Solid lipid nanoparticles based drug delivery for major infectious diseases: A narrative review

Vivek Kumar
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Abstract

Solid lipid nanoparticles (SLNs) have long been recognized as a promising and versatile lipid-based drug delivery system. This approach offers an alternative to conventional drug delivery methods by utilizing nanocarriers while overcoming many of their inherent limitations. SLNs possess several advantages, including ease of fabrication, scalability for commercial production, low toxicity, a large encapsulation capacity, and suitability for oral administration. However, research on the application of SLNs in infectious diseases remains highly fragmented. This review aims to consolidate current knowledge on the effectiveness of SLNs in delivering drugs to treat infections caused by bacteria, fungi, viruses, and parasites. Particular attention is given to diseases associated with Mycobacterium, ESKAPE pathogens, Candida spp., Fusarium spp., HIV, SARS-CoV-2, Leishmania spp., Trypanosoma spp., and Plasmodium spp. Additionally, this review highlights key studies published by various research groups investigating SLN-based drug delivery for these pathogens and diseases.
固体脂质纳米颗粒为基础的主要传染病给药:叙述综述
固体脂质纳米颗粒(SLNs)长期以来被认为是一种很有前途的多用途脂质给药系统。这种方法通过利用纳米载体提供了传统药物递送方法的替代方案,同时克服了许多固有的局限性。sln具有几个优点,包括易于制造,可用于商业生产,低毒性,大封装容量和适合口服给药。然而,sln在传染病中的应用研究仍然非常零散。本综述旨在巩固sln在递送药物治疗细菌、真菌、病毒和寄生虫引起的感染方面的有效性。特别关注与分枝杆菌、ESKAPE病原体、念珠菌、镰刀菌、HIV、SARS-CoV-2、利什曼原虫、锥虫和疟原虫相关的疾病。此外,本综述还重点介绍了各研究小组发表的针对这些病原体和疾病的基于sln的药物递送的关键研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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