{"title":"Molecular mechanisms of the red cell storage lesion","authors":"William C. Horne PhD","doi":"10.1016/0278-6222(88)90002-2","DOIUrl":"10.1016/0278-6222(88)90002-2","url":null,"abstract":"<div><p>Preserved erythrocytes undergo several changes during storage, collectively referred to as the storage lesion, which reduce the effectiveness of stored erythrocytes following transfusion. This review describes the mechanisms leading to these changes, so far as they are known, and discusses the relationship of the changes to one another and how they contribute to the diminished function of stored erythrocytes.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 3","pages":"Pages 259-273"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90002-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84439231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Automated plasmapheresis with a nylon membrane","authors":"J.C. Faber MD , A.J. Reppucci BA, SBB(ASCP) , J.M. Mathias MS , J.P. Hoffmann ChemEng","doi":"10.1016/0278-6222(88)90013-7","DOIUrl":"10.1016/0278-6222(88)90013-7","url":null,"abstract":"<div><p>A new nylon membrane is an effective alternate to the original polycarbonate membrane in the Autopheresis-C<sup>®</sup> plasmapheresis system. With the original membrane some donors were noted to have reduced plasma flow rates (less than 15 mL/min) and therefore increased plasmapheresis times. In the study reported here, 30 of these low-flow donors were matched for age, sex, and blood group with 32 normal-flow donors, and all underwent plasmapheresis using the new nylon membrane. No significant differences could be found between the groups in apheresis time, plasma flow rate, amount of plasma donated or amount of Factor VIII:C or other biological parameters measured in the plasma.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 4","pages":"Pages 347-350"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90013-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89914501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of AIDS on blood donors","authors":"Peter L. Page MD","doi":"10.1016/0278-6222(88)90055-1","DOIUrl":"10.1016/0278-6222(88)90055-1","url":null,"abstract":"","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 2","pages":"Pages 241-256"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90055-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79607361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Björeman , E. Björsell-Östling , J. Schollin , B. Sandström , T. Ström
{"title":"Case report: Thrombotic thrombocytopenic purpura during pregnancy: Treatment with plasma substitution","authors":"M. Björeman , E. Björsell-Östling , J. Schollin , B. Sandström , T. Ström","doi":"10.1016/0278-6222(88)90039-3","DOIUrl":"10.1016/0278-6222(88)90039-3","url":null,"abstract":"<div><p>Thrombotic thrombocytopenic purpura (TTP) is presently regarded as one of the most clearcut indications for plasma exchange (PE). We describe a young woman with TTP during pregnancy who initially received PE but during the last months of her pregnancy needed only infusions of plasma to control her TTP. Furthermore, during his first days of life, her newborn son showed signs of microangiopathic hemolytic anemia (MAH). These signs rapidly vanished after an exchange transfusion.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 1","pages":"Pages 89-94"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90039-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74969409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Hombach MD, M. Kochs MD, T. Eggeling MD, M. Höher MD, H.H. Hilger MD
{"title":"Quantitative techniques for the control of regression of coronary atherosclerosis","authors":"V. Hombach MD, M. Kochs MD, T. Eggeling MD, M. Höher MD, H.H. Hilger MD","doi":"10.1016/0278-6222(88)90032-0","DOIUrl":"10.1016/0278-6222(88)90032-0","url":null,"abstract":"<div><p>The extent and degree of coronary atherosclerosis may be assessed by indirect parameters and by direct angiographic measurements. Determinations of the hemodynamic significance and properties of coronary stenoses by classical fluid dynamics, and semi-quantitative evaluation of regional hypoperfusion or abnormalities of metabolism and of regional contractile performance are indirect parameters, that do not provide precise information on progression or regression of coronary atherosclerosis. To obtain reliable and reproducible angiographic measurements of coronary stenoses, angiographic pitfalls (film exposure and processing as well as distance of the patient to x-ray tube and image intensifier must be constant, pincushion distortion must be compensated for, standard reference must be used), physiological variables (respiratory and cardiac cycle and coronary vascular tone must be identical on repeat films, slitlike stenoses must be visualized in different projections), and problems with the measurement procedure itself (reproducibility is important, inter- and intra-observer variability must be minimized, stenosis dynamics and plaque volume can only be quantitated by a computer system) have to be overcome or be compensated for. Using a standardized angiographic protocol, we were able to follow progression and regression in a cohort of 10 patients with familial hypercholesterolemia IIa, who were successfully treated with long-term specific LDL-cholesterol immunoabsorption (LDL-apheresis), that favorably influenced the long-term atherosclerotic activity in the coronary arteries of these patients.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 1","pages":"Pages 49-57"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90032-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73703898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Changes in the activation state of stored platelets","authors":"David T. Miller MD, PhD , Arthur P. Bode PhD","doi":"10.1016/0278-6222(88)90004-6","DOIUrl":"10.1016/0278-6222(88)90004-6","url":null,"abstract":"","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 3","pages":"Pages 283-294"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90004-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77057381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Current status of plasma exchange in Neurology","authors":"Kurt Heininger MD, PhD, Klaus V. Toyka MD","doi":"10.1016/0278-6222(88)90035-6","DOIUrl":"10.1016/0278-6222(88)90035-6","url":null,"abstract":"","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 1","pages":"Pages 69-72"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90035-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85522262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Current status of bone marrow purging prior to autografting for Hematological malignancies—future directions","authors":"P. Hervé","doi":"10.1016/0278-6222(88)90042-3","DOIUrl":"10.1016/0278-6222(88)90042-3","url":null,"abstract":"<div><p>While the debate remains largely open concerning the importance of purging in malignant hemopathies, we are currently witness to the extraordinary development of complex and expensive technologies associating several methods (immunochemoseparation procedure, drug cocktails …). Such techniques may be justified for acute leukemias at high risk of relapse when the residual disease is almost perceptible. Current objectives are oriented in several directions: development of techniques for detecting residual disease, development of immunophysical procedure (magnetic and floating immunobeads) and long-term human marrow cultures for selection of normal hematopoietic stem cells. Future progress in ABMT depends not only on the effective <em>ex-vivo</em> purging of marrow but also on development of more effective conditioning regimens (<em>in vivo</em> purging).</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 1","pages":"Pages 103-113"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90042-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80453054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Variables involved in regression of atherosclerosis in familial hypercholesterolemic patients under long-term LDL-apheresis","authors":"K. Oette, H. Borberg","doi":"10.1016/0278-6222(88)90026-5","DOIUrl":"10.1016/0278-6222(88)90026-5","url":null,"abstract":"","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 1","pages":"Pages 17-23"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90026-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89659618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}