A. Tichelli, A. Gratwohl, C. Nissen, A. Lori, A. Würsch, R. Wenger, B. Osterwalder, H.P. Burri, B. Speck
{"title":"abo血型不相容骨髓移植:清除红细胞抗体的三种方法","authors":"A. Tichelli, A. Gratwohl, C. Nissen, A. Lori, A. Würsch, R. Wenger, B. Osterwalder, H.P. Burri, B. Speck","doi":"10.1016/S0278-6222(87)80043-8","DOIUrl":null,"url":null,"abstract":"<div><p>We analyzed three different methods for removing red blood cell (RBC) antibodies in 28 patients before a major ABO-incompatible bone marrow transplantation (BMT). Six patients were treated with extensive plasma exchange. Antibody titers were lowered from 1:512 to 1:4 (median values). In ten patients antibodies were removed by extracorporeal immunoadsorption using an adsorbent column. Titers decreased from 1:128 to 1:32. In four of these ten patients plasma exchange was added to complete antibody removal. Twelve patients were treated with simple in vivo adsorption with donor-type RBCs before marrow infusion. In eight of them, titers became undetectable. Advantages and disadvantages of the three methods are discussed.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"8 4","pages":"Pages 355-359"},"PeriodicalIF":0.0000,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0278-6222(87)80043-8","citationCount":"3","resultStr":"{\"title\":\"ABO-incompatible bone marrow transplantation: Three methods for the removal of red blood cell antibodies\",\"authors\":\"A. Tichelli, A. Gratwohl, C. Nissen, A. Lori, A. Würsch, R. Wenger, B. Osterwalder, H.P. Burri, B. Speck\",\"doi\":\"10.1016/S0278-6222(87)80043-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>We analyzed three different methods for removing red blood cell (RBC) antibodies in 28 patients before a major ABO-incompatible bone marrow transplantation (BMT). Six patients were treated with extensive plasma exchange. Antibody titers were lowered from 1:512 to 1:4 (median values). In ten patients antibodies were removed by extracorporeal immunoadsorption using an adsorbent column. Titers decreased from 1:128 to 1:32. In four of these ten patients plasma exchange was added to complete antibody removal. Twelve patients were treated with simple in vivo adsorption with donor-type RBCs before marrow infusion. In eight of them, titers became undetectable. Advantages and disadvantages of the three methods are discussed.</p></div>\",\"PeriodicalId\":101030,\"journal\":{\"name\":\"Plasma Therapy and Transfusion Technology\",\"volume\":\"8 4\",\"pages\":\"Pages 355-359\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1987-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0278-6222(87)80043-8\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Plasma Therapy and Transfusion Technology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0278622287800438\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Plasma Therapy and Transfusion Technology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0278622287800438","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
ABO-incompatible bone marrow transplantation: Three methods for the removal of red blood cell antibodies
We analyzed three different methods for removing red blood cell (RBC) antibodies in 28 patients before a major ABO-incompatible bone marrow transplantation (BMT). Six patients were treated with extensive plasma exchange. Antibody titers were lowered from 1:512 to 1:4 (median values). In ten patients antibodies were removed by extracorporeal immunoadsorption using an adsorbent column. Titers decreased from 1:128 to 1:32. In four of these ten patients plasma exchange was added to complete antibody removal. Twelve patients were treated with simple in vivo adsorption with donor-type RBCs before marrow infusion. In eight of them, titers became undetectable. Advantages and disadvantages of the three methods are discussed.
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