Next Nanotechnology最新文献

{"title":"An overview on developing the formulation to keep away the food impact on absorption","authors":"Gangadhar B. Magar ,&nbsp;Umesh D. Laddha ,&nbsp;Sachin S. Gaikwad ,&nbsp;Shruti V. Wani ,&nbsp;Neelam L. Dashputre ,&nbsp;Smita P. Kakad","doi":"10.1016/j.nxnano.2025.100186","DOIUrl":"10.1016/j.nxnano.2025.100186","url":null,"abstract":"<div><div>The most preferable route for the delivery of therapeutic molecules is the oral site. However; the physicochemical factors of drug and biological processes significantly affects the absorption of drug. The co-administration of oral formulations along with the meal is a major factor that governs the bioavailability of drugs in comparison to the fasting state by varying the transit time. Presence of food alters the gastric emptying rate, gastric pH, bile flow, hepatic and splanchnic blood flow along with it leads to the physical interaction with drug which creates trouble in rate and extent of absorption. One needs to consider the possible food-drug interaction while deciding the dose and type of formulation. The presence of food can dramatically change the effect of a drug, with both possibilities being either a less therapeutic effect than expected due to a lower absorption of the drug or unexpected side effects as a consequence of the rapid absorption of the drug. Commonly used drugs like propranolol and ketoconazole showed improved absorption in presence of food, whereas; levothyroxine and ciprofloxacin found to be 40–50 % less bioavailable after meal. Henceforth; by considering the food impact on the drug’s bioavailability, many of regulatory agencies are now demanding the data in association with the food-induced dissolution and absorption of drugs. In recent years, researchers have taken the initiative and developed different kinds of dosage forms to tackle the problem of drug-food interactions. The present review provides emphasis on the food interactions along with the approaches to uplift drug bioavailability.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100186"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ingestible devices for oral delivery of biotherapeutics: A Mini Review","authors":"Akshay Khandke ,&nbsp;Sanika Dhaybar ,&nbsp;Avani Mandke ,&nbsp;Ananya Joshi ,&nbsp;Amol D. Gholap ,&nbsp;Amarjitsing Rajput","doi":"10.1016/j.nxnano.2025.100195","DOIUrl":"10.1016/j.nxnano.2025.100195","url":null,"abstract":"<div><div>Bioactive macromolecules (like antibodies and peptides) are promising therapeutic agents for treating several diseases. However, oral administration of these macromolecules is challenging due to gastrointestinal (GI) tract degradation due to the harsh pH conditions, digestive enzymes, mucus layers and gastric acid. These barriers cause degradation affect the absorption and reduce the bioavailability of drugs. Thus, the bioavailability achieved by oral administration is less compared to parenteral administration. But parenteral administration of drugs causes reduced patient compliance, invasive and most painful. On the other hand, oral administration is non-invasive painless, but also results in higher patient compliance. Smart ingestible devices like microneedle devices, microrobots, magnetically triggered capsules, self-unfolding foils, smart pills, SOMA, LUMI, nano-straws and gastric auto-injectors can help resolve the issues related to oral delivery of bioactive agents and therapeutics. These devices overcome the GI tract barriers and successfully carry out the oral delivery of these drugs in the GI tract. This review explores how these smart ingestible devices can be an innovative alternative to the parenteral administration of bioactive macromolecules and biotherapeutics. It also covers the devices' functioning, mechanism, clinical stages and challenges in clinical transition. Our review article stands out in the current body of literature by comprehensively compiling all categories of ingestible devices for oral delivery, including the mechanism of drug release, monitoring, therapeutic systems and applications. This integrative approach is notably absent in previous review articles, which tend to focus on isolated aspects or specific types of devices. Furthermore, our article incorporates and analyzes the most recent advancements, offering a current, relevant, and more comprehensive overview than existing review articles by covering the latest literature.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100195"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and characterization of hydroxyapatite biocomposite using Syzygium aromaticum for biomedical application","authors":"Kavya Menon ,&nbsp;Anusuya Nagaraj ,&nbsp;Anjali Sudha ,&nbsp;Neveen Kumar Kalagatur ,&nbsp;Seethalakshmi Subramaniam ,&nbsp;Suja Samiappan","doi":"10.1016/j.nxnano.2025.100202","DOIUrl":"10.1016/j.nxnano.2025.100202","url":null,"abstract":"<div><div>The study aimed to prepare a hydroxyapatite biocomposite with clove (<em>Syzygium aromaticum</em>) bud ethanol extract and demonstrate antibacterial and antioxidant functions. The phytochemical profile of clove bud ethanol extract showed prominent presence of eugenol and gallocatechin by LC-MS/MS analysis. Hydroxyapatite and a biocomposite of hydroxyapatite with clove bud ethanolic extract were prepared using sol-gel and precipitation methods, respectively. Fourier Transform Infrared analysis showed that clove bud ethanolic extract biomolecules were successfully imparted onto the hydroxyapatite surface. The X-ray diffraction study revealed that as-synthesized hydroxyapatite and biocomposite of hydroxyapatite with clove bud ethanolic extract were crystalline and had crystal sizes of 42 nm and 126 nm, respectively. The field emission scanning electron microscopy showed that hydroxyapatite and the biocomposite of hydroxyapatite with clove bud ethanolic extract were spherical in shape and agglomerated. The average particle size distribution of hydroxyapatite and biocomposite of hydroxyapatite with clove bud ethanolic extract was 298.39 and 478.48 nm, respectively. Energy-dispersive X-ray analysis revealed that hydroxyapatite consists of calcium, phosphorus, and oxygen. In contrast, the biocomposite of hydroxyapatite with clove bud ethanolic extract contain carbon in addition to calcium, phosphorus, and oxygen. Thermogravimetric analysis revealed that hydroxyapatite and biocomposite of hydroxyapatite with clove bud ethanolic extract were thermostable. The biocomposite of hydroxyapatite with clove bud ethanolic extract exhibited potential antibacterial action, and the zone of inhibition against <em>S. aureus</em>, <em>E. faecalis</em>, <em>S. enterica</em>, and <em>E. coli</em> was determined as 20.10 ± 0.08, 25.08 ± 0.07, 14.20 ± 0.04, and 24.08 ± 0.08 mm, respectively. Biocomposite of hydroxyapatite with clove bud ethanolic extract exhibited potential antioxidant activity. Hydroxyapatite and biocomposite of hydroxyapatite with clove bud ethanolic extract showed hemolysis &lt; 2 % and were found hemocompatible and safe. Thus, the as-synthesized biocomposite of hydroxyapatite with clove bud ethanolic extract could help overcome oxidative stress-mediated complications and microbial infections in orthopaedics.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"8 ","pages":"Article 100202"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144490592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing magnetic hyperthermia: Investigating iron oxide nanoparticle coating and stability","authors":"Joana Santos ,&nbsp;Jorge Carvalho Silva ,&nbsp;Manuel A. Valente ,&nbsp;Tânia Vieira ,&nbsp;Paula I.P. Soares","doi":"10.1016/j.nxnano.2025.100141","DOIUrl":"10.1016/j.nxnano.2025.100141","url":null,"abstract":"<div><div>Cancer treatment research focuses on overcoming the limitations of conventional treatment methods, especially in addressing treatment-resistant malignancies. Magnetic hyperthermia (MH) is an innovative approach that uses superparamagnetic iron oxide nanoparticles (SPIONs) to increase the temperature locally, triggering cancer cell death. However, challenges related to the SPIONs coating impact their stability and MH heating mechanism, hindering its clinical adoption. This work explores diverse SPIONs coating options - oleic acid (OA), dimercaptosuccinic acid (DMSA), and (3-aminopropyl)triethoxysilane (APTES), to improve SPIONS stability under storage while keeping their heating capacity. OA- and DMSA-coated SPIONs, both negatively charged NPs, exhibited similar behavior in protein corona formation and MH tests. The heating capacity of the three types of SPIONs was maintained after 1 month of storage; however, these values significantly decreased to about 60 % of the initial value after 6 months. APTES-coated SPIONs displayed higher protein corona formation, mainly related to the positively charged surface. Interaction studies with three cell lines (fibroblasts, melanoma, and macrophages) revealed enhanced internalization of APTES-coated SPIONs. Only APTES-coated SPIONs achieved therapeutic temperatures in MH assays, reducing melanoma cell viability significantly. The study underscores the importance of nanoparticle surface modifications and the complexity of factors influencing treatment efficacy. Further research is essential for a better understanding of the cell death mechanism induced by MH and for its clinical translation.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100141"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143305669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrothermal synthesis of nitrogen-doped CQDs for detection of Cr6+ and removal of MB dye in wastewater","authors":"Aysenur Aygun ,&nbsp;Nihed Bennini ,&nbsp;Rima Nour Elhouda Tiri ,&nbsp;Idris Kaynak ,&nbsp;Fatih Sen","doi":"10.1016/j.nxnano.2025.100150","DOIUrl":"10.1016/j.nxnano.2025.100150","url":null,"abstract":"<div><div>Research has demonstrated the feasibility of synthesizing nitrogen-doped carbon quantum dots (CQDs) without the passivation or oxidation chemicals. Given that lemon peels are a rich, renewable carbon source and a common agricultural waste and that these peels are readily available, we chose to use them to prepare fluorescent CQDs to detect metal ions. Synthesis of N-CQDs using biowastes appears to be an environmentally friendly, fast, and efficient method. N-CQDs are preferred for sensing applications due to their various characteristic properties. N-CQDs are important for fluorescent sensors since they produce strong fluorescence emissions. In addition, since N-CQDs have high water solubility, they can work without any problems in biological and environmental sensing in aqueous solutions. The surface composition of N-CQDs was determined by Fourier transform infrared (FTIR) analysis and electronic transitions by UV–visible (UV-Vis) analysis. The morphology and average size of N-CQDs were determined by transmission electron microscope (TEM). In TEM analysis, the average particle size of the nanoparticles was determined to be 5.96 nm. N-CQDs were tested for heavy metal determination and exhibited a low detection limit of 19.37 µM for Cr⁶⁺. N-CQD exhibited 85.73 % photocatalytic activity for the degradation of methylene blue (MB) under visible light. The development of lemon peel-based N-CQDs has significant potential in environmental protection through the treatment of wastewater contaminated with MB dyes and the detection of Cr⁶⁺ metal ions.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"8 ","pages":"Article 100150"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Covalent functionalization of boron nitride nanotubes: A brief review","authors":"Thang Quoc Huynh","doi":"10.1016/j.nxnano.2025.100166","DOIUrl":"10.1016/j.nxnano.2025.100166","url":null,"abstract":"<div><div>Boron nitride nanotubes (BNNT) have garnered significant attention recently due to their unique properties, such as high thermal conductivity, excellent mechanical strength, neutron shielding capacity, and chemical stability. However, their inherent hydrophobic nature and poor solubility in most solvents hinder their widespread application in various fields. Covalent functionalization of BNNT offers a promising solution to enhance their dispersibility, tailor their properties, and enable their integration into diverse applications. This work examines advancements in covalent functionalization strategies to improve BNNT dispersibility and broaden their applicability. Key aspects explored include identifying effective functionalization methods, understanding their impact on BNNT structure, and evaluating current challenges. Various approaches, such as defect-site functionalization, defect generation, and direct functionalization, are analyzed. Therefore, this study will provide a systematic evaluation of emerging reactions, current limitations, and potential breakthroughs in BNNT modification.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100166"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoparticles assisted drug delivery for effective management of Glioblastoma","authors":"Mansi Damani ,&nbsp;Nagesh Nilawar ,&nbsp;Munira Momin ,&nbsp;Raghumani Singh Ningthoujham ,&nbsp;Tabassum Khan","doi":"10.1016/j.nxnano.2025.100137","DOIUrl":"10.1016/j.nxnano.2025.100137","url":null,"abstract":"<div><div>Glioblastoma multiforme (GBM) is one of the most aggressive forms of primary brain tumor with a dire prognosis due to its heterogeneity, invasive nature, and resistance to conventional therapies. Standard treatments, including surgery, radiotherapy, and chemotherapy with temozolomide (TMZ), are often limited by the ability of the tumor to circumvent therapeutic effects and by the physiological barriers that restrict drug delivery to the brain parenchyma. Specifically, the blood-brain barrier (BBB) and the blood-brain tumor barrier (BBTB) impede the effective concentration of therapeutic agents within the brain, posing a significant challenge in treating GBM. The primary focus of current research has pivoted towards nanotechnology to address these limitations. Due to their size, surface modifications, and capability to encapsulate drugs, nanocarriers like polymeric, metallic, and lipid nanoparticles have shown potential in enhancing the penetration of anticancer agents across the BBB and BBTB, thus increasing treatment efficacy and minimizing general toxicity. Moreover, lipid-based nanoparticles, such as solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs), offer advantages in drug encapsulation, stability, and controlled release metal nanoparticles, including gold and silver nanoparticles, provide unique properties for imaging and photothermal therapy, potentially augmenting the efficacy of conventional treatments. This review elucidates the mechanisms by which nanocarriers cross the BBB and BBTB, emphasizing the importance of physicochemical properties such as size, charge, and surface functionality. The integration of nanotechnology in GBM treatment highlights the potential for nanoparticles to revolutionize drug delivery systems, overcoming the inherent challenges posed by the BBB and the tumor microenvironment. The promise of nanomedicine advances in this field could lead to more effective therapeutic strategies, significantly impacting patient outcomes in GBM management.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100137"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143146414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of transition metal dopants (V, Nb, and Ta) on armchair and chiral structured gallium nitride (Ga30N30) nanotubes: A comprehensive DFT study","authors":"Bonganur Khan ,&nbsp;Aoly Ur Rahman ,&nbsp;Md Masud Alam ,&nbsp;Noor Ahammad ,&nbsp;Md. Alamgir Kabir ,&nbsp;Md. Kabir Uddin Sikder","doi":"10.1016/j.nxnano.2025.100155","DOIUrl":"10.1016/j.nxnano.2025.100155","url":null,"abstract":"<div><div>Recently nanotubes have drawn the attention of researchers because of their unique properties such as fast response, high sensitivity, small size, exceptional electron mobility, significant heat capacity, and voltage characteristics suitable for various technological applications. Owing to the success of former studies of different group III-V binary nanotubes, this study has been performed by using density functional theory (DFT) with the B3LYP functional and LanL2DZ basis set in Gaussian 09 to explore the impact of transition metals (TMs) Vanadium (V), Niobium (Nb), and Tantalum (Ta) on structural, electrical, thermodynamic, and optical properties of two different variants- armchair and chiral structured GaNNTs (Ga₃₀N₃₀) to understand their comparative behavioral changes. The study reveals that doping GaNNTs with V, Nb, and Ta significantly enhances structural stability, especially when replacing the Ga atom. This improved structural stability suggests the potential for tailoring their electronic and mechanical properties. Again, in the case of Nb doping, replacing the N atom increases surface area and enhances reactivity, indicating its potential application in sensor development. Moreover, IR spectroscopy predicts the possibility of the natural existence of energetic favorability of all dopant-modified nanotubes with distinct vibrational signatures. The electronic properties suggest armchair (3, 3) systems especially, Ga₂₉N₃₀-Nb and Ga₂₉N₃₀- Ta, possess bandgaps suitable for replacing silicon-based electronics. On the other hand, the chiral (5, 3) Ga₃₀N₃₀ systems, exhibit metallic or near-metallic behavior with a bandgap of 0.2–0.4 eV, opening new avenues for material design. Also, the thermodynamic study demonstrates a correlation between Ga-site substitution and increased exothermicity during doping. Furthermore, the armchair (3, 3) Ga₃₀N₃₀ systems exhibit higher structural ordering after doping than the chiral (5, 3) Ga₃₀N₃₀ systems. Additionally, distinct UV-Vis absorption characteristics observed for both armchairs (3, 3) Ga₃₀N₃₀, and Ga₃₀N₂₉-Ta indicate their promising potential for optoelectronic, photodetectors, and photovoltaic applications. Considering all factors, armchair (3, 3) pristine and doped nanotubes have the potential for real-world applications, particularly in emerging technologies like supercapacitors, optoelectronic sensors, gas sensing devices, biosensors, and energy storage devices.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"8 ","pages":"Article 100155"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marginal-zone B cells as promising targets of an mRNA-loaded, lipid-nanoparticle cancer vaccine","authors":"Yuichi Suzuki ,&nbsp;Mai Yakuwa ,&nbsp;Mina Sato ,&nbsp;Eleni Samaridou ,&nbsp;Moritz Beck-Broichsitter ,&nbsp;Masatoshi Maeki ,&nbsp;Manabu Tokeshi ,&nbsp;Yuma Yamada ,&nbsp;Hideyoshi Harashima ,&nbsp;Yusuke Sato","doi":"10.1016/j.nxnano.2025.100154","DOIUrl":"10.1016/j.nxnano.2025.100154","url":null,"abstract":"<div><div>Combining mRNA-based cancer vaccines and lipid nanoparticles (LNPs) is a highly versatile and effective delivery technology that achieves efficient mRNA delivery to antigen-presenting cells (APCs). Marginal zone B (MZB) cells have been recognized as a promising APC target for cancer vaccines. However, no report has yet introduced a carrier that could efficiently deliver mRNA to MZB cells; hence, their potential as a target for cancer vaccines has yet to be demonstrated. In this study, we describe our application of an LNP formulation containing 15 mol% DSPC (15%DSPC) as a systemically administered cancer vaccine. The 15%DSPC selectively delivered mRNA to MZB cells, and the MZB cells subsequently accumulated in splenic follicles, which suggests a concentration of antigen proteins in the follicles. In addition, the delivery of antigen-coding mRNA to MZB cells induced MZB cell-specific major histocompatibility complex class I antigens, which was followed by cytotoxic T lymphocyte responses. Furthermore, with no signs of significant toxicity, 15%DSPC shows an anti-tumor effect that is equal to, or perhaps even better than, mRNA cancer vaccines that target dendritic cells in clinical trials. In summary, the results of this study demonstrate the efficacy of using an LNP formulation to target splenic MZB cells as a cancer vaccine. Antigen presentation and cellular immune responses were induced in an MZB cell-dependent manner, which proves that mRNA-based cancer vaccines could be effective at targeting MZB cells as APCs.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"8 ","pages":"Article 100154"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of biosilica nanoparticles from rice husk for fabrication of colloidosomes in advanced drug delivery","authors":"Sunday M. Ajayi ,&nbsp;Samuel O. Olusanya ,&nbsp;Sunday F. Abimbade ,&nbsp;Abiodun Aladetuyi ,&nbsp;Oluwabamise L. Faboya ,&nbsp;Emmanuel G. Olumayede ,&nbsp;Cecilia O. Akintayo ,&nbsp;Dosu Malomo ,&nbsp;Oluwaseyi R. Ogede","doi":"10.1016/j.nxnano.2025.100192","DOIUrl":"10.1016/j.nxnano.2025.100192","url":null,"abstract":"<div><div>The study of colloidosomes is rapidly expanding due to their potential as drug carriers and their capacity for tailoring active ingredient delivery to specific biological targets. While synthetic particles like cadmium selenide, polystyrene, synthetic silica, and zinc oxide are commonly used for colloidosome preparation, they are not eco-friendly and can be harmful if their permitted concentration is exceeded. This review assesses the physicochemical properties of biosilica nanoparticles derived from rice husks as a potential material for colloidosome fabrication, focusing on their potential as advanced drug delivery vehicles. Biosilica nanoparticles (BSiO₂-NPs) have gained significant attention from researchers due to their biomedical properties such as porosity, biocompatibility, large specific surface area, biodegradability, and shape. It has surface area 110–1000 m³/g, pore volume 0.4 – 1.5 cm³/g and pore diameter 2 – 15 nm. Other physicochemical properties of amorphous biosilica are whiteness index (93.24–96.66), water content (0.49–2.81 %), density (0.56–0.95 g /ml) and antifungal properties. A mesoporous biosilica nanoparticles from rice husk have a spherical shape, highly ordered hexagonal structure, large specific surface area (&gt;973 m²/g), high pore volume (&gt;0.87 cm³/g), and pore diameter (&gt;2.7 nm), which make it a potential material for colloidosome fabrication. Therefore, preparation, structural characterization, loading factors, and merits of biosilica nanoparticles in colloidosome fabrication for drug delivery are discussed, as well as their health risk assessment, benefits, and prospects. The study also highlights that the resulting colloidosome microcapsules and their resistance to harsh conditions are influenced by factors like particle’s porosity, shape, surface chemistry, and surface-area-to-volume ratio, which are characteristic of biosilica nanoparticles derived from rice husks.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100192"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}