Hydrophobic starch acetate nanoparticles: A biopolymer-based system for sustained antitubercular drug release

Next Nanotechnology Pub Date : 2025-01-01 DOI:10.1016/j.nxnano.2024.100120

Gaurang Rami , Pruthviraj Limbachiya , Mohyuddin Maradiya , Girish Acharya , Jabali Vora

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Abstract

The objective of the research was to evaluate the utilization of starch acetate nanoparticles (SANPs) as drug delivery carriers for antitubercular drugs (Isoniazid, Rifampicin, and Pyrazinamide). The SANPs were synthesized employing ultrasonic-assisted double emulsification solvent evaporation method, permitting effective drug encapsulation. Chemical modification of native starch strengthened its hydrophobicity, as indicated by lower crystallinity in XRD analysis. The TGA validated the thermal stability of SANPs. Morphological investigation indicated a beehive-like structure with constant porosity changed to evenly dispersed spherical nanoparticles when Starch acetate is converted into SANPs. Dynamic light scattering measured the particle sizes of SANPs to be 161 nm. Drug encapsulation brought up the SANPs particle size to 249 nm. Isoniazid, Rifampicin, and Pyrazinamide exhibited 72 %, 83 %, and 75 % encapsulation efficiency at a 2:1 polymer-drug ratio, respectively. In phosphate-buffered saline (pH 7.4), drug release behavior exhibited 55 %, 30 %, and 45 % release of isoniazid, rifampicin, and pyrazinamide over 24 hours. The Korsmeyer-Peppas model demonstrated non-Fickian diffusion for all drug-encapsulated SANPs. Thus, these results contribute to the development of biopolymer-based drug delivery systems for sustainable release of antitubercular drugs.

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疏水醋酸淀粉纳米颗粒：一种基于生物聚合物的持续抗结核药物释放系统

本研究的目的是评估醋酸淀粉纳米颗粒（SANPs）作为抗结核药物（异烟肼、利福平和吡嗪酰胺）的药物递送载体的应用。采用超声辅助双乳化溶剂蒸发法制备SANPs，实现了有效的药物包封。对天然淀粉进行化学改性，增强了其疏水性，XRD分析表明其结晶度降低。TGA验证了SANPs的热稳定性。形态学研究表明，当醋酸淀粉转化为SANPs时，具有恒定孔隙率的蜂窝状结构转变为均匀分散的球形纳米颗粒。动态光散射测得SANPs的粒径为161 nm。药物包封使SANPs的粒径达到249 nm。异烟肼、利福平和吡嗪酰胺在2:1聚合物药比下的包封率分别为72 %、83 %和75 %。在磷酸盐缓冲盐水（pH 7.4）中，异烟肼、利福平和吡嗪酰胺在24 小时内的释放率分别为55 %、30 %和45 %。Korsmeyer-Peppas模型显示所有药物包封的SANPs都具有非菲克扩散。因此，这些结果有助于开发基于生物聚合物的药物传递系统，以实现抗结核药物的可持续释放。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Next Nanotechnology

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