Fabrication of pullulan/Syzygium kanarense-ZnO nanocomposite films for effective topical treatment of diabetes-induced wounds

Next Nanotechnology Pub Date : 2025-01-01 DOI:10.1016/j.nxnano.2025.100176

Avinash Arasidda Kamble , BK Sarojini , MS Divakar , Vinuta Kamat , Delicia Avilla Barretto , Raju Krishna Chalannavar , Anjanapura V. Raghu

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Abstract

In this study Zinc oxide nanoparticles (ZnONPs) were synthesized via co-precipitation using aqueous Syzygium kanarense (Sk) leaf extract, followed by successful fabrication of pullulan/Sk-ZnONPs composites. UV-Vis spectroscopy unveiled absorption peaks at 362 nm for Sk-ZnONPs and 217 nm for pullulan. FE-SEM confirmed rod-shaped nanoparticles integrated into the pullulan matrix, while PXRD aligned with ZnO ICDD reference, revealing a crystallite size of 36.89 nm and 71.2 % crystallinity. EDX and FT-IR analyses highlighted phytochemical roles in reducing and stabilizing ZnONPs. Water contact angle measurements indicated reduced hydrophilicity of the pullulan matrix upon Sk-ZnONPs doping. The nanocomposite exhibited potent antibacterial activity, antioxidant activity (IC₅₀: 18.97 ± 0.28 µg, comparable to ascorbic acid), anti-inflammatory effects (IC₅₀: 17.81 ± 0.98 µg, surpassing diclofenac sodium), and antidiabetic potential (α-amylase IC₅₀: 16.59 ± 0.45 µg; α-glucosidase inhibition: 98.95 ± 0.57 %, rivaling acarbose). These results underscore the eco-friendly potential of pullulan/Sk-ZnONPs for topical treatments for diabetes-induced wounds, offering a sustainable alternative to conventional methods.

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普绿兰/卡奈兰-氧化锌纳米复合膜的制备及其对糖尿病创面的治疗作用

本研究以卡arense （Sk）叶提取物为原料，通过共沉淀法合成了氧化锌纳米粒子（ZnONPs），并成功制备了蒲鲁兰/Sk-ZnONPs复合材料。紫外可见光谱显示Sk-ZnONPs的吸收峰为362 nm，普鲁兰的吸收峰为217 nm。FE-SEM证实棒状纳米颗粒集成在普鲁兰基体中，而PXRD与ZnO ICDD对照物一致，显示晶粒尺寸为36.89 nm，结晶度为71.2 %。EDX和FT-IR分析强调了ZnONPs还原和稳定的植物化学作用。水接触角测量表明，掺杂Sk-ZnONPs后，普鲁兰基体的亲水性降低。纳米复合材料表现出强大的抗菌活性、抗氧化活性(IC50: 18.97 ±0.28  µg,与抗坏血酸),抗炎作用(IC50: 17.81 ±0.98  µg,超过双氯芬酸钠),和抗糖尿病的潜在(α淀粉酶IC50: 16.59±0.45  µg;α-葡萄糖苷酶抑制率：98.95 ± 0.57 %，与阿卡波糖相当)。这些结果强调了pululan /Sk-ZnONPs在糖尿病伤口局部治疗中的环保潜力，为传统方法提供了一种可持续的替代方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Next Nanotechnology

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