Nano Trends最新文献

{"title":"Recent studies on bio-imaging applications of hydrogel, QDs and nanoparticles","authors":"Mohammad Amir Qureshi","doi":"10.1016/j.nwnano.2026.100232","DOIUrl":"10.1016/j.nwnano.2026.100232","url":null,"abstract":"<div><div>Proper monitoring of cell-to-cell and cell-to-matrix interaction or cell behavior inside the animal body or cell morphology, immobilization, labeling, can be visualized through probes labeled hydrogels, quantum dots and nanoparticles as carrier. Recent days doctors face the problems regarding the end result of targeted delivery of the drug which is loaded in the carrier. Keeping in view of recent problems in medical science, this review article discusses different categories of probe labeled cell imaging gels, quantum dots and nanoparticles. The article gives handy information about the role of supramolecular hydrogels, and nanogels in observing activities in very small organisms. Discussion on different quantum dots also included in this article. Their light emitting property have been utilizing in deep tissue imaging. Cell imaging nanoparticles like Silicon NPs, lipid NPs, metal organic framework NPs and polymer-dots have been discussed extensively because of their application through Forster Resonance Energy Transfer to visualize certain protein. This discussion on cell imaging carriers with their applications in monitoring cell activity, detection of unknown biomolecules and enhancement of available fluorescent techniques will give the future course of research plan for researchers to unfold hidden truth of biological reactions and behavior of injected therapeutics inside the human body.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"15 ","pages":"Article 100232"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148940642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation, optimization and in vitro cytotoxicity study of Kaempferol-loaded PLGA nanoparticles in glioblastoma multiforme cell line","authors":"Moulika Todaria,&nbsp;Rajendra Awasthi","doi":"10.1016/j.nwnano.2026.100234","DOIUrl":"10.1016/j.nwnano.2026.100234","url":null,"abstract":"<div><div>Glioblastoma is one of the most aggressive primary brain tumors, and it is difficult to treat since the blood-brain barrier restricts the transport of many therapeutic medicines to the tumor site. Kaempferol (KMP), a naturally occurring flavonoid, has exhibited promising anticancer action, but its therapeutic applicability is restricted by low bioavailability and water solubility. This study demonstrated systematic Box–Behnken design-based optimization of KMP-loaded poly(lactic-co-glycolic acid)-nanoparticles (PLGA-NPs) and the integrated evaluation of their physicochemical and biological performance against glioblastoma cells. The effect of sonication time, concentration of polyvinyl alcohol (PVA), and PLGA on NP size and entrapment efficiency was assessed. The optimized formulation resulted in NPs of an average particle size of 103.7 ± 2.08 nm, entrapment efficiency of 75.73 ± 0.39%, polydispersity index value of 0.184, and zeta potential of −21.1 mV, showing that the particles were uniform and stable. FE-SEM micrographs showed that the NPs were spherical in shape. FTIR and XRD studies confirmed the incorporation of KMP into the PLGA matrix without undergoing any chemical reaction. In contrast to free KMP, the optimized formulation demonstrated sustained KMP release, enhanced antioxidant activity, greater cytotoxicity toward U87 glioblastoma cells, and comparatively better compatibility with normal L929 fibroblasts, highlighting the potential of PLGA nanoencapsulation to improve the therapeutic performance of KMP. All these results reveal the significant effect of PLGA nanoencapsulation on the physicochemical and biological characteristics of KMP.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"15 ","pages":"Article 100234"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148940641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and numerical analysis of hybrid plasmonic–photonic crystal quantum-dot nanolasers with enhanced spontaneous emission","authors":"Priyanka,&nbsp;Ravindar Tadi,&nbsp;Ram Soorat","doi":"10.1016/j.nwnano.2026.100233","DOIUrl":"10.1016/j.nwnano.2026.100233","url":null,"abstract":"<div><div>Hybrid plasmonic–photonic crystal cavities offer an attractive paradigm for achieving both ultra-high quality factors and deep subwavelength mode confinement. However, establishing rigorous design rules that balance Purcell enhancement against parasitic non-radiative quenching remains a critical challenge. In this work, we develop a self-consistent multiscale computational framework, validated against analytical and numerical benchmarks, to investigate six hybrid metallic nanoparticle architectures (gold and silver nanospheres, nanorods, and nanostars) integrated into a GaAs L3 photonic crystal cavity coupled to InAs quantum dots. Multi-solver cross-validation between analytical Mie theory, the boundary element method (BEM), and 3D finite-difference time-domain (FDTD) simulations demonstrates close agreement across resonance wavelengths, cross-sections, and field enhancements. We show that the localized density of states (LDOS) and cavity-mode Purcell factors fundamentally decouple for emitter–metal gap distances below 5 nm, where non-radiative Ohmic absorption dominates over radiative decay. Coupling the electrodynamic cavity parameters into semiclassical four-level laser rate equations predicts lasing threshold reductions of up to 85% under the local-response approximation (and over 82% under generalized nonlocal optical response hydrodynamic analysis) for the silver nanorod geometry, driven by optimal longitudinal plasmon resonance alignment at the 900 nm emission wavelength and strong near-field concentration (<span><math><mrow><msup><mrow><mrow><mo>|</mo><mi>E</mi><mo>/</mo><msub><mrow><mi>E</mi></mrow><mrow><mn>0</mn></mrow></msub><mo>|</mo></mrow></mrow><mrow><mn>2</mn></mrow></msup><mo>≈</mo><mn>300</mn></mrow></math></span>). This work provides quantitative design guidelines and operational boundaries for developing high-efficiency, subwavelength hybrid quantum-dot nanolasers.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"15 ","pages":"Article 100233"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148951083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical performance of spray-pyrolyzed CNT@NiO electrodes for supercapacitor applications","authors":"Oluwasegun Emmanuel Ojodun,&nbsp;Tien-Chien Jen,&nbsp;Patrick Ehi Imoisili","doi":"10.1016/j.nwnano.2026.100236","DOIUrl":"10.1016/j.nwnano.2026.100236","url":null,"abstract":"<div><div>In this study, spray pyrolysis was employed to fabricate pristine NiO and a CNT@NiO composite electrode at 350 °C for supercapacitor applications. The structural and morphological properties of both materials were characterized via X-ray diffraction, Fourier-transform infrared spectroscopy, Brunauer-Emmett-Teller analysis, and scanning electron microscopy. Electrochemical performance was evaluated by cyclic voltammetry, galvanostatic charge-discharge, and electrochemical impedance spectroscopy in 2 M KOH over a potential window of 0 to 0.7 V vs. SCE. BET analysis showed that CNT incorporation increased the specific surface area from 29.55 to 46.51 m² g⁻¹ and the mean pore diameter from 6.10 to 27.37 nm. The 350-CNT@NiO electrode delivered a specific capacitance of 472.4 F g⁻¹ at 2 A g⁻¹, exceeding that of 350-NiO (18.92 F g⁻¹), with a rate capability of 68.8% compared to 13.6% for 350-NiO. After 1000 cycles at 2 A g⁻¹, 350-CNT@NiO retained 93.3% of its initial capacitance compared to 81.5% for 350-NiO, with both electrodes maintaining 100% Coulombic efficiency. The results demonstrate that 350-CNT@NiO is a promising electrode material for supercapacitor applications and that spray pyrolysis is a low-cost, scalable fabrication route suitable for supercapacitor electrode preparation.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"15 ","pages":"Article 100236"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148940691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PBA-modified α-cyano-4-hydroxycinnamate and gefitinib liposomes for macrophage metabolic reprogramming to boost antitumor immunity","authors":"Yueci Sun,&nbsp;Shuang Chang,&nbsp;Xue Wang,&nbsp;Haiyang Hu","doi":"10.1016/j.nwnano.2026.100237","DOIUrl":"10.1016/j.nwnano.2026.100237","url":null,"abstract":"<div><h3>Objectives</h3><div>Tumor cells produce and release significant amounts of lactic acid (LA) via glucose glycolysis, creating an acidic, high-LA tumor microenvironment. This microenvironment promotes the M2 polarization of tumor-associated macrophages (TAMs) and leads to immunosuppression. This study aims to reprogram TAM metabolism and boost antitumor immunity by synergistically reducing extracellular LA levels using a dual-liposome formulation strategy.</div></div><div><h3>Methods</h3><div>We prepared phenylboronic acid (PBA)-modified α-cyano-4-hydroxycinnamate (CHC) liposomes (PBA-CHC-LIP) to target 4T1 tumor cells and inhibit monocarboxylate transporter 4 (MCT4), thereby suppressing LA efflux. Concurrently, gefitinib lactate (GFB-LA) was synthesized to construct high-loading gefitinib liposomes (GFB-LIP) via an active loading method. In vitro experiments were conducted using 4T1 and RAW264.7 cells, and in vivo experiments were performed using a 4T1 tumor-bearing mouse model to evaluate the synergistic effects of the combined therapy on LA efflux, cell apoptosis, macrophage polarization, and tumor progression.</div></div><div><h3>Results</h3><div>PBA-CHC-LIP effectively targeted 4T1 cells and significantly inhibited LA efflux. GFB-LIP achieved an ideal drug loading of 5.3% and an encapsulation efficiency of 94%, promoting 4T1 cell apoptosis and further reducing LA production. The synergistic treatment significantly decreased LA concentrations in the tumor microenvironment both in vitro and in vivo, thereby inhibiting the M2 polarization of TAMs (evidenced by decreased CD206, IL-10, Arg-1, and TGF-β1) and enhancing the M1-TAM-mediated immune response (indicated by elevated IL-12, iNOS, and TNF-α). The combined therapy also effectively inhibited the growth of tumor volume and weight in vivo.</div></div><div><h3>Conclusions</h3><div>The synergistic therapy of PBA-CHC-LIP and GFB-LIP successfully reduced LA levels in the tumor microenvironment and achieved the metabolic reprogramming of tumor-associated macrophages. This provides a novel and effective strategy for reshaping the tumor immune microenvironment and enhancing antitumor therapy.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"15 ","pages":"Article 100237"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148940639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustainable biomass-derived graphitic carbon/MoS₂ nanoflower hybrid as an efficient bifunctional material for hydrogen evolution reaction and organic dye removal","authors":"Amrutha Thomas,&nbsp;E.J. Jelmy,&nbsp;Pramod Gopinath,&nbsp;Honey John","doi":"10.1016/j.nwnano.2026.100231","DOIUrl":"10.1016/j.nwnano.2026.100231","url":null,"abstract":"<div><div>Harnessing waste-derived materials for advanced functional applications offers significant environmental and technological benefits. In this study, a MoS₂ nanoflower decorated carbon hybrid was prepared via a facile hydrothermal route by dispersing pre-synthesized MoS₂ nanoflowers onto potassium hydroxide-assisted activated carbon derived from the waste tea leaves, providing a eco-friendly approach for biomass valorisation. To optimize the hybrid composition, samples were prepared with varying mass ratios of activated carbon to MoS₂ (1:1, 1:2, and 2:1). The structural, compositional, and morphological properties of the hybrids were systematically analyzed using X-ray diffraction, Raman spectroscopy, X-ray photoelectron spectroscopy and FESEM characterization confirmed the uniform decoration of MoS₂ nanoflowers on the porous carbon surface, while X-ray diffraction and Raman spectroscopic studies verified the effective formation of the hybrid structure. Catalytic performance for the hydrogen evolution reaction was evaluated under acidic electrolyte conditions. Among the prepared materials, the 1:1 MoS₂/carbon hybrid exhibited the highest hydrogen evolution catalytic activity achieving a comparatively small overpotential of 274 mV corresponding to a current density of 10 mA cm⁻² and a Tafel slope value of 162 mV dec⁻¹ with long-term electrochemical durability over a duration of 12 h. Furthermore, the hybrid demonstrated significant adsorption of the cationic dye Crystal Violet, achieving an adsorption capacity of 45 mg g⁻¹ after 60 min of contact, highlighting its potential for simultaneous energy conversion and environmental remediation applications.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"15 ","pages":"Article 100231"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148934693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cryogenic defect and microstructure engineering for ultrafast room-temperature ethanol sensing in TiO₂ nanoparticles","authors":"Vrushali E Kalokhe,&nbsp;Sanju Rani,&nbsp;Rupali Nagar","doi":"10.1016/j.nwnano.2026.100235","DOIUrl":"10.1016/j.nwnano.2026.100235","url":null,"abstract":"<div><div>Titanium dioxide (TiO₂) is a commercially available and widely used gas sensing material. Here, TiO₂ nanoparticles (TNPs) are first synthesized using the sol-gel method (as-synthesized, T1). The samples are heated in an air environment at 400 °C and then allowed to cool (to room temperature, T2) or quenched to different final temperatures (ice at -4 °C, T3 and liquid nitrogen, i.e. LN2 at -196 °C, T4) to initiate thermally induced microstructural changes. These thermally treated TNPs are then evaluated for their gas sensing performance by testing them against ethanol vapours (1–6 ppm). The response and recovery times are measured to be ∼ 5.7 s and 7 s, respectively, for 6 ppm ethanol under ambient conditions for the LN2-quenched sample. However, the best response and recovery times are measured as 1.3 s and 3.7 s, respectively for 4 ppm ethanol. Interestingly, while T1, T2, and T3 samples exhibited p-type behaviour upon ethanol exposure, T4 showed n-type behaviour. Crystallite size, porosity, oxygen vacancies, band gap changes and the presence of functional groups are understood to be important attributes influencing the sensor performance. This work demonstrates that cryogenic quenching can be a simple, effective strategy to control conduction type, charge carrier dynamics, and gas sensing performance, offering a route for high-performance, selective and tunable ethanol sensors. A switch from p- to n–type conduction in the same material, demonstrated here, opens various avenues like dual-mode sensing, homojunction sensing and highly tunable sensor design.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"15 ","pages":"Article 100235"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148934759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in nose to brain targeted nano drug delivery system for Alzheimer’s disease: Emphasis on preparative techniques, preclinical, clinical, and toxicity assessment","authors":"Sanjay Nagdev ,&nbsp;Junaid Tantray ,&nbsp;Nitin Ghanshamdas Haswani ,&nbsp;Laxmikant Zawar ,&nbsp;Suhaskumar Patel ,&nbsp;Bhupendra Prajapati","doi":"10.1016/j.nwnano.2026.100214","DOIUrl":"10.1016/j.nwnano.2026.100214","url":null,"abstract":"<div><div>Alzheimer’s disease (AD), a progressive neurological disorder, is marked by a gradual deterioration of cognitive abilities. Contemporary therapeutic strategies predominantly entail the delivery of pharmaceuticals by oral, parenteral, and transdermal methods, with the objective of enhancing cognitive performance and mitigating symptoms. Nonetheless, these therapies encounter constraints, including limited bioavailability and insufficient permeability. Consequently, the creation of a non-invasive and effective delivery mechanism is essential. Intranasal administration has surfaced as a viable alternative, however, limited by the specific characteristics of the nasal canal. A novel method employs nanotechnology-based nano-carriers for intranasal administration, offering a promising approach to deliver therapeutic agents directly to the brain. Additionally, nanoplatform such as liposomes, solid lipid nanoparticles, nanoemulsion etc. can transport the medication via nose to brain delivery for AD. This technique may address existing constraints by offering increased bioavailability, greater penetration, efficient passage through the blood-brain barrier, prolonged retention in the body, and accurate targeting of the brain. Nasal medication administration has become a dependable technique to circumvent the blood-brain barrier and efficiently administer various neurotherapeutic drugs to the brain. This article provides a comprehensive discussion of nose to brain targeted nano drug delivery system for AD. Moreover, we have limited our discussion to the preparative method, experimental models used to evaluate the efficacy and safety of intranasal nano drug delivery systems, and toxicity profiling of nose to brain targeted nano drug delivery system. These advancements in nasal targeted-based delivery systems represent a promising direction for improving AD treatment outcomes, offering the potential for more effective, targeted therapies with fewer systemic side effects.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"14 ","pages":"Article 100214"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148241865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compositional effects of rice husk based activated carbon on properties of steel waste derived magnetite nanoparticles","authors":"Joseph Jjagwe ,&nbsp;Peter Wilberforce Olupot ,&nbsp;Robinah Kulabako ,&nbsp;Sandro Carrara","doi":"10.1016/j.nwnano.2026.100218","DOIUrl":"10.1016/j.nwnano.2026.100218","url":null,"abstract":"<div><div>Magnetite nanoparticles (Fe₃O₄ NPs) are limited by low surface area, fewer functional groups, high agglomeration tendency, and poor dispersibility in aqueous media. In this study, Fe₃O₄ NPs were functionalized with activated carbon (Fe₃O₄@AC) through co-precipitation in compositional weight ratios of Fe₃O₄: AC of 1:1, 2:1, 3:1, designated as Fe₃O4@AC-1, Fe₃O4@AC-2, Fe₃O4@AC-3, respectively. Ferric chloride from acid leached iron oxide waste powder was used as a starting material for Fe₃O₄ NPs, while AC was derived through chemical activation of rice husks with zinc chloride. Materials were characterized by XRD, BET, SEM, TEM, FTIR, SAED, DLS-zeta potential (ZP), UV–vis spectroscopy, VSM, as well as electro-transfer properties using cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS). Pure Fe₃O₄ NPs, and the nanocomposites were all polycrystalline with crystallite sizes between 6- 9 nm. The nanocomposites had more functional groups, higher band gap energies, less agglomerated, and better colloidal stability than bare Fe₃O₄ NPs. The surface area (SA), and microporosity percentages of the nanocomposites decreased in the order Fe₃O4@AC-1 (440 m²/g, 33.25%) &gt; Fe₃O4@AC-2 (400 m²/g, 28.14%) &gt; Fe₃O4@AC-3 (233 m²/g, 10.04%). Saturation magnetization decreased in the reverse order of 66.2 emu/g &gt; 43.8 emu/g &gt; 32.2 emu/g with all materials retaining sufficient magnetic response for magnetic separation applications. Fe₃O4@AC-1 show properties consistent with suitability for pollutant removal in water. Fe₃O₄@AC-2 exhibited superior performance with highest peak currents in CV and lowest charge transfer resistance in EIS, factors typical for electrochemical applications.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"14 ","pages":"Article 100218"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148185067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Piezoelectric protein biomaterials","authors":"Zhenyu Han","doi":"10.1016/j.nwnano.2026.100217","DOIUrl":"10.1016/j.nwnano.2026.100217","url":null,"abstract":"<div><div>Piezoelectric biomaterials that convert mechanical deformation into electrical signals are emerging as promising platforms for applications in health and medicine. A wide range of synthetic and natural systems—including polymers, ceramics, amino acids, and peptides—have been shown to exhibit piezoelectricity and have been explored in applications such as drug delivery, biosensing, and tissue engineering. Proteins are three-dimensional biopolymers composed of polypeptide chains and play central roles in biological structure and function. However, their piezoelectric properties remain underexplored due to their chemical, structural, and functional complexity. Here, we review recent advances in piezoelectricity in protein-based materials, discuss key challenges in their experimental characterization and theoretical understanding, and outline opportunities in this emerging area of materials research.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"14 ","pages":"Article 100217"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148185066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}