Marcell U. Heim MD , Markus Böck MD , Rainer J. Haas MD , Piroska Schmidt MD , Reinhold Eckstein MD , Wolfgang Mempel MD
{"title":"Transfusion of Neocytes: Cell harvesting with the Fenwal CS-3000 cell separator. Clinical effectiveness","authors":"Marcell U. Heim MD , Markus Böck MD , Rainer J. Haas MD , Piroska Schmidt MD , Reinhold Eckstein MD , Wolfgang Mempel MD","doi":"10.1016/0278-6222(88)90023-X","DOIUrl":null,"url":null,"abstract":"<div><p>We used the Fenwal CS-3000 cell separator to harvest units of neocytes for transfusion in patients with chronic hemolytic anemia. Neocyte enrichment was evaluated by reticulocyte count. These units were contaminated by a large number of leukocytes. In order to minimize immunization to HLA-antigens, these cells could be eliminated by an additional freeze-thaw-wash procedure. To determine the clinical effectiveness, four patients were transfused with neocyte concentrates over a period of six months. This study fails to show a significant benefit of neocyte transfusion, although there was a trend in terms of transfusion requirement.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 1","pages":"Pages 3-6"},"PeriodicalIF":0.0000,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90023-X","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Plasma Therapy and Transfusion Technology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/027862228890023X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
We used the Fenwal CS-3000 cell separator to harvest units of neocytes for transfusion in patients with chronic hemolytic anemia. Neocyte enrichment was evaluated by reticulocyte count. These units were contaminated by a large number of leukocytes. In order to minimize immunization to HLA-antigens, these cells could be eliminated by an additional freeze-thaw-wash procedure. To determine the clinical effectiveness, four patients were transfused with neocyte concentrates over a period of six months. This study fails to show a significant benefit of neocyte transfusion, although there was a trend in terms of transfusion requirement.