{"title":"Alternatives to homologous blood transfusion","authors":"Sharhabil S. Ammus MD, Bruce A. Lenes MD","doi":"10.1016/0278-6222(88)90054-X","DOIUrl":"10.1016/0278-6222(88)90054-X","url":null,"abstract":"","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 2","pages":"Pages 231-240"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90054-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73565599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of plasticizers on red blood cells and platelets during storage","authors":"Alan A. Waldman PhD","doi":"10.1016/0278-6222(88)90008-3","DOIUrl":"10.1016/0278-6222(88)90008-3","url":null,"abstract":"<div><p>The introduction of plastic bags into routine use in Blood Banks began a revolution in how human blood and blood components were prepared, stored and used.</p><p>The plastic film is not inert, however, and plasticizers added to increase flexibility of the bags can be extracted into the stored components. In this report, the characteristics of this extraction, and the effect of exposure to the extracted material on the components in storage, is reviewed and discussed.</p><p>Particular emphasis is placed on the organic compound, di(2-ethylhexyl) phthalate (DEHP), which can constitute up to 40% of the weight of classic PVC films. DEHP has been shown to interact both with erythrocytes, where the interaction aids in preservation of erythrocyte integrity, and with platelets, where the interaction has been shown to be deleterious to maintenance of platelet function.</p><p>The advantages and disadvantages of plastics formulated without DEHP are also presented and evaluated.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 3","pages":"Pages 317-330"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90008-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73072410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"AIDS and treatment of hemophilia patients","authors":"Margaret V. Ragni MD","doi":"10.1016/0278-6222(88)90050-2","DOIUrl":"10.1016/0278-6222(88)90050-2","url":null,"abstract":"","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 2","pages":"Pages 173-191"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90050-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87093925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G.J. Tijhuis, J.J. van Doormaal MD, L. Rijskamp, C.Th.Smit Sibinga MD, PhD, H. Doorenbos MD, PhD
{"title":"Plasma exchange and low-density lipoprotein filtration therapy in heterozygous familial hypercholesterolemia","authors":"G.J. Tijhuis, J.J. van Doormaal MD, L. Rijskamp, C.Th.Smit Sibinga MD, PhD, H. Doorenbos MD, PhD","doi":"10.1016/0278-6222(88)90029-0","DOIUrl":"10.1016/0278-6222(88)90029-0","url":null,"abstract":"<div><p>We studied serum lipids during and shortly after a single plasma exchange (PE) on seven separate occasions in four patients, and during long-term treatment by regular PE in three patients with heterozygous familial hypercholesterolemia. Also, a comparison was made for efficacy in lipid and apolipoprotein removal between long-term weekly PE therapy and three consecutive weekly low-density lipoprotein (LDL) filtration procedures in one patient. PE was done by intermittentflow centrifugation (IFC) with Haemonetics V50 apparatus, exchanging one plasma volume. LDL filtration consisted of a cascade PE, in which the plasma was separated by IFC and the LDL fraction was subsequently removed by membrane filtration over a polyalcohol filter (Evaflux<sup>®</sup>). From the results, we concluded that (1) LDL cholesterol is reduced about 50% by both methods; (2) after PE, high-density lipoprotein (HDL) cholesterol does not increase during the first two hours, but rises thereafter faster than LDL cholesterol and can reach baseline within three days; (3) by LDL filtration, HDL cholesterol decreases about 30% less than LDL cholesterol and tends to increase above the starting levels found during weekly PE treatment; (4) the reductions in LDL and HDL cholesterol are larger than those in apolipoprotein B and A-I, respectively, in both methods; and (5) connection of the LDL filter device to the Haemonetics V50 system simplifies the cascade procedure, resulting in a single needle approach and avoidance of hemolysis in the primary plasma separation.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 1","pages":"Pages 29-34"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90029-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90871935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Invitation to the 3rd International Congress of the World Association of Apheresis","authors":"","doi":"10.1016/0278-6222(88)90009-5","DOIUrl":"https://doi.org/10.1016/0278-6222(88)90009-5","url":null,"abstract":"","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 3","pages":"Page 331"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90009-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136556063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jose L. Gomez-Villagran MD, Concepcion Herrera MD, Francisco Velasco MD, Antonio Torres MD
{"title":"Studies on contact phase and platelet activation during thrombopheresis in donors. Preliminary results of a comparison between continuous and intermittent flow systems","authors":"Jose L. Gomez-Villagran MD, Concepcion Herrera MD, Francisco Velasco MD, Antonio Torres MD","doi":"10.1016/0278-6222(88)90015-0","DOIUrl":"10.1016/0278-6222(88)90015-0","url":null,"abstract":"<div><p>Two different groups of healthy donors underwent thrombopheresis either with continuous (CS-3000) or intermittent (Haemonetics-30) flow centrifugation systems. Determinations of β-thromboglobulin, Factor XII, Factor XI, Prekallikrein, Kallikrein Inhibitor and High Molecular Weight Kininogen, were carried out at 0, 60 and 120 min after the onset of the procedure. All the contact phase factors remained unchanged during the whole procedure in both groups of donors. β-Thromboglobulin plasma levels increased significantly in the two systems; the overall percentage increases were significantly higher in the CS-3000 donors when compared with those in the H-30 donors.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 4","pages":"Pages 353-357"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90015-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73451585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Changes in plasma coagulation factors during blood storage","authors":"Toby L. Simon MD","doi":"10.1016/0278-6222(88)90007-1","DOIUrl":"10.1016/0278-6222(88)90007-1","url":null,"abstract":"<div><p>Changes in plasma coagulation factors during blood storage primarily consist of a gradual reduction in biologic activity. The major exception is the more rapid loss of coagulation factor V and VIII activity due to their lability. By 35 days of storage of whole blood in CPD-Adenine, factor V falls to 15–21% activity and factor VIII 16–20%. Only slight declines are seen in factor II and X during the same time, while other factors, except for factor VII, are virtually unchanged. Factor VII may be activated in the cold, but otherwise declines slightly. In fresh frozen plasma stored for a year only factor VIII declines, and this is reduced by more rapid freezing to lower temperatures. In platelet concentrates, coagulation factors are well maintained, with the exception of the labile factors. Paradoxically, factor V falls more rapidly with room temperature storage and agitation while factor VIII decline is lessened.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 3","pages":"Pages 309-315"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90007-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73438910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marcell U. Heim MD , Markus Böck MD , Rainer J. Haas MD , Piroska Schmidt MD , Reinhold Eckstein MD , Wolfgang Mempel MD
{"title":"Transfusion of Neocytes: Cell harvesting with the Fenwal CS-3000 cell separator. Clinical effectiveness","authors":"Marcell U. Heim MD , Markus Böck MD , Rainer J. Haas MD , Piroska Schmidt MD , Reinhold Eckstein MD , Wolfgang Mempel MD","doi":"10.1016/0278-6222(88)90023-X","DOIUrl":"10.1016/0278-6222(88)90023-X","url":null,"abstract":"<div><p>We used the Fenwal CS-3000 cell separator to harvest units of neocytes for transfusion in patients with chronic hemolytic anemia. Neocyte enrichment was evaluated by reticulocyte count. These units were contaminated by a large number of leukocytes. In order to minimize immunization to HLA-antigens, these cells could be eliminated by an additional freeze-thaw-wash procedure. To determine the clinical effectiveness, four patients were transfused with neocyte concentrates over a period of six months. This study fails to show a significant benefit of neocyte transfusion, although there was a trend in terms of transfusion requirement.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 1","pages":"Pages 3-6"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90023-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74280241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Brunner, W. Konen, W. Sickel, K. Gothe, J. Kadar, H. Borberg
{"title":"Plasma exchange in the treatment of uveitis posterior","authors":"R. Brunner, W. Konen, W. Sickel, K. Gothe, J. Kadar, H. Borberg","doi":"10.1016/0278-6222(88)90034-4","DOIUrl":"10.1016/0278-6222(88)90034-4","url":null,"abstract":"<div><p>The morphologic alterations of progressive posterior uveitis observed in the chorioid, retina, and subsequently in the vascular system are generally controlled by hemorheologic and/or anti-inflammatory/ immunosuppressive drug therapy. Plasma exchange therapy using 5% serum albumin or serum preserve also appears to be indicated if these conventional treatments do not suffice and if side effects of the drugs applied limit their efficacy, as has been shown from the experience of 22 patients treated. The mechanisms discussed are: elimination of an underlying pathogenic substance, immunomodulatory effects of the plasma exchange fluids, and an improvement of the blood rheology. Further work needs to be done to evaluate the different variables under consideration.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 1","pages":"Pages 63-67"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90034-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86576586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}