{"title":"应用免疫吸附柱去除重症肌无力患者血浆中抗乙酰胆碱受体抗体","authors":"Carlo Antozzi MD , Renato Mantegazza MD , Dionisio Peluchetti MD , Fulvio Baggi PhD , Paola Romagnoli PhD , Maurizio Marconi MD , Angelo Vescoyv PhD , Ferdinando Cornelio MD","doi":"10.1016/0278-6222(88)90036-8","DOIUrl":null,"url":null,"abstract":"<div><p>The best apheretic approach to myasthenia gravis is the selective removal of antiacetylcholine receptor antibodies (antiAchR-Ab) from plasma. A new tryptophan-linked polyvinyl-alcohol gel recently reported to be able to adsorb IgG autoantibodies semiselectively from plasma was investigated in vitro. A consistent reduction of antiAchR-Ab ranging from 76% to 100% was observed in all plasma samples tested. Various degrees of reduction of other immunoglobulins were noted. The regeneration of the immunocolumn did not reduce the efficiency in autoantibody removal. Further in vitro and in vivo investigations are needed to confirm the clinical usefulness of this promising apheretic approach to myasthenia gravis.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 1","pages":"Pages 73-75"},"PeriodicalIF":0.0000,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90036-8","citationCount":"0","resultStr":"{\"title\":\"Use of immunoadsorbent columns for antiacetylcholine receptor antibody removal from plasma of myasthenia gravis patients\",\"authors\":\"Carlo Antozzi MD , Renato Mantegazza MD , Dionisio Peluchetti MD , Fulvio Baggi PhD , Paola Romagnoli PhD , Maurizio Marconi MD , Angelo Vescoyv PhD , Ferdinando Cornelio MD\",\"doi\":\"10.1016/0278-6222(88)90036-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The best apheretic approach to myasthenia gravis is the selective removal of antiacetylcholine receptor antibodies (antiAchR-Ab) from plasma. A new tryptophan-linked polyvinyl-alcohol gel recently reported to be able to adsorb IgG autoantibodies semiselectively from plasma was investigated in vitro. A consistent reduction of antiAchR-Ab ranging from 76% to 100% was observed in all plasma samples tested. Various degrees of reduction of other immunoglobulins were noted. The regeneration of the immunocolumn did not reduce the efficiency in autoantibody removal. Further in vitro and in vivo investigations are needed to confirm the clinical usefulness of this promising apheretic approach to myasthenia gravis.</p></div>\",\"PeriodicalId\":101030,\"journal\":{\"name\":\"Plasma Therapy and Transfusion Technology\",\"volume\":\"9 1\",\"pages\":\"Pages 73-75\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1988-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0278-6222(88)90036-8\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Plasma Therapy and Transfusion Technology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0278622288900368\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Plasma Therapy and Transfusion Technology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0278622288900368","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Use of immunoadsorbent columns for antiacetylcholine receptor antibody removal from plasma of myasthenia gravis patients
The best apheretic approach to myasthenia gravis is the selective removal of antiacetylcholine receptor antibodies (antiAchR-Ab) from plasma. A new tryptophan-linked polyvinyl-alcohol gel recently reported to be able to adsorb IgG autoantibodies semiselectively from plasma was investigated in vitro. A consistent reduction of antiAchR-Ab ranging from 76% to 100% was observed in all plasma samples tested. Various degrees of reduction of other immunoglobulins were noted. The regeneration of the immunocolumn did not reduce the efficiency in autoantibody removal. Further in vitro and in vivo investigations are needed to confirm the clinical usefulness of this promising apheretic approach to myasthenia gravis.
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