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Quantum optics in photocatalytic hydrogen production: Light-matter interaction at the quantum scale 光催化制氢中的量子光学:量子尺度上的光-物质相互作用
Next Nanotechnology Pub Date : 2026-06-01 Epub Date: 2025-12-16 DOI: 10.1016/j.nxnano.2025.100355
Sarah Susan Jolly , A.R. Twinkle , B.S. Arun Sasi , R. Reshma
{"title":"Quantum optics in photocatalytic hydrogen production: Light-matter interaction at the quantum scale","authors":"Sarah Susan Jolly ,&nbsp;A.R. Twinkle ,&nbsp;B.S. Arun Sasi ,&nbsp;R. Reshma","doi":"10.1016/j.nxnano.2025.100355","DOIUrl":"10.1016/j.nxnano.2025.100355","url":null,"abstract":"<div><div>Photocatalytic hydrogen production offers a sustainable path to clean energy, yet conventional approaches are limited by inefficiencies in light absorption and charge separation. This review explores how principles from quantum optics—such as coherence, entanglement, and nonclassical photon statistics—can fundamentally enhance photocatalytic processes. We delve into three key themes: (1) coherence-enhanced charge separation and exciton dynamics, (2) the impact of nonclassical light sources (e.g., squeezed and entangled photons) on catalytic efficiency, and (3) quantum optical control of light–matter interaction may offer new mechanisms for selective excitation, suppressed recombination, and low-intensity hydrogen evolution, though these remain largely theoretical or at proof-of-principle stages. Challenges in materials integration, decoherence management, and photonic engineering are critically examined. This review highlights a promising frontier in solar fuels research, where quantum light is not just a tool, but a resource for redefining the limits of photocatalytic efficiency.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100355"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transforming polyethylene terephthalate (PET) into carbon-based nanomaterials: Advancing sustainable solutions for green energy and environmental remediation 将聚对苯二甲酸乙二醇酯(PET)转化为碳基纳米材料:推进绿色能源和环境修复的可持续解决方案
Next Nanotechnology Pub Date : 2026-06-01 Epub Date: 2025-12-18 DOI: 10.1016/j.nxnano.2025.100341
Suvarshitha Pusuluru , Sai Kumar Punna , Karrun Velmurugan , Melvin S. Samuel , Selvarajan Ethiraj , Needhidasan Santhanam
{"title":"Transforming polyethylene terephthalate (PET) into carbon-based nanomaterials: Advancing sustainable solutions for green energy and environmental remediation","authors":"Suvarshitha Pusuluru ,&nbsp;Sai Kumar Punna ,&nbsp;Karrun Velmurugan ,&nbsp;Melvin S. Samuel ,&nbsp;Selvarajan Ethiraj ,&nbsp;Needhidasan Santhanam","doi":"10.1016/j.nxnano.2025.100341","DOIUrl":"10.1016/j.nxnano.2025.100341","url":null,"abstract":"<div><div>Polyethylene terephthalate (PET), a widely used polymer in transparent bottles for water, sanitizers, and other liquids, has seen a surge in consumption, particularly during the COVID-19 pandemic. This increase has resulted in a significant rise in PET-based waste, posing serious environmental and waste management challenges. PET waste, with approximately 11 % fixed carbon, low ash, and 30 % oxygen content, presents a promising raw material for the synthesis of activated carbon and other nanoporous carbon materials. However, conventional methods for converting PET into carbonaceous sorbents often yield limited output and face competition from other recycling pathways, rendering large-scale application impractical. This review critically examines both traditional and emerging techniques for activating PET, comparing its suitability and performance with other polymeric wastes, such as scrap tires. The broader context of plastic waste management is discussed, highlighting its non-biodegradable nature, toxic byproduct release, and impact on ecosystems and human health. Innovative approaches such as recycling and upcycling plastic into carbon-based nanomaterials (CBMs)—including carbon quantum dots, nanoparticles, nanotubes, graphene, and 3D porous carbons—are explored as sustainable alternatives. These plastic waste-derived carbon materials (PWCMs) offer high-value applications in clean energy storage, environmental remediation, and green technologies. The review also identifies eco-friendly production methods, aiming to bridge the gap between academic research and industrial practices. In addressing global energy demands and environmental degradation, PWCMs are positioned as key players in the transition to a circular economy and the development of renewable energy solutions. By consolidating recent advancements and outlining future research directions, this study underscores the potential of PET and other plastic wastes to serve as sustainable feedstocks for high-performance materials, encouraging innovative recycling strategies and contributing to the global effort against plastic pollution.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100341"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative study on the mechanical and durability performance of concrete incorporating nanomaterials 纳米材料掺入混凝土力学性能与耐久性对比研究
Next Nanotechnology Pub Date : 2026-06-01 Epub Date: 2026-01-06 DOI: 10.1016/j.nxnano.2025.100361
Suresh Kumar Verma , Md Daniyal , Dulal Goldar
{"title":"Comparative study on the mechanical and durability performance of concrete incorporating nanomaterials","authors":"Suresh Kumar Verma ,&nbsp;Md Daniyal ,&nbsp;Dulal Goldar","doi":"10.1016/j.nxnano.2025.100361","DOIUrl":"10.1016/j.nxnano.2025.100361","url":null,"abstract":"<div><div>This study investigated the influence of nano-SiO<sub>2</sub>, nano-Al<sub>2</sub>O<sub>3</sub>, and nano-CaCO<sub>3</sub> on the workability, strength, and durability of cementitious composites at 1 %, 3 %, and 5 % replacement levels of OPC. The slump test results showed a steady decline in workability with increasing nanoparticle content due to their ultrafine size and large surface area, which raised water demand. Among the additives, nano-SiO<sub>2</sub> produced the greatest reduction in slump, while nano-CaCO<sub>3</sub> had the least effect. Compressive strength improved in all nano-modified mixes, with the highest enhancement at 3 % replacement viz. 26.3 % for nano-SiO<sub>2</sub>, 24.6 % for nano-Al<sub>2</sub>O<sub>3</sub>, and 12.3 % for nano-CaCO<sub>3</sub> compared with the control. After 360 days of exposure to tap, saline, and acidic media, the nano-modified concretes exhibited superior strength retention and durability. Electrical resistivity tests confirmed higher resistivity for all nano-concretes, particularly for the 3 % nano-SiO<sub>2</sub> mix (NS3), indicating a denser and less permeable structure. Electrochemical analysis revealed that NS3 had the lowest corrosion rate and current density, providing maximum protection to steel reinforcement. Microstructural observations demonstrated denser microstructures, reduced porosity, and increased calcium silicate hydrate (C–S–H) gel formation in nano-modified mixes, particularly NS3. These findings establish the potential of nano-engineered concretes in enhancing mechanical performance and durability for infrastructure exposed to aggressive environments.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100361"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomedical and insecticidal efficacy of green synthesized nanoparticles from underexplored Tanzanian medicinal plants: A comparative study using Pueraria montana, Vernonia amygdalina, and Tephrosia vogelii 从未开发的坦桑尼亚药用植物中合成的绿色纳米颗粒的生物医学和杀虫功效:对蒙大拿葛根、苦杏仁花和灰根草的比较研究
Next Nanotechnology Pub Date : 2026-06-01 Epub Date: 2025-12-09 DOI: 10.1016/j.nxnano.2025.100323
Sylvanus Bisaba Ruvubu , Indrajit Roy
{"title":"Biomedical and insecticidal efficacy of green synthesized nanoparticles from underexplored Tanzanian medicinal plants: A comparative study using Pueraria montana, Vernonia amygdalina, and Tephrosia vogelii","authors":"Sylvanus Bisaba Ruvubu ,&nbsp;Indrajit Roy","doi":"10.1016/j.nxnano.2025.100323","DOIUrl":"10.1016/j.nxnano.2025.100323","url":null,"abstract":"&lt;div&gt;&lt;div&gt;This study explores the biomedical and insecticidal potential of green-synthesized nanoparticles (NPs) from &lt;em&gt;Pueraria montana&lt;/em&gt; roots, &lt;em&gt;Vernonia amygdalina&lt;/em&gt;, and &lt;em&gt;Tephrosia vogelii&lt;/em&gt; leaves. Antibacterial activity of ZnO, CuO, AgNPs, and NiO–CuO nanocomposites was tested against &lt;em&gt;S. aureus&lt;/em&gt;, &lt;em&gt;S. pyogenes&lt;/em&gt;, and &lt;em&gt;E. coli&lt;/em&gt;. The nanoparticles (ROS) generation, disruption of the cell membrane, release of metal ions, and synergistic effects of phytochemical capping agents. The AgNPs showed the strongest activity against gram-positive strains, while ZnO was more effective against &lt;em&gt;E. coli.&lt;/em&gt; CuO and AgNPs outperformed ZnO due to smaller size and higher reactivity. At 50 µg/disc, most of these NPs achieved over 70 % of standard antibiotic efficacy. Insecticidal testing against &lt;em&gt;Periplaneta americana&lt;/em&gt; showed that &lt;em&gt;T. vogelii&lt;/em&gt; derived ZnO NPs caused 33.3 % mortality in 20 min at 50 ppm and over 99 % at 100–200 ppm in 2–6 h. Based on MIC assays conducted using standard broth microdilution methods, AgNPs exhibited the lowest inhibitory concentrations (12.5 ± 0.5 µg/ml) against &lt;em&gt;S. aureus&lt;/em&gt; and &lt;em&gt;S. pyogenes&lt;/em&gt;, demonstrating stronger antibacterial potency than CuO, ZnO, and NiO–CuO nanoparticles. In contrast, ZnO nanocomposites showed the greatest efficacy against &lt;em&gt;E. coli&lt;/em&gt; (MIC value of 14.2 ± 1.4 µg/ml), highlighting differential activity of the green-synthesized nanoparticles depending on bacterial type. These quantitative results provide robust experimental support for the comparative efficacy, linking nanoparticle physicochemical properties, ion release, ROS generation, and phytochemical capping to observed antibacterial performance and thus indicating AgNPs’ superior activity against Gram-positive bacteria. Statistical analysis confirmed significant effects of these plant-based nanoparticles’ type, dose, and exposure. Characterization with UV–Vis, FTIR, SEM, and XRD confirmed desirable physicochemical properties and strong bioactivity. The two-way ANOVA for corrected mortality in (%) showed that both time and treatment type had statistically significant effect (p &lt; 0.05) on insecticidal efficacy (Corrected Mortality). Insecticidal activity was found not only depended on what is applied and nature of treatment such as NPs type, but also how long it has been applied and the dosage or concentration used. Therefore, both formulation type and exposure duration were critical for insect control strategies. The Tukey’s Honestly Significant Difference (HSD) as a post hoc (analysis after ANOVA test) showed that &lt;em&gt;Tephrosia vogelii&lt;/em&gt; was significantly more effective than both &lt;em&gt;Puéraria montana&lt;/em&gt; (p = 0.001) and &lt;em&gt;Vernonia amygdalina&lt;/em&gt; (p = 0.001) in causing insect mortality. Additionally, there was no significant difference between &lt;em&gt;Puéraria montana&lt;/em&gt; and &lt;em&gt;Vernonia amygdalina&lt;/em&gt; (p = 0.368), suggesting comparable efficacy between them since ANOVA f","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100323"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adsorption process of heavy metals from wastewater: A comprehensive review of adsorbents and process optimization 废水中重金属的吸附工艺:吸附剂及工艺优化综述
IF 3.7
Next Nanotechnology Pub Date : 2026-06-01 Epub Date: 2026-05-13 DOI: 10.1016/j.nxnano.2026.100514
Najlae Zaki, Asmae Charki, Oumaima Fraiha, Hossain El Ouarghi, Hassan Amhamdi, Amin Salhi, Abdellah Elyoussfi, M’hamed Ahari
{"title":"Adsorption process of heavy metals from wastewater: A comprehensive review of adsorbents and process optimization","authors":"Najlae Zaki,&nbsp;Asmae Charki,&nbsp;Oumaima Fraiha,&nbsp;Hossain El Ouarghi,&nbsp;Hassan Amhamdi,&nbsp;Amin Salhi,&nbsp;Abdellah Elyoussfi,&nbsp;M’hamed Ahari","doi":"10.1016/j.nxnano.2026.100514","DOIUrl":"10.1016/j.nxnano.2026.100514","url":null,"abstract":"<div><div>Contamination of heavy metal in wastewater presents a major environmental challenge due to the toxicity, persistence, and bioaccumulative nature of these pollutants. Adsorption is recognized as a reliable and flexible approach for the removal of heavy metals. This review explores the mechanisms of adsorption and highlights various types of adsorbents, including natural, synthetic, and nanomaterial-based options, which have shown high efficiency in capturing metal ions. The study examines the main factors affecting adsorption performance, including different parameters such as initial metal concentration, and characteristics of adsorbent. Additionally, it discusses the advantages and limitations of various adsorbents, as well as the need for further research on optimizing adsorption conditions and developing new materials. Overall, adsorption, combined with advances in adsorbent technologies, represents a promising solution for mitigating heavy metal pollution in wastewater, contributing to both environmental and human health protection.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100514"},"PeriodicalIF":3.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148523559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasonic investigation of PEG–Ethanol–Epoxy–TiO₂ nanocomposite: Insights into coating suitability via thermoacoustic parameters 聚乙二醇-乙醇-环氧树脂-二氧化钛纳米复合材料的超声研究:热声参数对涂层适用性的影响
Next Nanotechnology Pub Date : 2026-06-01 Epub Date: 2026-01-28 DOI: 10.1016/j.nxnano.2026.100373
Niharika Das , Subhraraj Panda , Manoj Kumar Praharaj
{"title":"Ultrasonic investigation of PEG–Ethanol–Epoxy–TiO₂ nanocomposite: Insights into coating suitability via thermoacoustic parameters","authors":"Niharika Das ,&nbsp;Subhraraj Panda ,&nbsp;Manoj Kumar Praharaj","doi":"10.1016/j.nxnano.2026.100373","DOIUrl":"10.1016/j.nxnano.2026.100373","url":null,"abstract":"<div><div>This study employs ultrasonic techniques within the temperature range of 298–328 K to examine the molecular interactions and structural dynamics of a novel PEG–ethanol–epoxy–TiO₂ nanocomposite system, which consists of 5 % (w/w) PEG-6000, 10 % (w/w) epoxy resin, and 2 % (w/w) TiO₂ nanoparticles. Thermoacoustic parameters, including free volume, available volume, molar volume, internal pressure, Rao’s constant, and Wada constant, were obtained through experimental measurements of ultrasonic velocity, viscosity, and density. The findings indicate that as temperature rises, there is a progressive increase in free volume, available volume, molar volume, Rao’s constant, and Wada constant, while internal pressure decreases. This suggests an enhancement in molecular mobility and a reduction in cohesive forces within the composite matrix. The uniform distribution of TiO₂ nanoparticles greatly enhances structural consistency and acoustic responsiveness, indicating robust interfacial interactions among PEG, ethanol, epoxy, and TiO₂ via hydrogen bonding and dipole–dipole mechanisms. The findings confirm that ultrasonic analysis demonstrates a high sensitivity to molecular rearrangements and thermal behavior in polymer nanocomposites. The optimized PEG–epoxy–TiO₂ formulation demonstrates significant potential for advanced coating applications, including thermally adaptable, UV-resistant, and acoustically responsive materials for biomedical and electronic devices.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100373"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nano-hydroxyapatite (n-HAp) and its composites for heavy metal removal from water: A comprehensive review 纳米羟基磷灰石(n-HAp)及其复合材料去除水中重金属的研究进展
Next Nanotechnology Pub Date : 2026-06-01 Epub Date: 2025-12-11 DOI: 10.1016/j.nxnano.2025.100339
Vaishali , Anjaneyulu Bendi , Sushma Singh , Rashmi Pundeer
{"title":"Nano-hydroxyapatite (n-HAp) and its composites for heavy metal removal from water: A comprehensive review","authors":"Vaishali ,&nbsp;Anjaneyulu Bendi ,&nbsp;Sushma Singh ,&nbsp;Rashmi Pundeer","doi":"10.1016/j.nxnano.2025.100339","DOIUrl":"10.1016/j.nxnano.2025.100339","url":null,"abstract":"<div><div>The removal of heavy metals from wastewater presents a significant environmental challenge because these contaminants can have serious effects on human health and ecosystems. This study assesses the effectiveness of various adsorption materials, focusing particularly on nano-hydroxyapatite (nHAp), known for its biocompatibility, stability, and sorption capacity. nHAp and its composites has been shown in numerous studies to remove toxic heavy metal ions from water. The adsorption process is influenced by key parameters, including temperature and pH, which can affect the performance of the material. This study provides valuable insights (from 2018 to 2024) into the mechanisms and conditions that optimize the removal of heavy metal ions, highlighting the potential of nHAP as a sustainable solution for water treatment.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100339"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanomedicine approaches for Alzheimer’s disease: Advances in drug delivery and theranostic applications 阿尔茨海默病的纳米医学方法:药物传递和治疗应用的进展
IF 3.7
Next Nanotechnology Pub Date : 2026-06-01 Epub Date: 2026-05-07 DOI: 10.1016/j.nxnano.2026.100495
Paliishree Bhukta, Pratap Kumar Sahu, Biswajeet Acharya
{"title":"Nanomedicine approaches for Alzheimer’s disease: Advances in drug delivery and theranostic applications","authors":"Paliishree Bhukta,&nbsp;Pratap Kumar Sahu,&nbsp;Biswajeet Acharya","doi":"10.1016/j.nxnano.2026.100495","DOIUrl":"10.1016/j.nxnano.2026.100495","url":null,"abstract":"<div><div>This review aims to provide an updated overview of nanoparticle-based drug delivery strategies and emerging nanotheranostic applications for Alzheimer’s Disease. It is the most common cause of dementia worldwide and represents a major global health challenge due to its progressive neurodegeneration and multifactorial pathology, including amyloid-β plaque deposition, tau hyperphosphorylation, neuroinflammation, oxidative stress, and blood-brain barrier dysfunction. Despite extensive research efforts, currently approved pharmacological therapies, such as cholinesterase inhibitors and NMDA receptor antagonists, offer only temporary symptomatic relief and do not prevent disease progression. Moreover, these treatments often suffer from limited blood-brain barrier penetration, rapid systemic clearance, and undesirable side effects. Recently approved monoclonal antibodies targeting amyloid-β have generated clinical interest; however, their therapeutic benefit remains modest and is accompanied by high costs and potential safety concerns. Nanomedicine has emerged as a promising strategy to overcome these limitations by enabling targeted drug delivery to the brain, improved bioavailability, and controlled therapeutic release. Various nanoparticle platforms—including lipid-based systems such as liposomes, solid lipid nanoparticles, and nanostructured lipid carriers, as well as polymeric nanoparticles based on PLGA, PEG, and chitosan—have demonstrated significant potential for enhancing drug stability, blood-brain barrier transport, and sustained delivery. Furthermore, the development of nanotheranostic systems integrating diagnostic imaging with therapeutic delivery offers new opportunities for real-time monitoring of treatment response. Collectively, these advances highlight the potential of nanotechnology to improve therapeutic outcomes and support future clinical translation in Alzheimer’s Disease management.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100495"},"PeriodicalIF":3.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148523557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synergistic potential of medicinal plant–derived phytochemicals and nanotechnology-based delivery systems in modern cancer therapy 药用植物衍生的植物化学物质和基于纳米技术的递送系统在现代癌症治疗中的协同潜力
IF 3.7
Next Nanotechnology Pub Date : 2026-06-01 Epub Date: 2026-05-15 DOI: 10.1016/j.nxnano.2026.100516
Biswajeet Acharya, Durga Prasad Mishra, Dhakshnamoorthy Vellingiri, Prafulla Kumar Sahu
{"title":"Synergistic potential of medicinal plant–derived phytochemicals and nanotechnology-based delivery systems in modern cancer therapy","authors":"Biswajeet Acharya,&nbsp;Durga Prasad Mishra,&nbsp;Dhakshnamoorthy Vellingiri,&nbsp;Prafulla Kumar Sahu","doi":"10.1016/j.nxnano.2026.100516","DOIUrl":"10.1016/j.nxnano.2026.100516","url":null,"abstract":"<div><div>Cancer remains a major global health challenge due to its molecular complexity, heterogeneity, and frequent resistance to conventional therapies. Although chemotherapy, radiotherapy, and immunotherapy remain central to cancer management, their clinical effectiveness is often limited by toxicity, poor selectivity, and drug resistance. In this context, medicinal plants and their bioactive phytochemicals have gained increasing attention as complementary and alternative strategies owing to their multi-targeted anticancer properties and favorable safety profiles. This review comprehensively explores the synergistic potential of plant-derived compounds—including flavonoids, alkaloids, terpenoids, phenolics, and saponins—in cancer prevention and therapy, with particular emphasis on their ability to modulate key molecular pathways involved in apoptosis, proliferation, angiogenesis, metastasis, inflammation, oxidative stress, and epigenetic regulation. The manuscript further highlights the advantages of combinational phytotherapy, wherein natural compounds are used alone or in conjunction with conventional anticancer agents to enhance therapeutic efficacy, overcome drug resistance, and reduce treatment-related toxicity. Importantly, recent advances in nanotechnology-based drug delivery systems are discussed as a transformative approach to address the major pharmacokinetic limitations of phytochemicals, such as poor solubility, low bioavailability, and rapid metabolism. Nanoparticle formulations—including polymeric nanoparticles, liposomes, nanoemulsions, micelles, and carrier-free self-assembled systems—have demonstrated improved stability, controlled release, tumor-targeted delivery, and enhanced anticancer outcomes across multiple cancer types. Collectively, this review underscores the integration of medicinal plant–derived bioactives with advanced nanotechnology platforms as a promising, sustainable, and multi-targeted strategy for modern cancer therapy. Such approaches bridge traditional medicine with contemporary biomedical innovation and offer new directions for the development of safer, more effective, and personalized anticancer interventions.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100516"},"PeriodicalIF":3.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148523670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanoparticles in ocular cancer: Diagnosis and treatment 纳米粒子在眼癌中的诊断和治疗
Next Nanotechnology Pub Date : 2026-06-01 Epub Date: 2026-01-19 DOI: 10.1016/j.nxnano.2026.100369
Sailee Chowdhury , Koyel Kar , Priyanka Chakraborty , Rana Mazumder , Bhupendra G. Prajapati
{"title":"Nanoparticles in ocular cancer: Diagnosis and treatment","authors":"Sailee Chowdhury ,&nbsp;Koyel Kar ,&nbsp;Priyanka Chakraborty ,&nbsp;Rana Mazumder ,&nbsp;Bhupendra G. Prajapati","doi":"10.1016/j.nxnano.2026.100369","DOIUrl":"10.1016/j.nxnano.2026.100369","url":null,"abstract":"<div><div>The complicated nature of the human eye structure makes diagnosing and treating ocular disorders difficult, particularly given the low effectiveness of ocular drug delivery. As nanomaterials continue to advance, numerous ocular nano-drug delivery systems like liposome, nanofibers, nano emulsions with their extended drug delivery, long-term controlled release, and targeted administration have been done to address shortcomings in standard ophthalmology diagnosis and therapy. These unique nanomaterials, which have numerous properties, are intended to give controllability, accuracy, and individualization when treating eye problems. Nanotechnology has advanced significantly, resulting in the production of nanometer-sized items as medical implants or gadgets. Many of these nanodevices have lately been tested in various cancer diagnostic and therapeutic applications, including leukemia, melanoma, breast tumors, prostate tumors, and brain cancer. Despite the growing importance of nanotechnology in cancer, the potential of these nanodevices for identifying and treating ophthalmic tumors has not been thoroughly investigated. This review highlights key advancements and potential future directions in the application of nanotechnology for the treatment and diagnosis of ocular cancer, emphasizing novel approaches and emerging trends.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100369"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146038083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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