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Caffeic acid functionalized silver nanoparticles: A bionanoformulation and its assessment of cell cycle and in vitro cytotoxicity 咖啡酸功能化银纳米粒子:一种仿生制剂及其细胞周期和体外细胞毒性评估
Next Nanotechnology Pub Date : 2024-09-13 DOI: 10.1016/j.nxnano.2024.100105
Sangeetha Pushpanathan , Showket yahya , Amsaveni Gunasekaran , Sathan Raj Natarajan , Kayilainayaki Kannan , Kathiravan Krishnan
{"title":"Caffeic acid functionalized silver nanoparticles: A bionanoformulation and its assessment of cell cycle and in vitro cytotoxicity","authors":"Sangeetha Pushpanathan ,&nbsp;Showket yahya ,&nbsp;Amsaveni Gunasekaran ,&nbsp;Sathan Raj Natarajan ,&nbsp;Kayilainayaki Kannan ,&nbsp;Kathiravan Krishnan","doi":"10.1016/j.nxnano.2024.100105","DOIUrl":"10.1016/j.nxnano.2024.100105","url":null,"abstract":"<div><p>Caffeic acid, a potent polyphenol belonging to the hydroxycinnamic acid derivative class, was utilized in the synthesis of silver nanoparticles (AgNPs) at ambient temperature. The resultant conjugates underwent comprehensive characterization employing various analytical techniques, including UV–visible spectroscopy, FTIR, RAMAN spectroscopy, dynamic light scattering (DLS) for size and zeta potential analysis, atomic force microscopy (AFM), and scanning electron microscopy (SEM). Through these analyses, the morphological characteristics of the synthesized nanoparticles were elucidated, providing valuable insights into their structural properties. Subsequently, the cytotoxic effects of the caffeic acid-synthesized silver nanoparticles were assessed against A549 cells over a 48-h period by MTT assay. Remarkably, these nanoparticles exhibited significant toxicity towards the cells, with inhibitory effects observed at concentrations of 141 μg/ml for CA AgNPs. This underscores their potential as potent agents against cancer cells. Furthermore, the profound significance of caffeic acid-synthesized silver nanoparticles was evaluated specifically against A549 lung cancer cells. This was corroborated through cell cycle analysis, which demonstrated the potent anticancer activity of the caffeic acid-synthesized silver nanoparticles. Such findings suggest promising prospects for their utilization in diverse cancer treatment modalities. Overall, the successful synthesis and characterization of caffeic acid-synthesized silver nanoparticles underscore their potential as potent agents against cancer, particularly in combating A549 lung cancer cells. Further research and exploration into their mechanisms of action and potential synergistic effects with existing anticancer therapies could unveil additional avenues for their clinical translation and utilization in cancer management.</p></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949829524000664/pdfft?md5=9247219ae7cadd0a89f02eb40bd67711&pid=1-s2.0-S2949829524000664-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142228813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental investigation on plant extract-induced biosynthesis of Nickel nanoparticles 植物提取物诱导镍纳米颗粒生物合成的实验研究
Next Nanotechnology Pub Date : 2024-09-12 DOI: 10.1016/j.nxnano.2024.100104
Nimish Kumar , Anjali Singh , Vijay Devra
{"title":"Experimental investigation on plant extract-induced biosynthesis of Nickel nanoparticles","authors":"Nimish Kumar ,&nbsp;Anjali Singh ,&nbsp;Vijay Devra","doi":"10.1016/j.nxnano.2024.100104","DOIUrl":"10.1016/j.nxnano.2024.100104","url":null,"abstract":"<div><p>Here, we describe the phytosynthesis of nickel nanoparticles (NiNPs) utilizing an extract from the leaves of Azadirachta indica as a reducing and capping agent. The optimal conditions for synthesizing stable NiNPs were pH 6.8, temperature 70°C, and 5 % leaf extract and [NiNO<sub>3</sub>.6H<sub>2</sub>O] = 1.0×10<sup>−3</sup> mol dm<sup>−3</sup>. The X-ray diffraction (XRD) analysis revealed a face-centered cubic crystalline structure, and the Transmission Electron Microscope (TEM) and Scanning Electron Microscope (SEM) analyses verified a triangular form with particles ranging in size from 7 to 18 nm. The study examined the impact of reactant concentrations, reaction temperature, and solution pH on the nickel nanoparticle fabrication method. The following are the ideal parameters for synthesis: 5 % leaf extract, pH = 6.8, temperature = 70 °C, and [NiNO<sub>3</sub>.6H<sub>2</sub>O] = 1.0×10<sup>−3</sup> mol dm<sup>−3</sup>. Plant biomolecules induce the reduction of nickel ions to NiNPs and function as a capping and stabilizing agent, as confirmed by the FTIR technique. The findings indicated that the synthesis of NiNPs from A. indica leaf extracts are safe technology and may have significant impacts on the industrial synthesis of metallic nanoparticles.</p></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949829524000652/pdfft?md5=db91375cf9c2572af8cb7de515711868&pid=1-s2.0-S2949829524000652-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142168535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A review of chalcogenide-based perovskites as the next novel materials: Solar cell and optoelectronic applications, catalysis and future perspectives 综述作为下一代新型材料的卤化物基包晶石:太阳能电池和光电应用、催化和未来展望
Next Nanotechnology Pub Date : 2024-09-11 DOI: 10.1016/j.nxnano.2024.100102
George G. Njema, Joshua K. Kibet
{"title":"A review of chalcogenide-based perovskites as the next novel materials: Solar cell and optoelectronic applications, catalysis and future perspectives","authors":"George G. Njema,&nbsp;Joshua K. Kibet","doi":"10.1016/j.nxnano.2024.100102","DOIUrl":"10.1016/j.nxnano.2024.100102","url":null,"abstract":"<div><p>The increasing demand for renewable energy has stimulated significant advancements in the photovoltaic technology (PV), with perovskite solar cells (PSCs) emerging as leading alternatives because of their impressive efficiency and versatile characteristics. Nevertheless, conventional lead-based PSCs face critical challenges such as environmental instability, lead toxicity, and limited durability, which hinder their broader commercial applications. Chalcogenide-based perovskites, on the other hand have been advanced as promising options, offering improved stability, less toxic compositions, and the potential for more cost-effective, scalable production. This review thoroughly examines the progress made in chalcogenide perovskite research, highlighting their tunable bandgaps for diverse applications, superior charge transport properties, and resilience against advanced weathering conditions such as moisture, oxygen, and UV light. The graphene-like characteristics of certain chalcogenide perovskites, which contribute to their high charge mobility and flexibility, make them strong candidates for the next-generation PV technologies. Furthermore, this work explores the expanding potential for indoor applications of these materials, including their integration into flexible indoor PSCs and other optoelectronic devices designed for controlled environments. Also, various synthesis and optimization strategies, such as advanced deposition techniques, precise doping methods, and innovative interface and additive engineering are presented, aimed at enhancing the PV performance of these materials. Accordingly, this review bridges the gap between fundamental research and practical applications, outlining a strategic direction for developing chalcogenide-based PSCs and optoelectronic devices that meet the global energy demand while advancing sustainability and environmental safety.</p></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949829524000639/pdfft?md5=dd3ed0170f165e8d903bbbbe631861b2&pid=1-s2.0-S2949829524000639-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142168534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In-human nanofluidic air transport through respirators and masks 通过呼吸器和面罩的人体内纳米流体空气传输
Next Nanotechnology Pub Date : 2024-09-09 DOI: 10.1016/j.nxnano.2024.100097
K.V. Chinmaya , Moumita Ghosh , G. Mohan Rao , Siddharth Ghosh
{"title":"In-human nanofluidic air transport through respirators and masks","authors":"K.V. Chinmaya ,&nbsp;Moumita Ghosh ,&nbsp;G. Mohan Rao ,&nbsp;Siddharth Ghosh","doi":"10.1016/j.nxnano.2024.100097","DOIUrl":"10.1016/j.nxnano.2024.100097","url":null,"abstract":"<div><p>During the COVID-19 pandemic, the mandatory use of multiple surgical masks or N95 respirators in public raised concerns about potential health issues associated with the increased breathing force needed to maintain the breathing cycle. To address these concerns, we conducted a comprehensive study investigating the transportation and filtering mechanisms of heterogeneous nanoparticles and virus-like particles through surgical masks and N95 respirators. Our multifaceted approach combined <em>in vitro</em> experiments utilising aerosol spray paints containing nanoparticles and <em>in vivo</em> validation on human volunteer inhaling city air. We employed scanning electron microscopy and transmission electron microscopy to analyse the distribution of nanoparticles across various mask layers and pristine silicon substrates placed on human skin. In addition, we provide analytical insights into the pressure distribution and fluid velocity profiles within the complex polymer fibre network of the masks. Our findings remarkably revealed that both single surgical masks and N95 respirators exhibited similar nanofluidic performance in filtering colloidal and jet-stream nanoparticles in the air. These results have significant implications for policymakers in developing regulations to manage airborne pandemics and air pollution control, ultimately enhancing public health and safety during respiratory health crises.</p></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949829524000585/pdfft?md5=9779e9197bbf8212d3d0f548a1955d24&pid=1-s2.0-S2949829524000585-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142164240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on the performance of InGaN-based micro-LED by plasma etching combined with ion implantation process 等离子刻蚀结合离子注入工艺的 InGaN 基微型 LED 性能研究
Next Nanotechnology Pub Date : 2024-09-07 DOI: 10.1016/j.nxnano.2024.100101
Yun-Cheng Hsu , Yu-Hsuan Hsu , Chien-Chung Lin , Ming Hsien Wu , Hao Chung Kuo , Dong-Sing Wuu , Ching-Lien Hsiao , Ray-Hua Horng
{"title":"Study on the performance of InGaN-based micro-LED by plasma etching combined with ion implantation process","authors":"Yun-Cheng Hsu ,&nbsp;Yu-Hsuan Hsu ,&nbsp;Chien-Chung Lin ,&nbsp;Ming Hsien Wu ,&nbsp;Hao Chung Kuo ,&nbsp;Dong-Sing Wuu ,&nbsp;Ching-Lien Hsiao ,&nbsp;Ray-Hua Horng","doi":"10.1016/j.nxnano.2024.100101","DOIUrl":"10.1016/j.nxnano.2024.100101","url":null,"abstract":"<div><p>This study utilized blue-light epitaxial wafers and employed semiconductor processes such as maskless laser writing, dry etching, wet etching, passivation layer deposition, electron beam evaporation, and ion implantation to fabricate micro-light emitting diode (μLED) arrays with different pixel sizes but the same emitting area (900 μm²). The μLED arrays with single pixel sizes of 5 μm, 10 μm, and 15 μm were fabricated, with array numbers of 6×6, 3×3, and 2×2, respectively. This study proposes etching the material in the channel region while retaining a certain width for implantation, known as the sidewall ion implantation process, aiming to achieve better insulation characteristics by using ion implantation technology to insulate the sidewall regions. It involves ion bombardment of the defect areas generated after plasma etching and the use of a passivation layer for protection. The isolation characteristics of μLED arrays processed by sidewall implantation exhibited better electrical isolation than those of μLED arrays processed only by plasma. The light output power, external quantum efficiency, and wall-plug efficiency were all superior for the sidewall implantation process when the device was miniaturized to 5 μm. Overall, the sidewall implantation process combined with plasma dry etching effectively improved the light output characteristics, with the enhancement ratio increasing as the device was miniaturized.</p></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949829524000627/pdfft?md5=98f01b6e8bc7e76376acd14e964a6970&pid=1-s2.0-S2949829524000627-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142147567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the nature of nano bacterial cellulose-poly(vinyl alcohol) as a composite packaging material 探索纳米细菌纤维素-聚乙烯醇复合包装材料的性质
Next Nanotechnology Pub Date : 2024-09-03 DOI: 10.1016/j.nxnano.2024.100099
Keerthi Kumari Haralakal , Ashwini M. , Geeta D. Goudar , Venugopal C. K , Sharanappa Achappa , Bipin S. Chikkatti , Nagaraj R. Banapurmath , Ashok M. Sajjan
{"title":"Exploring the nature of nano bacterial cellulose-poly(vinyl alcohol) as a composite packaging material","authors":"Keerthi Kumari Haralakal ,&nbsp;Ashwini M. ,&nbsp;Geeta D. Goudar ,&nbsp;Venugopal C. K ,&nbsp;Sharanappa Achappa ,&nbsp;Bipin S. Chikkatti ,&nbsp;Nagaraj R. Banapurmath ,&nbsp;Ashok M. Sajjan","doi":"10.1016/j.nxnano.2024.100099","DOIUrl":"10.1016/j.nxnano.2024.100099","url":null,"abstract":"<div><p>Nano bacterial cellulose (NBC) being a biopolymer has unique physical and chemical properties with high biocompatibility. It is pure cellulose with nanometer size, produced by certain group of bacteria. Its properties can be further improved by combining with poly(vinyl alcohol) (PVA), which is a fascinating polymer soluble in water and biocompatible. Composite films of PVA and NBC were prepared by solution casting method. Composite films of PVA-NBC (0,1,2,3,4,5 %) were tested for major packaging properties like water vapor transmission rate, swelling measurement, film solubility and moisture retention capacity. Among all concentration films, film with 5 % NBC- PVA showed better results for all the tests. Films were also checked for antimicrobial properties against spoilage-causing bacteria and fungi. Further, the films were applied to study the shelf life in the Mitli Banana (<em>Musa</em> sp<em>.</em>) followed by Organoleptic evaluation during storage. Results showed that the banana packed with 5 % NBC- PVA film has retained maximum acceptable characters than other packages.</p></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949829524000603/pdfft?md5=821991d73daaadd5153543b4f0309e3f&pid=1-s2.0-S2949829524000603-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142130161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Graphene incorporated zinc oxide hybrid nanofluid for energy-efficient heat transfer application: A thermal lens study 用于高能效传热应用的石墨烯与氧化锌混合纳米流体:热透镜研究
Next Nanotechnology Pub Date : 2024-08-30 DOI: 10.1016/j.nxnano.2024.100100
Vijayakumar Gokul , Mohanachandran Nair Sindhu Swapna , Sankaranarayana Iyer Sankararaman
{"title":"Graphene incorporated zinc oxide hybrid nanofluid for energy-efficient heat transfer application: A thermal lens study","authors":"Vijayakumar Gokul ,&nbsp;Mohanachandran Nair Sindhu Swapna ,&nbsp;Sankaranarayana Iyer Sankararaman","doi":"10.1016/j.nxnano.2024.100100","DOIUrl":"10.1016/j.nxnano.2024.100100","url":null,"abstract":"<div><p>The work focuses on the development of a hybrid nanofluid (NF) comprising zinc oxide-graphene (ZG) to address heat transfer (HT) limitations in thermal systems. The study employs a highly sensitive mode-mismatched dual-beam thermal lens (MDTL) method to analyze the lattice dislocation-induced thermal diffusivity (D) modifications of the hybrid NF. The hybrid composite (HC) is synthesized by solid-state mixing and annealing of ZG. The formation of ZG hybrid composites is revealed through X-ray diffraction (XRD), Fourier transform infrared, X-ray photoelectron, and Raman spectroscopic analyses. The structural dislocations present in the HC are understood from XRD and Raman analyses. Ultraviolet-visible and photoluminescence spectroscopic studies revealed the optical properties of the samples. The MDTL study is carried out by preparing the NFs of the synthesized samples in the base fluid, ethylene glycol (EG), and reveals the impact of crystallite defects on the thermal characteristics of the synthesized composites. Thus, the study suggests the potential capability of ZG composites in tuning the thermal behaviour of EG for HT applications.</p></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949829524000615/pdfft?md5=1cc71aad37807fbfb09943eb1ef72847&pid=1-s2.0-S2949829524000615-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142098251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Laser-induced modulation of Magnon and Phonon excitations: Size and defect dependency in antiferromagnetic NiO nanoparticles with rhombohedral distortion 激光诱导的 Magnon 和 Phonon 激发调制:具有斜方体畸变的反铁磁性氧化镍纳米粒子的尺寸和缺陷依赖性
Next Nanotechnology Pub Date : 2024-08-24 DOI: 10.1016/j.nxnano.2024.100098
Adiba Adiba , Ph Nonglen Meitei , Tufail Ahmad
{"title":"Laser-induced modulation of Magnon and Phonon excitations: Size and defect dependency in antiferromagnetic NiO nanoparticles with rhombohedral distortion","authors":"Adiba Adiba ,&nbsp;Ph Nonglen Meitei ,&nbsp;Tufail Ahmad","doi":"10.1016/j.nxnano.2024.100098","DOIUrl":"10.1016/j.nxnano.2024.100098","url":null,"abstract":"<div><p>NiO nanoparticles were synthesized using jasmine flower and orange peel. The transition from cubic to rhombohedral phase was observed with peak splitting in the XRD patterns as the annealing temperature increased. Differences in the annealing environment resulted in particles with different crystallite sizes and amounts of nickel vacancy, directly impacting their magnetic properties. Notably, particles below 30 nm exhibited weak ferromagnetism, while those above 30 nm showed antiferromagnetic properties. Moreover, the power of the laser was tuned to 5 mW to achieve the disappearance of the 2 M peak. A key highlight of this work is the identification of the transverse acoustic phonon mode and the splitting of the transverse optical (TO) mode in NiO.</p></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949829524000597/pdfft?md5=503adb539bb83616389fbfe586a7faab&pid=1-s2.0-S2949829524000597-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142048638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aloe vera gel mediated green synthesis of ruthenium nanoparticles and their potential anticancer activity 芦荟胶介导的钌纳米粒子的绿色合成及其潜在的抗癌活性
Next Nanotechnology Pub Date : 2024-08-14 DOI: 10.1016/j.nxnano.2024.100095
Tanjila Begum , Sangeeta Agarwal , Pranjal Bhuyan , Jumi Das , Akalesh Kumar Verma , Ankur Guha , Mausumi Ganguly
{"title":"Aloe vera gel mediated green synthesis of ruthenium nanoparticles and their potential anticancer activity","authors":"Tanjila Begum ,&nbsp;Sangeeta Agarwal ,&nbsp;Pranjal Bhuyan ,&nbsp;Jumi Das ,&nbsp;Akalesh Kumar Verma ,&nbsp;Ankur Guha ,&nbsp;Mausumi Ganguly","doi":"10.1016/j.nxnano.2024.100095","DOIUrl":"10.1016/j.nxnano.2024.100095","url":null,"abstract":"<div><p>Metal nanoparticles have a noteworthy future in cancer treatment research because of their smaller size and large active surface area. Though gold, silver, platinum, palladium, copper, zinc, iron and several other metal nanoparticles have been explored for their anticancer potential in different pathways, the main limitation of these particles is their toxicity which may be controlled through their size, surface modification and route of administration. Compared to other metal nanoparticles, ruthenium nanoparticles have high bio compatibility and they exhibit excellent photo-thermal effect. Though there are several reports in the literature on the anticancer potential of ruthenium complexes, ruthenium nanoparticles are not much investigated. In the present work, therefore, an attempt has been made to synthesize ruthenium nanoparticles in an easy and eco-friendly way using Aloe vera gel. Ruthenium chloride was used as a precursor and Aloe vera gel acted both as reducing and capping agent. The synthesized ruthenium nanoparticles were characterized using UV-Visible spectrophotometry, Fourier Transform Infrared Spectroscopy (FT-IR), High Resolution Transmission Electron Microscopy (HRTEM), Powder X-ray Diffraction (PXRD), Dynamic Light Scattering (DLS) and Field Emission Scanning Electron Microscopy (FESEM). The analyses confirmed the formation of nano globules of Aloe vera gel of diameter in the range 90–300 nm with ruthenium nanoparticles of average size 1.5 nm embedded in them. The synthesized Ru nanoparticles embedded in the nano globules of Aloe vera gel (ALV RuNPs) were explored for their anticancer potential in the Dalton's lymphoma ascites (DL) cell line using Trypan Blue assay. The results of the assay showed that the ALV RuNPs can induce concentration dependent cytotoxicity in DL cancer cells. Approximately 40 % cytotoxicity was obtained for concentration range 5–50 mg/mL of the sample while negligible cytotoxicity was observed for healthy PBMC cells. Theoretical study indicates significant interaction between the components present in Aloe vera and Ru-nanoparticles. The results showed tha<del>t</del> ruthenium nanoparticles can emerge as a promising bio-compatible candidate with the ability to selectively target cancer cells while sparing normal cells.</p></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949829524000561/pdfft?md5=b82c606dc6e62b9523ea9304291e2df9&pid=1-s2.0-S2949829524000561-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141990604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanoemulsion as an effective delivery vehicle for essential oils: Properties, formulation methods, destabilizing mechanisms and applications in agri-food sector 纳米乳液作为精油的有效输送载体:特性、配制方法、不稳定机制以及在农业食品领域的应用
Next Nanotechnology Pub Date : 2024-08-12 DOI: 10.1016/j.nxnano.2024.100096
Amit Kumar , Rohini Kanwar , S.K. Mehta
{"title":"Nanoemulsion as an effective delivery vehicle for essential oils: Properties, formulation methods, destabilizing mechanisms and applications in agri-food sector","authors":"Amit Kumar ,&nbsp;Rohini Kanwar ,&nbsp;S.K. Mehta","doi":"10.1016/j.nxnano.2024.100096","DOIUrl":"10.1016/j.nxnano.2024.100096","url":null,"abstract":"<div><p>The growing interest in the utilization of natural plant-derived products, particularly essential oils as eco-friendly agrochemicals has spurred the consumer demand for clean-label products. Due to their robust antimicrobial and pesticidal properties, essential oils (EOs) exhibit significant potential in food preservation and agricultural applications. However, the poor aqueous stability and highly volatile nature of EOs limit their potential for practical applications in their pure form. In response, nanoemulsions (NEms) have emerged as promising delivery vehicles for EOs, offering advantages such as smaller size, high solubilization capacity, excellent encapsulation efficiency, and controlled release characteristics.</p><p>Here we review the recent advancements in the fabrication, optimization, and stability of EO NEms. The present article provides an in-depth exploration of all the currently available high-energy (ultrasonication, micro fluidization, high-pressure homogenization, rotor-stator mixer) and low-energy (spontaneous emulsification, phase inversion composition, emulsion inversion point, phase inversion temperature) methods being used for the fabrication of NEms and the respective advantages and disadvantages associated with them. Additionally, the review discusses various destabilization mechanisms such as Ostwald ripening, coalescence, etc. that generally impact essential oil NEms, providing a comprehensive understanding of the challenges associated with their stability. Furthermore, the review focuses on the recent practical applications of NEms in the sector of food preservation, flavoring agents, and sustainable agricultural practices.</p></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949829524000573/pdfft?md5=e8b901babbc611143159af82f3a261e0&pid=1-s2.0-S2949829524000573-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141978848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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