Next Nanotechnology最新文献

{"title":"Mechanistic study of iron oxide nanoparticles synthesized from sapota leaves extract for the removal of crystal violet from model industrial effluent: Experimental, simulation and RSM modelling","authors":"Pooja Patil ,&nbsp;Narasimha Raghavendra ,&nbsp;Latha M. S ,&nbsp;Shashidhar","doi":"10.1016/j.nxnano.2026.100379","DOIUrl":"10.1016/j.nxnano.2026.100379","url":null,"abstract":"<div><div>There are serious health and environmental hazards when toxic dyes from the textile industry are dumped into waterways. These dyes were not removed by conventional adsorbents. Therefore, the current study offers a novel method for creating environmentally friendly iron oxide nanoparticles using sapota leaves extract. The physical and chemical characteristics of iron oxide nanoparticles were analysed by utilizing a variety of instrumental techniques. Batch adsorption studies revealed the ideal conditions for eliminating Crystal Violet (C₂₅ H ₃₀ N ₃ Cl) dye. With a pH of 10, 0.5 g of nanoparticles, 60 min of reaction time, 30 mg/L of dye, and 303 K of reaction temperature. The environmentally friendly iron oxide nanoparticles demonstrated successful removal of 93.90 % of Crystal Violet (CV) dye in the aqueous solution and the computed equilibrium adsorption capacity value (Q_e) was 2.817 mg/g at optimal conditions. Isotherm studies showed that, the Langmuir isotherm model described the adsorption of crystal violet dye by environmentally benign iron oxide nanoparticles. Thermodynamic studies revealed that the adsorption process was exothermic and spontaneous. The adsorption of crystal violet dye onto environmentally friendly iron oxide nanoparticles was described by kinetic parameters that were determined to be a pseudo-second-order model (R² = 0.9996). The CV adsorption methods suggested surface complexation, cation π-π interaction, hydrogen bonding, electrostatic interaction, and physical adsorption through various internal and surface moieties. Additionally, Response Surface Methodology (RSM) was assessed, and it was shown that while higher temperatures will negatively affect % removal, the low temperature of 303 K is advantageous for % removal. The outcomes of the RSM model are consistent with the observations from the experiments. To analyze the associated adsorption mechanism, theoretically sophisticated models such as Monte Carlo (MC) simulation, fractional free volume (FFV), adsorption loading and isotherm were employed.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100379"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of silver nanoparticles synthesized from Stachytarpheta jamaicensis leaf extract on Macrotyloma uniflorum germination","authors":"K. Deeksha ,&nbsp;Dakshayini","doi":"10.1016/j.nxnano.2026.100363","DOIUrl":"10.1016/j.nxnano.2026.100363","url":null,"abstract":"<div><div>This research focuses on the synthesis of silver nanoparticles (AgNPs) using leaf extract of <em>Stachytarpheta jamaicensis</em> (SJLE) and examines their effectiveness in plant growth stimulation under agricultural conditions. On addition of SJLE to a 1.0 mM AgNO₃ solution, a visible colour change to reddish brown was observed within 45 min, indicating the formation of silver nanoparticles. UV-Vis spectrum depicted a prominent peak at 434 nm, confirming the generation of AgNPs from SJLE (SJ-AgNPs). The one-parameter-at-a-time approach for optimizing synthesis parameters revealed maximum SJ-AgNP formation (SPR at 434 nm) at 5 % (v/v) SJLE, 2.0 mM AgNO3, with a 5 h reaction time. SEM images indicated that the nanoparticles were moderately agglomerated and spherical, with a size range of 10–30 nm. In contrast, EDS confirmed the presence of Ag, C, and O elements, signifying their high purity. The capping of SJLE phytochemicals on the SJ-AgNP surface was confirmed by identification of functional groups such as C – H, C – O – C or C – O, C – N, C= O and O – H. XRD pattern showed peaks at 2Ɵ values corresponding to the (111), (200), (220) and (311) planes confirming the crystalline nature and face centred cubic structure of the AgNPs. Biological evaluation showed that these SJ-AgNPs exhibited a dose-dependent influence on horse gram seed germination and early growth. At low to moderate concentrations (2 – 8 mg/L), the nanoparticles enhanced both germination rate and seedling growth. However, concentrations above 10 mg/L drastically inhibited germination percentage, delayed germination, and reduced seedling biomass and root length, indicating phytotoxicity at elevated levels.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100363"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic nanocomposites of gold nanorods and reduced graphene oxide for optical and electrochemical sensing of hydrogen peroxide","authors":"Sumit Dokwal ,&nbsp;Poonam Mahendia ,&nbsp;Monika Matiyani ,&nbsp;Suman Mahendia","doi":"10.1016/j.nxnano.2025.100344","DOIUrl":"10.1016/j.nxnano.2025.100344","url":null,"abstract":"<div><div>Hydrogen peroxide (H₂O₂) plays important roles in biological and industrial processes, making its reliable detection essential. But its excessive levels pose health and ecological risks, necessitating sensitive detection methods. The present study presents synthesis and characterization of gold nanorods (AuNRs) and their reduced graphene oxide (RGO) nanocomposites as a dual optical–electrochemical platform for H₂O₂ sensing. AuNRs show a clear LSPR response with an optical detection limit of ∼18 µM, while integrating them with RGO greatly enhances electrochemical performance through improved charge transfer and structural stability. The electrochemical studies identify RGO-AuNRs electrode delivery for a broad linear range (17 nM–1 mM) with almost 3 times enhancement in sensitivity compared to AuNRs alone which shows only lower detection limit for H₂O₂ sensing. The combined optical and electrochemical behavior, together with improved stability and cost-effective synthesis, demonstrates the advantage of this hybrid material and highlights its potential for practical biosensing applications.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"100344"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genotype-guided liposome engineering for precision pulmonary therapy: Linking genetic variants to nanocarrier design and clinical translation","authors":"Nourhan Elsayed","doi":"10.1016/j.nxnano.2026.100492","DOIUrl":"10.1016/j.nxnano.2026.100492","url":null,"abstract":"<div><div>Inhalable liposomal nanomedicines hold transformative potential for the treatment of pulmonary diseases, yet their clinical translation is hindered by formulation instability, unpredictable lung deposition, and the absence of patient-specific design criteria. Conventional one-size-fits-all approaches fail to accommodate the genetic heterogeneity that governs disease pathogenesis and therapeutic response. This review establishes a pharmacogenomics-driven engineering framework in which patient-specific genetic variants serve as the foundational design parameters for inhalable liposomes. Within this framework, clinically actionable polymorphisms are translated into formulation specifications: the <em>MUC5B</em> rs35705950 variant, associated with hyper-viscous mucus, requires surface engineering with muco-penetrating polymers to enable diffusion through the airway barrier; loss-of-function <em>CYP3A4</em> polymorphisms, which reduce drug metabolism, necessitate sustained-release lipid compositions to prevent toxicity; <em>GSTM1</em> null genotypes, characterized by impaired oxidative stress response, demand antioxidant co-encapsulation strategies; and <em>EGFR</em>-mutant lung cancers require pH-responsive, ligand-targeted liposomes for on-demand drug release in the acidic tumor microenvironment. Advanced material engineering and drying technologies are strategically selected to preserve these genetically informed specifications during manufacture. A tiered bioassessment cascade, comprising regulatory-grade cascade impaction, epithelial barrier integrity assays, and high-resolution molecular imaging, validates that aerodynamic performance and targeted biodistribution align with predefined genetic criteria. By synthesizing pharmacogenomics, rational material design, and predictive analytics into a unified workflow, this framework transforms liposome engineering from an empirical process into a precision discipline. Translational scalability is addressed through a modular platform strategy that enables cost-effective, genotype-adaptable production. This convergent approach provides an operational foundation for next-generation inhalable nanotherapies calibrated to the individual molecular landscape of each patient.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100492"},"PeriodicalIF":3.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148523552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive review on various synthesis approaches and application of inorganic and carbon quantum dots","authors":"Manish Kumar,&nbsp;Madhulata Shukla","doi":"10.1016/j.nxnano.2026.100512","DOIUrl":"10.1016/j.nxnano.2026.100512","url":null,"abstract":"<div><div>Quantum dots (QDs) are nanostructures that are confined to a zero-dimensional electronic structure. QDs exhibit different optical and electronic properties due to variations in size, making them highly appealing for use in optoelectronics, photocatalysis, sensing, and biomedicine. Both inorganic quantum dots (IQDs) and Carbon Quantum Dots (CQDs) have been effectively employed as nanomaterials, due to their excellent photoluminescence properties, high levels of biocompatibility, and vast surface area. Variant synthesis methods have been recognized for their ability to control size, morphology, and surface chemistry. There are two main strategies for synthesizing these two QDs. One is top-down method and another is the bottom-up method. Further, green synthesis techniques and synthesis in ionic liquids have been discussed and reviewed. Application of QD in various fields such as LEDs, bioimaging, antibacterial activity, drug delivery, etc. has been discussed comprehensively. Finally, some perspectives and possible directions for the future development of IQDs and CQDs are discussed.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100512"},"PeriodicalIF":3.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148523558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellulose nanocrystals: A versatile biobased nano material","authors":"Tapasi Das","doi":"10.1016/j.nxnano.2026.100522","DOIUrl":"10.1016/j.nxnano.2026.100522","url":null,"abstract":"<div><div>Cellulose nanocrystals (CNCs) are a type of bio-based nanomaterial derived from cellulose, the most abundant biopolymer on Earth. CNCs are rod-shaped sustainable nanoparticles with exceptional mechanical strength, high aspect ratio, and high crystallinity, among other special qualities. Due to their potential applications in various domains, including materials science, biomedical engineering, and renewable energy, these nanomaterials have garnered significant attention in recent years. Using acid hydrolysis or other top-down methods, CNCs can be recovered from various cellulosic sources, including cotton, wood, and bacterial cellulose. The surface chemistry of CNCs can be modified to provide specific functions, thereby expanding their range of applications to include energy storage, biomedicine, and nanocomposites. This article outlines CNC production, characteristics, and uses, emphasizing the material's promise as a sustainable nanomaterial for cutting-edge technologies. The importance of CNCs in the creation of high-performance and sustainable materials is emphasized by the discussion of recent developments in CNC-based materials and their possible effects on different industries.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100522"},"PeriodicalIF":3.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148523676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioimaging potential: Comparative study of ZnO nanoparticles synthesized via green and chemical routes","authors":"Anjali Mehto,&nbsp;Prashant Shukla","doi":"10.1016/j.nxnano.2024.100118","DOIUrl":"10.1016/j.nxnano.2024.100118","url":null,"abstract":"<div><div>Zinc Oxide Nanoparticles (ZnO NPs) were synthesized through chemical and green synthesis methods employing Ficus religiosa (peepal) leaf extract. The synthesized nanoparticles underwent comprehensive characterization using various techniques such as Powder X-ray Diffractometry (PXRD), Fourier-transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), Photoluminescence (PL), UV–visible Spectroscopy, and Spectroscopic Ellipsometry. The PXRD analysis confirmed a hexagonal wurtzite structure with excellent crystallinity in the product. UV–visible studies indicated band gap energies of 3.13 eV and 2.7 eV for green-synthesized and chemically synthesized ZnO NPs, respectively. There was notable augmentation in the fluorescence characteristics of ZnO NPs derived through green synthesis when compared to chemically synthesized NPs. This observed enhancement in fluorescence renders the green-synthesized ZnO NPs particularly advantageous for bio-imaging.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100118"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143146329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrophobic starch acetate nanoparticles: A biopolymer-based system for sustained antitubercular drug release","authors":"Gaurang Rami ,&nbsp;Pruthviraj Limbachiya ,&nbsp;Mohyuddin Maradiya ,&nbsp;Girish Acharya ,&nbsp;Jabali Vora","doi":"10.1016/j.nxnano.2024.100120","DOIUrl":"10.1016/j.nxnano.2024.100120","url":null,"abstract":"<div><div>The objective of the research was to evaluate the utilization of starch acetate nanoparticles (SANPs) as drug delivery carriers for antitubercular drugs (Isoniazid, Rifampicin, and Pyrazinamide). The SANPs were synthesized employing ultrasonic-assisted double emulsification solvent evaporation method, permitting effective drug encapsulation. Chemical modification of native starch strengthened its hydrophobicity, as indicated by lower crystallinity in XRD analysis. The TGA validated the thermal stability of SANPs. Morphological investigation indicated a beehive-like structure with constant porosity changed to evenly dispersed spherical nanoparticles when Starch acetate is converted into SANPs. Dynamic light scattering measured the particle sizes of SANPs to be 161 nm. Drug encapsulation brought up the SANPs particle size to 249 nm. Isoniazid, Rifampicin, and Pyrazinamide exhibited 72 %, 83 %, and 75 % encapsulation efficiency at a 2:1 polymer-drug ratio, respectively. In phosphate-buffered saline (pH 7.4), drug release behavior exhibited 55 %, 30 %, and 45 % release of isoniazid, rifampicin, and pyrazinamide over 24 hours. The Korsmeyer-Peppas model demonstrated non-Fickian diffusion for all drug-encapsulated SANPs. Thus, these results contribute to the development of biopolymer-based drug delivery systems for sustainable release of antitubercular drugs.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100120"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143146332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical review of ultra-lightweight foam materials","authors":"Ridhi Saini ,&nbsp;Dipen Kumar Rajak ,&nbsp;Tilak Joshi ,&nbsp;Dwesh Kumar Singh ,&nbsp;Venkat A.N. Chilla ,&nbsp;Sriram Sathaiah","doi":"10.1016/j.nxnano.2025.100138","DOIUrl":"10.1016/j.nxnano.2025.100138","url":null,"abstract":"<div><div>Ultra-lightweight foam (ULF) materials have emerged as transformative solutions across many industries, driven by the increasing demand for lightweight yet high-performance materials. Characterized by their low density, high porosity, and remarkable thermal insulation properties, including exceptional cushioning and shock absorption capabilities. These attributes make them essential in the aerospace, automotive, medical, and construction sectors, where efficiency and performance are paramount. Current trends in ULF materials highlight a strong commitment to sustainability by utilizing bio-based resources and recycled materials. The ULF materials revolutionize various industries by providing lightweight solutions, contributing to energy savings and reducing environmental impact. As industries increasingly prioritize sustainability and performance, ULF materials stand at the forefront of material science innovation, promising a future marked by enhanced efficiency and environmental responsibility. This review explores the classifications, manufacturing techniques, properties, applications, advantages, and challenges associated with ULF materials. This exploration aims to lighten the enormous possibilities that ULF materials present in achieving a more sustainable and high-performance future across diverse applications.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"7 ","pages":"Article 100138"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143146407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring plant-based metallic nanoparticles for advanced medicinal application in diabetes","authors":"Priya ,&nbsp;Anurag Chaudhary ,&nbsp;Chandrababu Rejeeth ,&nbsp;Shobhit Kumar ,&nbsp;Xianting Ding ,&nbsp;Alok Sharma","doi":"10.1016/j.nxnano.2025.100243","DOIUrl":"10.1016/j.nxnano.2025.100243","url":null,"abstract":"<div><div>The emergence of plant based metallic nanoparticles (PMNPs) offers a transformative approach to diabetes therapeutics by merging nanotechnology with green synthesis for enhanced biocompatibility and eco-sustainability. Derived from phytochemical rich plant extracts, PMNPs including gold, silver, zinc oxide and selenium exhibit potent antidiabetic properties through modulation of oxidative stress, insulin sensitivity and β-cell regeneration. Their bio-reductive synthesis not only eliminates hazardous reagents but also harnesses phytoconstituents for targeted delivery and controlled drug release. Recent studies highlight their ability to inhibit key enzymes like α-amylase and α-glucosidase, reduce glucose uptake and improve lipid profiles, positioning them as multifunctional agent in managing Type 2 diabetes. Furthermore, their nanoscale dimensions enable precision medicine application, including sensor-integrated diagnostics and nano-formulated oral therapies. Notably, emerging evidence underscores the role of microRNAs especially miR-21 and miR-12a in regulating pancreatic function and insulin signaling, with PMNP-based systems offering enhanced sensitivity and specificity in miRNA detection. This review explores the therapeutic mechanisms and translational promise of PMNPs and miRNA-based strategies in diabetes care, advocating for integrative, sustainable nanomedicine.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"8 ","pages":"Article 100243"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145264830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}