fang,&nbsp;Fu-Bing Zhu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To observe the relationship between blood stasis state and activation of nuclear factor-κ-gene binding (NF-κB) signaling pathway/miRNA-146 in osteoarthritis (OA) patients and the effect of Xinfeng Capsule (XFC) on them. Methods Totally 70 OA patients were assigned to the treatment group and the control group according to random number table, 35 in each group. Patients in the treatment group took XFC, 3 pills each time, 3 times per day, while those in the control group took Glucosamine, 1 pill each time, 3 times per day. The therapeutic course for all was 3 months. Serum con- tents of p50, p65, inhibitor of nuclear factor κB O (IκBα) , nuclear factor kappa B activator 1 (Act1) , TGF-β-activated kinase 1 (TAK1) , IL-1, IL-17, IL-10, and thromboxane A₂(TXA₂) , prostacycline (PGI₂) were detected by ELISA. mRNA levels of Act1 , p65, p50, and TAK1 were detected using fluorescent quantitative PCR. The protein levels of p50 and p65 were detected using Western blot. The level of miRNA- 146 was detected using in one-step PCR. Results (1) Compared with pre-treatment in the same group, the levels of blood stasis score, platelets (PLT) , D-dimer (D-D) , TXA₂, IL-1, IL-17, high-sensitivity C- reactive protein (hs-CRP), and erythrocyte sedimentation rate (ESR) all decreased; mRNA levels of p50, p65, Act1, and TAK1 were lowered; protein expressions of p50 and p65 decreased; serum levels of miRNA-146 decreased; activated partial thromboplastin time (APTT) , prothrombin time ( PT) , prosta- glandin 2 (PGI₂), IL-10 increased in the two groups after treatment with statistical difference (P <0. 05, P <0. 01). Compared with the control group, the levels of blood stasis score, PLT, FIB,TXA₂, IL-17, hs- CRP, and ESR were lowered; mRNA expressions of p65 and TAK1 were lowered; protein expressions of p50 decreased; levels of PT and PGI₂ increased in the treatment group after treatment (P <0. 05, P < 0.01). Conclusion XFC could regulate the immunity and restore the equilibrium of cytokine network, and protect vascular endothelial cells possibly by up-regulating miRNA-146 expression and inhibiting acti- vation of NF-κB signaling pathway, thus improving blood stasis state of OA.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"36 12","pages":"1449-1455"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36869202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of Jian'erle Granule on Thl7/Treg Imbalance of Asthma Mice].","authors":"Zhui-En Wang,&nbsp;Xue-Na Zhou,&nbsp;Yii Yang,&nbsp;Zhu-Yun Liu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To observe the levels of Th17 associated inflammatory factor IL-17 and Treg associated inflammatory factor IL-10 in serum and bronchoalveolar lavage fluid (BALF) of bronchial asthma mice, and to explore the mechanism of Jian'erle Granule (JG) for preventing and treating asth- ma. Methods Totally 40 Balb/c mice were divided into 4 groups according to random digit table, i.e., the normal control group, the asthma group, the post-excitation asthma group, the JG +asthma group, 10 in each group. Asthma model was established by 1% ovalbumin (OVA) (grade V) solution sensitization and excitation after intraperitoneal injection of antigen suspension in all groups except the normal control group. JG (0. 36 g/mL) was administrated to mice in the JG +asthma group after modeling. Equal volume of normal saline was administrated to mice in the rest 3 groups. All medication lasted for 14 successive days. After medication mice in the JG +asthma group and the asthma group were excited with 1% OVA (grade I) again for 40 min by atomization inhalation. Lung inflammation was examined by HE staining. Levels of IL-10 and IL-17 in BALF and serum were measured by ELISA. Results Bronchial structure in lung tissue was normal in mice of the normal control group, with no inflammatory infiltration seen. Mucosal epithelial cells of bronchial wall were injured in the asthma group and the post-excitation asthma group, with inflammatory infiltration seen. Inflammation around bronchus and blood vessels was obviously attenuated in the JG+asthma group. Compared with the normal control group,the IL-17 level in serum and BALF significantly increased, IL-10 level significantly decreased in the asthma group (P <0.01). Compared with the asthma group, IL-17 level in serum and BALF increased and IL-10 level in serum and BALF decreased in the post-excitation asthma group (P <0.01). Compared with the asthma group, the IL-17 level in serum and BALF significantly decreased, IL-10 level significantly increased in the JG +asth- ma group (P <0. 01). Compared with the post-excitation.asthma group,the IL-17 level in serun and BALF significantly decreased and IL-10 level in serum and BALF significantly increased in the JG + asthma group (P <0. 01). Conclusion The mechanism for JG preventing and treating asthma might be correla- ted with regulating Th17/Treg cytokine balance in serum and BALF.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"36 12","pages":"1510-1514"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36912875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of Modified Dihuang Yinzi Recipe and Huatan Tongluo Decoction on Neurological Function of MCAO Rats].","authors":"Xiang-Chun Wu,&nbsp;Shao-Qing Wang,&nbsp;Lu Tang,&nbsp;Wen-Hao Zhu,&nbsp;Ying Gao","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To observe the effect of Modified Dihuang Yinzi Recipe (MDYR) and Hua- tan Tongluo Decoction (HTD) on neurological function of middle cerebral artery occlusion (MCAO) model rats. Methods Forty SD rats were randomly divided into 5 groups, i.e., the sham-operation group, the model group, the nimodipine (NMDP) group, the MDYR group, and the HTD group, 8 in each group. NMDP liquid was administered to rats in the NMDP group by gastrogavage at the daily dose of 12 mg/kg. MDYR liquid was administered to rats in the MDYR group by gastrogavage at the daily dose of 7. 9 mg/kg. HTD liquid was administered to rats in the HTD group by gastrogavage at the daily dose of 6. 5 mg/kg. Equal volume of distilled water as administered to rats in the sham-operation group and the model group by gastrogavage. All intervention lasted for 7 successive days. MCAO rat model was established. The Zealonga neurology score was measured. Neurological function was scored at 3 and 6 h, day 1 , 6, and 7, respectively. Levels of corticotropin releasing hormone ( CRH) in plasma, adrenocorticotropic hormone (ACTH) and cortisone (CORT) in serum were detected using radioimmunoassay. The expression of ma- trix metalloproteinase-9 ( MMP9 ) in brain tissue was detected using immunohistochemical staining. Results Compared with the sham-operation group, the Zea-longa neurological score increased; levels of CRH and ACTH decreased (P <0. 05, P <0. 01) , expression levels of CORT and MMP-9 (in brain tis- sue) increased in the model group (P <0. 01). Compared with the model group, the Zea-longa neurologi- cal score obviously decreased, levels of CRH and ACTH increased, expression levels of CORT and MMP-9 (in brain tissue) decreased (P <0. 05, P <0. 01) in the MDYR group and the HTD group. Com- pared with the NMDP group, serum CORT decreased in the MDYR group (P <0. 05) ; MMP-9 expression level decreased in the HTD group (P <0. 01). Conclusions MDYR and HTD could obviously improve neurologic function of MCAO rats. Its mechanism might be related to MDYR regulating disordered HPA ax- is and HTD inhibiting MMP-9 expression.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"36 11","pages":"1352-1357"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36852034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of Shengqing Capsule on Serum Cholesterol Content and Hepatic Scavenger Receptor Class B of Rats with Cholesterol Calculus].","authors":"Jiong Li,&nbsp;Wei Lu,&nbsp;Xiao-Qiang Liang,&nbsp;Tian-Bi Lin,&nbsp;Hai-Tao Jiang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To observe the effect of Shengqing Capsule (SC) on serum contents of TC, LDL-C, and HDL-C, hepatic scavenger receptor B I (SRB I ) , and CD36 in rats with cholesterol cal- culus. Methods Totally 80 mice were divided into 4 groups according to random number table, i.e., the normal group, the model group, the Western medicine (WM) group, and the Chinese medicine (CM) group, 20 in each group. Mice in the normal group were fed with common forage, while mice in the other 3 groups were fed with lithogenic diet. Mice in the CM group and the WM group were fed with SC (at the daily dose of 0.35 g/kg) and Ursodeoxycholic Acid Tablet (UDCA, at the daily dose of 39. 55 mg/kg) re- spectively for 7 weeks. The general condition and gallstone formation rate were observed. Serum contents of TC, LDL-C, and HDL-C, and protein expressions of SBR I and CD36 were detected by oxidase meth- od and Western blot respectively. Results No gallbladder stone formed in the normal group, and gall- stone formed in 15 mice of the model group with gallstone formation rate of 75%. Compared with the nor- mal group, serum contents of TC and LDL-C and protein expressions of SRB I and CD36 increased, HDL-C content decreased in the model group (P <0. 01). The gallstone formation rate was 35% (7 mice) in the WM group and 30% (6 mice) in the CM group, lower than that of the model group (75%; P <0. 05). Contents of TC and LDL-C, and protein expressions of SRB I and CD36 decreased, HDL-C content in- creased in the WM group and the CM group (P <0.01). Compared with the WM group, TC content and protein expressions of SRB I and CD36 decreased in the CM group (P <0.01). Conclusion SC could prevent and treat gallbladder stone possibly through lowering expression levels of SRB I and CD36.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"36 11","pages":"1369-1372"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36852037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Evaluation of Criterion Validity of CHF-Quality of Life Scale of Integrative Medicine].","authors":"Jie Wan,&nbsp;Qian Lin,&nbsp;Jing-Ze Su,&nbsp;Hong Tan,&nbsp;Pin-Hui Li","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To evaluate the criterion validity of Chronic Heart Failure (CHF) -Quality of Life (QOL) Scale of Integrative Medicine (abbreviated as Scale). Methods Clinical data of 249 CHF in- patients were collected. Using Pearson and Spearman correlation analyses, the indicators such as NT- proBNP, cardiac function classification (NYHA) , 6 Minutes Walk Test (6MWT) , left ventricular ejection fraction (LVEF) were taken as exterior contrasts of standard validity, the correlation between the Scale and physicochemical indices of modern medicine were analyzed. The standard validity of the Scale was evaluated. Results Compared with before treatment, the numerical value of the overall index score of the Scale, LVEF, LVEF≤40%, and 6MWT all increased (P <0. 05, P <0. 01) ; NT-proBNP level decreased (P <0. 01). The numerical value of the overall index score of the Scale was negatively correlated with NY- HA classification and NT-proBNP level, but positively correlated with LVEF and 6MWT, all with statistical difference (P <0. 01). NT-proBNP, 6MWT, and NYHA classification were all correlated with the scores of the Scale in each field (P <0. 05). LVEF was correlated with the scores of the Scale in each field (P < 0. 05) except social function. Conclusion The Scale had favorable criterion validity, which could be taken as an indicator for comprehensive curative effect evaluation system of CHF.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"36 11","pages":"1300-1303"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36862649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Astragalus Granule Combined Auricular Point Sticking for Cough Variant Asthma in Children].","authors":"Li-Wen Zhang,&nbsp;Ming-Xin Reng,&nbsp;Guo-Chang Xue,&nbsp;Lin-Na Shen,&nbsp;Huan Xia,&nbsp;Yue-Juan Song,&nbsp;Xue-Xia Xia","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To observe the clinical efficacy and effect of Astragalus Granule (AG) , auricular point sticking combined with aerosol inhalation on the levels of tumor necrosis factor-α (TNF- a), interleukin-4 (IL-4), interleukin-10 (IL-10), eosinophil cell count (EOS), and immunoglobulin E (IgE) in cough variant asthma (CVA) children. Methods Totally 150 CVA children patients were ran- domly assigned to three group, the Western medicine group (WM) , the Chinese medicine group (CM) , and the combined group, 50 in each group. All patients received basic treatment of aerosol inhalation with Budesonide suspension and Terbutaline Sulphate Solution. Patients in the WM group received basic treatment alone. Those in the CM group additionally took AG. Those in the combined group additionally took AG and received auricular point sticking. The therapeutic course for all was 8 weeks. Expression levels of TNF-α, IL-4, and IL-10 were detected in each group using ELISA before and after treatment. Levels of EOS and IgE were detected using hematology analyzer. Results Compared with before treatment in the same group, the expression levels of TNF-α and IgE decreased in the WM group after treatment (P < 0. 05) ; the expression levels of TNF-α, IL-4, EOS, and IgE decreased, but the level of IL-10 increased in the CM group and the combined group after treatment (P <0. 05). Compared with the WM group at the same time, the expression level of IL-10 increased, and the level of IgE decreased in the CM group (P < 0. 05). The control rate, the markedly effective rate, and the total effective rate were elevated (P < 0. 05), and the ineffective rate was lowered (P <0. 05) in the CM group. In the combined group the expression levels of TNF-α, IL-4, EOS, and IgE decreased, and the level of IL-10 increased after treatment (P <0. 05). The cough alleviation time and the disappearance time were shortened in the combined group after treatment (P <0. 05). The control rate, the markedly effective rate, and the total effective rate were elevated (P <0. 05), and the ineffective rate was lowered (P <0. 05) in the combined group after treatment. Compared with the CM group at the same time point, the expression level of IL-10 increased (P < 0. 05), the levels of IgE and EOS were lowered (P <0. 05), the cough alleviation time and the disappear- ance time were shortened (P <0. 05) , the control rate and the total effective rate were elevated in the combined group after treatment (P <0. 05). Conclusion AG, auricular point sticking combined with aerosol inhalation could significantly reduce the levels of TNF-α, IL-4, EOS, and IgE, and improve the level of IL-10 in CVA children patients, with significant clinical effects.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"36 11","pages":"1308-1311"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36862652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Serum Levels of Interleukin-17 and Tumor Necrosis Factor-α in Dermatomyositis Patients with Dif- ferent Syndrome Types of Chinese Medicine].","authors":"Han-Chun Niu,&nbsp;Ju-Fang Han,&nbsp;Xiao-Yun Li,&nbsp;Hai-Qing Ge,&nbsp;Wen-Xiao Ren","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To observe serum levels of interleukin-17 (IL-17) and tumor necrosis factor-α (TNF-α) in dermatomyositis (DM) patients with different syndrome types of Chinese medicine (CM). Methods Totally 68 dermatomyositis patients were recruited and grouped by syndrome typing of CM, i.e., heat-toxin flourishing syndrome (20 cases) , damp-heat accumulation syndrome (14 cases) , cold-dampness obstruction syndrome (12 cases) , Pi-Shen deficiency syndrome (12 cases) , Gan-Shen yin deficiency syndrome (10 cases). Meanwhile, 64 healthy volunteers were recruited as healthy con- trols. The levels of IL-17 and TNF-α in serum were detected in patient groups and the healthy group. Results Compared with the healthy control group, the serum IL-17 level increased in patients with heat-toxin flourishing syndrome, damp-heat accumulation syndrome, and cold-dampness obstruction syndrome (P <0. 01) ; the serum TNF-α level increased in DM patients with each syndrome (P <0. 01 , P < 0. 05). Compared with the heat-toxin flourishing syndrome group, the serum IL-17 level decreased in patients with cold-dampness obstruction syndrome, Pi-Shen deficiency syndrome, and Gan-Shen yin deficiency syndrome (P <0. 01) ; and the serum TNF-α level decreased in patients with Pi-Shen deficiency syndrome and Gan-Shen yin deficiency syndrome (P <0. 01). Compared with the dampheat accumulation syndrome group, the serum IL-17 level decreased in patients with cold-dampness obstruction syn- drome, Pi-Shen deficiency syndrome, and Gan-Shen yin deficiency syndrome (P <0. 01) , and the serum TNF-α level decreased in patients with Pi-Shen deficiency syndrome and Gan-Shen yin deficiency syndrome (P <0. 01). Compared with the cold-dampness obstruction syndrome group, the serum levels of IL-17 and TNF-α decreased in patients with Pi-Shen deficiency syndrome and Gan-Shen yin deficiency syndrome (P <0. 01 , P <0. 05). Conclusion Serum levels of IL-17 and TNF-α are different in DM patients with different syndrome types of CM.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"36 11","pages":"1316-1318"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36862653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}