Progenitor cell cytapheresis using a discontinuous-flow blood cell separator for the management of a pregnant patient with Chronic Myelogenous Leukemia
{"title":"Progenitor cell cytapheresis using a discontinuous-flow blood cell separator for the management of a pregnant patient with Chronic Myelogenous Leukemia","authors":"V. Hermosa, J.M. Pastor, E. Conde, A. Zubizarreta","doi":"10.1016/0278-6222(88)90018-6","DOIUrl":null,"url":null,"abstract":"<div><p>Cytapheresis of progenitor cells and immature granulocytes was employed in the initial management of a pregnant patient with Chronic Myelogenous Leukemia (CML). A semicontinuousflow blood cell separator was used; no sedimenting agents were applied. Over a period of 16 weeks the patient underwent 15 therapeutic Cytapheresis. Mean efficiency for CFU-GM was 72% and for mature granulocytes 8%. Hb loss per session was equivalent to 80 mL of whole blood and transfusion was unnecessary.</p><p>The decrease in the peripheral blood leucocytes was linear and overall leucocyte reduction was 89%. Our results suggest that preferential elimination of granulopoietic stem cells is an alternative strategy to intensive leucapheresis in the management of pregnant patients with CML; utility in other situations must be evaluated.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 4","pages":"Pages 369-375"},"PeriodicalIF":0.0000,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90018-6","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Plasma Therapy and Transfusion Technology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0278622288900186","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Cytapheresis of progenitor cells and immature granulocytes was employed in the initial management of a pregnant patient with Chronic Myelogenous Leukemia (CML). A semicontinuousflow blood cell separator was used; no sedimenting agents were applied. Over a period of 16 weeks the patient underwent 15 therapeutic Cytapheresis. Mean efficiency for CFU-GM was 72% and for mature granulocytes 8%. Hb loss per session was equivalent to 80 mL of whole blood and transfusion was unnecessary.
The decrease in the peripheral blood leucocytes was linear and overall leucocyte reduction was 89%. Our results suggest that preferential elimination of granulopoietic stem cells is an alternative strategy to intensive leucapheresis in the management of pregnant patients with CML; utility in other situations must be evaluated.
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