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Multifunctional scaffolds of β-tricalcium phosphate/bioactive glass coated with zinc oxide and copper oxide nanoparticles 涂有氧化锌和氧化铜纳米颗粒的β-磷酸三钙/生物活性玻璃多功能支架
Nano Trends Pub Date : 2024-11-10 DOI: 10.1016/j.nwnano.2024.100059
Rodrigo L.M.S. Oliveira , Lucas Barbosa , Thaís C. Pereira , Luísa R.M. Dona , Thiago G. Tabuti , Dayane B. Tada , Eduardo R. Triboni , Luciane D. de Oliveira , Eliandra S. Trichês
{"title":"Multifunctional scaffolds of β-tricalcium phosphate/bioactive glass coated with zinc oxide and copper oxide nanoparticles","authors":"Rodrigo L.M.S. Oliveira ,&nbsp;Lucas Barbosa ,&nbsp;Thaís C. Pereira ,&nbsp;Luísa R.M. Dona ,&nbsp;Thiago G. Tabuti ,&nbsp;Dayane B. Tada ,&nbsp;Eduardo R. Triboni ,&nbsp;Luciane D. de Oliveira ,&nbsp;Eliandra S. Trichês","doi":"10.1016/j.nwnano.2024.100059","DOIUrl":"10.1016/j.nwnano.2024.100059","url":null,"abstract":"<div><div>Incorporating nanoparticles into scaffolds with regenerative potential is a promissory strategy to provide them with antimicrobial activity. Bioceramics, such as β-tricalcium phosphate (β-TCP) and bioactive glasses (BGs), stand out among synthetic materials for bone regeneration. In this context, we report the incorporation of zinc oxide (ZnO) and copper oxide/copper nitrate (CuO/Cu<sub>2</sub>H<sub>3</sub>NO<sub>5</sub>) nanoparticles onto the surface of the β-TCP/BG scaffolds. This report addresses the physicochemical characterization of the scaffolds, their antimicrobial activity, and their response to MC3T3-E1 cells. Our findings show that the incorporation of both nanoparticles effectively inhibited <em>S. aureus</em> growth<em>,</em> including its biofilm formation. While the presence of the nanoparticles initially decreased MC3T3-E1 cell viability, cell proliferation improved with prolonged incubation. Overall, the β-TCP/BG_Zn and β-TCP/BG_Cu scaffolds showed an early antimicrobial response, aiding infection eradication, while also supporting cell proliferation over time.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"8 ","pages":"Article 100059"},"PeriodicalIF":0.0,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142661330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanotechnology platforms for antigen and immunostimulant delivery in vaccine formulations 用于疫苗制剂中抗原和免疫刺激剂递送的纳米技术平台
Nano Trends Pub Date : 2024-11-08 DOI: 10.1016/j.nwnano.2024.100058
Patricio G. Márquez , Federico J. Wolman , Romina J. Glisoni
{"title":"Nanotechnology platforms for antigen and immunostimulant delivery in vaccine formulations","authors":"Patricio G. Márquez ,&nbsp;Federico J. Wolman ,&nbsp;Romina J. Glisoni","doi":"10.1016/j.nwnano.2024.100058","DOIUrl":"10.1016/j.nwnano.2024.100058","url":null,"abstract":"<div><div>Vaccines represent a cornerstone in global health history, marking one of the most significant scientific achievements. Initially consisting of live or attenuated microorganisms, vaccines have evolved to include subunit vaccines, which offer greater specificity, safety, and production advantages. However, subunit vaccines require adjuvants due to the low immunogenicity of their antigens. These adjuvants include immunostimulatory molecules and particulate systems, which serve as carriers for both antigens and immunostimulants. The nanoscale dimensions of these particulate systems confer distinct advantages. This review comprehensively discusses FDA- and EMA-approved vaccines that incorporate adjuvants, emphasizing the growing use of nanoparticulate adjuvants in enhancing vaccine efficacy and safety. The unique physicochemical properties of nanoscopic systems, such as hydrodynamic size, shape, surface charge, hydrophobicity and degradation profiles are explored, that determine their effectiveness in vaccine formulations.</div><div>Furthermore, innovations in production scalability and alternative delivery routes, such as oral or transdermal vaccines, offer promising solutions to global vaccine accessibility challenges, particularly in resource-limited settings. The ongoing integration of nanotechnology platforms thus continues to expand the potential of vaccines, ensuring safer, more effective, and more accessible solutions for global immunization efforts.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"8 ","pages":"Article 100058"},"PeriodicalIF":0.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in cardiac sounds monitoring enabled by triboelectric sensors 三电传感器在心音监测方面取得的进展
Nano Trends Pub Date : 2024-11-03 DOI: 10.1016/j.nwnano.2024.100057
Xindan Hui , Hengyu Guo
{"title":"Advances in cardiac sounds monitoring enabled by triboelectric sensors","authors":"Xindan Hui ,&nbsp;Hengyu Guo","doi":"10.1016/j.nwnano.2024.100057","DOIUrl":"10.1016/j.nwnano.2024.100057","url":null,"abstract":"<div><div>Cardiac sounds sensor as a noninvasive instrument plays a pivotal role in the early diagnosis of various heart disease. In recent years, triboelectric nanogenerators (TENGs) have been employed widely for sensing different physiological information benefiting from abundant materials choices, simplicity of construction and low cost. More importantly, the fast saturated constitutive characteristic of the contact-separation mode (C-S) TENG demonstrates ultrahigh sensitivity in the detection of micromechanical quantities than traditional piezoelectric sensing mechanism. This article presents an overview of the C-S TENG enabled self-powered cardiac sounds monitoring, focusing on the working principle, performance comparison between C-S TENG and piezoelectric generator (PEG), and related applications. The challenges and future research directions of cardiac sounds sensor and C-S TENG toward micro-displacement region have also been proposed.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"8 ","pages":"Article 100057"},"PeriodicalIF":0.0,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142661329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel non-catalytic plasmonic immunoabsorbant assay amplification mechanism 新型非催化质子免疫吸附测定放大机制
Nano Trends Pub Date : 2024-10-15 DOI: 10.1016/j.nwnano.2024.100056
Aditya Saran , Shuai Hou , Yinglu Ji
{"title":"A novel non-catalytic plasmonic immunoabsorbant assay amplification mechanism","authors":"Aditya Saran ,&nbsp;Shuai Hou ,&nbsp;Yinglu Ji","doi":"10.1016/j.nwnano.2024.100056","DOIUrl":"10.1016/j.nwnano.2024.100056","url":null,"abstract":"<div><div>The amplification of signals is dependent upon enzyme/ catalyst. Enzyme activity, specificity, pH condition, enzyme linkers, stability, storage and efficiency are some very important factors that can eventually affect the detection results. We aimed to amplify signals without the assistance of enzyme/ catalyst so that the strategy can be used in the wide range of signal detection including immune-assay. Silver nanocrystals (Ag NCs) grown from self-nucleation are used as chromogens due to their strong plasmon band at ∼ 400 nm. During 140 s of reaction time in presence of 6.10 mM CTAB and 0.61 mM of AgNO<sub>3</sub>, the 0.57 mM of Ascorbic acid allows Ag over growth on antibody-tagged gold nanospheres (10±0.5 nm) that competes silver atoms from the self-nucleation growth and thus affects the growth kinetics of the latter. By utilizing the opened kinetic window, sensitive detection has been achieved from 6.67 × 10<sup>–14</sup> M (1 pg) to 3.33 × 10<sup>–9</sup> M (50 ng) using human IgG as a model protein. The non-catalytic plasmonic immunoabsorbant assay we developed herein adds a new possibility of plasmonic NPs for sensitive detection. The detection slope and resolution is higher and better than those via signal amplification through the assistance of enzymes/ catalysts. This work supports the concept that nanoparticles mediated reactions are sensitive enough that they have the potential to go independently without enzymes/ catalyst assistance.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"8 ","pages":"Article 100056"},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peeling-induced interfacial roughness and charging for enhanced triboelectric power generation 剥离诱导的界面粗糙度和充电,用于增强三电发电功能
Nano Trends Pub Date : 2024-10-05 DOI: 10.1016/j.nwnano.2024.100055
Da Woon Jin , Hyun Soo Ahn , Dheeraj Kumar , Joo Hyeong Lee , Min Su Kim , Yushin Eom , Ji Ho Youk , Huidrom Hemojit Singh , Jong Hun Kim , Jong Hoon Jung
{"title":"Peeling-induced interfacial roughness and charging for enhanced triboelectric power generation","authors":"Da Woon Jin ,&nbsp;Hyun Soo Ahn ,&nbsp;Dheeraj Kumar ,&nbsp;Joo Hyeong Lee ,&nbsp;Min Su Kim ,&nbsp;Yushin Eom ,&nbsp;Ji Ho Youk ,&nbsp;Huidrom Hemojit Singh ,&nbsp;Jong Hun Kim ,&nbsp;Jong Hoon Jung","doi":"10.1016/j.nwnano.2024.100055","DOIUrl":"10.1016/j.nwnano.2024.100055","url":null,"abstract":"<div><div>To date, there have been a lot of efforts to enhance the conversion efficiency of triboelectric nanogenerators (TENGs) via physical and chemical modifications of the polymer surface. Herein, we report that a facile peeling of polymer from a substrate can enhance the triboelectric power output. The peeling of spin-coated polydimethylsiloxane (PDMS) from glass and polytetrafluoroethylene (PTFE) substrates has revealed a considerable increase in interfacial roughness and lateral friction. Surface-sensitive X-ray photoemission spectroscopy and non-contact current measurements have also revealed the transfer of counter-material and interfacial charging. The surface roughness of peeled PDMS is significant for the PTFE substrate, while the surface charge is significant for the glass substrate. The triboelectric output power density for peeled PDMS from the substrate is similar, 10.3 µW/cm<sup>2</sup>, but significantly larger than that for as-grown PDMS (2.2 µW/cm<sup>2</sup>). The peeling strength of PDMS significantly increases for glass compared to PTFE after the oxygen plasma treatment of substrates. The triboelectric charge of peeled PDMS from a plasma-treated glass substrate is almost 1.3 times larger than that from a PTFE substrate. This work implies that peeling polymer from a rough substrate with a large adhesion force would be a facile and effective way to increase the triboelectric power output, without any delicate surface treatments.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"8 ","pages":"Article 100055"},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142417826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Review on nanocellulose production from agricultural residue through response surface methodology and its applications 通过响应面方法利用农业残留物生产纳米纤维素及其应用综述
Nano Trends Pub Date : 2024-10-02 DOI: 10.1016/j.nwnano.2024.100054
Marjun C. Alvarado , Ma. Cristine Concepcion D. Ignacio , Ma. Camille G. Acabal , Anniver Ryan P. Lapuz , Kevin F. Yaptenco
{"title":"Review on nanocellulose production from agricultural residue through response surface methodology and its applications","authors":"Marjun C. Alvarado ,&nbsp;Ma. Cristine Concepcion D. Ignacio ,&nbsp;Ma. Camille G. Acabal ,&nbsp;Anniver Ryan P. Lapuz ,&nbsp;Kevin F. Yaptenco","doi":"10.1016/j.nwnano.2024.100054","DOIUrl":"10.1016/j.nwnano.2024.100054","url":null,"abstract":"<div><div>Nanocellulose (NC) shows great potential across industries like food, pharmaceuticals, cosmetics, textiles, electronics, and construction. It can be sustainably extracted from agricultural residues using methods such as mechanical processes, acid hydrolysis, and bacterial biosynthesis. This review emphasizes the use of Response Surface Methodology (RSM) in optimizing NC extraction by examining variables like acid concentration, reaction time, and temperature. While RSM is effective, its assumptions of linear and quadratic relationships limit its accuracy in complex systems. Advanced techniques like artificial neural networks (ANN) offer a better alternative, capturing nonlinear relationships more effectively. However, ANN's application in NC extraction is underexplored, calling for future research to improve model precision. Expanding optimization to include response variables like thermal stability and surface charge is also essential for enhancing NC's industrial applications.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"8 ","pages":"Article 100054"},"PeriodicalIF":0.0,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142417762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The synergy of artificial intelligence and nanotechnology towards advancing innovation and sustainability - A mini-review 人工智能与纳米技术在推动创新和可持续发展方面的协同作用 - 综述
Nano Trends Pub Date : 2024-09-29 DOI: 10.1016/j.nwnano.2024.100052
David B. Olawade , Abimbola O. Ige , Abimbola G. Olaremu , James O. Ijiwade , Adedapo O. Adeola
{"title":"The synergy of artificial intelligence and nanotechnology towards advancing innovation and sustainability - A mini-review","authors":"David B. Olawade ,&nbsp;Abimbola O. Ige ,&nbsp;Abimbola G. Olaremu ,&nbsp;James O. Ijiwade ,&nbsp;Adedapo O. Adeola","doi":"10.1016/j.nwnano.2024.100052","DOIUrl":"10.1016/j.nwnano.2024.100052","url":null,"abstract":"<div><div>The convergence of Artificial Intelligence (AI) and nanotechnology is a transformative frontier, holding vast potential for scientific and technological advancements. This review explores the integration of AI and nanotechnology, aiming to uncover current trends, challenges, and future directions across various domains. A scientometric approach was employed, gathering and analyzing existing literature and research in the fields of AI and nanotechnology. Through a systematic examination of recent studies and developments, we identified key trends, challenges, and potential pathways for future research and applications. Findings from this review highlight the significant impact of AI-driven nanotechnology in materials discovery and design, healthcare, environmental monitoring, energy conversion, and quantum computing. These areas have witnessed remarkable advancements, such as the development of novel nanomaterials, precise drug delivery systems, advanced nanosensors, and efficient energy storage solutions. However, challenges persist, including insufficient interdisciplinary collaboration, data quality, ethical concerns, and regulatory frameworks. While challenges require careful consideration and mitigation, the potential for innovation and progress in diverse domains is undeniable. This review underscores the importance of responsible AI use and ongoing research to unlock the full potential of this convergence, ultimately shaping the future of science and technology.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"8 ","pages":"Article 100052"},"PeriodicalIF":0.0,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142417761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-powered highly stretchable ferroelectret nanogenerator towards intelligent sports 面向智能运动的自供电高伸展性铁电体纳米发电机
Nano Trends Pub Date : 2024-09-28 DOI: 10.1016/j.nwnano.2024.100053
Yiqin Wang , Xianfa Cai , Yufeng Guo , Zhi Chen , Yunqi Cao , Wangdi Du , Tian Xia , Nelson Sepulveda , Wei Li
{"title":"Self-powered highly stretchable ferroelectret nanogenerator towards intelligent sports","authors":"Yiqin Wang ,&nbsp;Xianfa Cai ,&nbsp;Yufeng Guo ,&nbsp;Zhi Chen ,&nbsp;Yunqi Cao ,&nbsp;Wangdi Du ,&nbsp;Tian Xia ,&nbsp;Nelson Sepulveda ,&nbsp;Wei Li","doi":"10.1016/j.nwnano.2024.100053","DOIUrl":"10.1016/j.nwnano.2024.100053","url":null,"abstract":"<div><div>Ferroelectret nanogenerators (FENGs), recognized for their porous structures that facilitate charge retention, thereby creating giant electric dipoles and exhibiting remarkable piezoelectric properties, are utilized in the development of various flexible transducers. However, despite their flexibility, most developed ferroelectret nanogenerators lack adequate stretchability and satisfactory transverse piezoelectric properties, significantly inhibiting their widespread deployment in wearable or skin-mounted electronics. Here, we introduce a highly stretchable ferroelectret nanogenerator (HS-FENG) built from laser-induced graphene (LIG), Ecoflex and anhydrous ethanol, demonstrating exceptional flexibility and stretchability, along with longitudinal and transverse piezoelectric effects. The stretchability of HS-FENG can reach a record of 468 %, while the quasi-static piezoelectric coefficients <em>d</em><sub>33</sub> and <em>d</em><sub>31</sub> are approximately 120 pC/N and 70 pC/N, respectively. To our knowledge, this is the first demonstration of the developed FENG with remarkably high stretchability. Furthermore, leveraging the performance of the created HS-FENG, we construct a skin-mounted intelligent kinesiology tape capable of effectively monitoring motion signals from human muscles and joints, thereby offering a deeper understanding of movement for users across different levels of physical activity, from professional athletes to individuals undergoing rehabilitation. The development of intelligent kinesiology tape exemplifies the potential of HS-FENG technology in enhancing professional athletic training and personalized healthcare. It contributes to the advancement of inconspicuous skin-mounted biomechanical feedback systems and human-machine interfaces, marking progress in the field.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"8 ","pages":"Article 100053"},"PeriodicalIF":0.0,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142444643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thermoelectric hydrogels for self-powered wearable biosensing 用于自供电可穿戴生物传感的热电水凝胶
Nano Trends Pub Date : 2024-09-01 DOI: 10.1016/j.nwnano.2024.100050
Xinru Yang , Xueliang Ma , Yu Niu , Yuxiu Yao , Saeed Ahmed Khan , Hulin Zhang , Xiaojing Cui
{"title":"Thermoelectric hydrogels for self-powered wearable biosensing","authors":"Xinru Yang ,&nbsp;Xueliang Ma ,&nbsp;Yu Niu ,&nbsp;Yuxiu Yao ,&nbsp;Saeed Ahmed Khan ,&nbsp;Hulin Zhang ,&nbsp;Xiaojing Cui","doi":"10.1016/j.nwnano.2024.100050","DOIUrl":"10.1016/j.nwnano.2024.100050","url":null,"abstract":"<div><p>Although the flourishing of the Internet of Things and artificial intelligence has accelerated the development of wearable smart bioelectronics, heavy reliance on external power remains a problem that needs to be solved. Thermoelectric materials have emerged as a promising solution, efficiently converting body heat into electrical energy to provide a stable and unrestricted power supply for wearables. Moreover, in the field of wearable thermoelectric biosensing, where flexibility is highly demanded, hydrogels with excellent electrical conductivity, flexibility and biocompatibility through structural and compositional optimization have become ideal materials for constructing biosensors and meet the diverse application needs of wearable bioelectronics. This article systematically reviews the latest research progress on thermoelectric gels for self-powered wearable biosensing, including the principles of thermoelectric operation, as well as the preparation, design, and application of thermoelectric hydrogels. The current state of thermoelectric gel-based wearable applications in the fields of temperature sensing, strain sensing, temperature-strain synergistic sensing, respiratory monitoring, and sweat analysis are displayed in the article. Finally, the paper summarizes the current challenges and prospects of thermoelectric gels in self-powered wearable bioelectronics, encouraging the rapid application and realization of thermoelectric gel-based smart wearables.</p></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"7 ","pages":"Article 100050"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666978124000205/pdfft?md5=2314bd935489ce343496bb14caa43189&pid=1-s2.0-S2666978124000205-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142149757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metal-organic framework-based off-on fluorescent probe for highly selective and sensitive phosphate detection 基于金属有机框架的离体荧光探针,用于高选择性和高灵敏度磷酸盐检测
Nano Trends Pub Date : 2024-09-01 DOI: 10.1016/j.nwnano.2024.100051
Nan-Si Li , Kai-An Cheng , Ying-Pei Hsu , Hung-Wei Yang
{"title":"Metal-organic framework-based off-on fluorescent probe for highly selective and sensitive phosphate detection","authors":"Nan-Si Li ,&nbsp;Kai-An Cheng ,&nbsp;Ying-Pei Hsu ,&nbsp;Hung-Wei Yang","doi":"10.1016/j.nwnano.2024.100051","DOIUrl":"10.1016/j.nwnano.2024.100051","url":null,"abstract":"<div><p>The escalating demand for versatile and precise diagnostic tools across various biomedical applications has led to the development of an advanced assay utilizing a fluorescent metal-organic framework (MOF). Our novel approach centers on the synthesis of a controlled-explosive NH<sub>2</sub>-MIL-53(Fe) MOF, composed of trivalent iron ions and 2-aminoterephthalic acid. This framework possesses the unique capability to produce explosively enhanced fluorescence upon environmental triggers such as phosphate conditions, where it disintegrates to release intensely fluorescent molecules. The surface of NH<sub>2</sub>-MIL-53(Fe) MOF was further functionalized with poly(acrylic acid-co-maleic acid) polymers (PAAcoMA) to form PAAcoMA@MIL-53(Fe) MOF, thereby enhancing its stability. The presence of phosphate ions is detected by the degree of fluorescence resulting from the unquenching of PAAcoMA@MIL-53(Fe) MOF. This system demonstrates not only high sensitivity but also a broad dynamic range, making it suitable for phosphate ion detection. This innovative technology holds promise for significant advancements in the field of phosphate indicator-based biosensing, with potential applications in the development of PCR kits, thereby supporting a wide range of diagnostic and therapeutic applications.</p></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"7 ","pages":"Article 100051"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666978124000217/pdfft?md5=7aedd26e7aaa94b4d1c5fa0fb55d7edb&pid=1-s2.0-S2666978124000217-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142232743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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