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Advances in cardiac sounds monitoring enabled by triboelectric sensors 三电传感器在心音监测方面取得的进展
Nano Trends Pub Date : 2024-11-03 DOI: 10.1016/j.nwnano.2024.100057
Xindan Hui , Hengyu Guo
{"title":"Advances in cardiac sounds monitoring enabled by triboelectric sensors","authors":"Xindan Hui ,&nbsp;Hengyu Guo","doi":"10.1016/j.nwnano.2024.100057","DOIUrl":"10.1016/j.nwnano.2024.100057","url":null,"abstract":"<div><div>Cardiac sounds sensor as a noninvasive instrument plays a pivotal role in the early diagnosis of various heart disease. In recent years, triboelectric nanogenerators (TENGs) have been employed widely for sensing different physiological information benefiting from abundant materials choices, simplicity of construction and low cost. More importantly, the fast saturated constitutive characteristic of the contact-separation mode (C-S) TENG demonstrates ultrahigh sensitivity in the detection of micromechanical quantities than traditional piezoelectric sensing mechanism. This article presents an overview of the C-S TENG enabled self-powered cardiac sounds monitoring, focusing on the working principle, performance comparison between C-S TENG and piezoelectric generator (PEG), and related applications. The challenges and future research directions of cardiac sounds sensor and C-S TENG toward micro-displacement region have also been proposed.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"8 ","pages":"Article 100057"},"PeriodicalIF":0.0,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142661329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel non-catalytic plasmonic immunoabsorbant assay amplification mechanism 新型非催化质子免疫吸附测定放大机制
Nano Trends Pub Date : 2024-10-15 DOI: 10.1016/j.nwnano.2024.100056
Aditya Saran , Shuai Hou , Yinglu Ji
{"title":"A novel non-catalytic plasmonic immunoabsorbant assay amplification mechanism","authors":"Aditya Saran ,&nbsp;Shuai Hou ,&nbsp;Yinglu Ji","doi":"10.1016/j.nwnano.2024.100056","DOIUrl":"10.1016/j.nwnano.2024.100056","url":null,"abstract":"<div><div>The amplification of signals is dependent upon enzyme/ catalyst. Enzyme activity, specificity, pH condition, enzyme linkers, stability, storage and efficiency are some very important factors that can eventually affect the detection results. We aimed to amplify signals without the assistance of enzyme/ catalyst so that the strategy can be used in the wide range of signal detection including immune-assay. Silver nanocrystals (Ag NCs) grown from self-nucleation are used as chromogens due to their strong plasmon band at ∼ 400 nm. During 140 s of reaction time in presence of 6.10 mM CTAB and 0.61 mM of AgNO<sub>3</sub>, the 0.57 mM of Ascorbic acid allows Ag over growth on antibody-tagged gold nanospheres (10±0.5 nm) that competes silver atoms from the self-nucleation growth and thus affects the growth kinetics of the latter. By utilizing the opened kinetic window, sensitive detection has been achieved from 6.67 × 10<sup>–14</sup> M (1 pg) to 3.33 × 10<sup>–9</sup> M (50 ng) using human IgG as a model protein. The non-catalytic plasmonic immunoabsorbant assay we developed herein adds a new possibility of plasmonic NPs for sensitive detection. The detection slope and resolution is higher and better than those via signal amplification through the assistance of enzymes/ catalysts. This work supports the concept that nanoparticles mediated reactions are sensitive enough that they have the potential to go independently without enzymes/ catalyst assistance.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"8 ","pages":"Article 100056"},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peeling-induced interfacial roughness and charging for enhanced triboelectric power generation 剥离诱导的界面粗糙度和充电,用于增强三电发电功能
Nano Trends Pub Date : 2024-10-05 DOI: 10.1016/j.nwnano.2024.100055
Da Woon Jin , Hyun Soo Ahn , Dheeraj Kumar , Joo Hyeong Lee , Min Su Kim , Yushin Eom , Ji Ho Youk , Huidrom Hemojit Singh , Jong Hun Kim , Jong Hoon Jung
{"title":"Peeling-induced interfacial roughness and charging for enhanced triboelectric power generation","authors":"Da Woon Jin ,&nbsp;Hyun Soo Ahn ,&nbsp;Dheeraj Kumar ,&nbsp;Joo Hyeong Lee ,&nbsp;Min Su Kim ,&nbsp;Yushin Eom ,&nbsp;Ji Ho Youk ,&nbsp;Huidrom Hemojit Singh ,&nbsp;Jong Hun Kim ,&nbsp;Jong Hoon Jung","doi":"10.1016/j.nwnano.2024.100055","DOIUrl":"10.1016/j.nwnano.2024.100055","url":null,"abstract":"<div><div>To date, there have been a lot of efforts to enhance the conversion efficiency of triboelectric nanogenerators (TENGs) via physical and chemical modifications of the polymer surface. Herein, we report that a facile peeling of polymer from a substrate can enhance the triboelectric power output. The peeling of spin-coated polydimethylsiloxane (PDMS) from glass and polytetrafluoroethylene (PTFE) substrates has revealed a considerable increase in interfacial roughness and lateral friction. Surface-sensitive X-ray photoemission spectroscopy and non-contact current measurements have also revealed the transfer of counter-material and interfacial charging. The surface roughness of peeled PDMS is significant for the PTFE substrate, while the surface charge is significant for the glass substrate. The triboelectric output power density for peeled PDMS from the substrate is similar, 10.3 µW/cm<sup>2</sup>, but significantly larger than that for as-grown PDMS (2.2 µW/cm<sup>2</sup>). The peeling strength of PDMS significantly increases for glass compared to PTFE after the oxygen plasma treatment of substrates. The triboelectric charge of peeled PDMS from a plasma-treated glass substrate is almost 1.3 times larger than that from a PTFE substrate. This work implies that peeling polymer from a rough substrate with a large adhesion force would be a facile and effective way to increase the triboelectric power output, without any delicate surface treatments.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"8 ","pages":"Article 100055"},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142417826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Review on nanocellulose production from agricultural residue through response surface methodology and its applications 通过响应面方法利用农业残留物生产纳米纤维素及其应用综述
Nano Trends Pub Date : 2024-10-02 DOI: 10.1016/j.nwnano.2024.100054
Marjun C. Alvarado , Ma. Cristine Concepcion D. Ignacio , Ma. Camille G. Acabal , Anniver Ryan P. Lapuz , Kevin F. Yaptenco
{"title":"Review on nanocellulose production from agricultural residue through response surface methodology and its applications","authors":"Marjun C. Alvarado ,&nbsp;Ma. Cristine Concepcion D. Ignacio ,&nbsp;Ma. Camille G. Acabal ,&nbsp;Anniver Ryan P. Lapuz ,&nbsp;Kevin F. Yaptenco","doi":"10.1016/j.nwnano.2024.100054","DOIUrl":"10.1016/j.nwnano.2024.100054","url":null,"abstract":"<div><div>Nanocellulose (NC) shows great potential across industries like food, pharmaceuticals, cosmetics, textiles, electronics, and construction. It can be sustainably extracted from agricultural residues using methods such as mechanical processes, acid hydrolysis, and bacterial biosynthesis. This review emphasizes the use of Response Surface Methodology (RSM) in optimizing NC extraction by examining variables like acid concentration, reaction time, and temperature. While RSM is effective, its assumptions of linear and quadratic relationships limit its accuracy in complex systems. Advanced techniques like artificial neural networks (ANN) offer a better alternative, capturing nonlinear relationships more effectively. However, ANN's application in NC extraction is underexplored, calling for future research to improve model precision. Expanding optimization to include response variables like thermal stability and surface charge is also essential for enhancing NC's industrial applications.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"8 ","pages":"Article 100054"},"PeriodicalIF":0.0,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142417762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The synergy of artificial intelligence and nanotechnology towards advancing innovation and sustainability - A mini-review 人工智能与纳米技术在推动创新和可持续发展方面的协同作用 - 综述
Nano Trends Pub Date : 2024-09-29 DOI: 10.1016/j.nwnano.2024.100052
David B. Olawade , Abimbola O. Ige , Abimbola G. Olaremu , James O. Ijiwade , Adedapo O. Adeola
{"title":"The synergy of artificial intelligence and nanotechnology towards advancing innovation and sustainability - A mini-review","authors":"David B. Olawade ,&nbsp;Abimbola O. Ige ,&nbsp;Abimbola G. Olaremu ,&nbsp;James O. Ijiwade ,&nbsp;Adedapo O. Adeola","doi":"10.1016/j.nwnano.2024.100052","DOIUrl":"10.1016/j.nwnano.2024.100052","url":null,"abstract":"<div><div>The convergence of Artificial Intelligence (AI) and nanotechnology is a transformative frontier, holding vast potential for scientific and technological advancements. This review explores the integration of AI and nanotechnology, aiming to uncover current trends, challenges, and future directions across various domains. A scientometric approach was employed, gathering and analyzing existing literature and research in the fields of AI and nanotechnology. Through a systematic examination of recent studies and developments, we identified key trends, challenges, and potential pathways for future research and applications. Findings from this review highlight the significant impact of AI-driven nanotechnology in materials discovery and design, healthcare, environmental monitoring, energy conversion, and quantum computing. These areas have witnessed remarkable advancements, such as the development of novel nanomaterials, precise drug delivery systems, advanced nanosensors, and efficient energy storage solutions. However, challenges persist, including insufficient interdisciplinary collaboration, data quality, ethical concerns, and regulatory frameworks. While challenges require careful consideration and mitigation, the potential for innovation and progress in diverse domains is undeniable. This review underscores the importance of responsible AI use and ongoing research to unlock the full potential of this convergence, ultimately shaping the future of science and technology.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"8 ","pages":"Article 100052"},"PeriodicalIF":0.0,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142417761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-powered highly stretchable ferroelectret nanogenerator towards intelligent sports 面向智能运动的自供电高伸展性铁电体纳米发电机
Nano Trends Pub Date : 2024-09-28 DOI: 10.1016/j.nwnano.2024.100053
Yiqin Wang , Xianfa Cai , Yufeng Guo , Zhi Chen , Yunqi Cao , Wangdi Du , Tian Xia , Nelson Sepulveda , Wei Li
{"title":"Self-powered highly stretchable ferroelectret nanogenerator towards intelligent sports","authors":"Yiqin Wang ,&nbsp;Xianfa Cai ,&nbsp;Yufeng Guo ,&nbsp;Zhi Chen ,&nbsp;Yunqi Cao ,&nbsp;Wangdi Du ,&nbsp;Tian Xia ,&nbsp;Nelson Sepulveda ,&nbsp;Wei Li","doi":"10.1016/j.nwnano.2024.100053","DOIUrl":"10.1016/j.nwnano.2024.100053","url":null,"abstract":"<div><div>Ferroelectret nanogenerators (FENGs), recognized for their porous structures that facilitate charge retention, thereby creating giant electric dipoles and exhibiting remarkable piezoelectric properties, are utilized in the development of various flexible transducers. However, despite their flexibility, most developed ferroelectret nanogenerators lack adequate stretchability and satisfactory transverse piezoelectric properties, significantly inhibiting their widespread deployment in wearable or skin-mounted electronics. Here, we introduce a highly stretchable ferroelectret nanogenerator (HS-FENG) built from laser-induced graphene (LIG), Ecoflex and anhydrous ethanol, demonstrating exceptional flexibility and stretchability, along with longitudinal and transverse piezoelectric effects. The stretchability of HS-FENG can reach a record of 468 %, while the quasi-static piezoelectric coefficients <em>d</em><sub>33</sub> and <em>d</em><sub>31</sub> are approximately 120 pC/N and 70 pC/N, respectively. To our knowledge, this is the first demonstration of the developed FENG with remarkably high stretchability. Furthermore, leveraging the performance of the created HS-FENG, we construct a skin-mounted intelligent kinesiology tape capable of effectively monitoring motion signals from human muscles and joints, thereby offering a deeper understanding of movement for users across different levels of physical activity, from professional athletes to individuals undergoing rehabilitation. The development of intelligent kinesiology tape exemplifies the potential of HS-FENG technology in enhancing professional athletic training and personalized healthcare. It contributes to the advancement of inconspicuous skin-mounted biomechanical feedback systems and human-machine interfaces, marking progress in the field.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"8 ","pages":"Article 100053"},"PeriodicalIF":0.0,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142444643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thermoelectric hydrogels for self-powered wearable biosensing 用于自供电可穿戴生物传感的热电水凝胶
Nano Trends Pub Date : 2024-09-01 DOI: 10.1016/j.nwnano.2024.100050
Xinru Yang , Xueliang Ma , Yu Niu , Yuxiu Yao , Saeed Ahmed Khan , Hulin Zhang , Xiaojing Cui
{"title":"Thermoelectric hydrogels for self-powered wearable biosensing","authors":"Xinru Yang ,&nbsp;Xueliang Ma ,&nbsp;Yu Niu ,&nbsp;Yuxiu Yao ,&nbsp;Saeed Ahmed Khan ,&nbsp;Hulin Zhang ,&nbsp;Xiaojing Cui","doi":"10.1016/j.nwnano.2024.100050","DOIUrl":"10.1016/j.nwnano.2024.100050","url":null,"abstract":"<div><p>Although the flourishing of the Internet of Things and artificial intelligence has accelerated the development of wearable smart bioelectronics, heavy reliance on external power remains a problem that needs to be solved. Thermoelectric materials have emerged as a promising solution, efficiently converting body heat into electrical energy to provide a stable and unrestricted power supply for wearables. Moreover, in the field of wearable thermoelectric biosensing, where flexibility is highly demanded, hydrogels with excellent electrical conductivity, flexibility and biocompatibility through structural and compositional optimization have become ideal materials for constructing biosensors and meet the diverse application needs of wearable bioelectronics. This article systematically reviews the latest research progress on thermoelectric gels for self-powered wearable biosensing, including the principles of thermoelectric operation, as well as the preparation, design, and application of thermoelectric hydrogels. The current state of thermoelectric gel-based wearable applications in the fields of temperature sensing, strain sensing, temperature-strain synergistic sensing, respiratory monitoring, and sweat analysis are displayed in the article. Finally, the paper summarizes the current challenges and prospects of thermoelectric gels in self-powered wearable bioelectronics, encouraging the rapid application and realization of thermoelectric gel-based smart wearables.</p></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"7 ","pages":"Article 100050"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666978124000205/pdfft?md5=2314bd935489ce343496bb14caa43189&pid=1-s2.0-S2666978124000205-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142149757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metal-organic framework-based off-on fluorescent probe for highly selective and sensitive phosphate detection 基于金属有机框架的离体荧光探针,用于高选择性和高灵敏度磷酸盐检测
Nano Trends Pub Date : 2024-09-01 DOI: 10.1016/j.nwnano.2024.100051
Nan-Si Li , Kai-An Cheng , Ying-Pei Hsu , Hung-Wei Yang
{"title":"Metal-organic framework-based off-on fluorescent probe for highly selective and sensitive phosphate detection","authors":"Nan-Si Li ,&nbsp;Kai-An Cheng ,&nbsp;Ying-Pei Hsu ,&nbsp;Hung-Wei Yang","doi":"10.1016/j.nwnano.2024.100051","DOIUrl":"10.1016/j.nwnano.2024.100051","url":null,"abstract":"<div><p>The escalating demand for versatile and precise diagnostic tools across various biomedical applications has led to the development of an advanced assay utilizing a fluorescent metal-organic framework (MOF). Our novel approach centers on the synthesis of a controlled-explosive NH<sub>2</sub>-MIL-53(Fe) MOF, composed of trivalent iron ions and 2-aminoterephthalic acid. This framework possesses the unique capability to produce explosively enhanced fluorescence upon environmental triggers such as phosphate conditions, where it disintegrates to release intensely fluorescent molecules. The surface of NH<sub>2</sub>-MIL-53(Fe) MOF was further functionalized with poly(acrylic acid-co-maleic acid) polymers (PAAcoMA) to form PAAcoMA@MIL-53(Fe) MOF, thereby enhancing its stability. The presence of phosphate ions is detected by the degree of fluorescence resulting from the unquenching of PAAcoMA@MIL-53(Fe) MOF. This system demonstrates not only high sensitivity but also a broad dynamic range, making it suitable for phosphate ion detection. This innovative technology holds promise for significant advancements in the field of phosphate indicator-based biosensing, with potential applications in the development of PCR kits, thereby supporting a wide range of diagnostic and therapeutic applications.</p></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"7 ","pages":"Article 100051"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666978124000217/pdfft?md5=7aedd26e7aaa94b4d1c5fa0fb55d7edb&pid=1-s2.0-S2666978124000217-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142232743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of B, Si, Ge, and As impurities on the electronic properties of graphene quantum dot: A density functional theory study B、Si、Ge 和 As 杂质对石墨烯量子点电子特性的影响:密度泛函理论研究
Nano Trends Pub Date : 2024-09-01 DOI: 10.1016/j.nwnano.2024.100049
Salam K. Khamees , Fouad N. Ajeel , Kareem H. Mohsin , Mohammed N. Mutier
{"title":"Influence of B, Si, Ge, and As impurities on the electronic properties of graphene quantum dot: A density functional theory study","authors":"Salam K. Khamees ,&nbsp;Fouad N. Ajeel ,&nbsp;Kareem H. Mohsin ,&nbsp;Mohammed N. Mutier","doi":"10.1016/j.nwnano.2024.100049","DOIUrl":"10.1016/j.nwnano.2024.100049","url":null,"abstract":"<div><p>The electronic features of chemically functionalized graphene quantum dots (GQDs) are investigated using density functional theory (DFT). The fabrication of nanoscale devices needs to enhance- the electronic performance of customized GQDs, which is crucial in many applications. GQDs can be used as a model with the molecule C<sub>24</sub>H<sub>12</sub>. We investigated the effects of adding metalloid impurities) boron B, silicon Si, germanium Ge, and arsenic As) on the structure and electronic properties of the dots at the B3LYP/6–31 level using the Gaussian 09 program package. The obtained results show efficient adding impurities B, Si, Ge, and As on the structure and electronic properties of GQDs, where it is noted that the energy gap change with -3.085, -12.340, -13.907, and -66.846 %, respectively.These results not only advance our knowledge of the mechanisms behind chemical doping, which may change the electronic features of quantum dots, but they also provide support for the development of nanodevices that have better electronic performance. As observed with As/GQD, it is anticipated that this system, which has the lowest possible chemical hardness values, will function as an effective corrosion inhibitor.</p></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"7 ","pages":"Article 100049"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666978124000199/pdfft?md5=b528ec7dbeb5be99f0dc4b9de2f3d87c&pid=1-s2.0-S2666978124000199-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142149756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photoacoustic features of nylon-11 nanoparticles for breast cancer imaging, and their modification with trastuzumab, sorafenib, and nutlin-3a for theranostic applications 用于乳腺癌成像的尼龙-11 纳米粒子的光声特征及其与曲妥珠单抗、索拉非尼和 nutlin-3a 的改性在治疗学中的应用
Nano Trends Pub Date : 2024-07-23 DOI: 10.1016/j.nwnano.2024.100047
Özlem Şen , Paolo Armanetti , Alessio Carmignani , Federico Catalano , Giammarino Pugliese , Luca Menichetti , Gianni Ciofani
{"title":"Photoacoustic features of nylon-11 nanoparticles for breast cancer imaging, and their modification with trastuzumab, sorafenib, and nutlin-3a for theranostic applications","authors":"Özlem Şen ,&nbsp;Paolo Armanetti ,&nbsp;Alessio Carmignani ,&nbsp;Federico Catalano ,&nbsp;Giammarino Pugliese ,&nbsp;Luca Menichetti ,&nbsp;Gianni Ciofani","doi":"10.1016/j.nwnano.2024.100047","DOIUrl":"10.1016/j.nwnano.2024.100047","url":null,"abstract":"<div><p>Breast cancer is a complex and diverse disease that requires accurate diagnostic methods and customized treatment approaches to enhance patient outcomes. In this study, we investigate the potential of nylon-11 nanoparticles (nylon NPs) for both imaging and therapy of breast cancer. Nylon NPs possess excellent photoacoustic properties, which enable them to detect and locate drug delivery to the tumor with high sensitivity. This suggests that nylon NPs may be a valuable tool for improving breast cancer diagnosis and treatment. Comprehensive characterization has been performed, including morphological analysis and spectroscopic studies. Further modification with diagnostic and therapeutic agents, such as trastuzumab, sorafenib, and nutlin-3a, enhances their specificity and efficacy in targeting breast cancer cells. The drug-loaded nanoparticles exhibit controlled release profiles under various pH conditions, mimicking the tumor microenvironment. Cytocompatibility studies reveal the biocompatibility of bare nylon NPs, while drug-loaded nanoparticles show concentration-dependent cytotoxic effects, indicating their potential as therapeutic agents. Moreover, cellular internalization studies confirm the efficient uptake by breast cancer cells. Overall, this research lays the groundwork for the development of novel nanomedicine approaches aimed at addressing the challenges associated with breast cancer diagnosis and treatment, offering promising avenues for precise cancer management.</p></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"7 ","pages":"Article 100047"},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666978124000175/pdfft?md5=31fa2074f9304cd7276fa9751f22df54&pid=1-s2.0-S2666978124000175-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141847926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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