Next Nanotechnology最新文献

{"title":"Combined Photothermal‐Photodynamic Therapy by Ce6 loaded on MoO2 functional nanoplatform","authors":"Songru Liang ,&nbsp;Zhongrong Qin ,&nbsp;Hang Lu ,&nbsp;Zhixin Wen ,&nbsp;Fazal Raziq ,&nbsp;Qixian Qin ,&nbsp;Yi-Fan Kang ,&nbsp;Wen-Huan Huang ,&nbsp;Ping Zhao","doi":"10.1016/j.nxnano.2025.100152","DOIUrl":"10.1016/j.nxnano.2025.100152","url":null,"abstract":"<div><div>In recent decades, a cocktail of different anticancer therapies has aroused intensive interest of many researchers. Drug delivery systems (DDS) based on nanoplatforms have exhibited great potential in this field. In this work, a novel photothermal DDS was designed with ZrO₂-coated MoO₂, which capped with Bi₂O₃ and modified with AS1411 aptamer. The photosensitizer, chlorin e6 (Ce6), was successfully delivered to the tumor sites by the designed DDS. Bi₂O₃ endows the nanoplatform with the ability of releasing Ce6 rapidly in tumor microenvironment while the AS1411 aptamer can target the nucleolin overexpressed on the tumors. The drug-loaded nanoagent exhibits great photothermal conversion ability, good tumor targeting, and better anti-cancer effects than the individual therapy both <em>in vitro</em> and <em>in vivo</em>. This work explores a new route for photothermal-photodynamic combined therapy and a new treatment modality for tumor ablation.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"8 ","pages":"Article 100152"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143760918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel green synthesis of silver nanoparticles from empty fruit bunch waste: Biomedical applications and mechanistic insights","authors":"Bashirat Olamide Yusuf-Salihu ,&nbsp;Shakirat Afodun Abdulmumini ,&nbsp;Toheeb Taiye Bajepade ,&nbsp;Halimah Adekunbi Durosinmi ,&nbsp;Muinat Olanike Kazeem ,&nbsp;Victoria Atinuke Ajayi ,&nbsp;Agbaje Lateef","doi":"10.1016/j.nxnano.2025.100136","DOIUrl":"10.1016/j.nxnano.2025.100136","url":null,"abstract":"<div><div>Agricultural waste, such as empty fruit bunches (EFB) from palm oil production, poses environmental and health risks if not effectively managed. This study addresses this issue by innovatively transforming EFB biomass into high-value silver nanoparticles (AgNPs) via a green synthesis approach, marking the first successful biosynthesis of AgNPs from EFB. UV-Vis, FTIR, TEM, SAED, and EDX studies were used to characterize biosynthesized EFB-AgNPs. Biosynthesized EFB-AgNPs were tested for antibacterial, antioxidant, antidiabetic, anticoagulant, and thrombolytic activities. EFB-AgNPs showed a surface plasmon resonance peak at 477 nm, hydroxyl and amine group stabilization, and a silver content of 75.56 %. TEM and SAED analyses confirmed nanoscale particle diameters ranging from 12.78 nm to 19.10 nm, with a characteristic face-centered cubic (FCC) crystalline structure. EFB-AgNPs inhibited <em>Escherichia coli</em>, <em>Klebsiella oxytoca, Staphylococcus aureus</em>, <em>Proteus mirabilis</em>, and <em>Pseudomonas aeruginosa</em> dose-dependently from 40 % to 80 %, and 100 % of <em>Aspergillus niger</em>, <em>A. fumigatus,</em> and <em>A. flavus</em>. Reactive oxygen species (ROS) may cause cell membrane rupture and oxidative stress. Antioxidant testing demonstrated concentration-dependent activity across multiple assays: DPPH scavenging reached 81.49 % at 160 µg/ml, ferric-reducing activity was 90.05 % at 150 µg/ml, H₂O₂ scavenging achieved 91.00 % at 80 µg/ml, and NO scavenging reached 83.43 % at 150 µg/ml. Furthermore, EFB-AgNPs prevented blood coagulation and dissolved blood clots. In addition, EFB-AgNPs inhibited α-amylase with 74.64 % at 100 µg/ml. This unique approach of transforming EFB trash into high-value AgNPs could help sustain waste management and the circular bioeconomy by enabling medicinal applications.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100136"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143146340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OLED-on-silicon (OLEDoS) microdisplays: Technology challenges, design considerations, and adaptation in eXtended Reality (XR) ecosystem – Review","authors":"Rifat Kaçar ,&nbsp;Ramis Berkay Seri̇n ,&nbsp;Esin Uçar ,&nbsp;Murat Artuç ,&nbsp;Alper Ülkü ,&nbsp;Barış Kınacı","doi":"10.1016/j.nxnano.2025.100132","DOIUrl":"10.1016/j.nxnano.2025.100132","url":null,"abstract":"<div><div>Microdisplay technologies include a variety of miniature display solutions designed to specific requirements in various applications, such as near-to-eye (NTE) platforms. Among these solutions, OLED based microdisplays stands out as an advanced micro-display technology that goes beyond the core principles of conventional OLED technology. This review investigates deeply into the landscape of OLED-on-Silicon (OLEDoS) microdisplays, providing a meticulous analysis of both the CMOS backplane and the OLED frontplane technology, along with subsidiary technologies. It thoroughly examines the challenges and potential drawbacks associated with each technology, offering a comprehensive understanding of their limitations. It also sheds light on the advancements and breakthroughs in the field and highlights the design considerations to overcome the outlined limitations. OLEDs are ideal for microdisplays due to their high contrast ratios, deep blacks, and fast response times, all essential for eXtended Reality (XR) experiences. Their self-emissive nature, which eliminates the need for backlighting, enabling thin, light, power-efficient displays with vibrant colors. These features make OLEDoS microdisplays particularly well-suited for NTE platforms. The review also examines the commercial landscape of OLEDoS, covering market trends, major industry players, and the adoption of these technologies across the industry. In conclusion, it provides a forward-looking perspective on the future of OLEDoS microdisplays, outlining emerging trends and opportunities within the rapidly evolving XR ecosystem.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100132"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143146411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating advanced synthesis techniques and AI-driven approaches with nanofiber technology: A state-of-the-art approach to wound care management","authors":"Nisha Shankhwar ,&nbsp;Awadhesh Kumar Verma ,&nbsp;Ashab Noumani ,&nbsp;Tanya Singh ,&nbsp;Kalakuntla Sriharshitha Rao ,&nbsp;Vivekanand ,&nbsp;Neeta Raj Sharma ,&nbsp;Satyendra Singh","doi":"10.1016/j.nxnano.2025.100147","DOIUrl":"10.1016/j.nxnano.2025.100147","url":null,"abstract":"<div><div>Wound healing is a complicated clinical problem when common topical therapies and dressings are insufficient for different kinds of wounds, such as burns, surgical, and chronic wounds. This review emphasizes the ground-breaking potential of nanofiber technology, a novel approach that imitates the extracellular matrix (ECM) to promote targeted therapeutic administration and support cellular regeneration. Because of their structural compatibility with skin tissue, nanofiber dressings enhance natural healing, maintain optimal moisture levels, and significantly reduce the risk of infection. The comprehensive analysis include methods for producing nanofibers, crucial design components, and applications appropriate for different wound types. Concurrently, the integration of the Internet of Things (IoT), Artificial Intelligence (AI), and Machine Learning (ML) is revolutionizing wound care. Because of this, \"smart\" dressings with real-time monitoring, dynamic data processing, and precise therapeutic release capabilities have been developed, allowing medical personnel to provide more individualized and responsive care. These developments can potentially revolutionize wound care through timely interventions and improving patient outcomes. Although combining nanofiber technology with AI-powered smart dressings seems promising, there are still barriers in implementing these developments for general clinical applications. This review offers a comprehensive overview of current research and the critical role nanofiber technology plays in enhancing wound care. We plan to highlight the path for robust, scalable, and customized wound treatments by identifying key implementation barriers and exploring potential developments. Nanofibers, with their exceptional capabilities, signify a profound advancement in wound healing, offering new optimism for improved patient recovery and enduring health benefits.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"8 ","pages":"Article 100147"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biosynthesis of silver nanoparticles using Aristolochia bracteolata Lam. ethyl acetate extract: Characterization and In Vitro anticancer activity against lung adenocarcinoma cells","authors":"H.S. Anil Kumar ,&nbsp;Santosh Mallikarjun Bhavi ,&nbsp;Sapam Riches Singh ,&nbsp;Bothe Thokchom ,&nbsp;Ramesh Babu Yarajarla ,&nbsp;D. Kotresha","doi":"10.1016/j.nxnano.2025.100174","DOIUrl":"10.1016/j.nxnano.2025.100174","url":null,"abstract":"<div><div>Lung cancer remains a leading cause of cancer-related mortality, necessitating novel therapeutic strategies. <em>Aristolochia bracteolata</em> Lam. has been traditionally studied for its potential in cancer treatment, and this study explores the green synthesis of silver nanoparticles (AgNPs) using its ethyl acetate extract to evaluate their anticancer potential against human lung adenocarcinoma (NCIH-460) cells. AgNPs biosynthesis was confirmed by a color change and characterized by UV-Vis spectroscopy, FTIR, XRD, zeta potential FE-SEM, and TEM. The UV-Vis spectrum exhibited a characteristic absorption peak at 450 nm, confirming nanoparticle formation. XRD analysis indicated the crystalline nature of AgNPs, while FTIR spectra identified key functional groups involved in nanoparticle stabilization, including O-H, C-H, C<img>C, and C-O bonds. FE-SEM and TEM images showed polydispersed, mostly spherical AgNPs ranging from 4 to 171 nm, with an average TEM-derived size of 10 nm. Zeta potential analysis showed a charge of −26 mV, suggesting moderate stability in solution. The AgNPs exhibited potent cytotoxicity against NCIH-460 cells (IC₅₀ = 13.44 µg mL⁻¹) while sparing normal L929 cells (IC₅₀ = 196.05 µg mL⁻¹). Annexin V/PI and TUNEL assays confirmed apoptosis induction, while cell cycle analysis demonstrated G0/G1 phase arrest, supported by caspase-3 upregulation. These findings suggest biosynthesized AgNPs as promising anticancer agents, capable of inducing apoptosis and disrupting cancer cell proliferation, making them potential candidates for lung cancer therapy.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100174"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143892331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative approaches to blood-brain barrier modelling: The chip revolution","authors":"Avijit Bej ,&nbsp;Nandita Mandal ,&nbsp;Anwesha Das ,&nbsp;Arijit Nandi","doi":"10.1016/j.nxnano.2025.100171","DOIUrl":"10.1016/j.nxnano.2025.100171","url":null,"abstract":"<div><div>The blood-brain barrier (BBB) is essentially involved in regulating the communication between the neurons in the central nervous system (CNS) and the rest of the body after excluding undesirable elements that may harm the neural tissues. The traditional in vivo models have some limitations in mimicking the sophisticated physiology and function of the BBB. As a result of these technical developments, researchers have been able to establish or design more controlled BBB platforms referred to as the BBB on a chip. These miniaturized models mimic structural and functional properties of the BBB and allow for monitoring of immediate integrity, permeability, and effects of drugs. This review aims to present the most recent advancement of BBB-on-a-chip technology by considering its design, fabrication method, and application in drug screening and disease modelling. It also discusses the difficulties in modelling the BBB, the comparison between various platforms, and the research direction that may help enhance these systems. Despite their limitations, BBB-on-a-chip platforms are a promising development for closing the disparity between the models and clinics and may help to improve the knowledge of neurovascular biology and the creation of new therapeutic interventions.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100171"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143881300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transforming oncology with carbon quantum dots: Synthesis, properties, and therapeutic potential","authors":"Vishakha G. Bodele,&nbsp;Swati. N. Lade,&nbsp;Diksha. S. Undirwade,&nbsp;Milind J. Umekar,&nbsp;Sushil S. Burle,&nbsp;Pratiksha S. Hanmante,&nbsp;Radheshyam T. Lohiya","doi":"10.1016/j.nxnano.2025.100181","DOIUrl":"10.1016/j.nxnano.2025.100181","url":null,"abstract":"<div><div>Cancer poses a serious challenge due to its impact on diminishing the quality of life and contributing to premature death. Advances in nanotechnology show tremendous potential in tackling cancer-related difficulties. Carbon nanotubes, nanoshells, nanorod arrays, polymer dots, and quantum dots are among the nanomaterials that have attracted much interest due to their potential to improve cancer diagnosis and therapy. A new family of carbon-based nanomaterials known as carbon quantum dots (CQDs) has surfaced with remarkable physicochemical qualities, such as low toxicity, high photoluminescence, water solubility, chemical stability, and biocompatibility. CQDs have garnered significant attention in oncology due to these unique characteristics since they exhibit potential as versatile agents for cancer treatment, imaging, and diagnostics. The synthesis techniques of CQDs are thoroughly examined in this review paper, focusing on both top-down and bottom-up approaches. It also addresses how synthesis parameter changes affect CQDs' structural and functional characteristics. Furthermore, the review highlights the photothermal, photodynamic, and drug delivery applications of CQDs in cancer treatment, alongside their role in bioimaging and biosensing. The therapeutic potential of CQDs is underscored by their capacity to improve targeted drug delivery, enhance tumor imaging, and facilitate minimally invasive treatments. Despite their promising applications, challenges such as large-scale production, long-term toxicity, and precise control over surface functionalization remain to be addressed. This review aims to provide a detailed overview of the current state of CQD research in oncology and offer insights into future directions for its clinical translation.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100181"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review on biodegradable microsphere with special emphasis on inflammatory bowel disease & recent patents","authors":"Supriya Shidhaye,&nbsp;Krutika Nagpurkar,&nbsp;Mayur Kale,&nbsp;Ruchi Khobragade,&nbsp;Milind Umekar,&nbsp;Shreya Koche,&nbsp;Rashmi Trivedi","doi":"10.1016/j.nxnano.2025.100184","DOIUrl":"10.1016/j.nxnano.2025.100184","url":null,"abstract":"<div><div>Inflammatory Bowel Disease (IBD) encompasses two major forms: Crohn's disease and ulcerative colitis, characterized by chronic inflammation of the gastrointestinal tract. These conditions present unique challenges in drug delivery due to the need for precise targeting of affected regions while minimizing systemic side effects. Biodegradable microspheres offer a promising solution, providing sustained, localized drug release that enhances therapeutic efficacy and patient compliance. Comprised of naturally degradable polymers, these microspheres encapsulate drugs, ensuring targeted delivery to inflamed sites and reducing systemic exposure. This review explores the potential of biodegradable microspheres in IBD management, emphasizing their role in addressing current drug delivery challenges. Key advantages include sustained drug release, improved drug stability, and the ability to reduce adverse effects. Recent advancements and patents are discussed, focusing on innovative microsphere formulations and targeting strategies that enhance therapeutic outcomes. Additionally, the significance of biodegradable polymers in enabling site-specific drug release is highlighted, showcasing their transformative potential in IBD therapy.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100184"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in polycaprolactone nanoparticles for targeted drug delivery in breast cancer treatment: Strategies and challenges","authors":"Kashyak L. Sahu ,&nbsp;Komal Naeem ,&nbsp;Miriya R. Carson ,&nbsp;Nabira Kanwal Nawaz ,&nbsp;Naila Gulfam ,&nbsp;Muhammad Zahoor","doi":"10.1016/j.nxnano.2025.100206","DOIUrl":"10.1016/j.nxnano.2025.100206","url":null,"abstract":"<div><div>Poly(ε-caprolactone; PCL) is a biodegradable and biocompatible polyester that can be suitable to develop nanoparticles for sustainable drug delivery applications and improve the efficacy of Breast cancer treatment. In this review, we summarize some latest advances in targeted delivery strategies Such as Active Targeting, Passive Targeting and Stimuli Responsive targeting for PCL-based drug carriers and explore their potential applications in delivering key anticancer agents used for effective Breast cancer therapy. We were intendent to analyse the effectiveness as well as limitations of different types of targeting delivery strategies for PCL-based drug carriers and the effectiveness of these approaches in improving drug bioavailability, reducing side effects, and achieving sustained release. By analysing current trends and narrowing knowledge gaps, this work provides insights into optimizing PCL-based systems to improve therapeutic efficacy and paves the way for innovative applications in Breast cancer treatment.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"8 ","pages":"Article 100206"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144548820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Citronella oil-loaded electro-spun single and core-shell nano fibers as sustained repellent systems against Aedes aegypti","authors":"Samali Udara Liyanaarachchi ,&nbsp;Sanjeewa K. Rodrigo ,&nbsp;Nilwala Kottegoda ,&nbsp;Veranja Karunaratne ,&nbsp;Menaka Hapugoda ,&nbsp;Tharaka Ranathunge ,&nbsp;Lahiru Udayanga ,&nbsp;Dushmantha Adikari","doi":"10.1016/j.nxnano.2024.100127","DOIUrl":"10.1016/j.nxnano.2024.100127","url":null,"abstract":"<div><div>Devising a natural and an effective repellent system is the challenge that needs to be addressed to meet the current demand among the people, despite the progress made in the mosquito control. The effort towards this goal should constitute; natural repellent, biodegradability, higher repellent loading, sustained release of the repellent. In this work, natural, biodegradable, eco-friendly and long-lasting mosquito repellent has been prepared with higher loading of citronella oil (1 %) in Polyvinyl alcohol (PVA) nanofibers. Uniaxial (CP-U) and coaxial (CP-C) nanofiber-composites were electrospun using non-toxic, biodegradable PVA at 10 % w/w and citronella oil. It was found that maintaining the outer:inner flow rate ratio at 5:2 in coaxial process is imperative to produce good fibers. Average fiber diameter of CP-U fibers was 138.5 ± 62.5 nm and for CP-C fibers it was 367.3 ± 160.1 nm. TEM analysis confirmed the core-shell structure formed in CP-C fibers by coaxial electrospinning. FTIR analysis indicated CEO incorporation in both composites and thermal analyses showed mass losses corresponding to CEO decomposition, with CP-U fibers exhibiting better thermal stability due to stronger interactions between the oil and polymer. Encapsulation efficiency and loading capacity were 20.19 % ± 0.34 and 1.83 % ± 0.03 for CP-U, and 50.25 % ± 0.32 and 14.85 % ± 0.09 for CP-C, respectively. Further, release patterns and release kinetics were studied. CP-C fibers can effectively release 94.14 % of the encapsulated oil providing an extended protection window compared to matrix encapsulation (68.75 %) after 168 hours. Release kinetics followed the Korsmeyer-Peppas model, with CP-U exhibiting Fickian diffusion (n &lt; 0.5) and CP-C showing non-Fickian diffusion (0.5 &lt;n &lt; 1). Mosquito repellent tests showed CP-C fibers were effective (85.4 ± 1.40 %) than CP-U (56.1 ± 2.79 %) and comparable to DEET (28.7 ± 4.94 %) even after 1 week. To the best of our knowledge, this is the first time neat-citronella oil has been encapsulated at the core of multi-layered nanofibers. Multi-layered encapsulation of essential oils turned out to be very effective in sustaining their repelling activity for longer periods. The outcome of this work has a high potential to be developed into an attractive-convenient product for the consumers and it can be more beneficial for infants and babies, adults with sensitive skin and school children.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100127"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143146409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}