Next Nanotechnology最新文献

{"title":"Performance study of UV micro-LEDs with AlGaN quantum dots and transparent tunnel junction","authors":"Yun-Cheng Hsu ,&nbsp;Ching-Ho Tien ,&nbsp;Yun-Han Chang ,&nbsp;Sunanda Mitra ,&nbsp;Sankesh Shetty ,&nbsp;Sébastien Chenot ,&nbsp;Mohamed Al Khalfioui ,&nbsp;Hao-Chung Kuo ,&nbsp;Chi-Wai Chow ,&nbsp;Chia-Yen Huang ,&nbsp;Julien Brault ,&nbsp;Ray-Hua Horng","doi":"10.1016/j.nxnano.2025.100179","DOIUrl":"10.1016/j.nxnano.2025.100179","url":null,"abstract":"<div><div>It is well known that the size of deep ultraviolet (DUV) micro LED (μLEDs) decreases, although bandwidth improves, the optical power drops sharply, severely limiting the application of DUV μLEDs in optical communication. This study focused on the fabrication of DUV μLED with 10 μm × 10 μm dimenstion, utilizing molecular beam epitaxy (MBE) technology to grow AlGaN quantum dots (QD) and improve the stress in the quantum dot structure through stress engineering, thereby enhancing the light emission efficiency. To improve the ohmic contact in the p-type region, a tunneling structure is designed and incorporated, which helps increase carrier injection efficiency and further optimize the electrical performance of device. Additionally, by combining neutral particle beam etching (NBE) technology, the μLED is precisely processed, suppressing the processing damage that typically reduces light emission efficiency in conventional dry etching methods. Test results demonstrate that the integration of these technologies significantly improves the optoelectronic properties of the DUV μLED with 10 μm × 10 μm dimenstion, providing a reliable technical solution for DUV communication applications.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100179"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic profiling of Saraca indica bark oil silver nanoparticles: Bioactivity and cytocompatibility in human keratinocyte (HaCaT) cells","authors":"K Preetha,&nbsp;Asha Anand","doi":"10.1016/j.nxnano.2025.100269","DOIUrl":"10.1016/j.nxnano.2025.100269","url":null,"abstract":"<div><div>This study explores the potential of silver nanoparticles synthesized from Ashoka (<em>Saraca indica</em>) bark oil, which has properties as a natural therapeutic agent. The silver nanoparticles (Ag-NPs) were produced using a green synthesis method from the <em>Saraca indica</em> bark oil and characterized through UV-Vis spectrophotometry, FTIR, and SEM techniques. Fungal infections are mainly caused by <em>Candida spp</em>., especially <em>Candida albicans</em>, which significantly contributes to diseases like candidiasis. The antifungal and antibacterial activities were tested against <em>Candida albicans</em> and <em>Bacillus subtilis</em>. Using the disk-diffusion method, different concentrations of Ag-NPs were evaluated and compared with fluconazole and streptomycin. Results showed that the inhibition zones were concentration-dependent, with a maximum inhibition zone of 21.75<span><math><mo>±</mo></math></span>1.768 mm, 21.75<span><math><mo>±</mo></math></span>1.06 mm at 100 µg/mL against <em>C. albicans</em> and <em>B. subtilis</em>. The DPPH assay showed 62.17 % antioxidant activity at 80 µg/mL, and IC₅₀ values were 36.43 µg/mL for AO-Ag NPs compared to 26.88 µg/mL for crude oil. The increasing resistance to antifungal drugs and limited effective treatments highlight the need for alternatives. The DPPH antioxidant assay confirmed the nanoparticles free radical scavenging ability, indicating antioxidant potential. An albumin denaturation anti-inflammatory assay revealed notable inhibition by the nanoparticles compared to Ascorbic acid. Cytotoxicity was assessed on human keratinocyte (HaCaT) cells, showing dose-dependent cytocompatibility, with &gt; 90 % viability at lower concentrations and 12.31<span><math><mo>±</mo></math></span> 1<strong>.</strong>62 % viability at 100 µg/mL. Compared to crude bark oil and positive controls, the nanoparticles exhibited enhanced bioactivity with reduced cytotoxicity to normal skin cells. Morphological observations also suggested apoptosis, possibly linked to ROS-mediated oxidative stress pathways. Overall, this research indicates that <em>Saraca indica</em>-silver nanoparticles are cost-effective, eco-friendly, and biocompatible, with antimicrobial, antioxidant, anti-inflammatory, and low cytotoxic properties. These properties support their potential use in developing nanomedicine treatments for infections and inflammation.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"8 ","pages":"Article 100269"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145157210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WO₃ nanoparticles: Synthesis and recent advances in their applications for radiotherapy and radioprotection","authors":"Carlos N. Kabengele ,&nbsp;Giresse N. Kasiama ,&nbsp;Clement L. Inkoto ,&nbsp;Pius T. Mpiana ,&nbsp;JP Ngbolua ,&nbsp;Damien S.T. Tshibangu ,&nbsp;Dorothée D. Tshilanda","doi":"10.1016/j.nxnano.2025.100262","DOIUrl":"10.1016/j.nxnano.2025.100262","url":null,"abstract":"<div><div>Tungsten oxide (WO₃) nanoparticles have attracted significant interest in radiotherapy and radioprotection due to their remarkable physicochemical properties, including high density, strong photon absorption, and easily functionalizable surfaces. This review provides an updated overview of WO₃ nanoparticle synthesis methods and recent advances in their biomedical applications. In oncology, WO₃ nanoparticles act as radiosensitizers by locally enhancing the effects of ionizing radiation within tumors, promoting the generation of reactive oxygen species (ROS) and disrupting DNA repair mechanisms, thereby increasing cytotoxicity towards cancer cells while sparing healthy tissues. In radioprotection, WO₃ nanoparticles embedded in polymer matrices offer a promising alternative to traditional shielding materials such as lead, enabling the development of lighter, less toxic composites with high X-ray and gamma-ray attenuation. This review discusses the principal synthetic approaches for WO₃ nanoparticle fabrication, emphasizing reaction mechanisms, advantages, limitations, and critical parameters affecting nanoparticle size, morphology, and purity. Overall, this study highlights the potential of WO₃ nanoparticles to drive future innovations at the intersection of nanotechnology and biomedicine, combining technological performance with enhanced safety profiles.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"8 ","pages":"Article 100262"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145157206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of Ag@AuNPs embedded h-BN Langmuir-Blodgett film as SERS active platform for trace detection of fungicide in solution and in grape skin","authors":"Chayan Kumar Mitra,&nbsp;Joydeep Chowdhury","doi":"10.1016/j.nxnano.2025.100153","DOIUrl":"10.1016/j.nxnano.2025.100153","url":null,"abstract":"<div><div>The work explicitly focuses on fabrication of Langmuir-Blodgett (LB) films of hexagonal Boron Nitride (h-BN) with infused gold-core silver-shell nano particles (Ag@Au nano particles) as an efficient noble Surface enhanced Raman Scattering (SERS) active hetero-architecture. The “hot spots” generated over the h-BN network work as an effective contributor for localization of electromagnetic field shows high enhancement in Raman Signals. The LB film and the as prepared substrate were meticulously characterized in this current work. The efficacy and reproducibility of Ag@Au-hBN nano-plate substrate as a SERS detection sensor was investigated up to ultrasensitive concentrations using Raman probe molecules. The as prepared SERS substrate was also engaged for detection of fungicide Thiabendazole at trace concentrations. The tests to check on shelf life was also performed. In the contemporary study the as fabricated SERS sensing platform elicits its precision and effectiveness as a potent next generation one-click SERS sensing chip in detecting fungicide. Thus, in future this substrate can be a novel SERS scaffold for ultrasensitive detections of chemical and bio-chemical composites.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"8 ","pages":"Article 100153"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green functionalization of silver nanoparticles using leaf extract of Cymbopogon citratus and assessment of their biological activities","authors":"Tijo Cherian ,&nbsp;Khursheed Ali ,&nbsp;Javed Musarrat","doi":"10.1016/j.nxnano.2025.100216","DOIUrl":"10.1016/j.nxnano.2025.100216","url":null,"abstract":"<div><div>In present study, silver nanoparticles (AgNPs) were produced by employing a “green” biosynthetic method using leaf extract of <em>Cymbopogon citratus</em> (CCLE). The reaction between CCLE and silver nitrate produced black coloured solution inferred as the visual confirmation of nanoparticle synthesis. The UV–visible spectrum of spherical oval shaped CCLE-AgNPs reported absorbance at 420 nm with FCC crystalline lattice confirmed by XRD. The average size of CCLE-AgNPs was reported as 30.6 nm (XRD) and 13.1–30.9 nm (TEM) along with the elemental composition by EDX evaluated to be 10.79 %. The presence of numerous organic metabolites was confirmed by FTIR and validated by GC-MS inferring diverse types of organic metabolites as capping and reducing mediators. The bioactivities reported were: antibacterial (MIC and MBC ranged from 15 to 35 µg/ml against both Gram + and - cells); anti-biofilm (70–82 %); antidiabetic (76–83 %); and anti-inflammation (60–65 %). The dye degradative kinetics of CCLE-AgNPs against dyes Rhodamine B and Methyl orange followed pseudo-first order reaction rate with % efficiency of 93 % and 95 %, respectively. Thus, our results explicated a quick, environmentally inert, economical method for CCLE-AgNPs amalgamation for viable applications as prospective nanomedicines and nanocatalysts.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"8 ","pages":"Article 100216"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144605736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing the potential of iron oxide nanoparticles: A comprehensive review on their synthesis, functionalization and pharmaceutical innovations","authors":"Hemanth Jijo ,&nbsp;Shamlath A ,&nbsp;Aji Abraham ,&nbsp;Francis Xavier P A ,&nbsp;Surjeet Chahal ,&nbsp;Arshid Numan ,&nbsp;Sanu Mathew Simon","doi":"10.1016/j.nxnano.2025.100270","DOIUrl":"10.1016/j.nxnano.2025.100270","url":null,"abstract":"<div><div>Iron oxide nanoparticles (IONPs), on account of their low cost, biocompatibility, and distinctive features, are often researched for pharmaceutical applications like cancer treatment and targeted drug delivery. This review offers a comparative analysis of physical, chemical, and biological methods employed for the synthesis of IONPs, emphasising their advantages and disadvantages. Several approaches for nanoparticle functionalization to enhance their properties and broaden their applications are also discussed. Special focus has also been given to the multifaceted applications of IONPs, like antiviral, antimicrobial, and tissue engineering applications, as well as their roles in medical imaging and cancer treatment, with special emphasis on targeted drug delivery. An attempt has also been made to assess the toxicity of nanoparticles and their interaction with biological systems, ensuring the safety of usage. This article provides a concise overview of the current research trends in IONPs, emphasising their role in enhancing therapeutic outcomes across diverse medical applications.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"8 ","pages":"Article 100270"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental investigation on plant extract-induced biosynthesis of Nickel nanoparticles","authors":"Nimish Kumar ,&nbsp;Anjali Singh ,&nbsp;Vijay Devra","doi":"10.1016/j.nxnano.2024.100104","DOIUrl":"10.1016/j.nxnano.2024.100104","url":null,"abstract":"<div><p>Here, we describe the phytosynthesis of nickel nanoparticles (NiNPs) utilizing an extract from the leaves of Azadirachta indica as a reducing and capping agent. The optimal conditions for synthesizing stable NiNPs were pH 6.8, temperature 70°C, and 5 % leaf extract and [NiNO₃.6H₂O] = 1.0×10⁻³ mol dm⁻³. The X-ray diffraction (XRD) analysis revealed a face-centered cubic crystalline structure, and the Transmission Electron Microscope (TEM) and Scanning Electron Microscope (SEM) analyses verified a triangular form with particles ranging in size from 7 to 18 nm. The study examined the impact of reactant concentrations, reaction temperature, and solution pH on the nickel nanoparticle fabrication method. The following are the ideal parameters for synthesis: 5 % leaf extract, pH = 6.8, temperature = 70 °C, and [NiNO₃.6H₂O] = 1.0×10⁻³ mol dm⁻³. Plant biomolecules induce the reduction of nickel ions to NiNPs and function as a capping and stabilizing agent, as confirmed by the FTIR technique. The findings indicated that the synthesis of NiNPs from A. indica leaf extracts are safe technology and may have significant impacts on the industrial synthesis of metallic nanoparticles.</p></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100104"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949829524000652/pdfft?md5=db91375cf9c2572af8cb7de515711868&pid=1-s2.0-S2949829524000652-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142168535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ingestible devices for oral delivery of biotherapeutics: A Mini Review","authors":"Akshay Khandke ,&nbsp;Sanika Dhaybar ,&nbsp;Avani Mandke ,&nbsp;Ananya Joshi ,&nbsp;Amol D. Gholap ,&nbsp;Amarjitsing Rajput","doi":"10.1016/j.nxnano.2025.100195","DOIUrl":"10.1016/j.nxnano.2025.100195","url":null,"abstract":"<div><div>Bioactive macromolecules (like antibodies and peptides) are promising therapeutic agents for treating several diseases. However, oral administration of these macromolecules is challenging due to gastrointestinal (GI) tract degradation due to the harsh pH conditions, digestive enzymes, mucus layers and gastric acid. These barriers cause degradation affect the absorption and reduce the bioavailability of drugs. Thus, the bioavailability achieved by oral administration is less compared to parenteral administration. But parenteral administration of drugs causes reduced patient compliance, invasive and most painful. On the other hand, oral administration is non-invasive painless, but also results in higher patient compliance. Smart ingestible devices like microneedle devices, microrobots, magnetically triggered capsules, self-unfolding foils, smart pills, SOMA, LUMI, nano-straws and gastric auto-injectors can help resolve the issues related to oral delivery of bioactive agents and therapeutics. These devices overcome the GI tract barriers and successfully carry out the oral delivery of these drugs in the GI tract. This review explores how these smart ingestible devices can be an innovative alternative to the parenteral administration of bioactive macromolecules and biotherapeutics. It also covers the devices' functioning, mechanism, clinical stages and challenges in clinical transition. Our review article stands out in the current body of literature by comprehensively compiling all categories of ingestible devices for oral delivery, including the mechanism of drug release, monitoring, therapeutic systems and applications. This integrative approach is notably absent in previous review articles, which tend to focus on isolated aspects or specific types of devices. Furthermore, our article incorporates and analyzes the most recent advancements, offering a current, relevant, and more comprehensive overview than existing review articles by covering the latest literature.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100195"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomedicine breakthroughs in cancer and neurodegenerative disease therapy","authors":"Abdul Haque ,&nbsp;Tariq Khan ,&nbsp;Rayees Ul Islam ,&nbsp;Swaleha Naseem","doi":"10.1016/j.nxnano.2025.100233","DOIUrl":"10.1016/j.nxnano.2025.100233","url":null,"abstract":"<div><div>Cancer is a significant medical concern that presents a substantial risk to the holistic health of persons. Moreover, afflictions affecting the central nervous system, including neurodegenerative disorders, offer a significant peril to the well-being of the general population and necessitate immediate scholarly focus. Brain cancer and Alzheimer's disease pose substantial treatment challenges due to the formidable task of effectively delivering medication over the protective fluid barrier of the brain. Compared to conventional medicine, nanotechnology-based treatments are more secure, effective, and selective in targeting molecular and cellular processes. The optimization of cancer treatment is an ongoing process driven by advancements in established treatment procedures and the emergence of novel therapeutic modalities. Nanomedicine plays a significant part in the progress of tumor therapy techniques. This article presents an in-depth review of the various applications of nanomedicine in the realms of chemotherapy, gene therapy, and immunotherapy. In light of prevailing challenges, including sub-optimal specificity of first-line chemotherapy agents, susceptibility of nucleic acid drugs to degradation, and frequent occurrence of negative symptoms associated with the immune system in immunotherapy, this discourse explores the potential integration of nanomedicine with these therapeutic approaches. The discussion encompasses illustrative instances and highlights the benefits associated with using nanomedicine.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"8 ","pages":"Article 100233"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144757142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and characterization of hydroxyapatite biocomposite using Syzygium aromaticum for biomedical application","authors":"Kavya Menon ,&nbsp;Anusuya Nagaraj ,&nbsp;Anjali Sudha ,&nbsp;Neveen Kumar Kalagatur ,&nbsp;Seethalakshmi Subramaniam ,&nbsp;Suja Samiappan","doi":"10.1016/j.nxnano.2025.100202","DOIUrl":"10.1016/j.nxnano.2025.100202","url":null,"abstract":"<div><div>The study aimed to prepare a hydroxyapatite biocomposite with clove (<em>Syzygium aromaticum</em>) bud ethanol extract and demonstrate antibacterial and antioxidant functions. The phytochemical profile of clove bud ethanol extract showed prominent presence of eugenol and gallocatechin by LC-MS/MS analysis. Hydroxyapatite and a biocomposite of hydroxyapatite with clove bud ethanolic extract were prepared using sol-gel and precipitation methods, respectively. Fourier Transform Infrared analysis showed that clove bud ethanolic extract biomolecules were successfully imparted onto the hydroxyapatite surface. The X-ray diffraction study revealed that as-synthesized hydroxyapatite and biocomposite of hydroxyapatite with clove bud ethanolic extract were crystalline and had crystal sizes of 42 nm and 126 nm, respectively. The field emission scanning electron microscopy showed that hydroxyapatite and the biocomposite of hydroxyapatite with clove bud ethanolic extract were spherical in shape and agglomerated. The average particle size distribution of hydroxyapatite and biocomposite of hydroxyapatite with clove bud ethanolic extract was 298.39 and 478.48 nm, respectively. Energy-dispersive X-ray analysis revealed that hydroxyapatite consists of calcium, phosphorus, and oxygen. In contrast, the biocomposite of hydroxyapatite with clove bud ethanolic extract contain carbon in addition to calcium, phosphorus, and oxygen. Thermogravimetric analysis revealed that hydroxyapatite and biocomposite of hydroxyapatite with clove bud ethanolic extract were thermostable. The biocomposite of hydroxyapatite with clove bud ethanolic extract exhibited potential antibacterial action, and the zone of inhibition against <em>S. aureus</em>, <em>E. faecalis</em>, <em>S. enterica</em>, and <em>E. coli</em> was determined as 20.10 ± 0.08, 25.08 ± 0.07, 14.20 ± 0.04, and 24.08 ± 0.08 mm, respectively. Biocomposite of hydroxyapatite with clove bud ethanolic extract exhibited potential antioxidant activity. Hydroxyapatite and biocomposite of hydroxyapatite with clove bud ethanolic extract showed hemolysis &lt; 2 % and were found hemocompatible and safe. Thus, the as-synthesized biocomposite of hydroxyapatite with clove bud ethanolic extract could help overcome oxidative stress-mediated complications and microbial infections in orthopaedics.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"8 ","pages":"Article 100202"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144490592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}