High dose intravenous immunoglobulin in post transfusion purpura—Changes in bound and free platelet antibody and in vitro lymphocyte transformation with Phytohemagglutinin

Abstract

A middle-aged female with posttransfusion purpura (PTP), serologically proven to be associated with anti-PLAI antibody was treated successfully with high-dose intravenous immunoglobulin (IVIG). Normalization of the Platelet Associated IgG-antibody (PAIgG) correlated with peak platelet count on day 6 of therapy. Anti-PLAI antibody was detectable until week 5 of the follow-up period. Impaired pre-therapy lymphocyte transformation with Phytohemagglutinin (PHA) corrected with the disappearance of the Anti-PLAI antibody.