{"title":"The fate of cells of the immune system during blood storage and after transfusion","authors":"Neil Blumberg MD","doi":"10.1016/0278-6222(88)90006-X","DOIUrl":"10.1016/0278-6222(88)90006-X","url":null,"abstract":"<div><p>Little is known concerning the biochemical and physiological changes that take place in lymphocytes and monocytes in various blood components stored under blood bank conditions. Several studies have suggested that these cells become nonviable after some days of storage, and that surface markers for various lymphocyte subsets may vary over time and with different conditions of storage. The best documented consequences of transfusion of such cells is graft versus host disease in the immunologically immature or dysfunctional recipient, and prolonged survival of renal allografts in previously transfused recipients. Recipient immunomodulation in other settings may be mediated by these cells, or their remnants, which are almost invariably transfused along with red blood cells, platelets or plasma factors. Some proposed consequences of homologous blood transfusions which may be related to transfusion of cells of the immune system include decreased host resistance to solid tumor recurrence, bacterial infection and HIV-1 infection.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 3","pages":"Pages 303-308"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90006-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84946869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Kamanabroo , H. Feldmann , H. Schriever , J. Van de Loo
{"title":"Heredopathia atactica polyneuritiformis (Refsum's disease) treated by diet and plasma exchange—follow-up study of one case over eight years","authors":"D. Kamanabroo , H. Feldmann , H. Schriever , J. Van de Loo","doi":"10.1016/0278-6222(88)90037-X","DOIUrl":"10.1016/0278-6222(88)90037-X","url":null,"abstract":"<div><p>A 39-year-old patient with severe heredopathia atactica polyneuritiformis (Refsum's disease) has responded well to treatment with large-volume plasma exchange in combination with a low phytanic acid diet. The follow-up study over eight years shows that the dietary control of the disease depends not only on a diet low in phytanic acid, but also on one high in calories. This is to prevent weight loss, which was always accompanied by clinical deterioration.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 1","pages":"Pages 77-81"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90037-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89239558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Plasma exchange in the successful treatment of severe drug-induced toxic epidermal necrolysis (Lyell's disease)","authors":"D. Kamanabroo , W. Schmitz-Landgraf","doi":"10.1016/0278-6222(88)90041-1","DOIUrl":"10.1016/0278-6222(88)90041-1","url":null,"abstract":"<div><p>Five patients with severe drag-induced toxic epidermal necrolysis improved rapidly after one to two plasma exchanges. The improvement of all five patients treated with plasmapheresis contrasts with the disease's mortality rate of up to 50%, as reported in the literature and as observed among our previously treated patients. Since there is no effective treatment for toxic epidermal necrolysis, a controlled clinical trial to evaluate the effectiveness of plasma exchange would seem worthwhile.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 1","pages":"Pages 99-101"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90041-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77518907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Kukharchuk, G. Konovalov, A. Vedernikov, I. Adamova, G. Benevolenskaya, V. Sinitsyn, I. Trakht, S. Pokrovsky
{"title":"Long-term application of three types of sorbents for LDL-apheresis","authors":"V. Kukharchuk, G. Konovalov, A. Vedernikov, I. Adamova, G. Benevolenskaya, V. Sinitsyn, I. Trakht, S. Pokrovsky","doi":"10.1016/0278-6222(88)90031-9","DOIUrl":"10.1016/0278-6222(88)90031-9","url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>(1) All types of columns used are effective for the reduction of total cholesterol and LDL levels with the procedures performed once in 7–10 days. HDL level remained unchanged, which had a favourable effect on <span><math><mtext>TC</mtext><mtext>HDL</mtext></math></span> ratio.</p></span></li><li><span>2.</span><span><p>(2) Prolonged treatment leads to the regression of xanthomata.</p></span></li><li><span>3.</span><span><p>(3) Studies of coronary atherosclerosis regression after long-term LDL-apheresis are in progress.</p></span></li></ul></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 1","pages":"Pages 45-47"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90031-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91433892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Perspectives of the symposium “Hemapheresis”, held in Dordrecht, The Netherlands, 10 September 1987","authors":"L. Kater MD, PhD , J.Ph. Sybesma MD, PhD","doi":"10.1016/0278-6222(88)90019-8","DOIUrl":"10.1016/0278-6222(88)90019-8","url":null,"abstract":"<div><p>The symposium “Haemapheresis” was held on 10 September 1987 in Dordrecht, The Netherlands, celebrating the 10th anniversary of the Blood Bank “Zuid-West Nederland”. Various aspects of donor and of therapeutic apheresis were discussed.</p><p>A main issue is the assessment of indications for the therapeutic use of haemapheresis. Haemapheresis has been attempted as a treatment modality in more than 150 diseases. In a report of the Health Council of the Netherlands “Therapeutic Haemapheresis” issued in 1986, categories have been described for indications (A-F): </p><ul><li><span>&#x02022;</span><span><p>• Category A pertained to an established indication fulfilling all criteria listed;</p></span></li><li><span>&#x02022;</span><span><p>• Category B holds for an acceptable indication, which is fully proved;</p></span></li><li><span>&#x02022;</span><span><p>• Category C is labelled, to be “an emergency indication”. This means that, although proof of efficacy is lacking, there are certain conditions in which haemapheresis cannot be withheld from a patient;</p></span></li><li><span>&#x02022;</span><span><p>• Category D comprises diseases, in which the indication is not yet established and more randomised clinical trials are needed;</p></span></li><li><span>&#x02022;</span><span><p>• Category E refers to more experimental indications for haemapheresis;</p></span></li><li><span>&#x02022;</span><span><p>• Category F means that there is no indication for haemapheresis. Reports on therapeutic haemapheresis have to be considered within the framework of these guidelines.</p></span></li></ul><p>In the presentations on donor apheresis an update was given on new developments in technology, including ways to obtain cell components and the side-effects and complications of the procedures.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 4","pages":"Pages 377-384"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90019-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84749734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Continuous-flow apheresis of microfilariae in Loa loa infestations","authors":"Peter Kern, Peter Wind, Manfred Dietrich","doi":"10.1016/0278-6222(88)90040-X","DOIUrl":"10.1016/0278-6222(88)90040-X","url":null,"abstract":"<div><p>Loiasis is endemic in the tropical rain forest of Central and some parts of West Africa and is transmitted by the insect vector <em>Chrysops silacea</em> and <em>Chrysops dimidiata</em>. Loa loa infestation causes local inflammation due to migrating adult worms in the subcutis (Calabar swelling) and in the conjunctivae (eye worm). The diagnosis is made by the demonstration of circulating blood microfilariae, the larvae of the adult worms. Since the density of the microfilariae is very low, they can only be identified by concentration methods, such as hemofiltration. During treatment with the specific antiparasitic drug (diethylcarbamazine, DEC), side effects such as allergic reactions due to the rapid disruption of circulating microfilariae may occur. Those symptoms are aggravated in patients with a high number of larvae, leading to meningo-encephalomyelitis or even death.<sup>1</sup></p><p>Since microfilariae accumulate in the buffy coat during leukocytapheresis,<sup>2</sup> it was thought that this technique might be a suitable tool to reduce the parasite load and to bypass the side effects of specific drug treatment. Muylle et al. achieved apheresis of microfilariae in two patients with Loa loa infestation by using a Haemonetics, M-300 blood processor.<sup>3</sup> The authors studied two patients with an excessive microfilarial count in the peripheral blood of up to 9/μL and achieved a high enrichment by discontinuous-flow centrifugation. A similar observation was reported by Saeed et al. later on. <sup>4</sup> We have studied two patients with loiasis and report the results of microfilarial apheresis using a continuous-flow IBM/Cobe cell separator.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 1","pages":"Pages 95-98"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90040-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86601378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Bussel, C. Cunningham-Rundles, C. Feldman, B. Horowitz
{"title":"Transmission of viral infection by preparations of intravenous immunoglobulin","authors":"J. Bussel, C. Cunningham-Rundles, C. Feldman, B. Horowitz","doi":"10.1016/0278-6222(88)90051-4","DOIUrl":"10.1016/0278-6222(88)90051-4","url":null,"abstract":"","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 2","pages":"Pages 193-205"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90051-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85381887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Case report: HIV infection after plasma exchanges for bullous pemphigoid","authors":"B. Guillot, J. Reynes, D. Donadio","doi":"10.1016/0278-6222(88)90014-9","DOIUrl":"10.1016/0278-6222(88)90014-9","url":null,"abstract":"","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 4","pages":"Pages 351-352"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90014-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89812005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Plasma exchange therapy in ophthalmology","authors":"R. Brunner, H. Borberg","doi":"10.1016/0278-6222(88)90033-2","DOIUrl":"10.1016/0278-6222(88)90033-2","url":null,"abstract":"<div><p>The ocular indication of PEX may be considered to exist in patients with uveitis posterior and Graves' disease. For both types of diseases only anecdotal case descriptions are available; controlled trials are lacking so far. Whereas the results of PEX are generally judged positively for uveitis posterior by all authors, PEX treatment in Graves' disease is debatable.</p><p>In myasthenia gravis and Sjögren's syndrome, PEX is generally applied after considerable deterioration of the general clinical status of the patient has occurred. A precise ophthalmologic examination could well be useful for documentation of the course of the disease and the therapeutic response.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"9 1","pages":"Pages 59-61"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0278-6222(88)90033-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89151687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}