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Gabapentin loaded nano-emulsion for the effective treatment of peripheral neurological pain: Formulation, characterization, and ex vivo studies 加巴喷丁纳米乳剂对周围神经疼痛的有效治疗:配方、表征和离体研究
Next Nanotechnology Pub Date : 2026-06-01 Epub Date: 2025-12-16 DOI: 10.1016/j.nxnano.2025.100354
Bhavna , Mohit Kumar , Ayesha Siddiqui , Syed Mahmood , Pooja Jain , M. Aamir Mirza , Zeenat Iqbal
{"title":"Gabapentin loaded nano-emulsion for the effective treatment of peripheral neurological pain: Formulation, characterization, and ex vivo studies","authors":"Bhavna ,&nbsp;Mohit Kumar ,&nbsp;Ayesha Siddiqui ,&nbsp;Syed Mahmood ,&nbsp;Pooja Jain ,&nbsp;M. Aamir Mirza ,&nbsp;Zeenat Iqbal","doi":"10.1016/j.nxnano.2025.100354","DOIUrl":"10.1016/j.nxnano.2025.100354","url":null,"abstract":"<div><div>Peripheral neuropathic pain remains a major clinical challenge due to its multifactorial pathophysiology and the limited efficacy of available therapies. Gabapentin, an anticonvulsant agent, has shown potential in alleviating neuropathic pain symptoms; however, its therapeutic performance is restricted by poor aqueous solubility and dose-dependent adverse effects. Nano emulsion-based delivery systems offer a promising strategy to overcome these limitations by enhancing solubility, stability, and targeted delivery to peripheral nerves. In the present study, the authors developed a gabapentin-loaded nanoemulsion. The developed nanoemulsion was optimized through systematic excipient screening, construction of pseudo-ternary phase diagrams, and comprehensive evaluation of physicochemical and performance parameters. The optimized formulation demonstrated a cumulative drug release with 97.42 ± 1.23 % (n = 3) within 2 h, indicating rapid and efficient drug release kinetics. Transmission electron microscopy confirmed the uniform nanoscale droplet morphology, while rheological analysis revealed favorable viscosity and spreadability characteristics. The <em>ex vivo</em> skin permeation study revealed a marked improvement in transdermal delivery of gabapentin, which was further supported by FT-IR and DSC results showing disruption of the skin’s lipid bilayer after treatment. The observations from confocal laser scanning microscopy confirmed that the formulation enabled deeper penetration of the drug into the skin layers. These results indicate that the optimized gabapentin nanoemulsion could enhance bioavailability and enable targeted delivery, offering promise for the management of peripheral neuropathic pain. However, the authors also highlight that <em>in vivo</em> efficacy studies will be essential to validate these findings and fully establish the therapeutic potential of the microemulsion.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100354"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Light attenuation and optical absorption characteristics of graphene-chitosan nanomaterials-based quandary nanocomposites 石墨烯-壳聚糖纳米复合材料的光衰减和光吸收特性
Next Nanotechnology Pub Date : 2026-06-01 Epub Date: 2025-12-30 DOI: 10.1016/j.nxnano.2025.100358
Sarah Aljelawy , Ehssan Al-Bermany , Ali Razzaq Abdulridha
{"title":"Light attenuation and optical absorption characteristics of graphene-chitosan nanomaterials-based quandary nanocomposites","authors":"Sarah Aljelawy ,&nbsp;Ehssan Al-Bermany ,&nbsp;Ali Razzaq Abdulridha","doi":"10.1016/j.nxnano.2025.100358","DOIUrl":"10.1016/j.nxnano.2025.100358","url":null,"abstract":"<div><div>Polymer-based graphene oxide nanocomposites represent an attractive class of materials due to their functional groups and wide range of applications in engineering and medicine. In this study, the interaction between nano-chitosan (CS) and graphene oxide (GO) nanosheets within polyvinylpyrrolidone (PVP) blended with polyacrylic acid (PAA) was investigated to fabricate two novel PVP–PAA–CS/GO nanocomposites. Fourier-transform infrared (FTIR) spectroscopy confirmed the presence of strong interfacial interactions and distinct functional groups. At the same time, X-ray diffraction (XRD) revealed a transition from amorphous to semicrystalline behavior after the incorporation of nanomaterials. Optical microscopy revealed the fracture surface characteristics and the fine dispersion of the components. UV–Vis spectroscopy demonstrated improved optical properties. Furthermore, the optical absorbance at 340 nm increased from 0.65 in PVP–PAA to 1.09 in PVP–PAA–CS/GO, indicating that ternary mix polymers and GO nanoparticles have formed a complex at around 300 nm, with a reduction of the optical band gap from 3.7 to 3.4 eV. The addition of nanomaterials enhanced the absorption behavior, dielectric constants (real and imaginary), and optical conductivity. Furthermore, the radiation attenuation of the composites improved significantly, with the half-value layer (HVL) increasing from 2.41 to 4.13 cm. These results highlight the potential of the prepared nanocomposites for diverse optoelectronic and light-shielding applications.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100358"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145884595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advanced perspectives on nanoparticle engineering: Green innovations, and characterization techniques 纳米粒子工程的先进观点:绿色创新和表征技术
IF 3.7
Next Nanotechnology Pub Date : 2026-06-01 Epub Date: 2026-05-15 DOI: 10.1016/j.nxnano.2026.100499
Isaac Alhamdu Baba, Saheed Mustapha, Oluwatobi Victoria Obayomi, Omoniyi Babajide Awe, Lukman Shehu Mustapha, Kehinde Shola Obayomi
{"title":"Advanced perspectives on nanoparticle engineering: Green innovations, and characterization techniques","authors":"Isaac Alhamdu Baba,&nbsp;Saheed Mustapha,&nbsp;Oluwatobi Victoria Obayomi,&nbsp;Omoniyi Babajide Awe,&nbsp;Lukman Shehu Mustapha,&nbsp;Kehinde Shola Obayomi","doi":"10.1016/j.nxnano.2026.100499","DOIUrl":"10.1016/j.nxnano.2026.100499","url":null,"abstract":"<div><div>The physicochemical and functional characteristics of nanoparticles have size-dependent variations that can neither be attained nor demonstrated in bulk systems. Though there have been many reviews that reported independently on progress made either on synthesis or characterization of nanoparticles during the past few years, there is still room for development when synthesis routes are correlated systematically with identifiable physicochemical properties and functional characteristics. In this review, we offer an integrated review on the synthesis and characterization of nanoparticles with well-clarified synthesis routes correlated with structural and practical properties. The conventional synthesis routes, such as mechanical milling, lithography, laser ablation, and arc discharge processes, are dealt with from the point of size, morphological changes, crystallographic development, surface modifications, and porosity. The bottom-up synthesis routes include sol–gel processing, chemical vapor deposition, and hydro- and solvothermal synthesis. The comparison of conventional synthesis routes with green synthesis is further given. The complementary characterization for established synthesis traits includes many advanced characterization tools such as X-ray diffraction studies, scanning and transmission electron microscopy (SEM and TEM), high-resolution transmission electron microscopy (HRTEM), Fourier transform infrared (FT-IR) spectroscopy, UV-Vis spectroscopy studies, Brunauer-Emmett-Teller (BET) surface area measurement technique, and energy dispersive spectroscopy. The comparison between conventional synthesis routes and green synthesis routes is further employed.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100499"},"PeriodicalIF":3.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148523562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deadly cures: Unlocking anticancer potential of reptile, amphibian, and arthropod venoms through molecular innovation and nanotechnology 致命治疗:通过分子创新和纳米技术释放爬行动物、两栖动物和节肢动物毒液的抗癌潜力
Next Nanotechnology Pub Date : 2026-06-01 Epub Date: 2026-01-29 DOI: 10.1016/j.nxnano.2026.100378
Pranav Ragavendra Shankar , Apsara Unni
{"title":"Deadly cures: Unlocking anticancer potential of reptile, amphibian, and arthropod venoms through molecular innovation and nanotechnology","authors":"Pranav Ragavendra Shankar ,&nbsp;Apsara Unni","doi":"10.1016/j.nxnano.2026.100378","DOIUrl":"10.1016/j.nxnano.2026.100378","url":null,"abstract":"<div><div>Venoms from reptiles, amphibians, and arthropods represent a rich source of bioactive molecules with promising anticancer potential. Recent studies have highlighted the selective cytotoxicity of venom components including snake phospholipase A2 enzymes, scorpion peptides (chlorotoxin), and frog derived antimicrobial peptides against cancer cells. These molecules exert multifaceted effects, such as inducing apoptosis, inhibiting metastasis, and modulating the tumor microenvironment, thereby impairing tumor growth and progression. Advances in nanotechnology based delivery systems and peptide engineering have significantly improved the stability, bioavailability, and specificity of venom derived agents, enhancing their safety and therapeutic efficacy. Preclinical investigations demonstrate potent anticancer activity across multiple tumor models, and early clinical studies suggest translational potential. Current research continues to explore the molecular mechanisms underlying venom-mediated cytotoxicity, while formulation strategies and regulatory considerations are being optimized to facilitate clinical development. Future directions include the design of synthetic venom analogs, AI assisted drug discovery, and personalized medicine approaches, which collectively aim to harness the full therapeutic potential of venom peptides. By integrating natural bioactivity with modern biomedical technologies, venom derived compounds are emerging as a novel and promising avenue in the development of next-generation oncological therapeutics. This review provides a comprehensive overview of venom diversity, anticancer mechanisms, recent advances in formulation and delivery, and the challenges and opportunities for translating venom-based agents into clinical practice.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100378"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sennoside-functionalized ZrO₂ nanoparticles via Cassia angustifolia: Gram-selective antibacterial and anticancer nanoplatform with green synthesis 以决明子为原料的senno苷功能化的ZrO 2纳米粒子:绿色合成的革兰氏选择性抗菌抗癌纳米平台
Next Nanotechnology Pub Date : 2026-06-01 Epub Date: 2025-12-06 DOI: 10.1016/j.nxnano.2025.100330
Aarti Jathar , Samreen Fatema , Mazahar Farooqui , Abhay Dashrath , Dattatraya Jirekar , Pramila Ghumare
{"title":"Sennoside-functionalized ZrO₂ nanoparticles via Cassia angustifolia: Gram-selective antibacterial and anticancer nanoplatform with green synthesis","authors":"Aarti Jathar ,&nbsp;Samreen Fatema ,&nbsp;Mazahar Farooqui ,&nbsp;Abhay Dashrath ,&nbsp;Dattatraya Jirekar ,&nbsp;Pramila Ghumare","doi":"10.1016/j.nxnano.2025.100330","DOIUrl":"10.1016/j.nxnano.2025.100330","url":null,"abstract":"<div><div>Sennoside-functionalized zirconium dioxide nanoparticles (Sen–ZrO₂ NPs) were engineered via a single-step green synthesis route using <em>Cassia angustifolia</em> leaf extract as both a bio reductant and stabilizer. Structural characterization confirmed phase-pure tetragonal ZrO₂ formation through X-ray diffraction (XRD), while Fourier-transform infrared spectroscopy (FTIR) verified sennoside anchoring via characteristic C<img>O and O–H vibrations at 1680 cm⁻¹ and 3605 cm⁻¹. Scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM/EDS) revealed spherical morphologies with uniform elemental distribution. The Sen–ZrO₂ NPs exhibited pronounced Gram-selective antibacterial activity, demonstrating a fourfold potency enhancement against <em>Staphylococcus aureus</em> (MIC = 64 µg mL⁻¹) compared to unmodified ZrO₂. Time-kill assays further demonstrated a rapid 4-log reduction in bacterial viability within 6 h. Against MCF-7 breast cancer cells, the nanoparticles displayed dose-dependent cytotoxicity (IC₅₀ = 61.44 µg mL⁻¹), representing a 2.3-fold improvement over bare ZrO₂. This dual bioactivity is attributed to sennoside-mediated redox modulation and surface functionalization, which act synergistically to enhance membrane disruption and reactive oxygen species (ROS) generation. This work establishes a sustainable plant-engineered ZrO₂ nanoplatform with integrated antibacterial–anticancer functionality, presenting a viable green approach to advanced nanotherapeutics for combating antimicrobial resistance and cancer.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100330"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145694949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From pollution to solution: Optimized UiO-66 based metal-organic framework for environmental cleanup 从污染到解决:优化的UiO-66基金属有机框架,用于环境净化
Next Nanotechnology Pub Date : 2026-06-01 Epub Date: 2025-12-10 DOI: 10.1016/j.nxnano.2025.100333
Azieyanti Nurain Azmin , Pua Fei Ling , Halina Misran
{"title":"From pollution to solution: Optimized UiO-66 based metal-organic framework for environmental cleanup","authors":"Azieyanti Nurain Azmin ,&nbsp;Pua Fei Ling ,&nbsp;Halina Misran","doi":"10.1016/j.nxnano.2025.100333","DOIUrl":"10.1016/j.nxnano.2025.100333","url":null,"abstract":"<div><div>Metal-organic framework (MOF) is known as an advanced material with high surface area and porosity and emerging for environmental remediation. In this study, a sustainable zirconium-based MOF, known as UiO-66 was synthesized using zirconium oxynitrate as a chloride-less metal precursor and organic linker from recycled polyethylene terephthalate (rPET). Synthesis parameters were optimized via Response Surface Methodology (RSM), and achieved the maximum BET surface area of 755 m<sup>2</sup>/g. To evaluate for microplastic removal, the UiO-66 were incorporated into polyvinylidene fluoride (PVDF)-based mixed-matrix membranes (MMM). The properties and characterizations including X-Ray Diffraction (XRD), Field Emission Scanning Electron Microscopy (FESEM), X-Ray Photoelectron Spectroscopy (XPS), Raman Spectroscopy, and Brunauer-Emmett-Teller (BET) surface analysis, confirmed the structure and composition of the materials. Filtration test demonstrated up to 105 ± 0.57 % removal efficiency against polymethylmethacrylate (PMMA), act as microplastic suspension. This work presents a sustainable approach to convert plastic waste into functional MOF and offer a green and effective strategy for environmental cleanup applications.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100333"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioinformatics models in drug delivery: Predicting biomaterial-biological interactions for targeted therapies 药物传递中的生物信息学模型:预测靶向治疗的生物材料-生物相互作用
Next Nanotechnology Pub Date : 2026-06-01 Epub Date: 2025-12-11 DOI: 10.1016/j.nxnano.2025.100335
Varshika Singh , Sukrat Sinha , Jaya Verma
{"title":"Bioinformatics models in drug delivery: Predicting biomaterial-biological interactions for targeted therapies","authors":"Varshika Singh ,&nbsp;Sukrat Sinha ,&nbsp;Jaya Verma","doi":"10.1016/j.nxnano.2025.100335","DOIUrl":"10.1016/j.nxnano.2025.100335","url":null,"abstract":"<div><div>The incorporation of bioinformatics into drug delivery research is revolutionizing the creation, development, and refinement of biomaterials utilized in therapeutic settings. Biomaterials, including nanomaterials, liposomes, and hydrogels, are essential components of drug delivery systems (DDS), as they enable controlled release, target specific tissues, and improve bioavailability. Nonetheless, grasping the interactions between these materials and biological systems poses a significant challenge. Increasingly, bioinformatics techniques such as molecular dynamics simulations, machine learning models, and docking analyses are being employed to forecast and enhance these interactions. These computational methods are vital for expediting the advancement of more effective and personalized drug delivery systems. This paper highlights the significance of bioinformatics in elucidating and predicting the interactions between biomaterials and biological systems, providing valuable perspectives on the future of drug delivery design.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100335"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An overview of structural, optical, and magnetic properties of Mn-doped, Cu-doped, and (Mn, Cu)-codoped ZnS nanoparticles and its applications Mn掺杂、Cu掺杂和(Mn, Cu)共掺杂ZnS纳米粒子的结构、光学和磁性及其应用综述
Next Nanotechnology Pub Date : 2026-06-01 Epub Date: 2025-12-23 DOI: 10.1016/j.nxnano.2025.100359
Pujarani Parida, Virendra Kumar Verma
{"title":"An overview of structural, optical, and magnetic properties of Mn-doped, Cu-doped, and (Mn, Cu)-codoped ZnS nanoparticles and its applications","authors":"Pujarani Parida,&nbsp;Virendra Kumar Verma","doi":"10.1016/j.nxnano.2025.100359","DOIUrl":"10.1016/j.nxnano.2025.100359","url":null,"abstract":"<div><div>Zinc Sulphide (ZnS) nanoparticles (NPs) are highly valued for their exceptional optical and magnetic properties, making them critical for applications in sensors, spintronics, and optoelectronic devices. This study explores the effects of Mn, Cu, and (Mn, Cu)-codoping on ZnS NPs prepared through wet chemical synthesis. It examines the variation of dopant concentrations that influence key characteristics such as crystalline size, band gap, and magnetic properties. The results show that Mn-doping widens the band gap from 3.32 eV to 4.51 eV, while Cu-doping further increases it from 2.97 eV to 4.99 eV, attributed to quantum confinement and the Burstein-Moss effect. Magnetically, pure and Cu-doped ZnS display ferromagnetism, whereas (Mn, Cu)-codoping leads to diminished ferromagnetic behavior due to reduced d<sup>0</sup> magnetization. These improvements in band gap and magnetic properties highlight the potential of doped ZnS NPs for cutting-edge technological advancements.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100359"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145840924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DNA-functionalized superparamagnetic Fe₃O₄ nanoparticles: In Vitro antioxidant and anticancer assessment in MCF-7 cancer cells dna功能化超顺磁性Fe₃O₄纳米颗粒:MCF-7癌细胞的体外抗氧化和抗癌评价
Next Nanotechnology Pub Date : 2026-06-01 Epub Date: 2026-01-21 DOI: 10.1016/j.nxnano.2026.100370
Pratikeswar Panda, Rajaram Mohapatra
{"title":"DNA-functionalized superparamagnetic Fe₃O₄ nanoparticles: In Vitro antioxidant and anticancer assessment in MCF-7 cancer cells","authors":"Pratikeswar Panda,&nbsp;Rajaram Mohapatra","doi":"10.1016/j.nxnano.2026.100370","DOIUrl":"10.1016/j.nxnano.2026.100370","url":null,"abstract":"<div><div>Magnet-mediated gene therapy has emerged as a promising alternative to conventional viral-based genetic strategies, with superparamagnetic iron oxide nanoparticles (Fe₃O₄NPs) being widely explored as non-viral vectors. Despite their availability for certain transfection applications, their broader biomedical potential remains underutilized. Moreover, ethical concerns surrounding human DNA limit translational research, making fish DNA a viable substitute. This study aimed to synthesize DNA-coated Fe₃O₄ nanoparticles (DMn) and further develop a Metformin (MRN)-conjugating DNA–Fe₃O₄ nanoconjugate (MDMn), evaluating their structural features, antioxidant activity, and anticancer potential against MCF-7 breast cancer cells. The synthesized DMn exhibited quasi-spherical morphology (90.4 nm) with a Zeta-potential of –42.20 mV, ensuring colloidal stability. Superparamagnetism was confirmed by the absence of hysteresis. FTIR, FESEM, AFM, and XRD validated DNA coating and decreased crystallinity. Docking studies revealed strong binding between MRN and DNA-Fe₃O₄NPs. Drug release was accelerated from MDMn (109 ± 0.05 % in 8 h) compared to pure MRN (110 ± 0.47 % in 26 h). Biologically, MDMn exhibited notable antioxidant activity (32.41 ± 1.62 % DPPH scavenging) and pronounced, dose-dependent cytotoxicity against MCF-7 cells, achieving 85.47 ± 1.62 % inhibition at 24 h, with a calculated IC₅₀ value of 28.47 ± 1.59 μM. DNA-functionalized Fe₃O₄ nanoparticles, especially MRN-conjugate MDMn, represent a promising non-viral therapeutic platform with potential for targeted breast cancer treatment.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100370"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pigment mediated biosynthesis of crystalline silver nanostructures: Structural characterization and enhanced multifunctional bioactivity 色素介导的结晶银纳米结构的生物合成:结构表征和增强的多功能生物活性
Next Nanotechnology Pub Date : 2026-06-01 Epub Date: 2026-01-13 DOI: 10.1016/j.nxnano.2026.100364
Akshay Chavan , Guruprasad Mavlankar , Prajakta Baikar , Parvindar Sah , Neha Mourya , Pravin Tirmali , Umesh Kakde
{"title":"Pigment mediated biosynthesis of crystalline silver nanostructures: Structural characterization and enhanced multifunctional bioactivity","authors":"Akshay Chavan ,&nbsp;Guruprasad Mavlankar ,&nbsp;Prajakta Baikar ,&nbsp;Parvindar Sah ,&nbsp;Neha Mourya ,&nbsp;Pravin Tirmali ,&nbsp;Umesh Kakde","doi":"10.1016/j.nxnano.2026.100364","DOIUrl":"10.1016/j.nxnano.2026.100364","url":null,"abstract":"<div><div>Harnessing the innate biochemical intelligence of nature is redefining nanotechnology. The present study reports the use of a red pigment from <em>Talaromyces australis</em> for the synthesis of AgNPs using sunlight. Color changes confirmed the formation of AgNPs, which was evidenced by the observation of a SPR peak at ∼ 430 nm. TEM revealed spherical AgNPs with an average size of 16 ± 2 nm, whereas NTA showed a narrow size distribution and excellent colloidal stability. The FCC structure was confirmed using XRD, and FTIR confirmed the involvement of three functional groups (hydroxyl, carbonyl, and C–O) in the reduction and stabilization of AgNPs. Disc diffusion assays indicated that the pigment inhibited the growth of <em>Escherichia coli</em>, <em>Staphylococcus aureus</em>, <em>Salmonella typhi</em>, <em>Pseudomonas aeruginosa</em>, and <em>Bacillus subtilis</em>, and that the inhibition was concentration-dependent (zones: 9.33–15.66 mm). Antimicrobial activity was pronounced at a higher concentration of AgNPs (1 mg/mL), with zones of inhibition between 12.33–13.00 mm. MIC confirmed that antimicrobial activity was enhanced for the AgNPs (500 µg/mL for crude pigment and 62.5 µg/mL for AgNPs). Improvements were also observed in antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay (DPPH IC₅₀ &lt; 10 µg/mL) and 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid assay (ABTS IC₅₀ &lt; 10 µg/mL) and dose-dependent cytotoxicity (GI₅₀ = &lt; 10 µg/mL and TGI = 53.0 µg/mL). These findings imply that <em>Talaromyces australis</em> pigment is a highly efficient and sustainable bio-reductant for the rapid biosynthesis of multifunctional AgNPs with improved biomedical potential.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100364"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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