Plasma Therapy and Transfusion Technology最新文献_第6页

AIDS and transfusion medicine: 1988 艾滋病和输血医学:1988年

Plasma Therapy and Transfusion Technology Pub Date : 1988-01-01 DOI: 10.1016/0278-6222(88)90047-2

Jay E. Menitove MD (Guest Editor)

引用次数: 0

Progenitor cell cytapheresis using a discontinuous-flow blood cell separator for the management of a pregnant patient with Chronic Myelogenous Leukemia 使用不连续流式血细胞分离器的祖细胞分离术治疗慢性粒细胞白血病妊娠患者

Plasma Therapy and Transfusion Technology Pub Date : 1988-01-01 DOI: 10.1016/0278-6222(88)90018-6

V. Hermosa, J.M. Pastor, E. Conde, A. Zubizarreta

引用次数: 0

Transplantation of hemapheresis-derived hemopoietic stem cells: A new concept in the treatment of patients with malignant lymphohemopoietic disorders 造血干细胞移植:治疗恶性淋巴造血疾病的新概念

Plasma Therapy and Transfusion Technology Pub Date : 1988-01-01 DOI: 10.1016/0278-6222(88)90044-7

Martin Körbling, Hans Martin

引用次数: 29

Inhibitors of complement activation and complement breakdown products 补体活化抑制剂和补体分解产物

Plasma Therapy and Transfusion Technology Pub Date : 1987-12-01 DOI: 10.1016/S0278-6222(87)80039-6

P.J. Späth

引用次数: 4

Platelet yield varies but in vitro function is maintained after leukocyte removal using terumo imugard™ filter and cutter Leukotrap™ 使用terumo imugard™过滤器和刀具Leukotrap™去除白细胞后，血小板产量变化，但体外功能维持

Plasma Therapy and Transfusion Technology Pub Date : 1987-12-01 DOI: 10.1016/S0278-6222(87)80051-7

A. Gerber, U.E. Nydegger

引用次数: 0

Platelet concentrate collection in a dual-stage channel using computer-generated algorithms for collection and prediction of yield 利用计算机生成的算法收集和预测产率，在双级通道中收集血小板精矿

Plasma Therapy and Transfusion Technology Pub Date : 1987-12-01 DOI: 10.1016/S0278-6222(87)80048-7

Jeane P. Hester MD , Gerard J. Ventura MD , Terry Boucher MSEE

{"title":"Platelet concentrate collection in a dual-stage channel using computer-generated algorithms for collection and prediction of yield","authors":"Jeane P. Hester MD , Gerard J. Ventura MD , Terry Boucher MSEE","doi":"10.1016/S0278-6222(87)80048-7","DOIUrl":"10.1016/S0278-6222(87)80048-7","url":null,"abstract":"<div><p>The automated collection of single-donor platelet concentrates is described for a dual-stage channel mounted in a continuous-flow cell separation system (Spectra). Research objectives included collection of a predicted yield of leukocyte-and erythrocyte-poor platelet concentrates using computer-controlled flow rates of anticoagulated whole blood and its separated components (packed erythrocytes, platelet-poor plasma, and platelet concentrates). To achieve these objectives, mathematic algorithms were generated that integrated the known major biologic and procedural contributions to platelet harvesting with the design characteristics of the channel in which blood was to be processed. Data to compute these algorithms are entered into the computer prior to the collection procedure.</p><p>It was perceived that the ability to predict platelet yield would provide a tool for collecting specific cell quantities for transfusion for a given recipient. A theoretical immunologic benefit to patients receiving lymphocyte-poor platelet concentrates is postulated but remains to be established. An additional objective was that of flexibility so that the predicted yield could be collected based on either volume requirements (for pediatric patients or patients with volume restrictions) or platelet concentration requirements (for storage). The following data summarize the results of some 100 research procedures conducted with this system.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"8 4","pages":"Pages 377-385"},"PeriodicalIF":0.0,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0278-6222(87)80048-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91472976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

A new technique for peripheral stem cell separation 外周干细胞分离新技术

Plasma Therapy and Transfusion Technology Pub Date : 1987-12-01 DOI: 10.1016/S0278-6222(87)80045-1

J. Zingsem, W. Siegert, H.G. Heuft, C. Frenzel, E. Baumgarten, G. Henze, D. Huhn, R. Eckstein

{"title":"A new technique for peripheral stem cell separation","authors":"J. Zingsem, W. Siegert, H.G. Heuft, C. Frenzel, E. Baumgarten, G. Henze, D. Huhn, R. Eckstein","doi":"10.1016/S0278-6222(87)80045-1","DOIUrl":"10.1016/S0278-6222(87)80045-1","url":null,"abstract":"<div><p>Using a Haemonetics V50.1 cell separator we compared the new lymphocyte-surge-program for peripheral stem cell preparation with the conventional combined buffy coat and Ficoll techniques. Eleven surge and four conventional separations were performed in 15 healthy cytapheresis donors who gave informed consent to the procedure. Using the conventional methods, mean recovery of peripheral blood mononuclear cells (PBM) was 55% in a preparation time of 80 minutes for the buffy coat and 25 minutes for the Ficoll step. Eighty percent of the PBM loss occurred during the buffy coat step, and 20% during the Ficoll procedure. In a preparation time of 105 minutes, 2500 mL peripheral blood could be processed without flow or citrate problems. The donors' red cell losses were about 100 mL packed red cells. Granulocyte depletion was about 98%, red cell depletion higher than 99% (hematocrit < 0.1%). Using the surge technique we achieved a PBM recovery of 60% (range 45% to 72%) by processing 2100 mL peripheral blood in a preparation time of only 75 minutes. The donors' red cell losses were about 8 mL of packed red cells, significantly lower (P < 0.01) compared to conventional techniques. Nevertheless, red cell contamination of the concentrates remained high (hematocrit = 1.8%). Colony-forming unit (CFU) tests showed comparable quantities of peripheral stem cells (90 colonies/10<sup>7</sup> PBM) in both separation techniques. Therefore, both techniques seem to be adequate for T-cell depletion and preparation of bone marrow for cryopreservation. Since preparing bone marrow for purging techniques requires extreme stem cell purity, the surge technique may be less suitable for those purposes due to the awkward problem of considerably higher red cell contamination, despite a shorter preparation time.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"8 4","pages":"Pages 363-367"},"PeriodicalIF":0.0,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0278-6222(87)80045-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85876091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

ABO-incompatible bone marrow transplantation: Three methods for the removal of red blood cell antibodies abo血型不相容骨髓移植:清除红细胞抗体的三种方法

Plasma Therapy and Transfusion Technology Pub Date : 1987-12-01 DOI: 10.1016/S0278-6222(87)80043-8

A. Tichelli, A. Gratwohl, C. Nissen, A. Lori, A. Würsch, R. Wenger, B. Osterwalder, H.P. Burri, B. Speck

引用次数: 3

An evaluation of automated platelet-rich plasma collection 富血小板血浆自动采集的评价

Plasma Therapy and Transfusion Technology Pub Date : 1987-12-01 DOI: 10.1016/S0278-6222(87)80049-9

Jennifer K.M. Duguid MB, ChB, MRC Path, P.L. Hughes BSc

引用次数: 1

Serum preserve as a replacement fluid for plasma exchange therapy 血清保存液作为血浆交换治疗的替代液

Plasma Therapy and Transfusion Technology Pub Date : 1987-12-01 DOI: 10.1016/S0278-6222(87)80040-2

G. Güsken , R. Kotitschke , A. Gaczkowski , J. Kadar , H. Borberg

{"title":"Serum preserve as a replacement fluid for plasma exchange therapy","authors":"G. Güsken , R. Kotitschke , A. Gaczkowski , J. Kadar , H. Borberg","doi":"10.1016/S0278-6222(87)80040-2","DOIUrl":"10.1016/S0278-6222(87)80040-2","url":null,"abstract":"<div><p>A considerable number of exchange fluids have been used for plasma exchange therapy. As they all have drawbacks, either 5% albumin and plasma protein fraction (PPF) or, less frequently, fresh frozen plasma (FFP) are generally used. Under critical conditions, appropriate mixtures of fluids specific for the patient, his disease, and his current condition, may be applied.</p><p>Albumin or PPF are generally well tolerated; however, the lack of coagulation factors and immunoglobulins may limit their application. In contrast, FFP replaces virtually all plasma proteins, but is characterized by essential drawbacks, e.g., colerability, ability to transfer virus-mediated diseases, and sometimes, limited availability.</p><p>Serum preserve may be an alternative for FFP, as it replaces all plasma proteins except for some coagulation factors, is a standardized product, is virus free, and is easily available commercially. As we used serum preserve occasionally as eplacement fluid and found that it was vell tolerated, we became interested in inrestigating it on a more systematic basis. We compared 5% albumin, 5% serum preserve, and 7.5% serum preserve as replacement fluids after extended plasma donations in the same subjects.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"8 4","pages":"Pages 333-341"},"PeriodicalIF":0.0,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0278-6222(87)80040-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84262249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2