Nano Trends最新文献

{"title":"Advancing topical drug delivery: NLC innovations in dermatological therepeutics","authors":"Balaji,&nbsp;Prakash Goudanavar","doi":"10.1016/j.nwnano.2025.100108","DOIUrl":"10.1016/j.nwnano.2025.100108","url":null,"abstract":"<div><div>Nanostructured lipid carriers (NLCs) are promising drug delivery systems with broad therapeutic applications. This review covers recent advancements, challenges, and future prospects in NLC-based drug delivery. It introduces the rationale and benefits of NLC use, discussing formulation strategies like high-pressure homogenization, solvent emulsification-evaporation, and micro emulsion techniques. Unique properties, such as enhanced drug loading, controlled release, and improved stability, are highlighted. The application of NLCs in targeted drug delivery is explored, addressing challenges like low solubility, poor bioavailability, and systemic toxicity. Development challenges, including scalability, characterization, and regulatory approval, are discussed, along with potential solutions. Recent advancements like surface modification, co-delivery systems, and engineered NLCs for targeted therapy are elucidated. NLCs in topical drug delivery, particularly in dermatology, are examined for treating skin conditions with minimal systemic effects. Future directions and trends, including personalized medicine and theranostic integration, are discussed, emphasizing NLCs' potential across diverse medical applications. This review provides insights into NLC-based drug delivery's current state, emphasizing their role in advancing therapeutic outcomes.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"10 ","pages":"Article 100108"},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adsorptive desulfurization of liquid fuels over green cost-effective Cu-Ni bimetallic nanoparticles-modified alum sludge","authors":"Aminu Musa ,&nbsp;Ibrahim Ahmad Dara ,&nbsp;Ahmed Salisu ,&nbsp;Abubakar Muhammad ,&nbsp;Tawfik A. Saleh","doi":"10.1016/j.nwnano.2025.100107","DOIUrl":"10.1016/j.nwnano.2025.100107","url":null,"abstract":"<div><div>The elimination of sulfur from liquid fuels in the refining process to a particular range to adhere to the environmental restriction with regards to the emission of toxic gasses. To address the limitation of hydro-desulfurization, several techniques have been used including adsorptive desulfurization. Adsorptive desulfurization has been used because of its efficiency and cost-effectiveness of the materials. In this study, Alum Sludge was modified to prepare alum sludge coupled with copper AS/Cu, alum sludge coupled with nickel AS/Ni, and alum sludge coupled with copper-nickel nanoparticles AS/Cu-Ni NPs. A comparative study was performed for the sulfur removal from liquid fuels diesel and kerosene by the Alum sludge coupled with metallic nanoparticles. The produced AS, AS/Cu, AS/Ni, and AS/Cu-Ni NPs were evaluated by Brunauer-Emmett-Teller (BET) analysis, Fourier Transform Infrared spectroscopy (FTIR), Scanning Electron Microscope (SEM), X-ray Diffraction (XRD), and X-ray Fluorescence (XRF). According to the BET results, AS/Cu had a surface area that was relatively higher at 557.9 (m²/g), while AS/Ni had a surface area that was lower at 127 (m²/g). The percentage rise of Cu metallic NPs from (0.00725 % - 1.69 %) and Ni metallic NPs from 0.0085 % Ni to 0.0595 % Ni was shown by the XRF data. Researchers looked into the effects of adsorbent dose, loaded metal nanoparticles, and adsorption process isotherms. The percentage removal of sulfur increases reaching ≈100 %. In comparison to the alum sludge combined with copper/nickel (AS/Cu-Ni) and the alum sludge combined with nickel (AS/Ni) NPs from both liquid fuels, the AS/Cu-Ni yields a higher percentage of sulfur removal. The experimental adsorption results for kerosene and diesel, which had higher correlation values, were better adapted to the Langmuir model than to the Freundlich and Temkin model, according to the data. The adsorption processes were exothermic, advantageous, and spontaneous. The desulfurization process is conducted responsibly, upholding laws, and institutions, and is based on evidence-based policies.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"10 ","pages":"Article 100107"},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143790849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"X-ray crystallographic structural Profiling of Polyvinyl Alcohol (PVA) caped Nickel Oxide Nanoparticle","authors":"Mahfuzul Islam ,&nbsp;Md. Tarikul Islam ,&nbsp;Md. Khalid Hossain Shishir ,&nbsp;Md. Ashikur Rahaman ,&nbsp;Shanawaz Ahmed ,&nbsp;Sumaiya Islam Sadia ,&nbsp;Md. Ashraful Alam","doi":"10.1016/j.nwnano.2025.100106","DOIUrl":"10.1016/j.nwnano.2025.100106","url":null,"abstract":"<div><div>A unique simple co-precipitation method was developed for synthesizing highly crystalline nickel oxide nanoparticles (NiO NPs) where poly vinyl alcohol (PVA) solution as capping agent. Rietveld refinement analysis explored whole powder pattern fitting (WPPF) method confirmed resulting nanoparticles (NPs) consist of 87 % pure NiO phase. X-ray diffraction (XRD) analysis revealed a distinct hexagonal NiO crystalline phase, with lattice parameters <em>a</em>=<em>b</em>= 2.955 Å, <em>c</em>= 7.2434 Å, and angles α=β= 90 ° and γ=120 ° The predominant (0 1 2) plane, associated with the strongest diffraction at 2θ= 43.228 °, underscored the crystallinity of the material. Key crystallographic parameters include an average dislocation density of 0.00206 nm⁻², lattice strain of 0.27 %, a unit cell volume of 54.776 ų, a specific surface area of 41.435 m²/g, micro-strain of 0.00288, crystallinity index of 2.174 and an atomic packing factor (APF) of 64.9 %. Remarkably, 47.21 % of the synthesized NiO NPs demonstrated a crystallinity closely aligned with ICDD standard. Transmission electron microscopy (TEM) imaging showing a uniform distribution of NPs throughout the inner core structure spherical in shape and an average particle size of 48 nm in interface. Without nickel and oxygen signal, no signals were found that conform the purity of NiO NPs where nickel and oxygen were 67 % and 33 %. This study offers a detailed analysis of the enhanced crystallinity through comprehensive approaches.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"10 ","pages":"Article 100106"},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2D binary transition metal iodides: Advances in synthesis and device applications","authors":"Ishaya Kindikah ,&nbsp;Mary Otuosorochukwu Nnyia ,&nbsp;Samuel Daniel ,&nbsp;Oluwasegun Samuel Odebiyi ,&nbsp;Milka Iliya","doi":"10.1016/j.nwnano.2025.100105","DOIUrl":"10.1016/j.nwnano.2025.100105","url":null,"abstract":"<div><div>A subclass of 2D metal halides referred here as binary transition metal iodide of a form MX₂ and MX₃ (M = transition metal X = iodide) possess electronic, optical and magnetic properties due to their layered structure. In this review, we emphasize the distinct characteristics of BTMIs—such as their tunable bandgaps, multifaceted magnetic behavior, and potential for heterostructure integration—that differentiate them from other 2D materials. This work also provides a detailed comparative analysis of synthesis techniques and device performances, thereby narrowing the scope of previous reviews and offering clear guidance for future research. We systematically examine synthesis methods—including exfoliation, solution-based techniques, and vapor deposition—and evaluate the performance of BTMIs in photodetectors, field-effect transistors, flexible devices, and magnetic applications. Finally, we discuss current challenges, limitations, and prospects for the future development of this promising class of 2D materials.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"10 ","pages":"Article 100105"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143738707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ion diffusivity and alkyl chain length-dependent triboelectric behavior of PVDF-HFP+IL composites","authors":"Sujeong Gwak ,&nbsp;Hyeonseo Joo ,&nbsp;Bonhyeop Koo ,&nbsp;Cheoljae Lee ,&nbsp;Hyosik Park ,&nbsp;Hochun Lee ,&nbsp;Ju-Hyuck Lee","doi":"10.1016/j.nwnano.2025.100104","DOIUrl":"10.1016/j.nwnano.2025.100104","url":null,"abstract":"<div><div>As the global demand for renewable and clean energy solutions grows, triboelectric nanogenerators (TENGs) have emerged as a promising technology for harvesting mechanical energy. In this context, our study focuses on incorporating ionic liquids (ILs) into poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) to explore how the alkyl chain length of ILs influences triboelectric polarity. Imidazolium-based ILs containing bis(trifluoromethylsulfonyl)imide (TFSI⁻) anions were used, with cations such as 1-ethyl-3-methylimidazolium (EMIM⁺) and 1-butyl-3-methylimidazolium (BMIM⁺) exhibiting tribo-positive characteristics, while those with longer alkyl chains, including 1-methyl-3-n-octylimidazolium (OMIM⁺) and 1-dodecyl-3-methylimidazolium (DoMIM⁺), displayed tribo-negative behavior. These trends were correlated with self-diffusion coefficient measurements of the ILs. The control of triboelectric behavior and the formation of an electric double layer (EDL) through IL incorporation significantly enhanced the surface charge density, thereby improving the output performance of TENGs. This work provides a novel strategy for enhancing TENG efficiency and offers material selection guidelines for sustainable energy applications.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"10 ","pages":"Article 100104"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143738708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polysaccharides carrier as oral colon-specific drug delivery for colon cancer treatment","authors":"Nafisah Musa ,&nbsp;Nagla A.M. Layas ,&nbsp;Nur Zahirah Mohamad Zin","doi":"10.1016/j.nwnano.2025.100102","DOIUrl":"10.1016/j.nwnano.2025.100102","url":null,"abstract":"<div><div>Colon cancer is the third highest incidence in cancer mortality in both sexes combined and a total of 639,000 deaths are reported worldwide each year. Typical chemotherapy is provided by injection route to reduce tumor growth and metastasis. In comparison to injection, oral administration of drugs in the form of a colon-specific delivery system is expected to increase drug bioavailability at target site, reduce drug dose and systemic adverse effects. Polysaccharides are suitable for use as matrix and/or coat material can protect drugs from chemical and enzymatic degradation concerning oral delivery. This present review gives an overview on application of chitosan, pectin, and alginate with respect to their use as drug carrier for oral colon cancer treatment.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"10 ","pages":"Article 100102"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elucidating the role of nano boron and zinc oxide-coated silane-treated cellulose nanocrystals (CNCs) on the mechanical, thermal, and flammability characteristics of high-density polyethylene (HDPE)","authors":"Amirmohammad Raeisi ,&nbsp;Ismat Ara ,&nbsp;Greg Holt ,&nbsp;Nicole Stark ,&nbsp;Dilpreet S. Bajwa","doi":"10.1016/j.nwnano.2025.100103","DOIUrl":"10.1016/j.nwnano.2025.100103","url":null,"abstract":"<div><div>The fire risk of synthetic polymers has emerged as a growing safety issue. High-density polyethylene (HDPE) is one of the most used polymers in different applications. However, HDPE has some drawbacks, such as low thermal and mechanical properties. To address this challenge, silane-functionalized cellulose nanocrystals (CNCs), nano boron oxide (B₂O₃) and nano zinc oxide (ZnO) were incorporated into the HDPE matrix in different percentages (3 %, and 5 %) and weight ratios (1:1, and 1:2). The CNCs were surface modified through silanization process to enhance dispersion and interfacial bonding, while metal oxides were introduced to improve thermal stability and flame retardancy. The composites were characterized using scanning electron microscopy (SEM), dynamic mechanical analyzer (DMA), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), thermogravimetric analyzer (TGA), horizontal burn test, and microcalorimetry tests. The results indicated that adding CNCs-ZnO resulted in a 64 % increase in mechanical properties, a 28 % decrease in weight loss, and a reduced flame spread rate of the composites. The CNCs- B₂O₃ composites showed a lower flame spread rate and a 52 % improvement in mechanical properties. Overall, adding nano metallic fillers, such as nano ZnO and B₂O₃, significantly enhanced HDPE composites' thermal stability, mechanical properties, and fire resistance. These improvements highlight the potential of nano metal oxides and CNC as functional fillers where mechanical strength and fire safety are essential.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"10 ","pages":"Article 100103"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Removal of rhodamine 6G from aqueous solution in a continuous mode using nano-micro composite membranes","authors":"Chris Ademola Bode-Aluko ,&nbsp;Omoniyi Pereao ,&nbsp;Alechine E. Ameh ,&nbsp;Emmanuel Omoniyi ,&nbsp;Alexander Nechaev ,&nbsp;Leslie Petrik","doi":"10.1016/j.nwnano.2025.100096","DOIUrl":"10.1016/j.nwnano.2025.100096","url":null,"abstract":"<div><div>This research presents the production of nanofibers, track-etched membrane, and nanofiber/track-etched composite membranes and their dye rejection studies. Polyamide 6 nanofibers (PA6-nfs) and polyacrylonitrile nanofibers (PAN-nfs) were fabricated using an electrospinning technique. Their respective composites with the metalized track-etched polyethylene terephthalate film (PET-TM), PET-TMPA6, and PET-TMPAN were also fabricated via electrospinning. The membranes were characterized using HRSEM, TEM, BET, and TGA techniques. The rejection experiments were studied with respect to the pH and the concentration of rhodamine 6G (RD), as well as the flow rate of the system. The pH is the most significant parameter in the filtration system at higher dye concentrations. At pH 10, the rejection percentages of 10 mg/L RD were 91.27% for PET-TMPAN and 70.66% for PET-TMPA6 at a flow rate of 1 mL/min. Also, PAN-nfs, PA6-nfs, and PET-TM gave 65.97%, 36.80%, and 24.53%, respectively. The composite membranes have higher rejection capabilities in comparison to their respective nanofibers. The performance of PET-TMPAN at a lower flow rate of 0.5 mL/min showed that the RD rejection by PET-TMPAN increased by ≈5 percent (91.27 to 96.01). At a lower concentration of 2 mg/L (to simulate higher dilution in river water) and pH (5.6), PET-TMPAN had a 99.59% RD rejection. All the membranes were regenerated and reused. The composite membrane PET-TMPAN has the capability to remove RD at both higher (96.01%) and lower concentrations (99.59%) of RD at lower flow rate, thereby making the system applicable and easy to use in river water purification.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"9 ","pages":"Article 100096"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143518856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of the bio-interaction of nitrogen-doped graphene quantum dots with human serum albumin aiming a quantification method","authors":"Rocio Soto-Chochocca ,&nbsp;Renan Lira de Farias ,&nbsp;Luis Miguel Gutierrez-Beleño ,&nbsp;Sonia Letichevsky ,&nbsp;Fernando Lázaro Freire-Jr ,&nbsp;York E. Serge-Correales ,&nbsp;Rogéria R. Gonçalves ,&nbsp;Marlin Pedrozo-Peñafiel ,&nbsp;Ricardo Q. Aucelio","doi":"10.1016/j.nwnano.2025.100099","DOIUrl":"10.1016/j.nwnano.2025.100099","url":null,"abstract":"<div><div>In recent years, carbon-based nanomaterials, such as graphene quantum dots (GQDs), have garnered significant attention due to their remarkable physicochemical and biological properties. This work presents a study evaluating the interaction between N-doped GQDs, produced from a mixture of citric acid and urea (referred here as GQDs-U), with human serum albumin (HSA). The GQDs-U were characterized using spectroscopic techniques, and their concentration was expressed in terms of total carbon content in aqueous dispersion. They present average diameter of about 8 nm, with average hydrodynamic diameter of around 12 nm, and a surface charge of -7 mV at pH 7.4. Assays revealed that a progressive increase in GQDs-U concentration led to the quenching of HSA fluorescence with quenching directly correlated with temperature, also indicating a mixed quenching mechanism with a predominance of the dynamic type, suggesting mutual conformational rearrangements of HSA/GQDs-U before reaching thermodynamic equilibrium. Additionally, it was shown that GQDs-U could be used as a probe to quantify HAS with the increase in photoluminescence of GQDs-U upon the addition of HSA demonstrating effective energy transfer, as GQDs-U were found to promote quenching in HSA photoluminescence. This study indicated sound evidence of stability of the nanomaterial, in aqueous dispersions, in terms of optical and morphological properties. The stability over time suggests the viability of GQDs-U as analytical probes for HSA even after a long period (30 days) of GQDs-U aging. The work also enhanced the understanding of the complex time-structure-activity relationship in this biomolecule/nanomaterial system.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"9 ","pages":"Article 100099"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143576763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A nano-enabled structural GFRP composite for self-powered multi-sensing applications","authors":"Lampros Koutsotolis,&nbsp;Angelos Voudouris Itskaras,&nbsp;George Karalis,&nbsp;Alkiviadis S. Paipetis","doi":"10.1016/j.nwnano.2025.100101","DOIUrl":"10.1016/j.nwnano.2025.100101","url":null,"abstract":"<div><div>Composites are the most widely used structural material in fields where weight reduction is crucial, since they capitalize on high strength and stiffness together with low density. With growing concerns around sustainability and energy consumption, the next generation of advanced composites needs to incorporate additional functionalities. Hence, multifunctional composites emerge as a promising technological area, enabling the design of structures that are lighter, more efficient, and capable of performing multiple roles. This study introduces a nano-enabled structural glass fiber-reinforced polymer (GFRP) composite that exhibits self-powered multi-sensing capabilities, utilizing the Seebeck effect. The Thermoelectric Generator (TEG)-enabled laminate was designed with the scope of achieving specific output characteristics. The composite functioned as a power supply for the Structural Health Monitoring (SHM) of composite coupons with various electrical resistances, showcasing the dependency of the sensitivity on the TEG output characteristics. Additionally, it was able to respond to environmental stimuli, including temperature changes, infrared (IR), and ultraviolet (UV) radiation, making it a versatile tool for various sensing applications. Since the response was a generated electrical signal, the sensing process was inherently self-powered. The amalgamation of functionalities marks the first time where a single structural element simultaneously exhibits all those capabilities. This approach reveals enticing aspects for the development of smart composite structures.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"9 ","pages":"Article 100101"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143576760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}