Next Nanotechnology最新文献

{"title":"Gabapentin loaded nano-emulsion for the effective treatment of peripheral neurological pain: Formulation, characterization, and ex vivo studies","authors":"Bhavna ,&nbsp;Mohit Kumar ,&nbsp;Ayesha Siddiqui ,&nbsp;Syed Mahmood ,&nbsp;Pooja Jain ,&nbsp;M. Aamir Mirza ,&nbsp;Zeenat Iqbal","doi":"10.1016/j.nxnano.2025.100354","DOIUrl":"10.1016/j.nxnano.2025.100354","url":null,"abstract":"<div><div>Peripheral neuropathic pain remains a major clinical challenge due to its multifactorial pathophysiology and the limited efficacy of available therapies. Gabapentin, an anticonvulsant agent, has shown potential in alleviating neuropathic pain symptoms; however, its therapeutic performance is restricted by poor aqueous solubility and dose-dependent adverse effects. Nano emulsion-based delivery systems offer a promising strategy to overcome these limitations by enhancing solubility, stability, and targeted delivery to peripheral nerves. In the present study, the authors developed a gabapentin-loaded nanoemulsion. The developed nanoemulsion was optimized through systematic excipient screening, construction of pseudo-ternary phase diagrams, and comprehensive evaluation of physicochemical and performance parameters. The optimized formulation demonstrated a cumulative drug release with 97.42 ± 1.23 % (n = 3) within 2 h, indicating rapid and efficient drug release kinetics. Transmission electron microscopy confirmed the uniform nanoscale droplet morphology, while rheological analysis revealed favorable viscosity and spreadability characteristics. The <em>ex vivo</em> skin permeation study revealed a marked improvement in transdermal delivery of gabapentin, which was further supported by FT-IR and DSC results showing disruption of the skin’s lipid bilayer after treatment. The observations from confocal laser scanning microscopy confirmed that the formulation enabled deeper penetration of the drug into the skin layers. These results indicate that the optimized gabapentin nanoemulsion could enhance bioavailability and enable targeted delivery, offering promise for the management of peripheral neuropathic pain. However, the authors also highlight that <em>in vivo</em> efficacy studies will be essential to validate these findings and fully establish the therapeutic potential of the microemulsion.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100354"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Light attenuation and optical absorption characteristics of graphene-chitosan nanomaterials-based quandary nanocomposites","authors":"Sarah Aljelawy ,&nbsp;Ehssan Al-Bermany ,&nbsp;Ali Razzaq Abdulridha","doi":"10.1016/j.nxnano.2025.100358","DOIUrl":"10.1016/j.nxnano.2025.100358","url":null,"abstract":"<div><div>Polymer-based graphene oxide nanocomposites represent an attractive class of materials due to their functional groups and wide range of applications in engineering and medicine. In this study, the interaction between nano-chitosan (CS) and graphene oxide (GO) nanosheets within polyvinylpyrrolidone (PVP) blended with polyacrylic acid (PAA) was investigated to fabricate two novel PVP–PAA–CS/GO nanocomposites. Fourier-transform infrared (FTIR) spectroscopy confirmed the presence of strong interfacial interactions and distinct functional groups. At the same time, X-ray diffraction (XRD) revealed a transition from amorphous to semicrystalline behavior after the incorporation of nanomaterials. Optical microscopy revealed the fracture surface characteristics and the fine dispersion of the components. UV–Vis spectroscopy demonstrated improved optical properties. Furthermore, the optical absorbance at 340 nm increased from 0.65 in PVP–PAA to 1.09 in PVP–PAA–CS/GO, indicating that ternary mix polymers and GO nanoparticles have formed a complex at around 300 nm, with a reduction of the optical band gap from 3.7 to 3.4 eV. The addition of nanomaterials enhanced the absorption behavior, dielectric constants (real and imaginary), and optical conductivity. Furthermore, the radiation attenuation of the composites improved significantly, with the half-value layer (HVL) increasing from 2.41 to 4.13 cm. These results highlight the potential of the prepared nanocomposites for diverse optoelectronic and light-shielding applications.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100358"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145884595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deadly cures: Unlocking anticancer potential of reptile, amphibian, and arthropod venoms through molecular innovation and nanotechnology","authors":"Pranav Ragavendra Shankar ,&nbsp;Apsara Unni","doi":"10.1016/j.nxnano.2026.100378","DOIUrl":"10.1016/j.nxnano.2026.100378","url":null,"abstract":"<div><div>Venoms from reptiles, amphibians, and arthropods represent a rich source of bioactive molecules with promising anticancer potential. Recent studies have highlighted the selective cytotoxicity of venom components including snake phospholipase A2 enzymes, scorpion peptides (chlorotoxin), and frog derived antimicrobial peptides against cancer cells. These molecules exert multifaceted effects, such as inducing apoptosis, inhibiting metastasis, and modulating the tumor microenvironment, thereby impairing tumor growth and progression. Advances in nanotechnology based delivery systems and peptide engineering have significantly improved the stability, bioavailability, and specificity of venom derived agents, enhancing their safety and therapeutic efficacy. Preclinical investigations demonstrate potent anticancer activity across multiple tumor models, and early clinical studies suggest translational potential. Current research continues to explore the molecular mechanisms underlying venom-mediated cytotoxicity, while formulation strategies and regulatory considerations are being optimized to facilitate clinical development. Future directions include the design of synthetic venom analogs, AI assisted drug discovery, and personalized medicine approaches, which collectively aim to harness the full therapeutic potential of venom peptides. By integrating natural bioactivity with modern biomedical technologies, venom derived compounds are emerging as a novel and promising avenue in the development of next-generation oncological therapeutics. This review provides a comprehensive overview of venom diversity, anticancer mechanisms, recent advances in formulation and delivery, and the challenges and opportunities for translating venom-based agents into clinical practice.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100378"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sennoside-functionalized ZrO₂ nanoparticles via Cassia angustifolia: Gram-selective antibacterial and anticancer nanoplatform with green synthesis","authors":"Aarti Jathar ,&nbsp;Samreen Fatema ,&nbsp;Mazahar Farooqui ,&nbsp;Abhay Dashrath ,&nbsp;Dattatraya Jirekar ,&nbsp;Pramila Ghumare","doi":"10.1016/j.nxnano.2025.100330","DOIUrl":"10.1016/j.nxnano.2025.100330","url":null,"abstract":"<div><div>Sennoside-functionalized zirconium dioxide nanoparticles (Sen–ZrO₂ NPs) were engineered via a single-step green synthesis route using <em>Cassia angustifolia</em> leaf extract as both a bio reductant and stabilizer. Structural characterization confirmed phase-pure tetragonal ZrO₂ formation through X-ray diffraction (XRD), while Fourier-transform infrared spectroscopy (FTIR) verified sennoside anchoring via characteristic C<img>O and O–H vibrations at 1680 cm⁻¹ and 3605 cm⁻¹. Scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM/EDS) revealed spherical morphologies with uniform elemental distribution. The Sen–ZrO₂ NPs exhibited pronounced Gram-selective antibacterial activity, demonstrating a fourfold potency enhancement against <em>Staphylococcus aureus</em> (MIC = 64 µg mL⁻¹) compared to unmodified ZrO₂. Time-kill assays further demonstrated a rapid 4-log reduction in bacterial viability within 6 h. Against MCF-7 breast cancer cells, the nanoparticles displayed dose-dependent cytotoxicity (IC₅₀ = 61.44 µg mL⁻¹), representing a 2.3-fold improvement over bare ZrO₂. This dual bioactivity is attributed to sennoside-mediated redox modulation and surface functionalization, which act synergistically to enhance membrane disruption and reactive oxygen species (ROS) generation. This work establishes a sustainable plant-engineered ZrO₂ nanoplatform with integrated antibacterial–anticancer functionality, presenting a viable green approach to advanced nanotherapeutics for combating antimicrobial resistance and cancer.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100330"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145694949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From pollution to solution: Optimized UiO-66 based metal-organic framework for environmental cleanup","authors":"Azieyanti Nurain Azmin ,&nbsp;Pua Fei Ling ,&nbsp;Halina Misran","doi":"10.1016/j.nxnano.2025.100333","DOIUrl":"10.1016/j.nxnano.2025.100333","url":null,"abstract":"<div><div>Metal-organic framework (MOF) is known as an advanced material with high surface area and porosity and emerging for environmental remediation. In this study, a sustainable zirconium-based MOF, known as UiO-66 was synthesized using zirconium oxynitrate as a chloride-less metal precursor and organic linker from recycled polyethylene terephthalate (rPET). Synthesis parameters were optimized via Response Surface Methodology (RSM), and achieved the maximum BET surface area of 755 m²/g. To evaluate for microplastic removal, the UiO-66 were incorporated into polyvinylidene fluoride (PVDF)-based mixed-matrix membranes (MMM). The properties and characterizations including X-Ray Diffraction (XRD), Field Emission Scanning Electron Microscopy (FESEM), X-Ray Photoelectron Spectroscopy (XPS), Raman Spectroscopy, and Brunauer-Emmett-Teller (BET) surface analysis, confirmed the structure and composition of the materials. Filtration test demonstrated up to 105 ± 0.57 % removal efficiency against polymethylmethacrylate (PMMA), act as microplastic suspension. This work presents a sustainable approach to convert plastic waste into functional MOF and offer a green and effective strategy for environmental cleanup applications.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100333"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinformatics models in drug delivery: Predicting biomaterial-biological interactions for targeted therapies","authors":"Varshika Singh ,&nbsp;Sukrat Sinha ,&nbsp;Jaya Verma","doi":"10.1016/j.nxnano.2025.100335","DOIUrl":"10.1016/j.nxnano.2025.100335","url":null,"abstract":"<div><div>The incorporation of bioinformatics into drug delivery research is revolutionizing the creation, development, and refinement of biomaterials utilized in therapeutic settings. Biomaterials, including nanomaterials, liposomes, and hydrogels, are essential components of drug delivery systems (DDS), as they enable controlled release, target specific tissues, and improve bioavailability. Nonetheless, grasping the interactions between these materials and biological systems poses a significant challenge. Increasingly, bioinformatics techniques such as molecular dynamics simulations, machine learning models, and docking analyses are being employed to forecast and enhance these interactions. These computational methods are vital for expediting the advancement of more effective and personalized drug delivery systems. This paper highlights the significance of bioinformatics in elucidating and predicting the interactions between biomaterials and biological systems, providing valuable perspectives on the future of drug delivery design.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100335"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An overview of structural, optical, and magnetic properties of Mn-doped, Cu-doped, and (Mn, Cu)-codoped ZnS nanoparticles and its applications","authors":"Pujarani Parida,&nbsp;Virendra Kumar Verma","doi":"10.1016/j.nxnano.2025.100359","DOIUrl":"10.1016/j.nxnano.2025.100359","url":null,"abstract":"<div><div>Zinc Sulphide (ZnS) nanoparticles (NPs) are highly valued for their exceptional optical and magnetic properties, making them critical for applications in sensors, spintronics, and optoelectronic devices. This study explores the effects of Mn, Cu, and (Mn, Cu)-codoping on ZnS NPs prepared through wet chemical synthesis. It examines the variation of dopant concentrations that influence key characteristics such as crystalline size, band gap, and magnetic properties. The results show that Mn-doping widens the band gap from 3.32 eV to 4.51 eV, while Cu-doping further increases it from 2.97 eV to 4.99 eV, attributed to quantum confinement and the Burstein-Moss effect. Magnetically, pure and Cu-doped ZnS display ferromagnetism, whereas (Mn, Cu)-codoping leads to diminished ferromagnetic behavior due to reduced d⁰ magnetization. These improvements in band gap and magnetic properties highlight the potential of doped ZnS NPs for cutting-edge technological advancements.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100359"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145840924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study on the mechanical and durability performance of concrete incorporating nanomaterials","authors":"Suresh Kumar Verma ,&nbsp;Md Daniyal ,&nbsp;Dulal Goldar","doi":"10.1016/j.nxnano.2025.100361","DOIUrl":"10.1016/j.nxnano.2025.100361","url":null,"abstract":"<div><div>This study investigated the influence of nano-SiO₂, nano-Al₂O₃, and nano-CaCO₃ on the workability, strength, and durability of cementitious composites at 1 %, 3 %, and 5 % replacement levels of OPC. The slump test results showed a steady decline in workability with increasing nanoparticle content due to their ultrafine size and large surface area, which raised water demand. Among the additives, nano-SiO₂ produced the greatest reduction in slump, while nano-CaCO₃ had the least effect. Compressive strength improved in all nano-modified mixes, with the highest enhancement at 3 % replacement viz. 26.3 % for nano-SiO₂, 24.6 % for nano-Al₂O₃, and 12.3 % for nano-CaCO₃ compared with the control. After 360 days of exposure to tap, saline, and acidic media, the nano-modified concretes exhibited superior strength retention and durability. Electrical resistivity tests confirmed higher resistivity for all nano-concretes, particularly for the 3 % nano-SiO₂ mix (NS3), indicating a denser and less permeable structure. Electrochemical analysis revealed that NS3 had the lowest corrosion rate and current density, providing maximum protection to steel reinforcement. Microstructural observations demonstrated denser microstructures, reduced porosity, and increased calcium silicate hydrate (C–S–H) gel formation in nano-modified mixes, particularly NS3. These findings establish the potential of nano-engineered concretes in enhancing mechanical performance and durability for infrastructure exposed to aggressive environments.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100361"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantum optics in photocatalytic hydrogen production: Light-matter interaction at the quantum scale","authors":"Sarah Susan Jolly ,&nbsp;A.R. Twinkle ,&nbsp;B.S. Arun Sasi ,&nbsp;R. Reshma","doi":"10.1016/j.nxnano.2025.100355","DOIUrl":"10.1016/j.nxnano.2025.100355","url":null,"abstract":"<div><div>Photocatalytic hydrogen production offers a sustainable path to clean energy, yet conventional approaches are limited by inefficiencies in light absorption and charge separation. This review explores how principles from quantum optics—such as coherence, entanglement, and nonclassical photon statistics—can fundamentally enhance photocatalytic processes. We delve into three key themes: (1) coherence-enhanced charge separation and exciton dynamics, (2) the impact of nonclassical light sources (e.g., squeezed and entangled photons) on catalytic efficiency, and (3) quantum optical control of light–matter interaction may offer new mechanisms for selective excitation, suppressed recombination, and low-intensity hydrogen evolution, though these remain largely theoretical or at proof-of-principle stages. Challenges in materials integration, decoherence management, and photonic engineering are critically examined. This review highlights a promising frontier in solar fuels research, where quantum light is not just a tool, but a resource for redefining the limits of photocatalytic efficiency.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100355"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transforming polyethylene terephthalate (PET) into carbon-based nanomaterials: Advancing sustainable solutions for green energy and environmental remediation","authors":"Suvarshitha Pusuluru ,&nbsp;Sai Kumar Punna ,&nbsp;Karrun Velmurugan ,&nbsp;Melvin S. Samuel ,&nbsp;Selvarajan Ethiraj ,&nbsp;Needhidasan Santhanam","doi":"10.1016/j.nxnano.2025.100341","DOIUrl":"10.1016/j.nxnano.2025.100341","url":null,"abstract":"<div><div>Polyethylene terephthalate (PET), a widely used polymer in transparent bottles for water, sanitizers, and other liquids, has seen a surge in consumption, particularly during the COVID-19 pandemic. This increase has resulted in a significant rise in PET-based waste, posing serious environmental and waste management challenges. PET waste, with approximately 11 % fixed carbon, low ash, and 30 % oxygen content, presents a promising raw material for the synthesis of activated carbon and other nanoporous carbon materials. However, conventional methods for converting PET into carbonaceous sorbents often yield limited output and face competition from other recycling pathways, rendering large-scale application impractical. This review critically examines both traditional and emerging techniques for activating PET, comparing its suitability and performance with other polymeric wastes, such as scrap tires. The broader context of plastic waste management is discussed, highlighting its non-biodegradable nature, toxic byproduct release, and impact on ecosystems and human health. Innovative approaches such as recycling and upcycling plastic into carbon-based nanomaterials (CBMs)—including carbon quantum dots, nanoparticles, nanotubes, graphene, and 3D porous carbons—are explored as sustainable alternatives. These plastic waste-derived carbon materials (PWCMs) offer high-value applications in clean energy storage, environmental remediation, and green technologies. The review also identifies eco-friendly production methods, aiming to bridge the gap between academic research and industrial practices. In addressing global energy demands and environmental degradation, PWCMs are positioned as key players in the transition to a circular economy and the development of renewable energy solutions. By consolidating recent advancements and outlining future research directions, this study underscores the potential of PET and other plastic wastes to serve as sustainable feedstocks for high-performance materials, encouraging innovative recycling strategies and contributing to the global effort against plastic pollution.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100341"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}