Next Nanotechnology最新文献

{"title":"Impact of bridging the gap between Artificial Intelligence and nanomedicine in healthcare","authors":"Divyam Mishra ,&nbsp;Bhavishya Chaturvedi ,&nbsp;Vishal Soni ,&nbsp;Dhairya Valecha ,&nbsp;Megha Goel ,&nbsp;Jamilur R. Ansari","doi":"10.1016/j.nxnano.2025.100203","DOIUrl":"10.1016/j.nxnano.2025.100203","url":null,"abstract":"<div><div>Nanotechnology encompasses the engineering and manipulation of materials at the nanoscale (10⁻⁹ m), focusing on the development and application of novel structures and concepts. Concurrently, Artificial Intelligence (AI) simulates human cognitive processes, enabling machines to make decisions and solve problems. Within AI, subfields such as Machine Learning and Deep Learning leverage vast datasets to predict outcomes based on historical trends. This research examines the intersection of AI and nanotechnology within the medical sector, with an emphasis on illness localization, diagnosis, and therapeutic interventions. AI's deployment in molecular imaging has proven invaluable for early disease detection and treatment via biosensors. A key aspect of our analysis is the utilization of AI to formulate personalized treatment plans, enhancing the probability of achieving optimal drug-patient synergy. Additionally, we explore the development of AI-powered nanobots, capable of autonomous logical reasoning to target malignant cells for localized cancer therapy. The optimization of AI-driven drug delivery systems using nanoparticles demonstrates significant potential for surpassing the efficacy of existing delivery mechanisms. We will also assess the long-term implications of lipid nanoparticles in drug delivery applications. Machine Learning algorithms are employed to create data-driven adaptive nanomaterials and paradigms, further advancing the field. Furthermore, this study investigates the application of AI in predicting nanomedicine interactions with biological systems, aiming to establish AI-enabled platforms for personalized nanomedicine therapies. In summary, our work highlights the synergistic potential of AI and nanotechnology in catalyzing breakthroughs in medical innovation.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"8 ","pages":"Article 100203"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced approaches in lung cancer therapy–Exploring the unique role of Multiwalled Carbon Nanotubes","authors":"Pushpendra Kumar Khangar ,&nbsp;Vivek Daniel","doi":"10.1016/j.nxnano.2025.100180","DOIUrl":"10.1016/j.nxnano.2025.100180","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Hypothesis&lt;/h3&gt;&lt;div&gt;This paper hypothesizes that Multiwalled Carbon Nanotubes (MWCNTs) can serve as effective nanocarriers for anticancer drug delivery in lung cancer therapy. Their high surface area, biocompatibility, and adaptable surface chemistry make them promising candidates for enhancing drug delivery efficiency. MWCNTs offer the potential to enable targeted transport of anticancer drugs directly to lung cancer cells, reducing systemic toxicity through controlled and prolonged drug release while also improving drug clearance mechanisms. However, despite these advantages, the study acknowledges significant concerns regarding toxicity, biocompatibility, and long-term safety. Addressing these challenges is crucial for the successful clinical translation of MWCNT-based drug delivery systems.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Experiments (review-based analysis)&lt;/h3&gt;&lt;div&gt;Although this study does not conduct direct experiments, it reviews existing research and experimental findings on the incorporation of anticancer drugs into Multiwalled Carbon Nanotubes (MWCNTs), which involves efficient loading and release methods that ensure drug stability and retention within the nanocarrier system. These approaches enhance the controlled delivery of therapeutic agents, preventing premature degradation and maximizing efficacy. MWCNTs play a crucial role in drug delivery by improving circulation, enabling controlled release, and minimizing systemic toxicity. Additionally, surface modifications of MWCNTs contribute to better drug delivery efficiency by enhancing solubility and targeting capabilities. However, concerns regarding safety and biocompatibility remain critical. Preclinical studies have been conducted to evaluate the toxicity, biodegradability, and inflammatory response associated with MWCNTs. Surface modifications have been explored as a strategy to mitigate adverse effects, improve cellular compatibility, and enhance the overall feasibility of MWCNT-based drug delivery systems for lung cancer therapy.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Findings&lt;/h3&gt;&lt;div&gt;MWCNT-based drug delivery demonstrates significant potential in improving lung cancer treatment by enabling targeted drug transport to cancer cells, thereby enhancing therapeutic efficacy. The controlled release of drugs from MWCNTs helps minimize systemic toxicity, ultimately improving patient safety and treatment outcomes. However, several challenges and limitations must be addressed before clinical implementation. Toxicity remains a primary concern, as MWCNTs may trigger inflammatory responses or accumulate in tissues, leading to potential long-term adverse effects. Additionally, the biocompatibility and overall safety of these nanocarriers require further validation through rigorous preclinical testing. Looking ahead, extensive research is essential to develop clinically viable MWCNT-based drug delivery systems. Further advancements in surface modifications and biodegradability enhancements are necessary to reduce ","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100180"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144170339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effects of Bi-metal oxide–graphene oxide nanocomposites in photodegradation applications","authors":"Govindarajalu Kishore ,&nbsp;Periyasamy Pritha ,&nbsp;S. Xavier ,&nbsp;D. Bhakiaraj ,&nbsp;Francisxavier Paularokiadoss ,&nbsp;Christian A. Celaya ,&nbsp;Mohammad Mansoob Khan","doi":"10.1016/j.nxnano.2025.100208","DOIUrl":"10.1016/j.nxnano.2025.100208","url":null,"abstract":"<div><div>The present study focuses on synthesizing two graphene-based composites, GO/CaO and GO/BaO, for photodegradation applications towards the methylene blue dye. The polycrystalline nature of the composites was determined by the XRD analysis with an average crystalline size of 14.9 nm. Raman analysis and FT-IR spectral analysis were used to determine the interaction between GO and the metal oxides. The optical band gap was evaluated to be 3.2 eV and 4.2 eV, with an absorbance λ_max of around 242 nm. The PL analysis confirms the electron mobility within the composites with an emission peak of 694 nm. The elemental composition and chemical state of the composites were evaluated using XPS analysis, providing valid results for the C1s peak at 284 eV, which corresponds to the C-C and C<img>C bonds. The photocatalytic degradation of the dye molecule was investigated by utilizing natural sunlight as the irradiation source to assess the practical applicability of the synthesized composites. The maximum degradation percentage achieved by the GO/CaO was 90 % with a period of 120 min under natural sunlight, showing a promising catalyst with a cost-effective and environmentally friendly composite for real-world wastewater treatment.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"8 ","pages":"Article 100208"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colocasia esculenta leaf extracted cobalt oxide nanoparticles: A comprehensive investigation of the microstructural, morphological, antibacterial, and photocatalytic activity","authors":"Md. Estabrak Ahammod Sakib ,&nbsp;Md. Lael Hasan ,&nbsp;Hridoy Roy ,&nbsp;Md. Mahfujul Hasan ,&nbsp;Md. Mintu Ali","doi":"10.1016/j.nxnano.2025.100215","DOIUrl":"10.1016/j.nxnano.2025.100215","url":null,"abstract":"<div><div>This research was carried out to explore the biosynthesized cobalt oxide nanoparticles (Co₃O₄ NPs) for biomedical and environmental applications by using <em>Colocasia esculenta</em> (Taro) leaf extract. Herein, the synthesized nanoparticles were then characterized through several analytical techniques, such as x-ray diffraction (XRD), scanning electron microscopy (SEM), fourier transform infrared spectroscopy (FTIR), energy dispersive spectroscopy (EDS), and uv–visible spectroscopy. The crystallographic nature of prepared cobalt oxide NPs was largely confirmed by XRD analysis, with an average crystallite size of 18.233918 nm. Later, the SEM micrograph revealed spherical shape nanoparticles (22.26654 nm ± 0.17983 nm) dispersed throughout the surface area. EDS ensured the presence of existing elements in the composition. The absorbance peak at 212.5 nm and the energy band gap of 5.46 eV were noted by the uv–visible analysis, The antibacterial activity of the prepared NPs was evaluated against gram-positive (<em>Staphylococcus aureus, Bacillus subtilis</em>) and gram-negative (<em>Pseudomonas aeruginosa, E. coli</em>) bacteria, which demolished the bacterial cell by increasing the zone of inhibition area. Besides, the photocatalytic activity of <span><math><mrow><msub><mrow><mi>Co</mi></mrow><mrow><mn>3</mn></mrow></msub><msub><mrow><mi>O</mi></mrow><mrow><mn>4</mn></mrow></msub></mrow></math></span> NPs for an organic dye (Methylene Blue) degradation reached 86.40 % within 90 min, which may be recommended to mitigate related industrial contamination problems. This exploration also suggested that synthesized Co₃O₄ could be a promising material for photocatalytic dye degradation.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"8 ","pages":"Article 100215"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144632315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano-coolants for thermal enhancement in heat exchangers: A review of prospects, challenges and applications","authors":"E.T. Bello ,&nbsp;A. Nasir ,&nbsp;A.S. Abdulkareem ,&nbsp;M.M. Muhammadu ,&nbsp;N.A. Musa ,&nbsp;J.O. Tijani ,&nbsp;Samson Oluwaseyi Bada","doi":"10.1016/j.nxnano.2025.100214","DOIUrl":"10.1016/j.nxnano.2025.100214","url":null,"abstract":"<div><div>The demand for efficient thermal systems has driven significant interest in nano-coolants due to their superior thermal properties as alternatives to traditional coolants like water, ethylene glycol (EG), synthetic oils (polyalphaolefins), and refrigerants (R134a, R410A). These coolants face operational and environmental challenges, including low heat transfer capacity, corrosion, toxicity and ecological effects that limit their efficiency under ideal conditions because of their poor thermophysical properties, which hinder their deployment. This review provides a comprehensive analysis of the prospects, challenges and applications of nano-coolants in various heat exchanger systems. Nanoparticles such as Al₂O_3, ZnO, Fe₃O_4, SiO₂ and CNTs are evaluated for their ability to enhance thermal conductivity, stability and heat transfer performance, with key factors influencing thermal enhancement, including size, shape, concentration and preparation methods, being critically examined. The study highlights applications across different heat exchanger configurations, including shell and tube, plate, double pipe, microchannel and spiral heat exchangers, which are evaluated through experimental and numerical results. Performance metrics such as Nusselt number, Reynolds number, heat transfer coefficient and overall heat transfer coefficient are discussed. In addition, the review addresses technical challenges, including agglomeration sedimentation, toxicity, increased viscosity and environmental impact, hindering widespread adoption. Furthermore, it outlines emerging prospects, including life cycle assessment, integration with renewablelar energy and the use of artificial intelligence and machine learning for predictive modeling and optimization, offering sustainable pathways for deployment and system miniaturization. The review demonstrates that, despite challenges, nano-coolants can effectively and efficiently enhance thermal exchange, impacting heat exchanger designs across various industries.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"8 ","pages":"Article 100214"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144633505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of Ag@AuNPs embedded h-BN Langmuir-Blodgett film as SERS active platform for trace detection of fungicide in solution and in grape skin","authors":"Chayan Kumar Mitra,&nbsp;Joydeep Chowdhury","doi":"10.1016/j.nxnano.2025.100153","DOIUrl":"10.1016/j.nxnano.2025.100153","url":null,"abstract":"<div><div>The work explicitly focuses on fabrication of Langmuir-Blodgett (LB) films of hexagonal Boron Nitride (h-BN) with infused gold-core silver-shell nano particles (Ag@Au nano particles) as an efficient noble Surface enhanced Raman Scattering (SERS) active hetero-architecture. The “hot spots” generated over the h-BN network work as an effective contributor for localization of electromagnetic field shows high enhancement in Raman Signals. The LB film and the as prepared substrate were meticulously characterized in this current work. The efficacy and reproducibility of Ag@Au-hBN nano-plate substrate as a SERS detection sensor was investigated up to ultrasensitive concentrations using Raman probe molecules. The as prepared SERS substrate was also engaged for detection of fungicide Thiabendazole at trace concentrations. The tests to check on shelf life was also performed. In the contemporary study the as fabricated SERS sensing platform elicits its precision and effectiveness as a potent next generation one-click SERS sensing chip in detecting fungicide. Thus, in future this substrate can be a novel SERS scaffold for ultrasensitive detections of chemical and bio-chemical composites.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"8 ","pages":"Article 100153"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing magnetic and electrochemical properties of cobalt modified ZnS nanoparticles: A facile synthesis approach","authors":"Pawan Kumar Pathak ,&nbsp;Devendra Kumar ,&nbsp;Santosh J. Uke ,&nbsp;Amit Kumar Singh ,&nbsp;Manika Chaudhary ,&nbsp;Neha V. Brahmankar ,&nbsp;Subodh Kumar Sharma ,&nbsp;Beer Pal Singh ,&nbsp;Ashwani Kumar","doi":"10.1016/j.nxnano.2025.100133","DOIUrl":"10.1016/j.nxnano.2025.100133","url":null,"abstract":"<div><div>In this investigation, we effectively fabricated zinc sulphide (ZnS) nanoparticles doped with cobalt (Co) using the facial synthesis method at different concentrations (3 %, 6 %, and 9 %). The Co doping-dependent structural, morphological, magnetic, optical, and electrochemical properties of the ZnS nanostructures were systematically explored. The analysis of magnetic properties revealed that the ferromagnetic ZnS nanoparticles exhibited superparamagnetic behaviour, showing an increased magnetization with higher Co doping content. Electrochemical assessments of the electrodes were conducted in 1 mol L⁻¹ Na₂SO₄ liquid electrolyte. The 3 % Co doped ZnS variant, which demonstrated the highest energy density (14.27 Whkg⁻¹) at 10 mAcm⁻² and capacity retention (94.76 %) after 2000 cycles at 50 mAcm⁻². Further, a trend of a decrease in specific capacitances and energy density with an increase in Co doping is observed. This outcome implies that optimal levels of Co doping can enhance the electrochemical and magnetic performances of ZnS nanoparticles, underscoring their potential for applications in energy storage.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100133"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143146339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced electrochemical properties of NiS@CeO2 spherical nanoflakes","authors":"Indumati D. Yadav ,&nbsp;Dineshkumar Yadav ,&nbsp;Aleem Ansari ,&nbsp;Shyamalava Mazumdar ,&nbsp;Shivram S. Garje","doi":"10.1016/j.nxnano.2024.100126","DOIUrl":"10.1016/j.nxnano.2024.100126","url":null,"abstract":"<div><div>Herein we report synthesis of bare cerium oxide nanoparticles from cerium hydroxide and NiS@CeO₂ nanocomposite (NC) from nickel cinnamaldehyde thiosemicarbazone complex (single source molecular precursor) and CeO₂ nanoparticles by solvothermal method using ethylene glycol as a capping agent. These materials were characterized using powder X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, high resolution transmission electron microscopy and energy dispersive X-ray techniques. The crystallite size of the composite nanoparticles calculated using XRD is 17.99 nm. TEM shows spherical shape morphology of NiS@CeO₂ nanocomposite with average particle size less than 10 nm. Electrochemical properties of bare CeO₂ and NiS@CeO₂ NC electrodes were evaluated by cyclic voltammetry, galvanostatic charge/discharge and electrochemical impedance spectroscopy. The electrochemical measurements show that the capacitance value of NiS@CeO₂ NC electrode is significantly higher (707.84 F g⁻¹) compared to bare CeO₂ electrode (80.91 F g⁻¹) at current density 1 A g⁻¹. This can be attributed to synergistic effect in nanocomposite. The cycle stability of NiS@CeO₂ NC electrode was found to be 98.41 % even after 6000 charge–discharge cycles at 2 A g⁻¹ current density.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100126"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143146406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomaterials-based Field Effect Transistor biosensor for cancer therapy","authors":"Silpa Sasikumar ,&nbsp;Kishore Sivaram ,&nbsp;N. Sreejisha ,&nbsp;Selvakumar Murugesan","doi":"10.1016/j.nxnano.2025.100170","DOIUrl":"10.1016/j.nxnano.2025.100170","url":null,"abstract":"<div><div>Biosensors made of nanomaterials play a prominent part in diagnostic applications in the biomedical domain. The peculiar characteristics of nanomaterials including quantum effects, self-assembly, and larger surface area make them an irresistible choice for biomedical applications. Cancer is one of the life-threatening diseases across the world and the second leading cause of death. Early diagnosing has its advantages, such as treating the cancer in the primary stage helps in the faster recovery of patients. Many enzymatic/protein assays and biosensors have been developed for early-stage cancer diagnosis. Despite many types of biosensors available for biosensing applications, Field Effect Transistor biosensors (FET) prove to be an excellent choice due to their minimalistic size, high versatility, low noise, and high reliability for detecting a life-threatening disease cancer. FETs made of nanomaterials can provide sensitive, specific, and precise detection of cancer biomarkers, assisting cancer diagnosis in its early stages. Certain significant factors like selectivity, anti-interference, sensitivity, reproducibility, reusability, disposability, economic viability, large-scale production, and operational conditions determine the efficiency of the FET biosensor in diagnosing cancers. Many works are being carried out to meet the above demands for FET-based biosensors. Various nanomaterials are employed to fabricate the FET, and their performances are so incredible. This review provides insight into various nanotechnology-based FET biosensors such as Graphene Carbon Dots-based FET, Carbon nanotubes (CNT)-based FET, Silicon nanowire-based FET, Polycrystalline Si nanowire-based FET, Graphene Oxide-based FET, Indium Selenide (InSe)-based FET, Molybdenum disulfide (MoS₂)-based FET, Zinc oxide (ZnO)-based FET, Tungsten diselenide (WSe₂)-based FET, MXene-based FET, and nanocomposites-based FET. Subsequently, their applications in early cancer diagnosis are also comprehensively discussed including their various fabrication approaches for binding different bioreceptors such as enzymes, cells, aptamers, deoxyribonucleic acid (DNA) and antibodies followed by targeting the specific analyte of cancer cells.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"8 ","pages":"Article 100170"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In situ template synthesized silver nanoparticulate banana fibre materials with antimicrobial and antibiotic release properties: Efficacy evaluation in ex vivo wound infection model","authors":"Pompi Das ,&nbsp;Debajit Mahanta ,&nbsp;Sharmila Giogi ,&nbsp;Tarh Kaha ,&nbsp;Ngurang Nisha ,&nbsp;Sanjeeb Kalita","doi":"10.1016/j.nxnano.2025.100134","DOIUrl":"10.1016/j.nxnano.2025.100134","url":null,"abstract":"<div><div>This study reports the <em>in-situ</em> template synthesis of silver nanoparticles (SNPs) within banana fibres (BF), non-woven sheets (BFS), and microparticles (BFM), yielding multifunctional biocomposites with broad-spectrum antimicrobial properties and controlled antibiotic release capabilities. The prepared SNPs exhibited a uniform size distribution with an average diameter of 12.6 ± 2.4 nm, confirmed through field emission scanning electron microscopy (FESEM) and energy-dispersive X-ray spectroscopy (EDX). Attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) analysis indicated strong interactions between the banana fibre matrix and SNPs, with characteristic peaks at 1384 and 1612 cm⁻¹ corresponding to the Ag-O bonds. Thermogravimetric analysis (TGA) revealed enhanced thermal stability, with BFS-SNP showing a 25 % improvement in decomposition onset temperature compared to pristine BFS. Mechanical testing demonstrated improved tensile strength in SNP-modified sheets (21.5 ± 0.8 MPa) compared to untreated sheets (16.8 ± 0.7 MPa), highlighting the reinforcement effect of SNP integration. The biocomposites exhibited potent antibacterial activity against <em>Escherichia coli</em>, <em>Staphylococcus aureus</em>, and methicillin-resistant <em>Staphylococcus aureus</em> (MRSA), with inhibition zones ranging from 18.5 ± 1.2 mm to 22.3 ± 1.1 mm. Controlled release studies of amoxicillin-loaded composites demonstrated sustained drug release over 72 hours, achieving a cumulative release of 81.6 % in BFS-SNP-AMOX. Cytotoxicity assessment on L929 fibroblasts confirmed the biocompatibility of the composites, with cell viabilities exceeding 90 %. These findings establish BF-SNP, BFS-SNP, and BFM-SNP as promising candidates for antimicrobial wound care applications and controlled drug delivery systems, offering a sustainable, bioresource-based solution for advanced biomedical materials.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100134"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}