Next Nanotechnology最新文献

{"title":"Artificial intelligence-driven insights into silver-doped zinc ferrite (SI=25): Advancing biofilm control, drug delivery, and tissue engineering for cancer therapy","authors":"B. Jyothish ,&nbsp;John Jacob","doi":"10.1016/j.nxnano.2025.100351","DOIUrl":"10.1016/j.nxnano.2025.100351","url":null,"abstract":"<div><div>This study synthesizes silver-doped zinc ferrite nanoparticles, comprehensively characterized using XRD, FESEM, UV-Vis, and FTIR, revealing their structural and optical properties. In vitro cytotoxicity assays on A549 lung cancer cells demonstrated a potent anticancer effect, with an LC50 of 7.1 µg/mL and a high selective index (SI) of 25. Mechanistically, the nanoparticles induced G0/G1 cell cycle arrest, significantly inhibited cell migration, and triggered enhanced reactive oxygen species (ROS) production, leading to apoptosis. Furthermore, the nanoparticles exhibited promising antioxidant properties by boosting catalase and superoxide dismutase (SOD) activities, coupled with the upregulation of p53 and p21 proteins. Leveraging artificial intelligence, this research aims to predict future applications, including biofilm inhibition, tissue engineering compatibility, enhanced anticancer efficacy through targeted drug delivery, and expanded therapeutic horizons. By integrating experimental data with AI-driven modeling, this work seeks to unlock the full potential of silver-doped zinc ferrite nanoparticles for advanced biomedical applications.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100351"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone tissue engineering and drug-eluting implants for enhanced bone regeneration: An update","authors":"Maitrayee Banerjee Mukherjee ,&nbsp;Oly Banerjee ,&nbsp;Siddhartha Singh ,&nbsp;Sandip Mukherjee","doi":"10.1016/j.nxnano.2025.100349","DOIUrl":"10.1016/j.nxnano.2025.100349","url":null,"abstract":"<div><div>Bone tissue engineering is an applied field of biomedical sciences which analyzes implantable bone substitutes for critical skeletal defects including geriatric decay and accidental injuries. For several years metallic drug-eluting implants have proven extraordinary prominence in orthopedics and dentistry for controlled drug release. The incorporated chemicals promote osteoconduction and angiogenesis, impeding bacterial infection and modulates host body reaction. Various types of proteins, growth factors, enzymes, anti-inflammatory drugs, non-viral genes (DNAs, RNAs) are nowadays used to treat different musculoskeletal syndromes. The scaffolds can be fabricated with different biomaterials such as biopolymers like collagen, chitosan, bioceramics like hydroxyapatite, nanocapsules, nanofibers, microcapsule, microsphere and also gel and film-based materials like hydrogel, polyelectrolyte films etc. Sustained local delivery of therapeutic agents <em>via</em> functionalized implant material has the potential to address the common intrinsic challenges of systematic drug delivery such as inadequate physiological stability.</div><div>This mini-review examines advancements in bone tissue engineering, focusing on metallic drug-eluting implants and innovative scaffold materials that support osteogenesis. By integrating localized drug delivery systems, these technologies enhance healing, reduce infection, and improve implant stability for complex bone injuries and degenerative conditions.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100349"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graphene-based flexible SERS substrates with Ag nanohole structures for biochemical sensing","authors":"Takashi Uchino ,&nbsp;Yanjun Heng ,&nbsp;Ryoma Kumagai ,&nbsp;Shigenobu Kasai ,&nbsp;Chao Tang ,&nbsp;Hirokazu Fukidome ,&nbsp;Akira Satou ,&nbsp;Taiichi Otsuji ,&nbsp;Shuji Ikeda","doi":"10.1016/j.nxnano.2026.100384","DOIUrl":"10.1016/j.nxnano.2026.100384","url":null,"abstract":"<div><div>Flexible substrates for surface-enhanced Raman spectroscopy (SERS) are essential for practical applications, such as point-of-care testing, wearable sensing, and environmental analysis that require high sensitivity, portability, and mechanical flexibility to fit curved surfaces. To meet these demands, we developed flexible SERS substrates consisting of graphene on thin mica with Ag nanohole structures. The biosensing capability of the substrates was demonstrated using a Raman-based enzyme-linked immunosorbent assay, in which bovine interleukin-6 was detected at concentrations as low as 50 pg/mL with a limit of detection of 6 pg/mL. The spectroscopic properties of the substrates were primarily characterized by using Raman measurements, along with scanning electron microscopy and atomic force microscopy. Raman analyses indicated that graphene contributed to the enhancement through fluorescence quenching and increased analyte adsorption associated with its hydrophobic surface. For chemical sensing of Rhodamine 6 G, we evaluated the geometrical enhancement effect of the Ag nanohole structures on mica under different Raman excitation configurations. Far-side illumination through the mica substrate increased the Raman intensity about twofold compared with near-side excitation. These results show the potential of graphene-based flexible SERS substrates for practical, high-sensitivity biochemical sensing.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100384"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring multi-component nanofiber architectures of ZnO, curcumin, and andrographis paniculata for advanced wound care applications","authors":"Umapathi Krishnamoorthy ,&nbsp;A. Ramjan Begam ,&nbsp;S. Keerthiga ,&nbsp;M. Sakthi kathir ,&nbsp;S. Selvaharini ,&nbsp;Sri sakthi vadivelan","doi":"10.1016/j.nxnano.2026.100362","DOIUrl":"10.1016/j.nxnano.2026.100362","url":null,"abstract":"<div><div>Nanofiber wound dressings (NFWDs) have become a promising biomaterial for wound care and tissue regeneration engineering. Significant factors that facilitate their reliable use in wound care includes, (i) ECM mimicry architecture, (ii) biocompatibility of polymers, (iii) capabilities for drug inclusion, (iv) biodegradability possibilities. Though single component NFWDs could provide the required structural integrity and biocompatibility, they become insufficient in satisfying the requirements of complex wound healing process which demands, simultaneous exudate absorption, maintaining moist environment, sustained drug release, antimicrobial functions, tissue regeneration. In addition, antimicrobial resistance (AMR) demands using novel and nature-derived drugs with wound dressings. Hence, multi-component wound dressing (MCWD) that integrate multiple functional components, nature derived drugs are vastly investigated to harvest the synergistic effect of its ingredient. This review investigates, the biomedical potentials of ZnO, Curcumin and Andrographis paniculata with the objective of exploring the feasibility of developing a MCWD integrating them in the form of a nano fibrous membrane. The article begins with the review of (i) wound healing potential, (ii) integrated nano fibrous realization and (iii) limitations of using ZnO nanoparticles, curcumin and Andrographis paniculata. Further, the article presents a brief introduction to electrospinning along with the methods employed for obtaining desired fiber properties. In addition, the synergistic benefits harvested by integrating the materials are presented and characterization, bio-activity testing to be conducted for validating the efficacy of a wound healing material are revealed. Finally, methods employed for addressing the limitations are presented. This article offers two-fold benefits, (i) it reveals NF fabrication methods, characterization, testing methods and (ii) presents the bio medical potentials of ZnO, Curcumin and Andrographis paniculata. Thus, this review could act as a reliable and readily understandable resource for promoting wound care research and development.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100362"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and characterization of lipid based solid dispersion of quassinoid enriched fraction of Simarouba glauca for enhanced lipid membrane permeability in MCF7 breast cancer cells","authors":"Vanitha Subburaj ,&nbsp;Umaa Kuppuswamy ,&nbsp;Sankar Veintraimuthu ,&nbsp;Saran Vijay ,&nbsp;Manju Velmurugan","doi":"10.1016/j.nxnano.2025.100350","DOIUrl":"10.1016/j.nxnano.2025.100350","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Simarouba glauca</em> leaves are rich in quassinoids, known for anticancer properties. This study aimed to develop a lipid-based solid dispersion of the quassinoid-enriched fraction (LBSD-QEF) to enhance permeability in MCF7 breast cancer cells.</div></div><div><h3>Methods</h3><div>LBSD-QEF of SG was prepared by hot homogenization using soy lecithin and Pluronic F68 (1:2) with varying concentrations of SGQEF.</div></div><div><h3>Results</h3><div>Out of the six developed formulations, the F5 (LBSD-QEF of SG) was chosen as the best one based on the zeta potential (-33.2 mV), polydispersity index (0.413), and an average mean particle size (275 nm). It comprises 50 mg of SG quassinoid enriched fraction in addition to 1:2 ratio of lipid (12.5 mg) and surfactant (25 mg). F5 remained stable for 3 months at 4 ± 2.0°C/50 % ± 5 % RH. <em>In vitro</em> drug release F5 (LBSD-QEF of SG) showed 76 % quassinoid release in the first hour and 80 % in the second through dialysis membrane. Cellular uptake of F5 in Caco-2 cells demonstrated strong FITC signal expression. Cytotoxicity studies showed F5 had an IC₅₀ of 12.45 µg/ml against MCF7 cells, outperforming SGQEF (IC₅₀ = 35.05 µg/ml) and crude methanol extract (IC₅₀ = 49.19 µg/ml).</div></div><div><h3>Conclusion</h3><div>The developed F5 (LBSD-QEF of <em>Simarouba glauca</em>) enhances membrane permeability and exhibits greater cytotoxicity in ER+ breast cancer cells.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100350"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145840923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in nanotechnology for enhancing the efficiency of advanced oxidation processes: A review","authors":"Ka Kin Wang,&nbsp;Pui Vun Chai","doi":"10.1016/j.nxnano.2025.100353","DOIUrl":"10.1016/j.nxnano.2025.100353","url":null,"abstract":"<div><div>Water deterioration has become increasingly severe due to industrialization and the growth of human populations. Different types of emerging pollutants have also created immense stress on the environment, with some showing strong resistance to conventional biological treatment systems. As a result, more sophisticated water and wastewater treatment technologies are required to ensure safe and reliable water supplies. Advanced oxidation processes (AOPs) have proven effective by generating strong reactive oxygen species, such as hydroxyl radicals, that can degrade highly resistant pollutants. These radicals may be produced through ultraviolet radiation, ultrasound, or electric power in the presence of appropriate catalysts. Incorporating nanotechnology as a catalyst in AOPs offers significant advantages, as nanomaterials exhibit high stability, large surface area, strong reactivity, and recyclability. Such properties not only enhance the purification of water for human and environmental health but also reduce the reliance on chemical additives, improve energy efficiency, and promote the sustainable use of resources. Collectively, these advances contribute to cleaner water access, more responsible treatment practices, and a lower environmental footprint that supports both ecosystem protection and climate resilience.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100353"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring mango (Mangifera indica) fruit peel extract mediated bio-preparation of CuO nanoparticles for biological, dye degradation and sensor applications","authors":"Hannah Numa ,&nbsp;T.M. Sharanakumar ,&nbsp;Lydia Yalambing ,&nbsp;T. Naveen Kumar ,&nbsp;K.V. Anasuya ,&nbsp;C.R. Ravikumar ,&nbsp;H.C. Ananda Murthy","doi":"10.1016/j.nxnano.2025.100356","DOIUrl":"10.1016/j.nxnano.2025.100356","url":null,"abstract":"<div><div>Green nanotechnology offers a sustainable, cost-effective, and environmentally beneficial way to create nanoparticles from organic materials rather than raw ones. Specifically, bio-waste such as fruit peels can be utilized to synthesize nanoparticles by extraction of their beneficial biomolecules. The present research reveals the green synthesis approach to produce copper oxide nanoparticles for antibacterial application by using the aqueous mango (<em>Mangifera indica</em>) (MGI) peel extract. The phytochemical testing of mango peel extract confirmed the presence of tannins, polyphenols, alkaloids, saponins, flavonoids, terpenoids, reducing sugars, and glycosides. The UV–visible and UV-DRS studies showed the maximum absorbance and energy gap value as 425 nm and 2.08 eV, respectively. The XRD pattern confirmed the formation of crystalline CuO NPs with a tenorite structure. The scanning electron microscopy confirmed nearly spherical CuO NPs. The antibacterial efficacy of the green CuO NPs was evaluated against the Gram-positive <em>Bacillus Cereus</em> and Gram-negative <em>Escherichia coli</em> bacteria. The maximum zone of inhibition of 11.6 mm was recorded for the calcined CuO NPs against the Gram-positive bacterial strain <em>Bacillus Cereus</em>. The synthesized CuO NPs proved to be potential candidates as antibacterial agents. The CuO NPs were also used for the sensor studies of lithium. The modified electrode's electrocatalytic response for Li sensing was found to be extremely concentration sensitive, as the anodic oxidation current rose progressively with the concentration of Li. The photocatalytic degradation study of Fast Orange dye revealed an absorbance at 495 nm during the time period of 90 min and exhibits a maximum percentage of 74 % absorbance value. The synthesized green CuO NPs proved to have multifunctional nature for futuristic applications.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100356"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Impact of bridging the gap between Artificial Intelligence and nanomedicine in healthcare” [Next Nanotechnol. 8 (2025) 100203]","authors":"Divyam Mishra ,&nbsp;Bhavishya Chaturvedi ,&nbsp;Vishal Soni ,&nbsp;Dhairya Valecha ,&nbsp;Megha Goel ,&nbsp;Jamilur R. Ansari","doi":"10.1016/j.nxnano.2025.100347","DOIUrl":"10.1016/j.nxnano.2025.100347","url":null,"abstract":"","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100347"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifaceted graphene-based materials for comprehensive environmental sustainability","authors":"Prashant H. Gohil ,&nbsp;Gopal Avashthi","doi":"10.1016/j.nxnano.2025.100348","DOIUrl":"10.1016/j.nxnano.2025.100348","url":null,"abstract":"<div><div>Graphite (Gt) derived graphene (Gr) and its exceptional mechanical strength, thermal conductivity and electrical properties make it a revolutionary material for 21st-century environmental technologies. This review focuses on the synthesis, functionalization and environmental remediation of graphene oxide (GO), reduced graphene oxide (rGO) and their derivatives for wastewater purification, pollutants adsorption, catalysis and sensing applications under controlled pH, temperature, and ionic strength. Hydrophilic surface of GO with oxygen functionalities enables strong electrostatic interactions with neonicotinoids of adsorption capacities 3.11 mg/g, ciprofloxacin of 500 mg/g, Zn(II) of 345 mg/g and Methylene blue of 450 mg/g for removing cationic impurities. Also, rGO efficiently removes cationic pollutants such as As(III), As(V) and Cr(VI), while functionalized graphene aerogel (fGA) shows recyclability along with improved oil, dyes and solvent adsorption. The microalgae Galdieria sulphuraria achieved 71 % COD, 80 % BOD and 66 % FOG reduction in restaurants’ wastewater with significant nutrient uptake of 96 % NH⁴⁺-N and 99 % TP removal which highlights bio-integrated remediation potential. Photocatalysts GO-TiO₂ and Ni-GO composites examined improved hydrogen evolution up to sevenfold, while rGO-TiO₂ photocatalyst generate reactive oxygen species for pollutants mineralization. Gr-based electrochemical sensors detect Hg²⁺ as low as 0.6 nM and Pb²⁺ at 5ppb, demonstrating ultrahigh sensitivity. So, Gr-based nanocomposites offer sustainable sensing, though scalable green synthesis. However, safety regulations remain essential for large-scale deployment.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100348"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous permeation, distribution and absorption of quantum dots","authors":"Varsha Sahu,&nbsp;Sunit Kumar Sahoo","doi":"10.1016/j.nxnano.2026.100368","DOIUrl":"10.1016/j.nxnano.2026.100368","url":null,"abstract":"<div><div>Quantum dots are one of the most developing semiconductor fluorescent nanoparticles, which are widely used in biomedical sciences. Their nano size, large surface area, biocompatibility, unique optical and physicochemical properties are appropriate for a various purposes including treatment, drug delivery, sensing, imaging and diagnosis. Till date, several researches performed on the properties and applications of quantum dots but there is very little evidence about their route of administration. In general, quantum dots are administered in the biological system through intravenous, intramuscular, and inhalation routes, but there is very little evidence of the percutaneous permeation of quantum dots, which limits their use in skin diseases. Drug delivery through the skin is a preferable route for the treatment of skin disease because it is non-invasive, avoid the first-pass metabolism effect, prevents the drug from enzymatic degradation, and provides targeted or sustainable release. Therefore, this review focuses on quantum dots and their percutaneous absorption within the skin. This study summarizes the percutaneous permeation and distribution of quantum dots via different pathways. It also includes available relevant articles that provide a new aspect to quantum dots and their delivery in the skin to facilitate medication therapy for several skin conditions, including psoriasis, eczema, inflammation, infections, wound healing, skin cancer, and cosmetology.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100368"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}