{"title":"Use of immunoadsorbent columns for antiacetylcholine receptor antibody removal from plasma of myasthenia gravis patients","authors":"Carlo Antozzi MD , Renato Mantegazza MD , Dionisio Peluchetti MD , Fulvio Baggi PhD , Paola Romagnoli PhD , Maurizio Marconi MD , Angelo Vescoyv PhD , Ferdinando Cornelio MD","doi":"10.1016/0278-6222(88)90036-8","DOIUrl":"10.1016/0278-6222(88)90036-8","url":null,"abstract":"<div><p>The best apheretic approach to myasthenia gravis is the selective removal of antiacetylcholine receptor antibodies (antiAchR-Ab) from plasma. A new tryptophan-linked polyvinyl-alcohol gel recently reported to be able to adsorb IgG autoantibodies semiselectively from plasma was investigated in vitro. A consistent reduction of antiAchR-Ab ranging from 76% to 100% was observed in all plasma samples tested. Various degrees of reduction of other immunoglobulins were noted. The regeneration of the immunocolumn did not reduce the efficiency in autoantibody removal. Further in vitro and in vivo investigations are needed to confirm the clinical usefulness of this promising apheretic approach to myasthenia gravis.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 1","pages":"Pages 73-75"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90036-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74034449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The human immunodeficiency virus and associated detection methods","authors":"Roger Y. Dodd PhD","doi":"10.1016/0278-6222(88)90048-4","DOIUrl":"10.1016/0278-6222(88)90048-4","url":null,"abstract":"","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 2","pages":"Pages 151-159"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90048-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73871213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Molecular biology of blood during storage","authors":"Edward L. Snyder MD","doi":"10.1016/0278-6222(88)90001-0","DOIUrl":"10.1016/0278-6222(88)90001-0","url":null,"abstract":"","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 3","pages":"Pages 257-258"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90001-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78632630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Occupational HIV infection in laboratory personnel","authors":"J.Louise Gerberding MD , Cary Littell BA","doi":"10.1016/0278-6222(88)90052-6","DOIUrl":"10.1016/0278-6222(88)90052-6","url":null,"abstract":"<div><p>The prevalence of HIV infection in the general population and in patients hospitalized with complications of immune suppression will no doubt increase in the next few years. As a result, an increasing number of laboratory personnel will be exposed to the potential for occupational infection with HIV. Although the magnitude of risk for infection with this pathogen following occupational exposure is not large, the consequences of infection are severe. It is therefore imperative that reasonable infection control measures to minimize exposure be implemented and enforced. In order to accomplish this, the modes of HIV transmission, the relative degree of risk from various types of contact, and effective strategies to reduce exposure must be ascertained.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 2","pages":"Pages 207-212"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90052-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78753235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Transplantation of hemapheresis-derived hemopoietic stem cells: A new concept in the treatment of patients with malignant lymphohemopoietic disorders","authors":"Martin Körbling, Hans Martin","doi":"10.1016/0278-6222(88)90044-7","DOIUrl":"10.1016/0278-6222(88)90044-7","url":null,"abstract":"","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 1","pages":"Pages 119-132"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90044-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88798636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exogenous human retroviruses other than HIV-1","authors":"Alan E. Williams PhD","doi":"10.1016/0278-6222(88)90053-8","DOIUrl":"10.1016/0278-6222(88)90053-8","url":null,"abstract":"","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 2","pages":"Pages 213-229"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90053-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74782459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The molecular pathobiology of stored neutrophils","authors":"Lewis Glasser MD","doi":"10.1016/0278-6222(88)90005-8","DOIUrl":"10.1016/0278-6222(88)90005-8","url":null,"abstract":"<div><p>The neutrophil is a short-lived cell because it has limited biosynthetic capacity to repair and maintain its component parts. Studies on neutrophil storage show generalized defects involving energy metabolism, phagocytosis, microbial killing, chemotaxis, membrane receptors, microtubules, microfilaments, and stimulus—response coupling. Some storage conditions are more detrimental to certain functions than others, e.g. cold induces a severe chemotactic defect. Thus, room temperature storage is preferable to refrigerated storage. For optimal storage, it is necessary to have sufficient glucose in the medium and to maintain an adequate pH. During storage, a dismantling of the functional integrity of the cell occurs with the most highly integrated functions being lost initially, while primitive functions are retained the longest. With minor exceptions, the generalized metabolic, structural, and functional defects noted in stored neutrophils are not peculiar to storage but most likely mirror the inexorable <em>in vivo</em> programmed senescence of the neutrophil.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 3","pages":"Pages 295-302"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90005-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82943425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Progenitor cell cytapheresis using a discontinuous-flow blood cell separator for the management of a pregnant patient with Chronic Myelogenous Leukemia","authors":"V. Hermosa, J.M. Pastor, E. Conde, A. Zubizarreta","doi":"10.1016/0278-6222(88)90018-6","DOIUrl":"10.1016/0278-6222(88)90018-6","url":null,"abstract":"<div><p>Cytapheresis of progenitor cells and immature granulocytes was employed in the initial management of a pregnant patient with Chronic Myelogenous Leukemia (CML). A semicontinuousflow blood cell separator was used; no sedimenting agents were applied. Over a period of 16 weeks the patient underwent 15 therapeutic Cytapheresis. Mean efficiency for CFU-GM was 72% and for mature granulocytes 8%. Hb loss per session was equivalent to 80 mL of whole blood and transfusion was unnecessary.</p><p>The decrease in the peripheral blood leucocytes was linear and overall leucocyte reduction was 89%. Our results suggest that preferential elimination of granulopoietic stem cells is an alternative strategy to intensive leucapheresis in the management of pregnant patients with CML; utility in other situations must be evaluated.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 4","pages":"Pages 369-375"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90018-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82802662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}