中国中西医结合杂志最新文献

{"title":"[Syndrome Types of Chinese Medicine and Clinical Characteristics of 660 Patients with Diabetic Peripheral Neuropathy].","authors":"Zhang Qian,&nbsp;Liang Xiao-Chun,&nbsp;Chao Wang,&nbsp;Qing Sun,&nbsp;Qun-Ii Wu,&nbsp;De-Hai Yin,&nbsp;Qiong Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To summarize the distribution and clinical characteristics of Chinese med- icine (CM) syndrome types in 660 patients with diabetic peripheral neuropathy (DPN). Methods Totally 660 inpatients at Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences were recruited from Jan 2000 to Dec 2014. Their first diagnoses were DNP. The distributions of their syndrome types were observed. Clinical characteristics in patients with different syndrome types were compared. Meanwhile, Logistic regression analysis was performed in independent variable by taking syndrome types of CM as quartering regression variables. Results The ratio of syndrome types was sequenced from high to low as yin deficiency blood stasis syndrome [39.24% (259/660)], yang deficiency blood stasis syndrome [29.39% (194/60)], phlegm stasis in collaterals syndrome [19. 24% (127/660) ] , yin deficiency induced wind stirring syndrome [12. 12% (80/ 660) ]. There was no significant difference in the constituent ratio of CM syndrome patterns among groups with different courses of diabetes (P >0. 05). The ratio of yang deficiency blood stasis syndrome had an increasing trend as the course increased. There was significant difference in HbAlc, fasting C pep- tide (FCP) , systolic blood pressure (SBP) , total cholesterol (TC) , 24 h total urinary protein (24 h UCP) , serum creatinine (SCr), blood urea nitrogen (BUN) among patient groups with different CM syndrome types (P <0. 05). Compared with yang deficiency blood stasis syndrome, HbAlc increased, SBP,SCr,BUN and 24 hUCP decreased in yin deficiency blood stasis syndrome with statistical difference (P = 0. 006, 0. 002,0. 001 ,0. 001, and 0. 007; P <0. 05) ; 24 h UCP also decreased in yin deficiency induced wind stirring syndrome (P =0. 34, P <0. 05). Multiclassified Logistic regression showed that when taking yin deficiency blood stasis syndrome as reference, HbAlc was a protective factor of yang deficiency blood stasis syn- drome, 8 h urinary albumin excretion (UAE) was a risk factor. Both TC and SCr were risk factors for yin deficiency induced wind stirring syndrome. SCr was a risk factor for phlegm stasis in collaterals syndrome. Conclusions Poor control of blood glucose in DPN patients might be related with yin deficiency blood sta- sis syndrome. Patients with yang deficiency blood stasis syndrome might have longer course of disease, and were correlated with poorer control of SBP and renal function. DPN patients complicated diabetic ne- phropathy were more liable to have yang deficiency blood stasis syndrome.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"37 1","pages":"62-67"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36909689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of Simiao Yong'an Decoction on the Expression of Wnt/p-catenin Signaling Pathway in Diabetic Ulcer Model Rats].","authors":"Zhao Ya-Nan,&nbsp;Ming Liu,&nbsp;Yue Zhang,&nbsp;Bin Wang,&nbsp;Yu-Dong Zhang,&nbsp;Qing-Zhi Hao,&nbsp;Jian-Liang Wei","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To observe the changes of the Wnt/β-catenin signaling pathway in diabetic ulcer (DU) model rats and to study the effect of Simiao Yong'an Decoction (SYD) on it. Methods Totally 51 female Wistar rats were divided into the normal control group (n =17) and the diabetes mellitus (DM) group (n =34) according to random digit table. Rats in the normal control group were fed with common forage. Those in the DM group were prepared for DM model by high fat high glucose forage +intrap- eritoneal injection of low-dose Streptozotocin (STZ). Successfully modeled rats were then randomly divided into the DU group and the DU-SYD group, 15 in each group. Fifteen rats were randomly selected from the normal control group, and then divided into the ulcer control group (CU). Rats in the DU-SYD group were administered with SYD by gastrogavage. Rats in the CU group and the DU group were administered with normal saline by gastrogavage. The conditions of wound healing were observed, histomorphological changes of the wound tissues were observed by HE staining at day 3, 7, and 14, respectively. Protein and mRNA expressions of p-catenin, GSK-3β, and Rspo-3 in wound tissues were detected by ELISA and RT-PCR. Results The wound healing rate was sequenced from high to low as Group CU, Group DU- SYD, Group DU at day 3, 7, and 14, respectively (P <0. 05). Compared with CU group, protein contents and mRNA expressions of β-catenin and Rspo-3 in wound tissues decreased, protein contents and mR- NA expressions of GSK-3β increased in the DU group at day 3, 7, and 14, respectively (P <0. 05). Compared with the DU group, protein contents and mRNA expressions of β-catenin in wound tissues increased, protein contents and mRNA expressions of GSK-3β decreased in the DU-SYD group at day 3, 7, and 14, respectively (P<0. 05). There was no significant difference in protein contents or mRNA ex- pressions of Rspo-3 between the DU group and the DU-SYD group (P >0. 05). Conclusions Down-regulation of Wnt/β-catenin pathway might result in difficult healing of UC. SYD could promote the healing of DU possibly by regulating Wnt/β-catenin signaling pathway.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"37 1","pages":"79-85"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36898482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Evaluating the Body of Evidence on Postmarketing Clinical Safety of Chinese Herbs].","authors":"Xing Liao,&nbsp;Yan-Ming Xie","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The traditional evidence evaluating hierarchy developed at the early stage in evidence-based medicine (EBM) , founded on an efficacy evaluation model of intervention, is generalized to whole medical research and clinical practice. However, such a hierarchy system were increasingly abused and misunderstood, which has become an obstacle for clinical decision making process. The hierarchical model is valid for limited questions of efficacy and inadequate for the evaluation of interventions in real world, especially safety evidence for postmarketing Chinese medicines. There are very few studies reporting the evidence grading and classification of postmarketing herbs' safety at home and abroad. Therefore, systematical collection and evaluation of evidence of postmarketing herbs' safety are of important significance. By referring to successful experiences in evidence grading and classification of drug effec- tiveness in EBM, authors studied the establishment of standards for evaluation, classification and grad- ing of safety evidence of postmarketing Chinese herbs, and the formation of basic frameworks of safety evidence evaluation, and comprehensively analyzed different sources of evidence from the perspectives of point, line, and surface, thus establishing the evidence body for safety evaluation of postmarketing Chinese herbs, and providing methodology and technical supports for future studies on evidence system in this field.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"37 1","pages":"109-114"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36898900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Overview and Future Thinking of Integrative Medicine].","authors":"Yun-Song Yang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective In this paper the author summarized the contents of clinical research of Chinese medicine ( CM) and Western medicine (WM) from thinking methods based on literature re- search. He believed there were two kinds of main contents: (1) Combine CM syndrome typing and WM disease identification based on clinical experiences; (2) Limit the flexibility of CM syndrome typing within recognition of WM depending on modern scientific researches, thus realizing the integration of macrosyndrome typing and micro-disease identification. Based on these contents, the author expounded future development of CM and WM from future goals, tasks, feasible ways, and specific work.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"37 1","pages":"106-108"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36898899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Changes of Main Syndromes of Gan Failing to Maintain Normal Flow of Qi in Premenstrual Dysphoric Disorder].","authors":"Xiang-Hong Zhan,&nbsp;Pan-Pan Wu,&nbsp;Li-Ping Yang,&nbsp;Hui-Yun Zhang,&nbsp;Guo-Li Yan,&nbsp;Chuan Zhao","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To observe the changes of Chinese medicine (CM) symptoms, the distri- bution characteristics of CM syndromes, and related neuroendocrine levels in premenstrual dysphoric disorder (PMDD) patients. Methods Totally 3 541 female outpatients (18 -45 years old) were inter- viewed by clinical epidemiological questionnaire. According to PMDD diagnostic criteria in DSM-IV , PMDD patients' CM syndromes were identified. Their scores of main symptoms and CM symptoms of common CM syndromes were compared. Contents of 8 neuroendocrine indicators in serum were detected [5- hydroxytryptamine (5-HT) , adrenocorticotropic hormore (ACTH) , angiotensin-II (Ang-II ) , glucocorti- coid (GC), homocysteine (Hcy), melatonin (MLT), nitrogen monoxide (NO), neuropeptide Y (NPY)]. Results Totally 258 PMDD were detected in 3 541 female outpatients (18 -45 years old). The main syn- drome and common syndromes of PMDD patients were reversed invasion of Gan qi syndrome [40.3% (104/258)] and stagnation of Gan qi syndrome [34. 9% (90/258) ], followed by Gan stagnation Pi deficiency syndrome [7.8%(20/258)], Gan stagnation blood stasis syndrome [7.4% (19/258)], Gan stagnation induced fire hyperactivity syndrome [ 6.2% ( 16258 )], Gan stagnation Shen deficiency syndrome [3.1%(8/258)], and Pi-Shen yang deficiency syndrome [0.4%(1258)]. Compared with reversed invasion of Gan qi syndrome, emotional depression and low spirits were main symptoms of stagnation of Gan qi syndrome. Scores for the two symptoms increased (P <0.05). Compared with stagnation of Gan qi syn- drome, irritability, upset, abdominal distension, anxiety, headache, dizziness, insomnia, head distension, bitter mouth, unclear vision were main symptoms of reversed invasion of Gan qi syndrome. Scores for the 10 symptoms increased (P <0.05). Compared with stagnation of Gan qi syndrome, the Hcy level in serum obviously decreased in reversed invasion of Gan qi syndrome (P <0.05). There was no statistical difference in the rest indices (P >0. 05). Conclusions PMDD is closely related to Gan failing to maintain normal flow of qi. Reversed invasion of Gan qi syndrome and stagnation of Gan qi syndrome have different scientif- ic connotations and biological bases. So regulating Gan should be considered as the first choice.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"37 1","pages":"45-49"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36909686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Expressions of MMP-7 and TIMP-1 in Chronic Stomach Disease Patients with Different Syndromes of Chinese Medicine].","authors":"Ling-Ling Su,&nbsp;Ling Hu,&nbsp;Qi Luo,&nbsp;Bin Chen,&nbsp;Xu Chen,&nbsp;Shao-Xian Lao","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To observe the expressions of matrix metalloproteinase-7 (MMP-7) and tissue inhibitor of metalloproteinase-1 (TIMP-1 ) in chronic stomach disease patients with different syn- dromes of Chinese medicine (CM) , and their relationships with Helicobacter pylori ( Hp ) infection. Meth- ods Totally 117 chronic stomach disease patients were recruited, and 11 healthy volunteers were also recruited. Chronic stomach disease patients were assigned to Pi-Wei dampness-heat syndrome (PWDHS, 57 cases) , disharmony of Gan and Wei syndrome (DGWS, 30 cases) , and Pi qi deficiency syndrome (PQDS, 30 cases) by syndrome typing. Healthy volunteers were recruited as the healthy con- trol group. Hp infection was detected using methylene blue dyeing and rapid urease test (RUT). The degree of inflammation was observed by conventional HE staining. The protein expressions of MMP-7 and TIMP-1 were detected qualitatively and positioningly using immunohistochemical method. Results Patients with PWDHS and patients with DGWS had equivalent Hp infection rate and degree. They showed a slightly increasing tendency than patients with PQDS, but with no statistical difference (P >0. 05). Com- pared with PWDHS and PQDS groups, more severe inflammation of mucosa occurred in patients with DG- WS (P <0. 05). More severe inflammation of mucosa occurred in patients with PWDHS than in those with PQDS, but with no statistical difference (P >0. 05). The severity of gastric mucosal inflammatory activity was sequenced from high to low as PWDHS, DGWS, PQDS, all with statistical difference (P <0. 05). Compared with Hp negative patients, the gastric mucosal inflammatory activity was more severe in Hp positive patients with PWDHS, DGWS, PQDS. The gastric mucosal inflammatory activity was more se- vere in Hp positive patients with PWDHS and PQDS (P <0. 05). Compared with the healthy control group, the expression level of TIMP-1 in gastric mucosa increased in patients with PWDHS, DGWS, PQDS (P <0. 05, P <0. 01) ; the expression level of MMP-7 increased in Hp negative patients with PWDHS (P < 0. 05). Compared with Hp negative patients with PWDHS, the expression level of MMP-7 decreased in Hp positive patients with PWDHS (P <0. 05). Compared with the PQDS group, the expression level of TIMP-1 decreased in the PWDHS group (P <0. 01). The severity of gastric mucosal inflammation was negatively correlated with the expression level of MMP-7, and positively correlated with the expression level of TIMP- 1 (P <0. 01). Hp infection degree was not obviously correlated with the expression level of MMP-7 in gastric mucosa (P >0. 05) , but positively correlated with the expression level of TIMP-1 in gastric mucosa (P <0. 05). Of them, the expression level of MMP-7 in gastric mucosa was positively correlated with the expression level of TIMP-1 in gastric mucosa (P <0. 01). Conclusions Comparatively lower expression of MMP-7 in gastric mucosal inflammation and imbalanced expression of TIMP-1 might be ","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"37 1","pages":"57-61"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36909688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Oxymatrine Diminished the Side Population and Inhibited Wnt/p-catenin Signaling Pathway in MCF- 7 Breast Cancer Cells].","authors":"Ying Zhang,&nbsp;Xin Qi,&nbsp;Xiao-Yun Zhu,&nbsp;Wei-Ru Xu,&nbsp;Ying-Xia Pei,&nbsp;Hong-Sheng Lin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To observe the effects of oxymatrine (OM) in inhibiting the proliferation and percentage of cancer stem cell like cell of human breast cancer MCF-7 cells, and to study its molecular mechanism. Methods MCF-7 cells were taken as subject. Side population cells (SP) of cancer stem cell like cells rich in MCF-7 cells were isolated using side population (SP) method. The proliferation properties of SP cells and non-side population (non-SP) cells were detected by MTT assay. The proliferation and intervention of cisplatin (DDP) and OM at various concentrations were detected as well. The ex- pression levels of β-catenin gene and protein were detected using flow cytometry and immunofluorescence technique. Results (1) OM in different concentrations had various inhibitions to the proliferation of subpopulations of MCF-7 cells. Of them, it had weakest inhibition on non-SP cells, weaker inhibition on unsorted cells, and strongest inhibition on SP cells. DDP in different concentrations had strongest inhibition on non-SP cells, weaker inhibition on unsorted cells, and weakest inhibition on SP cells. (2) SP cells accounted for 3. 1%, 1. 7%, and 0. 2% of the total cells after OM acted at 0. 25, 0. 50, 1. 00 mg/mL, respectively. The expression rate of phosphorylated β-catenin was 42. 62% ±2. 62% after SP cells were ac- ted by OM, with statistical difference as compared with the blank control group [ (22. 8% ±1. 66%) ,P < 0. 01]. (3) Compared with SP cells without OM treatment, the expression of β-catenin in OM treated SP cells was obviously reduced. Besides, they were specifically distributed under the cytomembrane, with nuclear translocation obviously reduced. Conclusion OM could intervene biological behaviors of cancer stem cell like cell of MCF-7 cells possibly through Inhibiting the activation of Wnt/β-catenin signaling pathway.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"36 12","pages":"1504-1509"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36912873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research on Dynamic Evolution of Blockade of Heart Vessel Syndrome Based on Metabonomics].","authors":"Wei-Xiong Jian,&nbsp;He-Ning Zuo,&nbsp;Sha Liu,&nbsp;Jie Li,&nbsp;Zhi-Xi Hu,&nbsp;Gui-Xiang Sun,&nbsp;Zhao-Kai Yuan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To observe the changes of metabolomics in the evolution process of blockade of heart vessel syndrome (BHVS). Methods The formation of BHVS in three stages were sim- ulated by using high-fat forage and ligating the left anterior descending coronary artery. Increased blood lipid was in the early stage of blood stasis syndrome (BSS) group. Atherosclerosis (AS) was formed in the middle stage of BSS group (sub-BSS). Coronary artery was ligated on the basis of AS was the 3rd stage of BSS (BHVS group). There were 8 rats in each group. Totally 24 rats was used as the blank con- trol group and each stage had 8 rats. The changes of metabolite contents were analyzed using principal component analysis (PCA) and partial least squares method (PLS) with gas chromatography-mass spectrometer (GC-MS) among different groups. Results (1) In the 32 kinds of identified metabolites, citric acid was closest associated with the evolution process of BHVS, followed by cholesterol, inositol, ornithine, proline, isoleucine, octadecanoic acid, lactic acid, urea, leucine, linoleic acid, mannose. (2) Metabolic markers in the three stages: octadecanoic acid, lactic acid (positively correlated) , and mannose (negatively correlated) in the early stage of BSS. Ornithine, proline, inositol (positively correla- ted) , and isoleucine (negatively correlated) in the middle stage of BSS (sub-BSS). Leucine, isoleucine, citric acid (positively correlated) , and lactic acid (negatively correlated) in the BHVS stage. Conclusions High fat diet causes disordered in vivo lipid metabolism in pre-stage BSS, and the organism initiates anti- inflammation. Continued high fat diet leads to disordered urea cycle, imbalanced intestinal flora, changed vascular morphology, and liver dysfunction in the sub-BSS stage. Acute myocardial ischemia leads to glucose metabolism disorder in the BHVS stage.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"36 12","pages":"1496-1503"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36912874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Discussion of Syndrome Elements for Chronic Glomerulonephritis on the Basis of Factor Analysis Method].","authors":"Bian-Ling Liu,&nbsp;Pei Sun,&nbsp;Po Cao,&nbsp;Shu-Zhai Miao","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To preliminarily observe syndrome elements of chronic glomerulonephritis by using factor analysis method. Methods Data of four diagnostics were collected from 289 chronic glo- merulonephritis outpatients and inpatients at Dongzhimen Hospital between February 2011 and February 2012. Under the guidance of Chinese medicine ( CM) , the distribution features of syndrome elements of chronic glomerulonephritis were preliminarily observed using factor analysis method. Results The primary locations of syndrome element were Pi and Shen, and followed by Gan and Fei. The primary nature of syndrome elements were qi deficiency, yin deficiency, and yang deficiency. The primary pathogenic factors of syndrome elements were water dampness, heat, and blood stasis. Conclusions Using factor analysis method, syndrome elements of chronic glomerulonephritis were primarily summarized as four aspects : dampness, heat, stasis, and deficiency. Of them , deficiency was an important pathogenic fac- tor. Sthenic syndrome was seldom seen. Dampness was an important pathogenic factor.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"36 12","pages":"1435-1438"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36869204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of Needle Embedded in Neiguan (PC6) on Changes of ECG in Chronic Myocardial Ischemia Model Mini-pigs].","authors":"Ji-Liang Fang,&nbsp;Sheng-Fang Zhou,&nbsp;Huan Liu,&nbsp;Gang Chen,&nbsp;Jin-Ling Zhang,&nbsp;Hai-Bin Tong,&nbsp;Xun He,&nbsp;Qing Zhao,&nbsp;Jin-Zhao Zhang,&nbsp;Gui-Yong Liu,&nbsp;Yang Hong,&nbsp;Yin-Qiu Gao,&nbsp;Shu-Yong Jia,&nbsp;Pei-Jing Rong","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective To observe the effect of needle embedded in Neiguan (PC6) on electro- cardiogram (ECG) changes in model mini-pigs with chronic myocardial ischemia. Methods The protein shrink narrow ring (Ameroid Ring) was placed in the proximal part of the left coronary anterior descend- ing branch of 12 Chinese mini-pigs to prepare animal model. One died during the modeling. Chronic myo- cardial ischemia mini-pig models were established after 4 weeks. Successfully modeled 11 mini-pigs were divided into the test group (n =6) and the control group (n =5). Needle were embedded in Neiguan (PC6) of the test group and Zusanli (ST36) of the control group at week 4 after modeling. Electroacupuncture (EA) at corresponding acupoint twice (once before embedding and at week 2 after embedding) , 20 min each time. Changes of Q wave of ECG, heart rate, and ST-T interval were observed in the two groups be- fore and after modeling, before and after EA. Results Compared with before modeling in the same group, the absolute value of Q wave both increased in the two groups after modeling (P <0. 05, P <0. 01J. No statistical difference existed in heart rate in the two groups between before and after modeling (P> 0. 05). Compared with before needling in the same group, ST-T interval was prolonged in the test group (P <0. 05). Compared with the control group at the same time point, the absolute value of Q wave was re- duced before EA, ST-T interval was prolonged after EA in the test group (P <0. 05). No statistical differ- ence existed in heart rate between the control group and the test group before EA (P >0. 05). Conclusion Needle embedded in Neiguan (PC6) could arrive at therapeutic effect of myocardial ischemia possibly through improving myocardial blood supply.</p>","PeriodicalId":10107,"journal":{"name":"中国中西医结合杂志","volume":"36 12","pages":"1470-1473"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36869206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}