Next Nanotechnology最新文献

{"title":"Transforming polyethylene terephthalate (PET) into carbon-based nanomaterials: Advancing sustainable solutions for green energy and environmental remediation","authors":"Suvarshitha Pusuluru ,&nbsp;Sai Kumar Punna ,&nbsp;Karrun Velmurugan ,&nbsp;Melvin S. Samuel ,&nbsp;Selvarajan Ethiraj ,&nbsp;Needhidasan Santhanam","doi":"10.1016/j.nxnano.2025.100341","DOIUrl":"10.1016/j.nxnano.2025.100341","url":null,"abstract":"<div><div>Polyethylene terephthalate (PET), a widely used polymer in transparent bottles for water, sanitizers, and other liquids, has seen a surge in consumption, particularly during the COVID-19 pandemic. This increase has resulted in a significant rise in PET-based waste, posing serious environmental and waste management challenges. PET waste, with approximately 11 % fixed carbon, low ash, and 30 % oxygen content, presents a promising raw material for the synthesis of activated carbon and other nanoporous carbon materials. However, conventional methods for converting PET into carbonaceous sorbents often yield limited output and face competition from other recycling pathways, rendering large-scale application impractical. This review critically examines both traditional and emerging techniques for activating PET, comparing its suitability and performance with other polymeric wastes, such as scrap tires. The broader context of plastic waste management is discussed, highlighting its non-biodegradable nature, toxic byproduct release, and impact on ecosystems and human health. Innovative approaches such as recycling and upcycling plastic into carbon-based nanomaterials (CBMs)—including carbon quantum dots, nanoparticles, nanotubes, graphene, and 3D porous carbons—are explored as sustainable alternatives. These plastic waste-derived carbon materials (PWCMs) offer high-value applications in clean energy storage, environmental remediation, and green technologies. The review also identifies eco-friendly production methods, aiming to bridge the gap between academic research and industrial practices. In addressing global energy demands and environmental degradation, PWCMs are positioned as key players in the transition to a circular economy and the development of renewable energy solutions. By consolidating recent advancements and outlining future research directions, this study underscores the potential of PET and other plastic wastes to serve as sustainable feedstocks for high-performance materials, encouraging innovative recycling strategies and contributing to the global effort against plastic pollution.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100341"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomedical and insecticidal efficacy of green synthesized nanoparticles from underexplored Tanzanian medicinal plants: A comparative study using Pueraria montana, Vernonia amygdalina, and Tephrosia vogelii","authors":"Sylvanus Bisaba Ruvubu ,&nbsp;Indrajit Roy","doi":"10.1016/j.nxnano.2025.100323","DOIUrl":"10.1016/j.nxnano.2025.100323","url":null,"abstract":"&lt;div&gt;&lt;div&gt;This study explores the biomedical and insecticidal potential of green-synthesized nanoparticles (NPs) from &lt;em&gt;Pueraria montana&lt;/em&gt; roots, &lt;em&gt;Vernonia amygdalina&lt;/em&gt;, and &lt;em&gt;Tephrosia vogelii&lt;/em&gt; leaves. Antibacterial activity of ZnO, CuO, AgNPs, and NiO–CuO nanocomposites was tested against &lt;em&gt;S. aureus&lt;/em&gt;, &lt;em&gt;S. pyogenes&lt;/em&gt;, and &lt;em&gt;E. coli&lt;/em&gt;. The nanoparticles (ROS) generation, disruption of the cell membrane, release of metal ions, and synergistic effects of phytochemical capping agents. The AgNPs showed the strongest activity against gram-positive strains, while ZnO was more effective against &lt;em&gt;E. coli.&lt;/em&gt; CuO and AgNPs outperformed ZnO due to smaller size and higher reactivity. At 50 µg/disc, most of these NPs achieved over 70 % of standard antibiotic efficacy. Insecticidal testing against &lt;em&gt;Periplaneta americana&lt;/em&gt; showed that &lt;em&gt;T. vogelii&lt;/em&gt; derived ZnO NPs caused 33.3 % mortality in 20 min at 50 ppm and over 99 % at 100–200 ppm in 2–6 h. Based on MIC assays conducted using standard broth microdilution methods, AgNPs exhibited the lowest inhibitory concentrations (12.5 ± 0.5 µg/ml) against &lt;em&gt;S. aureus&lt;/em&gt; and &lt;em&gt;S. pyogenes&lt;/em&gt;, demonstrating stronger antibacterial potency than CuO, ZnO, and NiO–CuO nanoparticles. In contrast, ZnO nanocomposites showed the greatest efficacy against &lt;em&gt;E. coli&lt;/em&gt; (MIC value of 14.2 ± 1.4 µg/ml), highlighting differential activity of the green-synthesized nanoparticles depending on bacterial type. These quantitative results provide robust experimental support for the comparative efficacy, linking nanoparticle physicochemical properties, ion release, ROS generation, and phytochemical capping to observed antibacterial performance and thus indicating AgNPs’ superior activity against Gram-positive bacteria. Statistical analysis confirmed significant effects of these plant-based nanoparticles’ type, dose, and exposure. Characterization with UV–Vis, FTIR, SEM, and XRD confirmed desirable physicochemical properties and strong bioactivity. The two-way ANOVA for corrected mortality in (%) showed that both time and treatment type had statistically significant effect (p &lt; 0.05) on insecticidal efficacy (Corrected Mortality). Insecticidal activity was found not only depended on what is applied and nature of treatment such as NPs type, but also how long it has been applied and the dosage or concentration used. Therefore, both formulation type and exposure duration were critical for insect control strategies. The Tukey’s Honestly Significant Difference (HSD) as a post hoc (analysis after ANOVA test) showed that &lt;em&gt;Tephrosia vogelii&lt;/em&gt; was significantly more effective than both &lt;em&gt;Puéraria montana&lt;/em&gt; (p = 0.001) and &lt;em&gt;Vernonia amygdalina&lt;/em&gt; (p = 0.001) in causing insect mortality. Additionally, there was no significant difference between &lt;em&gt;Puéraria montana&lt;/em&gt; and &lt;em&gt;Vernonia amygdalina&lt;/em&gt; (p = 0.368), suggesting comparable efficacy between them since ANOVA f","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100323"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study on the mechanical and durability performance of concrete incorporating nanomaterials","authors":"Suresh Kumar Verma ,&nbsp;Md Daniyal ,&nbsp;Dulal Goldar","doi":"10.1016/j.nxnano.2025.100361","DOIUrl":"10.1016/j.nxnano.2025.100361","url":null,"abstract":"<div><div>This study investigated the influence of nano-SiO₂, nano-Al₂O₃, and nano-CaCO₃ on the workability, strength, and durability of cementitious composites at 1 %, 3 %, and 5 % replacement levels of OPC. The slump test results showed a steady decline in workability with increasing nanoparticle content due to their ultrafine size and large surface area, which raised water demand. Among the additives, nano-SiO₂ produced the greatest reduction in slump, while nano-CaCO₃ had the least effect. Compressive strength improved in all nano-modified mixes, with the highest enhancement at 3 % replacement viz. 26.3 % for nano-SiO₂, 24.6 % for nano-Al₂O₃, and 12.3 % for nano-CaCO₃ compared with the control. After 360 days of exposure to tap, saline, and acidic media, the nano-modified concretes exhibited superior strength retention and durability. Electrical resistivity tests confirmed higher resistivity for all nano-concretes, particularly for the 3 % nano-SiO₂ mix (NS3), indicating a denser and less permeable structure. Electrochemical analysis revealed that NS3 had the lowest corrosion rate and current density, providing maximum protection to steel reinforcement. Microstructural observations demonstrated denser microstructures, reduced porosity, and increased calcium silicate hydrate (C–S–H) gel formation in nano-modified mixes, particularly NS3. These findings establish the potential of nano-engineered concretes in enhancing mechanical performance and durability for infrastructure exposed to aggressive environments.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100361"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eco-friendly synthesis of Ag/ZnO nanocomposite using Coleus amboinicus: Structural characterization and evaluation of antibacterial and anticancer activities","authors":"Muthuvel Surya ,&nbsp;Yugal Kishore Mohanta ,&nbsp;Zuhair M. Mohammedsaleh ,&nbsp;Muthupandi Sankar ,&nbsp;Chellasamy Panneerselvam ,&nbsp;Vincent Savariar ,&nbsp;Muthupandian Saravanan","doi":"10.1016/j.nxnano.2025.100334","DOIUrl":"10.1016/j.nxnano.2025.100334","url":null,"abstract":"<div><div>The pursuit of eco-friendly nanomaterials with both antibacterial and anticancer properties is gaining momentum in biomedical research. This study reports the green synthesis of Silver and Zinc oxide (Ag/ZnO) nanocomposite using <em>Coleus amboinicus</em> leaf extract as a natural reducing and stabilizing agent. Characterization via UV–Vis spectroscopy revealed absorption peaks at approximately 280 nm and 370 nm, indicative of Ag and ZnO nanoparticles, respectively. FTIR analysis identified phytochemical-derived functional groups responsible for particle stabilization, while SEM imaging showed agglomerated nanoparticles with diameters ranging from 100 to 150 nm. XRD analysis confirmed the crystalline nature of the nanocomposites. The biosynthesized Ag/ZnO nanocomposite exhibited potent antibacterial activity against multidrug-resistant strains including <em>Enterococcus faecalis</em>, <em>Pseudomonas aeruginosa</em>, MRSA, and <em>Klebsiella pneumoniae</em>, with significant zones of inhibition observed at a concentration of 80 μg/mL. Furthermore, the nanocomposite displayed promising anticancer activity against A549 lung cancer cells, achieving an IC₅₀ of 60 μg/mL after 24 h, as determined by MTT assay. Morphological features of apoptosis, such as membrane blebbing and nuclear condensation, were observed, while AO/EtBr, DCFDA, and Rhodamine 123 staining confirmed elevated reactive oxygen species (ROS) generation and disruption of mitochondrial membrane potential. These findings suggest a ROS mediated mechanism underlying the dual antibacterial and anticancer activities of the Ag/ZnO nanocomposite. This green synthesis approach provides a sustainable strategy for developing multifunctional nanomaterials, although further in vivo studies are required to confirm efficacy and elucidate the molecular mechanisms involved for future therapeutic applications.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100334"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoparticles in ocular cancer: Diagnosis and treatment","authors":"Sailee Chowdhury ,&nbsp;Koyel Kar ,&nbsp;Priyanka Chakraborty ,&nbsp;Rana Mazumder ,&nbsp;Bhupendra G. Prajapati","doi":"10.1016/j.nxnano.2026.100369","DOIUrl":"10.1016/j.nxnano.2026.100369","url":null,"abstract":"<div><div>The complicated nature of the human eye structure makes diagnosing and treating ocular disorders difficult, particularly given the low effectiveness of ocular drug delivery. As nanomaterials continue to advance, numerous ocular nano-drug delivery systems like liposome, nanofibers, nano emulsions with their extended drug delivery, long-term controlled release, and targeted administration have been done to address shortcomings in standard ophthalmology diagnosis and therapy. These unique nanomaterials, which have numerous properties, are intended to give controllability, accuracy, and individualization when treating eye problems. Nanotechnology has advanced significantly, resulting in the production of nanometer-sized items as medical implants or gadgets. Many of these nanodevices have lately been tested in various cancer diagnostic and therapeutic applications, including leukemia, melanoma, breast tumors, prostate tumors, and brain cancer. Despite the growing importance of nanotechnology in cancer, the potential of these nanodevices for identifying and treating ophthalmic tumors has not been thoroughly investigated. This review highlights key advancements and potential future directions in the application of nanotechnology for the treatment and diagnosis of ocular cancer, emphasizing novel approaches and emerging trends.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100369"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146038083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in nanostructured drug delivery systems: Innovations in targeted therapy and multifunctional nanomaterials","authors":"Pavithran Kumar ,&nbsp;Pasiyappazham Ramasamy ,&nbsp;Manjunathan Jagadeesan","doi":"10.1016/j.nxnano.2026.100381","DOIUrl":"10.1016/j.nxnano.2026.100381","url":null,"abstract":"<div><div>Recent advancements in nanotechnology have highlighted the potential of nanoparticles in medical applications. This is especially true for targeted drug delivery systems. Nanoparticles offer unique characteristics, such as stable ligand interactions, varied sizes and shapes, and high carrier capacities. These features make them ideal for carrying both hydrophilic and hydrophobic substances in disease therapy. Novel therapeutic nanostructures have shown promise in targeted drug delivery. They offer superior carrier capacity, specific targeting, and low toxicity. These advancements have led to significant improvements in stability and absorption efficiency. They also enhance the ability to reach cellular and intracellular targets with greater effectiveness. However, there are complex issues regarding toxicity, safety, and production scale of nanoparticles. Resolving these problems could lead to clinical treatments based on laboratory successes. The next generation of medication delivery systems could benefit from personalized therapeutic techniques combined with smart nanomaterials. The main aim of this review is to explore recent developments in the design, synthesis, and optimization of therapeutic nanoparticles. This includes understanding their size, shape, and multifunctional properties to enhance the effectiveness of drug delivery. This review covers various methods for designing and characterizing nanoparticles. It focuses on optimizing nanostructures for enhanced drug delivery. The synthesis techniques, analysis methods, and potential modifications of nanoparticle characterization are discussed. Properly synthesized and optimized therapeutic nanoparticles represent a significant breakthrough in the field of drug delivery systems. Their ability to overcome the limitations of traditional therapies holds promise for future medical applications. Further research into their characterization and development will enhance clinical relevance and ensure safe, effective use in therapeutic settings.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100381"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146188010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biocompatible and ecofriendly selenium nanoparticles in diabetes and wound healing","authors":"Kainat Mirza ,&nbsp;Laiba Hasan ,&nbsp;Mehak Pracha ,&nbsp;Tanveer Ahmad ,&nbsp;Meryam Sardar","doi":"10.1016/j.nxnano.2026.100366","DOIUrl":"10.1016/j.nxnano.2026.100366","url":null,"abstract":"<div><div>The present study reports the synthesis of Selenium nanoparticles (Se-NPs) through an eco-friendly method using guava leaf extract for their application in diabetes and wound healing. The synthesized nanoparticles were characterized by UV-Vis spectroscopy, Transmission electron microscopy, and Dynamic light scattering. TEM revealed the spherical morphology of Se-NPs and a size range of 2–5 nm. The Se-NPs inhibit carbohydrate digestive enzymes (alpha-amylase and glucosidase), which are key in managing intestinal glucose absorption. These Se-NPs exhibit IC50 values of 15 µg mL⁻¹ for α-amylase and 21 µg mL⁻¹ for α-glucosidase. These nanoparticles effectively adsorb glucose, and adsorption increases with an increase in glucose concentration. 10 mg mL⁻¹ of nanoparticles can adsorb as low as 5 mmol of glucose. The study also explored Se-NPs' ability to enhance glucose uptake by human RBCs (hRBCs), akin to insulin mechanisms. At a concentration of 20 µg mL⁻¹ of both Se-NPs and acarbose, glucose uptake by hRBCs is 83 %, which is higher than that of the standard drug acarbose (62 %). Additionally, cytotoxicity assays on human keratinocyte cells (HaCaT) demonstrated that Se-NPs have an IC50 value of 25 µg mL^−1, which shows much lower toxicity compared to sodium selenite salt (3.6 µg mL⁻¹). Further, the biocompatibility of Se-NPs was studied by measuring mitochondrial ROS, membrane potential, and cellular proliferation. In vitro wound healing assays indicated that at 15 µg mL⁻¹ of Se-NPs, around 100 % of wound closure was achieved after 15 h, whereas the control without nanoparticles showed only 37 % wound closure. Overall, this research underscores the multifaceted biomedical applications of Se-NPs synthesized via guava leaf extract, suggesting promising avenues for future therapeutic development.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100366"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonic investigation of PEG–Ethanol–Epoxy–TiO₂ nanocomposite: Insights into coating suitability via thermoacoustic parameters","authors":"Niharika Das ,&nbsp;Subhraraj Panda ,&nbsp;Manoj Kumar Praharaj","doi":"10.1016/j.nxnano.2026.100373","DOIUrl":"10.1016/j.nxnano.2026.100373","url":null,"abstract":"<div><div>This study employs ultrasonic techniques within the temperature range of 298–328 K to examine the molecular interactions and structural dynamics of a novel PEG–ethanol–epoxy–TiO₂ nanocomposite system, which consists of 5 % (w/w) PEG-6000, 10 % (w/w) epoxy resin, and 2 % (w/w) TiO₂ nanoparticles. Thermoacoustic parameters, including free volume, available volume, molar volume, internal pressure, Rao’s constant, and Wada constant, were obtained through experimental measurements of ultrasonic velocity, viscosity, and density. The findings indicate that as temperature rises, there is a progressive increase in free volume, available volume, molar volume, Rao’s constant, and Wada constant, while internal pressure decreases. This suggests an enhancement in molecular mobility and a reduction in cohesive forces within the composite matrix. The uniform distribution of TiO₂ nanoparticles greatly enhances structural consistency and acoustic responsiveness, indicating robust interfacial interactions among PEG, ethanol, epoxy, and TiO₂ via hydrogen bonding and dipole–dipole mechanisms. The findings confirm that ultrasonic analysis demonstrates a high sensitivity to molecular rearrangements and thermal behavior in polymer nanocomposites. The optimized PEG–epoxy–TiO₂ formulation demonstrates significant potential for advanced coating applications, including thermally adaptable, UV-resistant, and acoustically responsive materials for biomedical and electronic devices.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100373"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano-hydroxyapatite (n-HAp) and its composites for heavy metal removal from water: A comprehensive review","authors":"Vaishali ,&nbsp;Anjaneyulu Bendi ,&nbsp;Sushma Singh ,&nbsp;Rashmi Pundeer","doi":"10.1016/j.nxnano.2025.100339","DOIUrl":"10.1016/j.nxnano.2025.100339","url":null,"abstract":"<div><div>The removal of heavy metals from wastewater presents a significant environmental challenge because these contaminants can have serious effects on human health and ecosystems. This study assesses the effectiveness of various adsorption materials, focusing particularly on nano-hydroxyapatite (nHAp), known for its biocompatibility, stability, and sorption capacity. nHAp and its composites has been shown in numerous studies to remove toxic heavy metal ions from water. The adsorption process is influenced by key parameters, including temperature and pH, which can affect the performance of the material. This study provides valuable insights (from 2018 to 2024) into the mechanisms and conditions that optimize the removal of heavy metal ions, highlighting the potential of nHAP as a sustainable solution for water treatment.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100339"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking the bioactive potential: ZnO NPs synthesized from Chaetomorpha linum aqueous extract","authors":"Ragul Gunasekaran ,&nbsp;Krupa Jyotsnika ,&nbsp;Kamala Kannan ,&nbsp;Pitchiah Sivaperumal","doi":"10.1016/j.nxnano.2025.100346","DOIUrl":"10.1016/j.nxnano.2025.100346","url":null,"abstract":"<div><div><em>Chaetomorpha linum</em> is a green macroalgae genus known for its unbranched cylindrical cell filaments that are typically found in sea intertidal zones. Phytochemical screening of its crude and aqueous extracts revealed the presence of bioactive compounds such as flavonoids, steroids, tannins, saponins, and alkaloids, with flavonoids and steroids predominantly present in the aqueous extract. These phytochemicals acted as reducing and stabilizing agents for the green synthesis of ZnO NPs. UV–Vis absorption at 309 nm and a bandgap of 3.63 eV confirmed the formation of ZnO NPs. FTIR analysis identified functional groups including carboxylic acids, conjugated alkenes, and sulfones, correlating with the phytochemical constituents. X-ray diffraction revealed the semi-crystalline nature of the synthesized NPs, composed of both crystalline ZnO and amorphous organic matter. SEM analysis revealed that the ZnO NPs were spherical in shape, with diameters ranging from 15 to 35 nm. EDAX revealed the elemental composition of the NPs. DLS analysis showed an average size of 86.2 nm with a polydispersity index of 0.294, and a zeta potential of –28.7 mV indicated good colloidal stability. The antibacterial efficacy of the synthesized ZnO NPs was evaluated against various bacterial strains, demonstrating significant inhibitory zones, with <em>Streptococcus mutans</em> being the most susceptible among the tested strains. Furthermore, a protein denaturation assay revealed that the <em>Chaetomorpha linum</em> extract has dose-dependent anti-inflammatory activities, highlighting its potential for inflammation reduction.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100346"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}