Plasma Therapy and Transfusion Technology最新文献_第6页

Changes in red cell and platelet antigen strength during storage 储存期间红细胞和血小板抗原强度的变化

Plasma Therapy and Transfusion Technology Pub Date : 1988-01-01 Epub Date: 2004-04-15 DOI: 10.1016/0278-6222(88)90003-4

Marcus B. Simpson Jr MD

引用次数: 1

AIDS and transfusion medicine: 1988 艾滋病和输血医学:1988年

Plasma Therapy and Transfusion Technology Pub Date : 1988-01-01 Epub Date: 2004-04-15 DOI: 10.1016/0278-6222(88)90047-2

Jay E. Menitove MD (Guest Editor)

引用次数: 0

Comparison of manual and machine plasmapheresis techniques 人工与机器血浆置换技术的比较

Plasma Therapy and Transfusion Technology Pub Date : 1988-01-01 Epub Date: 2004-04-15 DOI: 10.1016/0278-6222(88)90011-3

G. Rock , N. McCombie , V. Fuller , P. Tittley

{"title":"Comparison of manual and machine plasmapheresis techniques","authors":"G. Rock , N. McCombie , V. Fuller , P. Tittley","doi":"10.1016/0278-6222(88)90011-3","DOIUrl":"10.1016/0278-6222(88)90011-3","url":null,"abstract":"<div><p>While the benefits of automated plasmapheresis have been described, little data is available to compare it to manual plasmapheresis. We therefore compared standard manual techniques (MP) with three automated devices (AP), Haemonetics<sup>®</sup> Models V50 and PCS, and the HemaScience Autopheresis-C<sup>™</sup> (HA). Plasma protein concentrations were 56 ± 4 g/L for MP, 63 ± 2 g/L for the V50, 59 ± 5 g/L for the PCS and 63 ± 5 g/L for the HA. Factor VIII recoveries averaged 105 ± 23 U/dL for the MP, 91 ± 18 U/dL and 125 ± 25 U/dL for the V50 (PPP and PRP modes) 95 ± 27 U/dL for the PCS and 121 ± 22 U/dL for the HA, showing a statistically significant difference (<em>P</em> < 0.05) between manual and automated procedures. Percentage recovery of activity in the cryoprecipitate was similar, giving 337 ± 80 U or 63% for MP, 262 ±70 U or 57% for V50, 252 ± 60 U or 57% for PCS and 367 ± 110 U or 59% for HA.</p><p>The plasma from MP and HA contained relatively few cells with 12 ± 5 × 10<sup>9</sup>/L and 6 ± 1 × 10<sup>9</sup>/L platelets; the V50 plasma (PPP mode) contained an average of 103 ± 4 × 10<sup>9</sup>/L platelets whereas the PCS plasma had 51 ± 22 × 10<sup>9</sup>/L. β-Thromboglobulin levels were significantly elevated in the plasma from the V50. Automated procedures took only 30–40 min whereas the manual procedures took a minimum of 2 hr. While different economic factors will affect the choice of methodology, there is considerable benefit to the use of certain automated devices rather than the widely used manual method for the collection of plasma.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 4","pages":"Pages 337-342"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90011-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84941021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Inhibitors of complement activation and complement breakdown products 补体活化抑制剂和补体分解产物

Plasma Therapy and Transfusion Technology Pub Date : 1987-12-01 Epub Date: 2010-05-14 DOI: 10.1016/S0278-6222(87)80039-6

P.J. Späth

引用次数: 4

Platelet yield varies but in vitro function is maintained after leukocyte removal using terumo imugard™ filter and cutter Leukotrap™ 使用terumo imugard™过滤器和刀具Leukotrap™去除白细胞后，血小板产量变化，但体外功能维持

Plasma Therapy and Transfusion Technology Pub Date : 1987-12-01 Epub Date: 2010-05-14 DOI: 10.1016/S0278-6222(87)80051-7

A. Gerber, U.E. Nydegger

引用次数: 0

Platelet concentrate collection in a dual-stage channel using computer-generated algorithms for collection and prediction of yield 利用计算机生成的算法收集和预测产率，在双级通道中收集血小板精矿

Plasma Therapy and Transfusion Technology Pub Date : 1987-12-01 Epub Date: 2010-05-14 DOI: 10.1016/S0278-6222(87)80048-7

Jeane P. Hester MD , Gerard J. Ventura MD , Terry Boucher MSEE

{"title":"Platelet concentrate collection in a dual-stage channel using computer-generated algorithms for collection and prediction of yield","authors":"Jeane P. Hester MD , Gerard J. Ventura MD , Terry Boucher MSEE","doi":"10.1016/S0278-6222(87)80048-7","DOIUrl":"10.1016/S0278-6222(87)80048-7","url":null,"abstract":"<div><p>The automated collection of single-donor platelet concentrates is described for a dual-stage channel mounted in a continuous-flow cell separation system (Spectra). Research objectives included collection of a predicted yield of leukocyte-and erythrocyte-poor platelet concentrates using computer-controlled flow rates of anticoagulated whole blood and its separated components (packed erythrocytes, platelet-poor plasma, and platelet concentrates). To achieve these objectives, mathematic algorithms were generated that integrated the known major biologic and procedural contributions to platelet harvesting with the design characteristics of the channel in which blood was to be processed. Data to compute these algorithms are entered into the computer prior to the collection procedure.</p><p>It was perceived that the ability to predict platelet yield would provide a tool for collecting specific cell quantities for transfusion for a given recipient. A theoretical immunologic benefit to patients receiving lymphocyte-poor platelet concentrates is postulated but remains to be established. An additional objective was that of flexibility so that the predicted yield could be collected based on either volume requirements (for pediatric patients or patients with volume restrictions) or platelet concentration requirements (for storage). The following data summarize the results of some 100 research procedures conducted with this system.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"8 4","pages":"Pages 377-385"},"PeriodicalIF":0.0,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0278-6222(87)80048-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91472976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

A new technique for peripheral stem cell separation 外周干细胞分离新技术

Plasma Therapy and Transfusion Technology Pub Date : 1987-12-01 Epub Date: 2010-05-14 DOI: 10.1016/S0278-6222(87)80045-1

J. Zingsem, W. Siegert, H.G. Heuft, C. Frenzel, E. Baumgarten, G. Henze, D. Huhn, R. Eckstein

{"title":"A new technique for peripheral stem cell separation","authors":"J. Zingsem, W. Siegert, H.G. Heuft, C. Frenzel, E. Baumgarten, G. Henze, D. Huhn, R. Eckstein","doi":"10.1016/S0278-6222(87)80045-1","DOIUrl":"10.1016/S0278-6222(87)80045-1","url":null,"abstract":"<div><p>Using a Haemonetics V50.1 cell separator we compared the new lymphocyte-surge-program for peripheral stem cell preparation with the conventional combined buffy coat and Ficoll techniques. Eleven surge and four conventional separations were performed in 15 healthy cytapheresis donors who gave informed consent to the procedure. Using the conventional methods, mean recovery of peripheral blood mononuclear cells (PBM) was 55% in a preparation time of 80 minutes for the buffy coat and 25 minutes for the Ficoll step. Eighty percent of the PBM loss occurred during the buffy coat step, and 20% during the Ficoll procedure. In a preparation time of 105 minutes, 2500 mL peripheral blood could be processed without flow or citrate problems. The donors' red cell losses were about 100 mL packed red cells. Granulocyte depletion was about 98%, red cell depletion higher than 99% (hematocrit < 0.1%). Using the surge technique we achieved a PBM recovery of 60% (range 45% to 72%) by processing 2100 mL peripheral blood in a preparation time of only 75 minutes. The donors' red cell losses were about 8 mL of packed red cells, significantly lower (P < 0.01) compared to conventional techniques. Nevertheless, red cell contamination of the concentrates remained high (hematocrit = 1.8%). Colony-forming unit (CFU) tests showed comparable quantities of peripheral stem cells (90 colonies/10<sup>7</sup> PBM) in both separation techniques. Therefore, both techniques seem to be adequate for T-cell depletion and preparation of bone marrow for cryopreservation. Since preparing bone marrow for purging techniques requires extreme stem cell purity, the surge technique may be less suitable for those purposes due to the awkward problem of considerably higher red cell contamination, despite a shorter preparation time.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"8 4","pages":"Pages 363-367"},"PeriodicalIF":0.0,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0278-6222(87)80045-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85876091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Adsorption and desorption of proteins on plasmafilter membrane and its effect on macromolecular sieving coefficient 蛋白质在质滤膜上的吸附与解吸及其对大分子筛分系数的影响

Plasma Therapy and Transfusion Technology Pub Date : 1987-12-01 Epub Date: 2010-05-14 DOI: 10.1016/S0278-6222(87)80034-7

Rafael Ponikvar MD, Joze Drinovec MD, PhD, Janez Varl MD, Andrej Bren MD, Radoslav Kveder MD

引用次数: 1

ABO-incompatible bone marrow transplantation: Three methods for the removal of red blood cell antibodies abo血型不相容骨髓移植:清除红细胞抗体的三种方法

Plasma Therapy and Transfusion Technology Pub Date : 1987-12-01 Epub Date: 2010-05-14 DOI: 10.1016/S0278-6222(87)80043-8

A. Tichelli, A. Gratwohl, C. Nissen, A. Lori, A. Würsch, R. Wenger, B. Osterwalder, H.P. Burri, B. Speck

引用次数: 3

Biocompatibility studies on a clinically well-tolerated extracorporeal system 临床耐受良好的体外系统的生物相容性研究

Plasma Therapy and Transfusion Technology Pub Date : 1987-12-01 Epub Date: 2010-05-14 DOI: 10.1016/S0278-6222(87)80037-2

Janos G. Kadar , Peter Späth , Andrzej Gaczkowski , Kurt Oette , Helmut Borberg

引用次数: 6