中国中西医结合杂志最新文献

{"title":"[Treatment of Guishen Zhiyang Recipe for Senile Pruritus Patients with Blood Deficiency and Hy- peractivity of Gan-yang Syndrome].","authors":"Dong Lan,&nbsp;Yu Cheng,&nbsp;Hong-Xia Jia,&nbsp;Xiao-Yang Li,&nbsp;Li-Wei Ran","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To observe the clinical efficacy of Guishen Zhiyang Recipe (GZR) in trea- ting senile pruritus patients with blood deficiency and hyperactivity of Gan-yang syndrome (BDHGYS) and to study the mechanism in nervous-endocrine-immune systems. Methods Ninety senile pruritus pa- tients were assigned to the treatment group and the control group by complete randomized lot, 45 in each group. Totally 41 patients in the treatment group and 38 patients in the control group completed the trial. Patients in the treatment group took GZR, while those in the control group took Fuyang Granule (FG). Ex- ternal application of Binghuang Fule Soft Ointment was performed to all patients. The therapeutic course for all was 8 weeks. Symptoms and efficacy changes in skin lesion were observed in the two groups. Lev- els of stem cell factor (SCF) , dynorphin (DYN) , testosterone (T) , estradiol (E₂) , and IL-4 were detec- ted in the two groups using double antibody sandwich ELISA. Results Compared with before treatment, pruritus degree, scratching area, scaling, lichenoid lesion, irritability and restlessness, dysphoria, dry pharynx, dizziness, and tinnitus all decreased in the two groups after 8 weeks of treatment (P <0. 05). Scores of Chinese medical syndromes all decreased after 4 and 8 weeks of treatment (P <0. 05). Levels of SCF and DYN obviously decreased in the two groups after 4 and 8 weeks of treatment (P <0. 05,P < 0. 01). Compared with the control group, obvious improvement was seen in pruritus degree, scratching number, scaling, irritability and restlessness , dysphoria, dizziness , and tinnitus(P <0. 05) ; total scores of Chinese medical syndromes decreased (P <0. 05) ; SCF also decreased (P <0. 05) in the treatment group after 8 weeks of treatment. Conclusions Based on external application of Binghuang Fule Soft Ointment, GZR showed better efficacy than that of the control. It had certain roles in regulating related mediator levels that might affect nervous-endocrine-immune systems.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"36 12","pages":"1460-1464"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36912868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Anti-renal Fibrosis Mechanism of Modified Huangqi Chifeng Decoction Based on TGF-p1/Smad Signal Pathway].","authors":"Yan-Hong Gao,&nbsp;Yu Zhang,&nbsp;Peng Li,&nbsp;Hong-Xia Liu,&nbsp;Shuang Li,&nbsp;Zi-Kai Yu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To observe the effect of Modified Huangqi Chifeng Decoction (MHCD) on TGF-β₁/Smad signal pathway, and to explore its anti-renal fibrosis mechanism. Methods Adopting ser- um pharmacology method, rats were intragastrically administered with MHCD and telmisartan to prepare drug containing serum. Mouse mesangial cells were cultured in vitro, using lipopolysaccharides (LPS) as stimulating factor. The cells were divided into six groups, i.e., the normal group, the model group, the telmisartan group, high, medium and low dose MHCD groups. The cell supernatant was collected in each group after mouse mesangial cells were intervened by drug containing serum for 72 h. Contents of laminin (LN) and fibronectin (FN) were measured using ELISA. Protein expression levels of TGF-P, , p-Smad2/3, Smad7, and connective tissue growth factor (CTGF) were detected using Western blot. Results (1) Compared with the normal group, contents of LN and FN in supernatant significantly increased in the model group (P <0. 01). Compared with the model group, contents of LN and FN were significantly reduced in the telmisartan group and the medium dose MHCD group (P <0. 05, P <0. 01). FN content in su- pernatant significantly decreased in the low dose MHCD group (P <0. 01). (2) Compared with the normal group, protein expressions of TGF-β₁ , p-Smad2/3, and CTGF were significantly increased, Smad7 protein expression significantly decreased in the model group, with statistical difference (P <0. 01). Compared with the model group, protein expressions of TGF-β₁ and CTGF significantly decreased in the telmisartan group and 3 MHCD groups (P <0. 01 , P <0. 05) ; protein expression of p-Smad23 significantly decreased in the telmisartan group, high and medium dose MHCD groups (P <0.01); Smad7 protein expression were significantly increased in high and medium dose MHCD groups (P <0. 05). Conclusion MHCD could inhibit increased inflammatory factors induced secretion of extracellular matrix in glomerular mesangial cells, and restrain excessive activation of TGF-β₁/Smad signal pathways, which might be one of its anti-renal fibrosis mechanisms.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"36 12","pages":"1486-1490"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36912871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Pathogenesis of Parkinson's Disease Viewing from Modern Chinese Medicine].","authors":"Qiao-Zhen Su,&nbsp;Hong-Feng Liang,&nbsp;Chang An,&nbsp;Zhe Li,&nbsp;Xiao-Dong Luo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Modern pathological studies of Parkinson's disease. (PD) reveal that 70% -80% sub- stantia nigra striatum nerve endings degenerate before -motor symptoms occur. But till now, Chinese medicine (CM) infers its pathogeneses still at the theoretical level. Braak H, et al. raised six pathological stages of PD. They also beleived that symptoms of PD occurred one by one acocrding to staging sequence. All these indicated important evidence for the developing process of PD's pathogenesis. Authors expounded modern CM pathogenesis of PD.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"36 12","pages":"1515-1517"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36870561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of Wenshen Yangxue Recipe on Inhibin-Activin-Follistatin System in Anovulatory Rats].","authors":"Ming-Wei Xin,&nbsp;Qiu-Xia Zhang,&nbsp;Hui Zhao,&nbsp;Yi-Iong Yang,&nbsp;Jun-Qin He,&nbsp;Ying Zhang,&nbsp;Xin-Yun Liang,&nbsp;Ying Wu,&nbsp;Wei Yang,&nbsp;Xiao-Dan Yin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To explore the effect of Wenshen Yangxue Recipe (WYR) on inhibin-ac- tivin-follistatin (INH-ACT-FS) system and gonadal hormone level in anovulatory rats. Methods Anovula- tory rat model was established in 76 rats (9 days old) by subcutaneous injecting testosterone propionate (1. 25 mg/0. 05 mL for each rat) from the nape. Totally 58 successfully modeled rats were divided into 5 groups according to random digit table, i.e., the model group (n =10), the Western medicine (WM) group (n =12), high, middle, and low dose WYR groups (n =12). Besides, another ten 22-day old rats were recruited as a normal group. Distilled water was daily administered to rats in the normal group and the model group by gastrogavage. Clomiphene citrate (0. 58 mg/100 g) was daily administered to rats in the WM group for 5 successive days. WYR at 5. 2, 2. 6, 1. 3 mg/100 g was daily administered to rats in high, middle, and low dose WYR groups for 21 successive days. Levels of follicular stimulating hormone (FSH) , luteinizing hormone (LH) , estradiol (E₂) , progesterone (P) , and prolactin (PRL) were detected using radioimmunoassay. Contents of inhibin (INH) , activin (ACT) , and follistatin (FS) were measured using ELISA. Results Compared with the normal group, serum levels of FSH and LH increased, and P level decreased in the model group (P <0. 05) ; INH level decreased and FS level increased in the model group (P<0. 05). Compared with the model group, serum FSH level decreased in the WM group and 3 WYR groups, P level decreased in the WM group (P <0. 05); INH increased and FS levels decreased in the WM group and 3 WYR groups; ACT level increased in the high dose WYR group, with statistical differ- ence (P <0. 05). Conclusion WYR promoted follicular development possibly through regulating INH- ACT-FS system and gonadal hormone level.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"36 12","pages":"1491-1495"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36912872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Multi-dimensional Clinical Profile for Functional Gastrointestinal Disorders and Diagnostic and Therapeutic Approaches of Chinese Medicine].","authors":"Yu Guo,&nbsp;Xiao-Lan Su,&nbsp;Yi-Lin Song,&nbsp;Jia-Jie Zhu,&nbsp;Wei Wei","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Functional gastrointestinal disorders (FGIDs) are manifested as digestive symptoms, but relative symptoms cannot be confirmed by traditional inspection methods. In 2015 Rome Foundation put forward the conception of multi-dimensional clinical profile (MDCP) for FGIDs, which emphasized multi-dimensional assessment of disease state and aimed to develop individualized treatment program. Chinese medicine also has multi-dimensional thoughts in diagnosis and treatment and has much in com- mon with MDCP in refining diagnosis, attaching importance to psychological factors and spirits, seeking biomarkers, and so on. The correlation between multi-dimensional diagnostic and therapeutic thoughts in Chinese medicine and MDCP was explored by combining functional dyspepsia as focal point.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"36 12","pages":"1420-1424"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36869199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of Rhizoma Polygonati on the Function of Endothelial Progenitor Cells and Telomerase Ac- tivity in Nature Senescent Rats].","authors":"Qing-Qing Zai,&nbsp;Zhen Qin,&nbsp;Lan Ye","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To observe the effect of Rhizoma Polygonati (RP) on the function of spi- nal endothelial progenitor cells (EPCs) and telomerase activity in nature senescent rats. Methods To- tally 48 natural senescent rats (20 months old) were randomly divided into 4 groups according to their body weight, i.e., the blank group, high, medium, low dose RP groups, 12 in each group. Meanwhile, 12 young rats (5 months old) were recruited as a normal control group. RP decoction at 4, 2, 1 g/kg was in- tragastrically administered to rats in high, medium, low dose RP groups, once per day for 12 successive weeks. Equal volume of normal saline was intragastrically administered to rats in the normal control group and the blank group, once per day for 12 successive weeks. Contents of antioxidant indices were detec- ted. Meanwhile, adherence cells were identified after in- vitro culture of mononuclear cells of bone marrow in each group. The proliferation was detected using MTT assay. The migration was detected by Transwell assay. The tubule function was detected using in vitro angiogenesis kit. And the telomerase activity was detected by real time fluorescent quantitative PCR. Results Compared with the normal control group, serum total-antioxidant capacity (T-AOC) , contents of superoxide dismutase (SOD) and glutathione-per- oxidase (GSH-Px) were obviously reduced, malondialdehyde (MDA) content obviously increased, the function of bone marrow EPCs was obviously damaged in the blank group (P <0. 01). Compared with the blank group, serum contents of T-AOC, SOD, and GSH-Px obviously increased and MDA content decreased in high and medium dose RP groups (P <0. 05,P <0. 01). The proliferation and migration of EPCs, the tubule function, and the telomerase activity could be promoted in high and medium dose RP groups (P <0. 05,P <0. 01). Conclusion RP could protect damaged function of EPCs in senescent rats by promoting serum antioxidant level and telomerase activity.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"36 12","pages":"1480-1485"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36912869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Intervention of Qingshen Granule for Immune Inflammation of Chronic Renal Failure Patients with Damp-heat Syndrome].","authors":"Yi-Ping Wang,&nbsp;Dong Wang,&nbsp;Hua Jin,&nbsp;Yong Lv,&nbsp;Wan Cheng,&nbsp;Shun-Jin Hu,&nbsp;Yan-Ping Mao,&nbsp;Ling Wei,&nbsp;Jia-Sheng Liu,&nbsp;Li-Yuan Wang,&nbsp;Xue-Lian Zhang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To observe the effect of Qingshen Granule (QG) on the immune function of chronic renal failure (CRF) patients with damp-heat syndrome (DHS). Methods A total of 162 CRF patients were assigned to the treated group and the control group by random digit table, 81 in each group. All patients were treated with conventional Western medical therapy. Those in the treated group addition- ally took QG, one package each time (10 g) , thrice per day. The therapeutic course for all was 12 weeks. The clinical efficacy was observed in the two groups. The contents of peripheral blood CD4 ⁺ T cells, CD8 ⁺ T cells, Thl7 cells, and nuclear factor-κB p65 (NF-κBp65) activity were detected using flow cy- tometry. Expressions of serum IL-17, tumor necrosis factor receptor-associated factor 6 (TRAF6), ma- trix metalloproteinase-9 (MMP-9) , matrix metalloproteinase inhibitor-I (TIMP-1 ) , collagen N (Col-V) were detected using ELISA. Results Finally 156 patients completed the trial (77 cases in the treated group and 79 cases in the control group). The total clinical curative effective rate was significantly higher in the treated group (80. 52%, 62/77) than in the control group (68. 35%, 54/79) with statistical differ- ences between the two groups (x² = 54. 849, P <0. 05). Compared with before treatment in the same group, the levels of peripheral blood CD4 ⁺ /CD8 ⁺ , Thl7 cell content, NF-κB p65 activity, serum levels of IL-17, TRAF6, and TIMP-1 , TIMP-1/MMP-9 ratio, Col-IV level all decreased in the treated group after treat- ment (P <0. 05) ; serum MMP-9 level decreased .(P <0. 05) and TIMP-1 /MMP-9 ratio increased (P <0. 05) in the control group. Compared with the control group, CD4⁺/CD8 ⁺ T cell ratio, Th17 cell content, NF-κB p65 activity decreased more obviously in the treated group after treatment (P <0. 05). Serum levels of IL- 17, TRAF6, TIMP-1, TIMP-1/MMP-9 ratio, and Col-IV all decreased (P <0.05) and MMP-9 level increased (P <0. 05) in the treated group (P <0. 05). Conclusion QG could adjust immune dysfunction and disar- ranged immunity mediated inflammatory response, and attenuate renal fibrosis in CKD patients with DHS.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"36 12","pages":"1425-1429"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36869224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of Dengzhan Xxin Injection Dosage on Renal function Using Propensity Score Estimation].","authors":"Yuan-Yuan Li,&nbsp;Hao Tang,&nbsp;Lin Li,&nbsp;Yan-Ming Xie","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To observe clinical dose of Dengzhan Xixin Injection (DZI) on renal func- tion and analyze its relation with abnormal changes of renal function indices [serum creatinine (SCr) and blood urea nitrogen (BUN) ]. Methods The information of 21 498 patients who used DZI were recruited from 20 hospital information system (HIS) database across China. Of them, 13 696 patients in line with 18 -80 years old were taken as subjects. They were assigned to the ultra-dose group ( >40 mL) and the conventional dose group ( ≤40 mL) according to whether the single DZI dosage exceeded the recommended dosage in the drug instruction. Changes of SCr and BUN were taken as outcome evaluation indicators 7 days before and after administration of DZI. There were 650 cases with two SCr values, 87 in the ultra-dose group and 563 in the conventional dose group. There were 651 cases with two BUN values, 87 in the ultra-dose group and 564 in the conventional dose group. Data were analyzed using stratified analysis and propensity score estimation. Results No statistical difference existed in age, gender, admission condi- tion, or stratification estimation results of DZI course between the ultra-dose group. and t6e conventional dose group (P >0. 05). No statistical difference existed in changes of abnormal renal functions between the ultra-dose group and the conventional dose group after balancing 71 confounders factors by propensity score estimation (P >0. 05). Conclusion Analyzed based on HIS data, use of DZI exceeding recommended dosage did not result in abnormal changes of renal function.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"36 12","pages":"1430-1434"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36869225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of Naoxintong Capsule on Vascular Remodeling in Type 2 Diabetic Patients with Subclinical Vascular Disease].","authors":"Sen-Hua Cheng,&nbsp;Jun Wang,&nbsp;Geng-Hua Xu,&nbsp;Guo-Xiang Sun,&nbsp;Xiao-Jian Tao,&nbsp;Xiao-Cui Yang,&nbsp;Yue-Jiao Zhu,&nbsp;Yin-Wei Chen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To observe the effect of Naoxintong Capsule (NC) on carotid artery vas- cular remodeling (VR) in type 2 diabetes mellitus (T2DM) patients with subclinical vascular disease. Methods A total of 180 T2DM patients with subclinical atherosclerosis (AS) were randomly assigned to the observation group and the control group in the ratio of 1:1 , 90 in each group. All patients took conven- tional hypoglycemic therapy, and the choices of therapeutic drugs and doses were selected according to patients' conditions. Patients in the observation group additionally took NC (3 pills each time, three times per day) , while those in the control group took no interventional drug. The therapeutic course for all was 6 months. The size and nature of bilateral carotid artery plaque were measured before and after treatment using color Doppler ultrasound diagnostic instrument. Bilateral carotid artery intimal-medial thickness (IMT) , plaque area (PA) , total vascular area (TVA) , lumen area (LA) , peak systolic velocity (PSV) , end diastolic velocity (EDV) , vascular resistance index (VRI) , and pulsatility index (PI) were measured. The total plaque score, unstable plaque detection rate, stenosis rate (S) , and refactoring index ( RI) were calculated. Levels of fasting plasma glucose (FPG) , glycated hemoglobin Al c (HbA1 c) , triglyceride (TG) , total cholesterol (TC) , high density lipoprotein cholesterol ( HDL-C) , and low density lipopro- tein cholesterol (LDL-C) were detected. Results Compared with before treatment in the same group, carotid artery IMT and plaque score decreased, levels of TC, TG, LDL-C, FPG, and HbAlc were reduced, PSV, EDV and PI increased, and VRI decreased in both two groups after treatment, with statisti- cal significance (P <0. 05). More obvious effects were shown in decreasing carotid artery IMT, plaque score, PA, and unstable plaque detection rate, reducing levels of TC, LDL-C and VRI, and increasing HDL-C, PSV, and EDV in the observation group, with statistical difference as compared with the control group (P <0. 05). After treatment the reconstruction rate and negative remodeling increased in the control group, with statistical difference as compared with before treatment (P <0. 05). Compared with the control group after treatment, the negative remodeling increased more in the observation group after treatment (X2 =6. 4615, P <0. 05). Conclusion NC could alleviate the carotid artery IMT, reduce and stabilize the plaque, improve blood flow parameters, and delay vascular reconstruction for treating T2DM patients with subclinical vascular disease.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"36 12","pages":"1439-1444"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36869200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Treatment of Benign Prostatic Hyperplasia by Longbishu Capsule Combined Doxazosin Mesylate Tablet].","authors":"Chun-Sheng Song,&nbsp;Jia-You Zhao,&nbsp;Jun Guo,&nbsp;De-Gui Chang,&nbsp;Lei Chen,&nbsp;Rui Zhang,&nbsp;Fu Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To observe the efficacy and safety of Longbishu Capsule (LBS) com- bined Doxazosin Mesylate Tablet (DMT) in treating benign prostatic hyperplasia (BPH). Methods Total- ly 360 BPH with Shen deficiency blood stasis syndrome (SDBSS) were randomly assigned to group A, B, and C, 120 cases in each group. Patients in Group A took LBS placebos combined DMT. Those in Group B took LBS combined DMT. Those in Group C took LBS combined DMT placebos. The dose for LBS was 3 pills each time, 0. 3 g/pill, twice per day. The dose of DMT was 1 tablet each time, 2 mg/tablet, once per day. The therapeutic course for all was 12 months. A total of 113 cases in Group A were recruited in FAS analysis, 115 cases in Group B, and 116 cases in Group C. Main efficacy indicators [International Prostate Symptom Score (IPSS) , maximum urinary flow rate (Qmax) , Quality of Life (QOL) ] , and sec- ondary efficacy indicators [postvoid residual urine volume (PVR) and prostate volume (PV) , symptoms scores of Chinese medicine (CM) I were observed in each group. The efficacy was analyzed in the three groups by taking average age of subjects (66 years) as the hierarchy factor (50 ≤age ≤66 and <66 <age ≤80). Results Compared with before treatment in the same group, IPSS, QOL score, and symptoms scores of CM all decreased, and Qmax increased in Group A, B, and C after treatment; PVR decreased in Group B and C (all P <0. 01). There was no statistical difference in main efficacy indicators or second- ary efficacy indicators among post-treatment groups (P >0. 05). There was no statistical difference in clinical efficacy among post-treatment groups (P >0. 05). The efficacy in subjects more than 66 years old of Group B was superior to that of Group A and C with statistical difference (P <0. 05). Conclusions LBS, DMT, or LBS combined DMT was safe and effective for treating BPH. LBS combined DMT was suit- able for patients complicated with abnormal PVR or aged over 66 years.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"36 12","pages":"1465-1469"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36869205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}