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A systematic review of integration frameworks of nanomaterials in additive manufacturing processes 增材制造过程中纳米材料集成框架的系统综述
Next Nanotechnology Pub Date : 2025-01-01 Epub Date: 2025-09-10 DOI: 10.1016/j.nxnano.2025.100259
T.A. Mukalay
{"title":"A systematic review of integration frameworks of nanomaterials in additive manufacturing processes","authors":"T.A. Mukalay","doi":"10.1016/j.nxnano.2025.100259","DOIUrl":"10.1016/j.nxnano.2025.100259","url":null,"abstract":"<div><div>This study examines the integration frameworks of nanomaterials into Additive Manufacturing (AM) processes. While nanomaterials offer improved mechanical, thermal, and electrical properties, their integration in AM process faces challenges. This study reviews works from the last decade as well as analyses existing integration frameworks. The findings demonstrate that inconsistent mechanical properties, material instability, non-uniform dispersion, limited scalability, inconsistent thermal properties, and biocompatibility are the key obstacles to nanomaterials integration in AM. Furthermore, the study investigates the gaps in current integration frameworks and proposes theoretical optimizations to address these limitations and improve outcomes of nanomaterials-enabled AM processes.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"8 ","pages":"Article 100259"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145026665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heat generation and Joule dissipation influence on Magnetohydrodynamic Cu- H2O and Al2O3-H2O nanofluid convection with nanoparticle volume fraction and ramped and isothermal wall temperature: A finite element approach 热生成和焦耳耗散对Cu- H2O和Al2O3-H2O纳米流体磁流体动力学对流的影响——基于纳米颗粒体积分数和梯度等温壁面温度的有限元方法
Next Nanotechnology Pub Date : 2025-01-01 Epub Date: 2025-09-10 DOI: 10.1016/j.nxnano.2025.100261
Thirupathi Thumma , Surender Ontela , Rupalakshmi Dharanikota
{"title":"Heat generation and Joule dissipation influence on Magnetohydrodynamic Cu- H2O and Al2O3-H2O nanofluid convection with nanoparticle volume fraction and ramped and isothermal wall temperature: A finite element approach","authors":"Thirupathi Thumma ,&nbsp;Surender Ontela ,&nbsp;Rupalakshmi Dharanikota","doi":"10.1016/j.nxnano.2025.100261","DOIUrl":"10.1016/j.nxnano.2025.100261","url":null,"abstract":"<div><div>In high-performance thermal engineering systems such as energy storage units, electronic cooling devices, and rotating heat exchangers, the combined effects of internal heat generation and viscous dissipation play a vital role in modulating heat and mass transfer during hydromagnetic nanofluid flow over vertical surfaces, especially in a rotating frame. Motivated by these practical demands, the present study is devoted to a comprehensive finite element analysis of the combined impact of heat source/sink and Joule heating on magnetohydrodynamic convection of Cu–H₂O and Al₂O₃–H₂O nanofluids, with varying nanoparticle volume fractions under ramped and isothermal wall thermal conditions. A system of nonlinear, dimensionless partial differential equations is numerically solved using the Galerkin-based finite element method (GFEM). Significant observations for the influence of various governing parameters are the elevation of thermal distribution with intensified heat source and Eckert number, while the buoyancy ratio was found to enhance momentum transfer across the fluid domain. Between the two nanofluids, <span><math><mrow><mi>Cu</mi><mo>−</mo><mi>H</mi><mi>₂</mi><mi>O</mi></mrow></math></span> consistently exhibited superior transport characteristics over <span><math><mrow><mi>Al</mi><mi>₂</mi><mi>O</mi><mi>₃</mi><mo>−</mo><mi>H</mi><mi>₂</mi><mi>O</mi></mrow></math></span>, attributed to its enhanced thermal conductivity and lower dynamic viscosity. The accuracy of the simulation is validated by benchmarking the computed values of skin friction, Nusselt number, and Sherwood number against established solutions in limiting scenarios, yielding excellent agreement. This study finds critical applications in the design and optimization of rotating chemical reactors, nano-enhanced energy systems, and magnetically controlled thermal processing equipment.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"8 ","pages":"Article 100261"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145026669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phyto-mediated synthesis of silver nanoparticles using Erythrina variegata L. leaf extract and evaluation of their anti-bacterial, anti-Alzheimer, antioxidant and cytotoxic activities 利用 Erythrina variegata L. 叶提取物植物介导合成银纳米粒子并评估其抗菌、抗老年痴呆、抗氧化和细胞毒性活性
Next Nanotechnology Pub Date : 2025-01-01 Epub Date: 2025-04-05 DOI: 10.1016/j.nxnano.2025.100157
Gangadhar Kodiyala , Kandrakonda Yelamanda Rao , Venakata Pratyusha Chapati , Kana Meenugula , Jayaraju Nadimikeri , Sunitha Salkapuram , Rajesh Nambi , Gangaiah Damu Amooru , Madakka Mekapogu
{"title":"Phyto-mediated synthesis of silver nanoparticles using Erythrina variegata L. leaf extract and evaluation of their anti-bacterial, anti-Alzheimer, antioxidant and cytotoxic activities","authors":"Gangadhar Kodiyala ,&nbsp;Kandrakonda Yelamanda Rao ,&nbsp;Venakata Pratyusha Chapati ,&nbsp;Kana Meenugula ,&nbsp;Jayaraju Nadimikeri ,&nbsp;Sunitha Salkapuram ,&nbsp;Rajesh Nambi ,&nbsp;Gangaiah Damu Amooru ,&nbsp;Madakka Mekapogu","doi":"10.1016/j.nxnano.2025.100157","DOIUrl":"10.1016/j.nxnano.2025.100157","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Owing to their growing prevalence, multi-drug-resistant bacterial infections, Alzheimer’s disease and cancer has emerged as a global health concern. To combat this real threat to humankind, biogenic silver nanoparticles (AgNPs) are considered as a prime strategy due to its wide-range of medical applications.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objectives&lt;/h3&gt;&lt;div&gt;The current study was aimed to investigate the green synthesis of silver nanoparticles using aqueous leaf extract of &lt;em&gt;Erythrina variegata&lt;/em&gt; and evaluation of anti-Alzheimer, antioxidant and anti-cancer efficacies.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Method&lt;/h3&gt;&lt;div&gt;The aqueous extract was prepared and initially assessed for its phytochemical composition. Then silver nanoparticles (AgNPs) were synthesized by reducing aqueous AgNO&lt;sub&gt;3&lt;/sub&gt; with aqueous leaf extract at nonphotomediated conditions, without any catalyst, template or surfactant. The Ev-AgNPs were characterized by ultraviolet-visible (UV–VIS) &amp; Fourier-transform infrared (FTIR) spectroscopy, zeta sizer, scanning electron microscopy (SEM), energy-dispersive X-ray (EDXA) and X-ray diffraction (XRD) analysis. The bio-activities of extract and Ev-AgNPs including antibacterial, anti-oxidant, anti-Alzheimer’s and anticancer activities were evaluated using well diffusion, ABTS &amp; DPPH radical scavenging, Ellman’s and MTT assays, respectively.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Phytochemical analysis revealed the leaf extract of &lt;em&gt;E. variegata&lt;/em&gt; as rich source of flavonoids and phenolics. Physicochemical and morphological characterization inferred that Ev-AgNPs were spherical in shape, small in size (59.5–90.2 nm), crystalline in nature with high stability (−38.8 mV) and associated with capping agents. In biological evaluation, extract of &lt;em&gt;E. variegata&lt;/em&gt; disclosed good activities, however, better potencies were noticed with Ev-AgNPs. Biogenic Ev-AgNPs exhibited high ABTS and DPPH radical scavenging abilities with IC&lt;sub&gt;50&lt;/sub&gt; values of 38.47 and 17.73 µg/mL, respectively. Ev-AgNPs had highest antibacterial activity against &lt;em&gt;Escherichia coli&lt;/em&gt; and &lt;em&gt;Pseudomonas aeruginosa&lt;/em&gt;, good activity with &lt;em&gt;Bacillus subtilis&lt;/em&gt; and &lt;em&gt;Staphylococcus aureus&lt;/em&gt;, while least inhibition zone against &lt;em&gt;Pseudomonas syringae&lt;/em&gt;. Ev-AgNPs displayed remarkable cytotoxicity against human breast cancer cell line MCF–7 with 53.11 % inhibition at a concentration of 0.5 µg/mL. Ev-AgNPs were found to be non-haemolytic in nature. In Elmann assay, Ev-AgNPs excelled high inhibitory efficiencies against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC&lt;sub&gt;50&lt;/sub&gt; values of 15.18 and 56.21 µg/mL, respectively with mixed mode of inhibition.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Based on these findings, it appears that Ev-AgNPs have promise as multi target directed ligand effective against bacterial infections, breast cancer, Alzheimer’s disease and also oxidative stress mediated illnesses.&lt;/div&gt;&lt;","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100157"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143783146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hydrothermal synthesis of nano-metal oxides for structural modification: A review 水热合成纳米金属氧化物的结构修饰研究进展
Next Nanotechnology Pub Date : 2025-01-01 Epub Date: 2025-04-22 DOI: 10.1016/j.nxnano.2025.100167
Tasnimul Quader Tazim , Md. Kawsar , Md. Sahadat Hossain , Newaz Mohammed Bahadur , Samina Ahmed
{"title":"Hydrothermal synthesis of nano-metal oxides for structural modification: A review","authors":"Tasnimul Quader Tazim ,&nbsp;Md. Kawsar ,&nbsp;Md. Sahadat Hossain ,&nbsp;Newaz Mohammed Bahadur ,&nbsp;Samina Ahmed","doi":"10.1016/j.nxnano.2025.100167","DOIUrl":"10.1016/j.nxnano.2025.100167","url":null,"abstract":"<div><div>Materials with a minimum of one dimension less than 100 nanometers (nm) are referred to as nanomaterials (NMs), granting them unique and intriguing properties due to their minimal size. NMs exhibit unique thermal, magnetic, optical, and chemical properties that distinguish them significantly from larger molecules such as micromolecular, bulk organic, or inorganic compounds. Metal oxide NMs are utilized in the medical sector for targeted drug delivery, environmental science for pollution management and water treatment, and electronics to improve energy production. Because of the rapidly growing demand for nanomaterials with precise morphological properties for specific applications, significant research efforts have been directed toward developing hydrothermal synthetic methodologies under various reaction conditions to achieve both scientifically and practically novel results. Several studies have been conducted to study the impact of various response parameters on the fundamental characteristics and morphology of MNs. Therefore, this review paper discussed the hydrothermal synthesis under different reaction conditions for seven important metal oxides (ZnO, CuO, Fe<sub>2</sub>O<sub>3</sub>, CdO, TiO<sub>2</sub>, Al<sub>2</sub>O<sub>3</sub>, and CaO). Furthermore, it analyzes how utilizing varied source materials alongside diverse reaction parameters affects the structural morphology of these nanoscale materials, facilitating their development for specific applications.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100167"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lysozyme functionalized zinc-oxide nanoparticles: Synthesis, characterization, and antibacterial assessment against Staphylococcus aureus with futuristic application in wastewater monitoring 溶菌酶功能化氧化锌纳米颗粒:合成、表征和对金黄色葡萄球菌的抗菌评估及其在废水监测中的未来应用
Next Nanotechnology Pub Date : 2025-01-01 Epub Date: 2025-07-17 DOI: 10.1016/j.nxnano.2025.100222
Suneeti Singh, Pavni Rekhi, Jewel Mary Saju
{"title":"Lysozyme functionalized zinc-oxide nanoparticles: Synthesis, characterization, and antibacterial assessment against Staphylococcus aureus with futuristic application in wastewater monitoring","authors":"Suneeti Singh,&nbsp;Pavni Rekhi,&nbsp;Jewel Mary Saju","doi":"10.1016/j.nxnano.2025.100222","DOIUrl":"10.1016/j.nxnano.2025.100222","url":null,"abstract":"<div><div>Access to clean drinking water remains a global concern, primarily due to the presence of biological, inorganic, and organic pollutants. Among the biological contaminants, waterborne pathogens pose a significant threat to human well-being. Since nanoparticle-based biosensors have a higher sensitivity for detecting bacteria than conventional detection techniques, they have become increasingly prevalent. In this context, the current study reports zinc oxide nanoparticles functionalized with lysozyme (ZnO@LY NPs) via a modified oxidation-reduction mechanism, followed by an assessment of their antibacterial activity. The morphology and size of the functionalized ZnO@LY NPs were determined using Transmission electron microscopy-energy dispersive X-ray spectroscopy (TEM-EDX), X-ray diffraction (XRD), dynamic light Scattering (DLS), and zeta potential analysis, which revealed nanoparticles of size between 14 and 32 nm with + 31.1 mV charge. Further, the functionalization of ZnO with lysozyme was confirmed using Fourier-transform infrared spectroscopy (FTIR) and Ultraviolet-Visible (UV-Vis) spectroscopy. The antibacterial efficacy of ZnO@LY NPs and ZnO NPs against Gram-positive bacteria (<em>Staphylococcus aureus</em>) was assessed in a comparative study. After 30 min and 24 h of treatment with ZnO@LY NPs at 250 ppm, the agar spot assay revealed the absence of colonies. Similarly, ZnO@LY NPs exhibited a 25 % stronger and statistically significant antibacterial impact than non-functionalized ZnO NPs in the bacterial growth inhibition assay, as confirmed by repeated measures (RM)-ANOVA analysis. Moreover, Dunnett's multiple comparison test revealed that ZnO@LY NPs showed a dose-dependent linear response when compared to ZnO NPs. The superior antibacterial performance of ZnO@LY NPs is attributed to improved bacterial surface interactions, stability, and biocompatibility facilitated by lysozyme functionalization. These findings suggest a potential application of ZnO@LY nanoparticles in biosensors for on-site pathogen detection in wastewater.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"8 ","pages":"Article 100222"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanofiberous composite with CuO-Ag0 supported on bamboo/lycra for protection against transmittable infectious diseases 在竹子/岩棉上添加 CuO-Ag0 的纳米纤维复合材料,用于预防可传播的传染病
Next Nanotechnology Pub Date : 2025-01-01 Epub Date: 2024-10-07 DOI: 10.1016/j.nxnano.2024.100108
Abdul Wahab Jatoi , Faisal Ahmed Memon , Muhammad Ishaque Abro
{"title":"Nanofiberous composite with CuO-Ag0 supported on bamboo/lycra for protection against transmittable infectious diseases","authors":"Abdul Wahab Jatoi ,&nbsp;Faisal Ahmed Memon ,&nbsp;Muhammad Ishaque Abro","doi":"10.1016/j.nxnano.2024.100108","DOIUrl":"10.1016/j.nxnano.2024.100108","url":null,"abstract":"<div><div>The transmittable infectious diseases, detrimental environmental contaminants and harmful UV radiations remained constant threat to human civilization. C<em>old, pneumonia, tuberculosis bacteria, rubella virus, RSV and COVID19, then urban and industrial emissions,</em> volcanic eruptions, pollen, aerosols on one hand and skin cancer, sunburn, premature ageing and skin tanning on the other hand are some of the examples of serious risks to health, safety and well-being. The WHO reported over 7million worldwide deaths due to hazardous air contaminants. Exploiting the tremendous features of nanofiberous structure and excellent microbiocidal properties of Ag<sup>0</sup> and CuO nanoparticles, a sustainable and stable nanofiber based composite Bmb-nanoNP was developed. Utilization of biocompatible, biodegradable, nontoxic and environmental friendly polymers enabled the composite as sustainable source for protective clothing purposes. The microparticulate filtration of Bmb-nanoNP was 99.13 % and 96 % with and without air suction respectively. The microbiocidal affect against <em>E. coli</em> and <em>S. aureus</em> strains was excellent(5.9 % and 8.86 % cell viabilities respectively). Similarly, the Bmb-nanoNP showed calculated UV protection factor (UPF) of 7954 (50 + rating).These characteristics demonstrated potential candidacy of the Bmb-nanoNP composite for multi-functional safety clothing applications.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100108"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142427762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Next-gen cancer therapy: The convergence of artificial intelligence, nanotechnology, and digital twin 新一代癌症治疗:人工智能、纳米技术和数字孪生的融合
Next Nanotechnology Pub Date : 2025-01-01 Epub Date: 2025-10-25 DOI: 10.1016/j.nxnano.2025.100286
Shreya S. Deshmukh , Khushwant S. Yadav
{"title":"Next-gen cancer therapy: The convergence of artificial intelligence, nanotechnology, and digital twin","authors":"Shreya S. Deshmukh ,&nbsp;Khushwant S. Yadav","doi":"10.1016/j.nxnano.2025.100286","DOIUrl":"10.1016/j.nxnano.2025.100286","url":null,"abstract":"<div><div>The combination of artificial intelligence [AI] and nanotechnology is revolutionizing cancer therapy by using precision medicine, enhancing early diagnosis, and optimizing drug delivery with a target. AI-driven nanocarriers are a next-generation platform for real-time biomarker identification, controlled drug release, and tailored treatment regimens that significantly augment the therapeutic effect and minimize systemic toxicity. Machine learning models aid rational nanomaterial design, predicting drug interactions, and formulating optimization for better bioavailability and tumor targeting. Quantum processing and AI-driven modeling are accelerating drug discovery, enhancing diagnostic accuracy, and automating clinical decisions. In addition, Digital Twin [DT] technology is turning out to be an oncology game-changer with virtual patient simulates that integrate genomic, clinical, and imaging data in order to forecast disease progression and tailor treatment. By bridging the gap between computer simulations and real-world clinical utilization, DTs allow for more effective treatment planning, dispense with trial-and-error approaches, and improve patient outcomes. However, major obstacles such as data harmonization, explainability of algorithms, regulation, and ethics remain challenges to large-scale uptake. Overcoming these constraints by interdisciplinary collaboration between researchers, clinicians, and regulatory bodies will be key to achieving the maximum potential of AI-based nanomedicine. This review explores the revolutionary impact of AI-driven nanocarriers and digital twin technology in cancer treatment, observing how they can transform cancer therapy through predictive analytics, intelligent drug delivery, and second-generation personalized therapy methods.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"8 ","pages":"Article 100286"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145361116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Solid lipid nanoparticles based drug delivery for major infectious diseases: A narrative review 固体脂质纳米颗粒为基础的主要传染病给药:叙述综述
Next Nanotechnology Pub Date : 2025-01-01 Epub Date: 2025-07-30 DOI: 10.1016/j.nxnano.2025.100228
Vivek Kumar
{"title":"Solid lipid nanoparticles based drug delivery for major infectious diseases: A narrative review","authors":"Vivek Kumar","doi":"10.1016/j.nxnano.2025.100228","DOIUrl":"10.1016/j.nxnano.2025.100228","url":null,"abstract":"<div><div>Solid lipid nanoparticles (SLNs) have long been recognized as a promising and versatile lipid-based drug delivery system. This approach offers an alternative to conventional drug delivery methods by utilizing nanocarriers while overcoming many of their inherent limitations. SLNs possess several advantages, including ease of fabrication, scalability for commercial production, low toxicity, a large encapsulation capacity, and suitability for oral administration. However, research on the application of SLNs in infectious diseases remains highly fragmented. This review aims to consolidate current knowledge on the effectiveness of SLNs in delivering drugs to treat infections caused by bacteria, fungi, viruses, and parasites. Particular attention is given to diseases associated with <em>Mycobacterium</em>, ESKAPE pathogens, <em>Candida</em> spp., <em>Fusarium</em> spp., HIV, SARS-CoV-2, <em>Leishmania</em> spp., <em>Trypanosoma</em> spp., and <em>Plasmodium</em> spp. Additionally, this review highlights key studies published by various research groups investigating SLN-based drug delivery for these pathogens and diseases.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"8 ","pages":"Article 100228"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144721560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stimuli-responsive nanogels in wound care: A comprehensive review 刺激反应纳米凝胶在伤口护理中的应用综述
Next Nanotechnology Pub Date : 2025-01-01 Epub Date: 2025-09-10 DOI: 10.1016/j.nxnano.2025.100260
Tanisha Das , Mouli Das , Shirin Sultana , Rakesh Swain
{"title":"Stimuli-responsive nanogels in wound care: A comprehensive review","authors":"Tanisha Das ,&nbsp;Mouli Das ,&nbsp;Shirin Sultana ,&nbsp;Rakesh Swain","doi":"10.1016/j.nxnano.2025.100260","DOIUrl":"10.1016/j.nxnano.2025.100260","url":null,"abstract":"<div><div>Chronic wounds, including diabetic ulcers, burns, and surgical scars, fail to follow the normal stages of wound healing due to persistent inflammation, infection, and impaired tissue regeneration. Smart nanogels- stimuli-responsive, nanoscale hydrogel systems-have emerged as promising carriers for targeted and controlled drug delivery in such complex wound environments. This review highlights the structural characteristics of nanogels and critically evaluates pH, temperature, enzyme, glucose, and ROS-responsive nanogels used for wound healing. Studies show that pH-sensitive nanogels selectively release antimicrobials in acidic wound environments, while thermos-responsive formulations enhance drug release under elevated wound temperatures. Enzyme-response nanogels regulate metalloproteinase activity and promote collagen deposition. ROS-scavenging systems restore redox balance, aiding tissue repair in oxidative-stressed wounds. Glucose-responsive nanogels improve diabetic wound care by releasing insulin or antioxidants in hyperglycemic conditions. Despite their therapeutic potential, challenges remain in maintaining nanogel stability, scalability, and precise responsiveness. This review synthesizes current advancements and identifies future directions for the clinical translation of smart nanogels in chronic wound management.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"8 ","pages":"Article 100260"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145026779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Graphene incorporated zinc oxide hybrid nanofluid for energy-efficient heat transfer application: A thermal lens study 用于高能效传热应用的石墨烯与氧化锌混合纳米流体:热透镜研究
Next Nanotechnology Pub Date : 2025-01-01 Epub Date: 2024-08-30 DOI: 10.1016/j.nxnano.2024.100100
Vijayakumar Gokul , Mohanachandran Nair Sindhu Swapna , Sankaranarayana Iyer Sankararaman
{"title":"Graphene incorporated zinc oxide hybrid nanofluid for energy-efficient heat transfer application: A thermal lens study","authors":"Vijayakumar Gokul ,&nbsp;Mohanachandran Nair Sindhu Swapna ,&nbsp;Sankaranarayana Iyer Sankararaman","doi":"10.1016/j.nxnano.2024.100100","DOIUrl":"10.1016/j.nxnano.2024.100100","url":null,"abstract":"<div><p>The work focuses on the development of a hybrid nanofluid (NF) comprising zinc oxide-graphene (ZG) to address heat transfer (HT) limitations in thermal systems. The study employs a highly sensitive mode-mismatched dual-beam thermal lens (MDTL) method to analyze the lattice dislocation-induced thermal diffusivity (D) modifications of the hybrid NF. The hybrid composite (HC) is synthesized by solid-state mixing and annealing of ZG. The formation of ZG hybrid composites is revealed through X-ray diffraction (XRD), Fourier transform infrared, X-ray photoelectron, and Raman spectroscopic analyses. The structural dislocations present in the HC are understood from XRD and Raman analyses. Ultraviolet-visible and photoluminescence spectroscopic studies revealed the optical properties of the samples. The MDTL study is carried out by preparing the NFs of the synthesized samples in the base fluid, ethylene glycol (EG), and reveals the impact of crystallite defects on the thermal characteristics of the synthesized composites. Thus, the study suggests the potential capability of ZG composites in tuning the thermal behaviour of EG for HT applications.</p></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100100"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949829524000615/pdfft?md5=1cc71aad37807fbfb09943eb1ef72847&pid=1-s2.0-S2949829524000615-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142098251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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