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Antioxidant potentials of gum kondagogu-based metal nanocomposites: An in vitro study 孔枣胶基金属纳米复合材料的体外抗氧化性能研究
Next Nanotechnology Pub Date : 2025-01-01 DOI: 10.1016/j.nxnano.2025.100188
Suresh Velpula, Mir Zahoor Gul, Sashidhar Rao Beedu, Karuna Rupula
{"title":"Antioxidant potentials of gum kondagogu-based metal nanocomposites: An in vitro study","authors":"Suresh Velpula,&nbsp;Mir Zahoor Gul,&nbsp;Sashidhar Rao Beedu,&nbsp;Karuna Rupula","doi":"10.1016/j.nxnano.2025.100188","DOIUrl":"10.1016/j.nxnano.2025.100188","url":null,"abstract":"<div><div>The living cell carries out various biochemical reactions, generating reactive oxygen species (ROS) and other free radicals that can be neutralised by the natural antioxidants present. However, when the concentration of the ROS exceeds, supplementation with potential antioxidants with fewer side effects plays a role in their elimination. In this regard, bio-nanocomposites, due to their eco-friendly nature, are being largely explored. This study uses <em>in vitro</em> DPPH and ABTS free radical scavenging assay methodologies to evaluate the antioxidant potential of gum kondagogu (GK) based monometallic [Silver (Ag), Gold (Au), and Palladium (Pd)], bimetallic (Ag-Au, Ag-Pd, and Au-Pd) and trimetallic (Ag Au Pd) nanocomposites. The known antioxidant, ascorbic acid, served as the positive reference standard, while native gum was utilised as the negative control. The per cent free radical scavenging activities of GK-based nanocomposites by DPPH (2–20 µg mL<sup>−1</sup>) and ABTS (1–5 µg mL<sup>−1</sup>) assays were: AgNPs (68.36; 85.33), AuNPs (52.34; 58.63), PdNPs (72.19; 72.09), AgAuPdNPs (84.69; 67.90), Ag-Au (54.07;76.24), Ag-Pd (67.29;85.87) and Au-Pd (95.0; 79.30), respectively. Among all the nanocomposites, the bimetallic exhibited the highest antioxidant potential, followed by the trimetallic and the monometallic in a concentration-dependent manner. Further, the AuPdNPs exhibited the highest (95.0 %) scavenging activity at 5 µg mL<sup>−1</sup> concentration and also the lowest IC<sub>50</sub> values of 0.87 ± 0.08 µg mL<sup>−1</sup> in DPPH and 1.99 ± 0.10 µg mL<sup>−1</sup> in ABTS assays. The present study demonstrated the antioxidant ability of the monometallic, bimetallic and the trimetallic nanocomposites and suggested that the presence of palladium greatly enhanced the antioxidant efficacy due to their synergistic properties.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"8 ","pages":"Article 100188"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and characterization of colloidal grapheneol quantum dots decorated with folic acid for highly selective drug delivery application potential 具有高选择性给药潜力的叶酸修饰胶体石墨烯量子点的合成与表征
Next Nanotechnology Pub Date : 2025-01-01 DOI: 10.1016/j.nxnano.2025.100201
Neama G. Saber, Magdy Y. El-Ashry, S. Mosaad, Waleed E. Mahmoud
{"title":"Synthesis and characterization of colloidal grapheneol quantum dots decorated with folic acid for highly selective drug delivery application potential","authors":"Neama G. Saber,&nbsp;Magdy Y. El-Ashry,&nbsp;S. Mosaad,&nbsp;Waleed E. Mahmoud","doi":"10.1016/j.nxnano.2025.100201","DOIUrl":"10.1016/j.nxnano.2025.100201","url":null,"abstract":"<div><div>The development of novel nanocarriers for drug delivery has established a foundation for enhancing the formulations of targeted cancer therapies. Graphene quantum dots (GQDs) and their derivatives have shown promising characteristics for precisely transporting anticancer drugs to tumor cells. Herein, grapheneol quantum dots (GQDs) derived from poly (L-lactic acid) and decorated with folic acid were prepared, for the first time, via a sonochemical approach. The synthesized GQDs were functionalized with folic acid to improve their affinity for folate-positive breast cancer cells, thereby extending their circulation time. Ultimately, these GQDs were loaded with the anticancer agent methotrexate (MTX) to mitigate its adverse effects. Transmission electron microscopy (TEM) and atomic force microscopy confirmed the formation of grapheneol quantum dots with a lateral size of around 2.1 ± 0.2 nm. The UV–vis spectrophotometer measurements showed that the GQDs exhibit a strong quantum confinement effect with an optical band gap energy around 3.2 eV. The photoluminescence measurements showed that the GQDs exhibited high luminescence with intense blue emission and a quantum yield exceeding 72 %. The Raman, X-ray photoelectron spectroscopy, and FTIR measurements revealed that the folic acid decorated the surface of the GQDs. The hydrodynamic light scattering (DLS) and zeta potential measurements indicated that the lateral size of GQDs increases from 2.1 nm to 10 nm, confirming the attachment of the folic acid to the surface of the GQDs. However, the zeta potential of the GQDs changed from −7.6 meV to −14.3 meV, implying the enhancement of the dispersion stability of the GQDs due to the presence of folic acid on their surfaces. The FA-decorated GQDs were used as nanocarriers for the pharmaceutical cancer drug (methotrexate). The results revealed that the FA/GQDs nanocarriers with co-receptors (FA and MTX) enhanced the therapeutic effectiveness with precise targeting to breast cancer cells.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"8 ","pages":"Article 100201"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144320397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decentralized electrochemical biosensors for biomedical applications: From lab to home 用于生物医学应用的分散式电化学生物传感器:从实验室到家庭
Next Nanotechnology Pub Date : 2025-01-01 DOI: 10.1016/j.nxnano.2024.100128
Pramod K. Kalambate , Vipin Kumar , Dhanjai
{"title":"Decentralized electrochemical biosensors for biomedical applications: From lab to home","authors":"Pramod K. Kalambate ,&nbsp;Vipin Kumar ,&nbsp;Dhanjai","doi":"10.1016/j.nxnano.2024.100128","DOIUrl":"10.1016/j.nxnano.2024.100128","url":null,"abstract":"<div><div>Integrated electrochemical biosensors represent the new generation of sensing tools in the biomedical field, delivering compact-sized, portable, wearable, and implantable devices. Advances in sensor fabrication methods, scalable material synthesis, microelectronics, flexible electronics, and wireless communication have enabled the evolution of biosensing devices from traditional hospital-centric systems to home-centric solutions, suitable for use by non-experts to analyze early signs of diseases. Despite these advancements, key challenges remain, including scalability, material durability, power management, and seamless integration of biosensor components into user-friendly platforms. The translation of these technologies involves strategies to overcome these challenges, such as developing cost-effective manufacturing methods and optimizing device design for real-world applications. Furthermore, the integration of these devices with the Internet-of-Things (IoT), Internet-of-Medical-Things (IoMT), artificial intelligence (AI), and machine learning (ML) algorithms has demonstrated breakthrough technological solutions for healthcare management, disease prognosis, and patient care. However, potential risks such as data security vulnerabilities, privacy concerns, and regulatory challenges must be addressed to ensure safe and ethical deployment of these technologies. Herein, we provide an in-depth analysis of the evolution of conventional electrochemical biosensors into miniaturized, integrated devices, focusing on their potential for better healthcare management and highlighting associated technical, regulatory, and ethical challenges. We also highlight key aspects of 6th generation sensing technology. Additionally, the role of IoT and AI-assisted technologies is critically discussed, presenting both their transformative benefits and the risks they pose in the biomedical field.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100128"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143146330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Next-generation nanocomposites: Optimizing Al2O3-CuO-ZnO and reduced graphene oxide for enhanced performance 下一代纳米复合材料:优化Al2O3-CuO-ZnO和还原氧化石墨烯以增强性能
Next Nanotechnology Pub Date : 2025-01-01 DOI: 10.1016/j.nxnano.2024.100119
Rahul Sharma , Harish Kumar , Rajni Kumari , Gaman Kumar , Bhawna Swami , Antresh Kumar , Gita Rani , Ramesh Kumar
{"title":"Next-generation nanocomposites: Optimizing Al2O3-CuO-ZnO and reduced graphene oxide for enhanced performance","authors":"Rahul Sharma ,&nbsp;Harish Kumar ,&nbsp;Rajni Kumari ,&nbsp;Gaman Kumar ,&nbsp;Bhawna Swami ,&nbsp;Antresh Kumar ,&nbsp;Gita Rani ,&nbsp;Ramesh Kumar","doi":"10.1016/j.nxnano.2024.100119","DOIUrl":"10.1016/j.nxnano.2024.100119","url":null,"abstract":"<div><div>Exceptional reduced graphene oxide-based nanocomposites (NCs) were synthesized using Al<sub>2</sub>O<sub>3</sub>-CuO-ZnO (ACZ) nanoparticles (NPs) through a controlled hydrothermal method. Nanomaterials with improved optical, magnetic, antibacterial, adsorption, anticorrosive, and photocatalytic characteristics were synthesized, showing synergistic behavior. To understand key structural features, the NCs were thoroughly examined using energy-dispersive X-ray analysis, SEM, X-ray diffraction, FTIR, and UV-Vis. spectroscopy. Adding ACZ NPs in the rGO matrix, increased magnetic, anticorrosive, improved antibacterial efficacy against Gram-positive bacteria, and photocatalytic activities. The NCs were exposed to sunlight and UVA and UVB light to degrade methylene blue (MB) dye i.e., 89.21 % in 75 min. The anti-corrosive characteristics (95.9 %) were examined against mild steel using a 1.0 N H<sub>2</sub>SO<sub>4</sub> at room temperature at a very low concentration i.e., 10 ppm. The magnetic behavior of the NCs was examined with the help of Gouy’s balance. The induced current showed a clear relationship to the applied magnetic field strength, indicating that the NCs are paramagnetic. The antibacterial effects of the NCs were evaluated against <em>S. aureus</em> and <em>E. coli</em> at different concentrations. The ACZ@rGO NCs exhibited exceptional versatility, showing great promise for water purification, adsorption, corrosion protection, photocatalytic processes, biomedical technologies, and environmental restoration.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100119"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143146331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Colletotrichum gloeosporioides (endophytic fungi) mediated biosynthesis of TiO2 nanoparticles for high-performance dye-sensitized solar cell 内生真菌介导的高性能染料敏化太阳能电池TiO2纳米颗粒的生物合成
Next Nanotechnology Pub Date : 2025-01-01 DOI: 10.1016/j.nxnano.2024.100122
Sakshi Singh , Shubham Sharma , Rajnish Bharti , Ravindra Nath Kharwar , Pankaj Srivastava
{"title":"Colletotrichum gloeosporioides (endophytic fungi) mediated biosynthesis of TiO2 nanoparticles for high-performance dye-sensitized solar cell","authors":"Sakshi Singh ,&nbsp;Shubham Sharma ,&nbsp;Rajnish Bharti ,&nbsp;Ravindra Nath Kharwar ,&nbsp;Pankaj Srivastava","doi":"10.1016/j.nxnano.2024.100122","DOIUrl":"10.1016/j.nxnano.2024.100122","url":null,"abstract":"<div><div>This work reports an environmentally friendly protocol for synthesizing TiO<sub>2</sub> nanoparticles (NPs) by utilizing endophytic fungi, <em>Colletotrichum gloeosporioides (C. gloeosporioides)</em>. The fungi isolated from Thevetia peruviana, worked as a bio-capping agent to regulate the growing TiO<sub>2</sub> NPs morphology and agglomeration behavior. The formation of TiO<sub>2</sub> NPs was validated by surface plasmon resonance, observed using UV–vis spectroscopy. Using XRD and HRTEM, the structure, size, and shape of the as-synthesized anatase TiO<sub>2</sub> NPs were characterized. BET analysis was used to examine the surface area and porosity. EIS revealed the greater charge collection efficiency and enhanced electron lifetime for the TiO<sub>2</sub> obtained with N-3 (endophytic fungal extract). The dye-sensitized solar cell (DSSC) fabricated with bio-capped TiO<sub>2</sub> (N-3) photoanode exhibited greater light-to-current conversion efficiency, 3.50 %; much enhanced compared to 0.98 % obtained with un-capped TiO<sub>2</sub> NPs (N-1) based cell. The study demonstrated that the endophytic fungus <em>C.gloeosporioides</em> played a vital role in enhancing the cell performance.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100122"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143146336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Green synthesis of silver nanoparticles using Nothapodytes foetida leaf extract: Optical, antibacterial and anticancer activities 利用野足草叶提取物绿色合成纳米银:具有光学、抗菌和抗癌活性
Next Nanotechnology Pub Date : 2025-01-01 DOI: 10.1016/j.nxnano.2025.100162
Sunitha Bai Dharavath , Narsimhulu Maduru , Mahendar Porika , Pavani Chirumamilla , Spoorthi Veera , Nirosha Ponnam , Shasthree Taduri
{"title":"Green synthesis of silver nanoparticles using Nothapodytes foetida leaf extract: Optical, antibacterial and anticancer activities","authors":"Sunitha Bai Dharavath ,&nbsp;Narsimhulu Maduru ,&nbsp;Mahendar Porika ,&nbsp;Pavani Chirumamilla ,&nbsp;Spoorthi Veera ,&nbsp;Nirosha Ponnam ,&nbsp;Shasthree Taduri","doi":"10.1016/j.nxnano.2025.100162","DOIUrl":"10.1016/j.nxnano.2025.100162","url":null,"abstract":"<div><div>This study represents the green synthesis of silver nanoparticles using <em>Nothapodytes foetida</em> leaf extract (<em>Nf</em>-AgNPs) and investigates the optical, antibacterial and anti-cancer activities. The plant extract acts both as reducing agent as well as capping agent. The synthesized <em>Nf</em>-AgNPs were characterized by UV-Visible spectroscopy (UV-Vis), Fourier transform infrared spectroscopy (FT-IR), Powder X-ray diffraction (XRD), Scanning electron microscopy (SEM), Energy dispersive X-ray analysis (EDX) and Photoluminescence (PL) techniques. The <em>Nf</em>-AgNPs exhibited maximum absorbance at 430 nm in UV–vis spectrum. The XRD analysis of <em>Nf</em>-AgNPs indicated the particles are a face-centered cubic (fcc) structure with an average crystallite size of 40.73 nm. FTIR analysis of <em>Nf</em>-AgNPs identified different functional groups. Photoluminescence (PL) spectra of <em>Nf</em>-AgNPs exhibited emission peak at 451 nm, when it excited at 330 nm. The <em>Nf</em>-AgNPs confirmed significant anticancer activity towards cancerous cells. The in vitro anticancer activity of <em>Nf</em>-AgNPs nanoparticles against the A549 and HepG2 cells showed the IC<sub>50</sub> value of 69.2 and 41.3 μg/mL, respectively. In addition, antibacterial activity was done by agar well diffusion method and <em>Nf-</em>AgNPs showed a greater ability to inhibit Gram-positive and Gram-negative bacteria compared to other treatments tested. These results confirm that <em>Nf</em>-AgNPs can serve as antibacterial and anticancer agents for biomedical applications.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100162"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanotechnology coatings in the defense and aerospace industry 纳米技术涂层在国防和航空航天工业中的应用
Next Nanotechnology Pub Date : 2025-01-01 DOI: 10.1016/j.nxnano.2025.100197
Victor U. Agbogo , Emmanuel R. Sadiku , Lucey Mavhungu , Williams K. Kupolati , Oryina M. Injor
{"title":"Nanotechnology coatings in the defense and aerospace industry","authors":"Victor U. Agbogo ,&nbsp;Emmanuel R. Sadiku ,&nbsp;Lucey Mavhungu ,&nbsp;Williams K. Kupolati ,&nbsp;Oryina M. Injor","doi":"10.1016/j.nxnano.2025.100197","DOIUrl":"10.1016/j.nxnano.2025.100197","url":null,"abstract":"<div><div>In the aerospace and defense industries, nanotechnology coatings have become essential facilitators for improving material performance. Usually less than 100 nm thick, these incredibly thin, multipurpose layers provide better defense against environmental stresses, corrosion, wear, and thermal deterioration than traditional coatings. Special physicochemical characteristics of materials at the nanoscale allow for revolutionary features like thermal insulation, radar stealth, self-healing, and smart sensing. To improve substrate longevity and operating efficiency, this review methodically looks at several important classes of nano-coatings, such as smart nanocontainers, carbon nanotube-reinforced systems, polymer-based nanoparticles, and barriers formed from graphene. Critical characterization techniques including SEM-EDS mapping, EBSD, and XRD for nanoscale structural evaluation are covered alongside advanced production techniques like atomic layer deposition, chemical vapor deposition, and sol-gel processing. Along with a candid evaluation of the present constraints about durability, scalability, and environmental safety, the strategic applications of nano-coatings across key aerospace and defense materials—aluminum alloys, titanium, stainless steels, and composites—are also highlighted. This article offers a thorough understanding of the revolutionary potential of nanotechnology coatings for next-generation aerospace and defense systems by placing both innovations and difficulties in context.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100197"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Feasibility of transition metal doped boron nitride fullerene as a nanocarrier of anticancer drugs: An insight from DFT 过渡金属掺杂氮化硼富勒烯作为抗癌药物纳米载体的可行性:来自DFT的见解
Next Nanotechnology Pub Date : 2025-01-01 DOI: 10.1016/j.nxnano.2025.100189
Mimi Saha Katha , Aoly Ur Rahman , Md. Ahsan Habib , Eshrat Ashraf Ema , Bonganur Khan , Mst. Tania Khatun , Md. Kabir Uddin Sikder
{"title":"Feasibility of transition metal doped boron nitride fullerene as a nanocarrier of anticancer drugs: An insight from DFT","authors":"Mimi Saha Katha ,&nbsp;Aoly Ur Rahman ,&nbsp;Md. Ahsan Habib ,&nbsp;Eshrat Ashraf Ema ,&nbsp;Bonganur Khan ,&nbsp;Mst. Tania Khatun ,&nbsp;Md. Kabir Uddin Sikder","doi":"10.1016/j.nxnano.2025.100189","DOIUrl":"10.1016/j.nxnano.2025.100189","url":null,"abstract":"<div><div>Globally, cancer is a severe health issue that leads to a substantial number of deaths and has a continuously increasing negative impact on society and the economy. However, conventional drug delivery systems exhibit limited efficacy in targeting specific tissues and pose adverse health hazards. So, it is necessary to develop targeted delivery to mitigate the current challenges. To achieve this, the work investigates the potentiality of transition metals (TMs) Pt and Au-doped B<sub>12</sub>N<sub>12</sub> nanocages as carriers for delivering two anticancer drugs, Floxuridine (C<sub>9</sub>H<sub>11</sub>FN<sub>2</sub>O<sub>5</sub>) and Carmustine (C<sub>5</sub>H<sub>9</sub>Cl<sub>2</sub>N<sub>3</sub>O<sub>2</sub>), using the DFT method in the Gaussian 09 program. The study reveals that due to the introduction of TMs, the adsorption energy enhances the adsorption of C<sub>9</sub>H<sub>11</sub>FN<sub>2</sub>O<sub>5</sub> (-3.72 ∼ −4.15 eV) and C<sub>5</sub>H<sub>9</sub>Cl<sub>2</sub>N<sub>3</sub>O<sub>2</sub> (-2.71 ∼ 3.58 eV) than the pristine structure (-3.58 eV and - 2.44 eV, respectively, for C<sub>9</sub>H<sub>11</sub>FN<sub>2</sub>O<sub>5</sub> and C<sub>5</sub>H<sub>9</sub>Cl<sub>2</sub>N<sub>3</sub>O<sub>2</sub>). The adsorbing distance favorably supports this initial investigation. The IR confirms that all complex structures form naturally in the most stable form, as no imaginary frequency is observed in IR spectroscopy. Moreover, suitable electric and thermodynamic properties confirm the feasibility of Pt and Au-doped B<sub>12</sub>N<sub>12</sub> fullerenes for developing nanocarriers for targeted delivery of C<sub>9</sub>H<sub>11</sub>FN<sub>2</sub>O<sub>5</sub> and C<sub>5</sub>H<sub>9</sub>Cl<sub>2</sub>N<sub>3</sub>O<sub>2</sub>. Finally, considering all combinations of studied structures, B<sub>12</sub>N<sub>11</sub>-Au could be the right selection to develop a nanocarrier for the targeted delivery of C<sub>9</sub>H<sub>11</sub>FN<sub>2</sub>O<sub>5</sub> and C<sub>5</sub>H<sub>9</sub>Cl<sub>2</sub>N<sub>3</sub>O<sub>2</sub> anticancer drugs.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100189"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Translational potential of nanoemulsion in wound healing – From discovery to product commercialization 纳米乳在伤口愈合中的转化潜力——从发现到产品商业化
Next Nanotechnology Pub Date : 2025-01-01 DOI: 10.1016/j.nxnano.2025.100187
Geethika Manohar, Priyanka Srivastava
{"title":"Translational potential of nanoemulsion in wound healing – From discovery to product commercialization","authors":"Geethika Manohar,&nbsp;Priyanka Srivastava","doi":"10.1016/j.nxnano.2025.100187","DOIUrl":"10.1016/j.nxnano.2025.100187","url":null,"abstract":"<div><div>Acute and chronic wound healing has been a subject of continuous intensive investigation among all health problems. Significant advances have been made to develop effective nanoenabled drug delivery systems for wound healing. Compared to conventional and nanoparticulate wound healing therapies, nanoemulsions have been generally considered a superior choice due to higher drug loading capacity, bioavailability, sustained drug release, and better penetration. They are colloidal isotropic systems that are thermodynamically stabilized by emulsifying agents. These nanoscale formulations are considered an effective method for delivering drugs to the target site in an efficient manner. The translational journey of nanoemulsions from laboratory to clinical side involves multiple stages, including preclinical efficacy studies, formulation optimization, regulatory approval, and large-scale manufacturing. Therefore, despite several advantages, challenges emerge from the practical limitations and regulatory gaps. This review highlights the latest developments in nanoemulsion-based wound healing, integration of nanoemulsions with advanced wound care technologies, barriers to clinical translation, and strategies to address the lacuna between research and commercial product development.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100187"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of eco-friendly rGO/ZrP nanocomposite as novel adsorbents for enhanced non-enzymatic salicylic acid delivery 新型非酶促水杨酸吸附剂rGO/ZrP的合成
Next Nanotechnology Pub Date : 2025-01-01 DOI: 10.1016/j.nxnano.2025.100142
Kalyani Adhikary, Pallabi Goswami
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