{"title":"原位模板合成具有抗菌和抗生素释放特性的纳米银香蕉纤维材料：体外伤口感染模型的疗效评估","authors":"Pompi Das , Debajit Mahanta , Sharmila Giogi , Tarh Kaha , Ngurang Nisha , Sanjeeb Kalita","doi":"10.1016/j.nxnano.2025.100134","DOIUrl":null,"url":null,"abstract":"<div><div>This study reports the <em>in-situ</em> template synthesis of silver nanoparticles (SNPs) within banana fibres (BF), non-woven sheets (BFS), and microparticles (BFM), yielding multifunctional biocomposites with broad-spectrum antimicrobial properties and controlled antibiotic release capabilities. The prepared SNPs exhibited a uniform size distribution with an average diameter of 12.6 ± 2.4 nm, confirmed through field emission scanning electron microscopy (FESEM) and energy-dispersive X-ray spectroscopy (EDX). Attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) analysis indicated strong interactions between the banana fibre matrix and SNPs, with characteristic peaks at 1384 and 1612 cm⁻¹ corresponding to the Ag-O bonds. Thermogravimetric analysis (TGA) revealed enhanced thermal stability, with BFS-SNP showing a 25 % improvement in decomposition onset temperature compared to pristine BFS. Mechanical testing demonstrated improved tensile strength in SNP-modified sheets (21.5 ± 0.8 MPa) compared to untreated sheets (16.8 ± 0.7 MPa), highlighting the reinforcement effect of SNP integration. The biocomposites exhibited potent antibacterial activity against <em>Escherichia coli</em>, <em>Staphylococcus aureus</em>, and methicillin-resistant <em>Staphylococcus aureus</em> (MRSA), with inhibition zones ranging from 18.5 ± 1.2 mm to 22.3 ± 1.1 mm. Controlled release studies of amoxicillin-loaded composites demonstrated sustained drug release over 72 hours, achieving a cumulative release of 81.6 % in BFS-SNP-AMOX. Cytotoxicity assessment on L929 fibroblasts confirmed the biocompatibility of the composites, with cell viabilities exceeding 90 %. These findings establish BF-SNP, BFS-SNP, and BFM-SNP as promising candidates for antimicrobial wound care applications and controlled drug delivery systems, offering a sustainable, bioresource-based solution for advanced biomedical materials.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100134"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"In situ template synthesized silver nanoparticulate banana fibre materials with antimicrobial and antibiotic release properties: Efficacy evaluation in ex vivo wound infection model\",\"authors\":\"Pompi Das , Debajit Mahanta , Sharmila Giogi , Tarh Kaha , Ngurang Nisha , Sanjeeb Kalita\",\"doi\":\"10.1016/j.nxnano.2025.100134\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>This study reports the <em>in-situ</em> template synthesis of silver nanoparticles (SNPs) within banana fibres (BF), non-woven sheets (BFS), and microparticles (BFM), yielding multifunctional biocomposites with broad-spectrum antimicrobial properties and controlled antibiotic release capabilities. The prepared SNPs exhibited a uniform size distribution with an average diameter of 12.6 ± 2.4 nm, confirmed through field emission scanning electron microscopy (FESEM) and energy-dispersive X-ray spectroscopy (EDX). Attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) analysis indicated strong interactions between the banana fibre matrix and SNPs, with characteristic peaks at 1384 and 1612 cm⁻¹ corresponding to the Ag-O bonds. Thermogravimetric analysis (TGA) revealed enhanced thermal stability, with BFS-SNP showing a 25 % improvement in decomposition onset temperature compared to pristine BFS. Mechanical testing demonstrated improved tensile strength in SNP-modified sheets (21.5 ± 0.8 MPa) compared to untreated sheets (16.8 ± 0.7 MPa), highlighting the reinforcement effect of SNP integration. The biocomposites exhibited potent antibacterial activity against <em>Escherichia coli</em>, <em>Staphylococcus aureus</em>, and methicillin-resistant <em>Staphylococcus aureus</em> (MRSA), with inhibition zones ranging from 18.5 ± 1.2 mm to 22.3 ± 1.1 mm. Controlled release studies of amoxicillin-loaded composites demonstrated sustained drug release over 72 hours, achieving a cumulative release of 81.6 % in BFS-SNP-AMOX. Cytotoxicity assessment on L929 fibroblasts confirmed the biocompatibility of the composites, with cell viabilities exceeding 90 %. These findings establish BF-SNP, BFS-SNP, and BFM-SNP as promising candidates for antimicrobial wound care applications and controlled drug delivery systems, offering a sustainable, bioresource-based solution for advanced biomedical materials.</div></div>\",\"PeriodicalId\":100959,\"journal\":{\"name\":\"Next Nanotechnology\",\"volume\":\"7 \",\"pages\":\"Article 100134\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Next Nanotechnology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2949829525000038\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Next Nanotechnology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2949829525000038","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
In situ template synthesized silver nanoparticulate banana fibre materials with antimicrobial and antibiotic release properties: Efficacy evaluation in ex vivo wound infection model
This study reports the in-situ template synthesis of silver nanoparticles (SNPs) within banana fibres (BF), non-woven sheets (BFS), and microparticles (BFM), yielding multifunctional biocomposites with broad-spectrum antimicrobial properties and controlled antibiotic release capabilities. The prepared SNPs exhibited a uniform size distribution with an average diameter of 12.6 ± 2.4 nm, confirmed through field emission scanning electron microscopy (FESEM) and energy-dispersive X-ray spectroscopy (EDX). Attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) analysis indicated strong interactions between the banana fibre matrix and SNPs, with characteristic peaks at 1384 and 1612 cm⁻¹ corresponding to the Ag-O bonds. Thermogravimetric analysis (TGA) revealed enhanced thermal stability, with BFS-SNP showing a 25 % improvement in decomposition onset temperature compared to pristine BFS. Mechanical testing demonstrated improved tensile strength in SNP-modified sheets (21.5 ± 0.8 MPa) compared to untreated sheets (16.8 ± 0.7 MPa), highlighting the reinforcement effect of SNP integration. The biocomposites exhibited potent antibacterial activity against Escherichia coli, Staphylococcus aureus, and methicillin-resistant Staphylococcus aureus (MRSA), with inhibition zones ranging from 18.5 ± 1.2 mm to 22.3 ± 1.1 mm. Controlled release studies of amoxicillin-loaded composites demonstrated sustained drug release over 72 hours, achieving a cumulative release of 81.6 % in BFS-SNP-AMOX. Cytotoxicity assessment on L929 fibroblasts confirmed the biocompatibility of the composites, with cell viabilities exceeding 90 %. These findings establish BF-SNP, BFS-SNP, and BFM-SNP as promising candidates for antimicrobial wound care applications and controlled drug delivery systems, offering a sustainable, bioresource-based solution for advanced biomedical materials.
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