Nano Trends最新文献

{"title":"Nanomaterials for biomedical applications: Addressing regulatory hurdles and strategic solutions","authors":"Sunil Gujjar ,&nbsp;Samiksha Kukal ,&nbsp;Prakash Jayabal ,&nbsp;Neha Balaji ,&nbsp;Saloni Sainger ,&nbsp;Srabaita Roy ,&nbsp;Suneel Rallapalli ,&nbsp;Ravikiran Mahadevappa ,&nbsp;Shilpi Minocha ,&nbsp;Saran Kumar ,&nbsp;Santosh Mathapati","doi":"10.1016/j.nwnano.2025.100127","DOIUrl":"10.1016/j.nwnano.2025.100127","url":null,"abstract":"<div><div>Nanotechnology has revolutionized modern healthcare by providing innovative solutions for the diagnosis, treatment, and monitoring of various medical conditions. The unique biological, chemical, and mechanical attributes of nanomaterials have favoured their use for various medical applications, including drug delivery, tissue engineering, implantable devices, bio-molecular detection, and diagnostics. However, potential risks associated with nanomaterial usage on health and environment raised concerns regarding their safety and regulatory oversight. Focusing exclusively on nanomaterial design with less attention towards nano-bio interaction has become a significant bottleneck to their clinical translation. This review aims to provide a concise overview of the characteristics of nanomaterials which find exciting applications in biological and biomedical fields. More importantly, we put forth the current regulation status of these advanced materials, highlighting the potential challenges and uncertainties in the regulatory assessment, and discussing potential strategies for effective regulation. A robust regulatory framework will allow a smooth clinical translation of such materials without compromising patient safety.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"11 ","pages":"Article 100127"},"PeriodicalIF":0.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144338759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoparticle-encapsulated metal-organic frameworks: innovative design strategies and biomedical applications","authors":"Pranita Rananaware ,&nbsp;Parimal Pandit ,&nbsp;Mahesh Narayan ,&nbsp;Varsha Brahmkhatri","doi":"10.1016/j.nwnano.2025.100125","DOIUrl":"10.1016/j.nwnano.2025.100125","url":null,"abstract":"<div><div>Extremely porous compounds containing metal ions connected by organic ligands are referred to as metal-organic frameworks or MOFs, with special features including distinct crystal structure, huge surface area, high pore volume, adjustable pore architecture, and remarkable drug loading capacity. The limitations of individual components are overcome by a unique combination of MOFs with diverse materials, such as polymers, nanoparticles, and enzymes, to build sophisticated functional composites. The most useful are MOF composites encased in nanoparticles (NPs), which incorporate NP characteristics into MOFs for improved applications. Bioimaging, magnetic resonance imaging, photothermal treatment, and luminescence, is made possible by encapsulating magnetic (iron oxide), plasmonic (AuNPs, AgNPs), and optically active quantum dots in MOFs respectively. With an emphasis on design strategies, synthesis techniques, and their effectiveness in imaging, targeted drug delivery, and therapy, this review is focusing on nanoparticle-encapsulated MOF composites for cancer drug delivery, diagnosis, and therapy.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"11 ","pages":"Article 100125"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved triboelectric nanogenerator by as-prepared lithium niobate for energy harvesting and sensing applications","authors":"Jahid Inam Chowdhury ,&nbsp;Md. Wasikur Rahman ,&nbsp;Md Arafat Hossain ,&nbsp;Nicholas Dimakis ,&nbsp;Mohammed Jasim Uddin","doi":"10.1016/j.nwnano.2025.100123","DOIUrl":"10.1016/j.nwnano.2025.100123","url":null,"abstract":"<div><div>Triboelectric nanogenerators (TENGs) have garnered significant research interest due to their ability to harvest mechanical energy efficiently. In this study, we report a TENG composed of polydimethylsiloxane (PDMS) and polyvinyl alcohol (PVA) as triboelectric layers. To enhance charge generation in the PDMS composite polymer, we incorporated lithium niobate (LiNbO₃) nanoparticles, leveraging their piezoelectric and ferroelectric properties. The LiNbO₃ nanoparticles were synthesized using a solid-state reaction method, resulting in two distinct phases: triclinic LiNbO₃ and monoclinic LiNb₃O₈. Various weight percentages of LiNbO₃ and LiNb₃O₈ nanoparticles were added to the PDMS matrix to optimize power generation. The maximum open-circuit voltage (V_OC) and short-circuit current (I_sc) were achieved with 7 wt% LiNbO₃ and LiNb₃O₈ added to the PDMS. The corresponding values were approximately 2.54 V and 10.24 V, and 170 nA and 2 μA, respectively. Furthermore, the fabricated TENG was employed to harvest energy from raindrops and human body movement. Using tap water as a raindrop source, the maximum V_OC was found to be approximately 2.25 V at a water pressure of 8 N/cm². The TENG also demonstrated remarkable capability in sensing human physiological motions, such as during regular walking, running, and jumping.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"11 ","pages":"Article 100123"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanostructured zinc stannate perovskite films synthesized via molten salt modified-solvothermal method for enhanced piezoelectric properties","authors":"Christopher Munoz ,&nbsp;Alyssah Fuentes ,&nbsp;Cristian Alaniz ,&nbsp;Tarik Dickens ,&nbsp;Mohammed Jasim Uddin","doi":"10.1016/j.nwnano.2025.100120","DOIUrl":"10.1016/j.nwnano.2025.100120","url":null,"abstract":"<div><div>Three dimensional (3D) piezoelectric zinc stannate (ZnSnO₃) nanoweb arrays are synthesized using a molten salt modified solvothermal method and deposited in PDMS films for electrochemical analysis of its piezoelectric response. This work is a preliminary assessment of comparative piezoelectric efficacy influenced by changes in synthesis, effecting dimension and particle size. Advantages of hydrothermal, molten salt, and solvothermal synthesis methods were leveraged to facilitate several chemical and surface engineering techniques to enhance piezoelectric properties by increasing the surface area of zinc stannate nanoparticles. The combination of these treatments reduce the size of zinc stannate to approximately ∼40nm-80nm weblike networks. Scanning electron microscopy (SEM) and X-Ray Diffraction (XRD) analysis reveal a mesoporous protonated tristannate (H₂Sn₃O₇) nanoweb template with connecting wirelike strands having diameters ranging from 12-27nm across and pores up to 50nm in diameter. Subsequent solvothermal treatment produces the perovskite nanoweb in a mixed solvent solution of critical dielectric conditions found to be 80% ethanol and 20% water for maximum Zn²⁺ deposition. ZnSnO₃ nanowebs (NW) were deposited in PDMS thin films and used as a piezoelectric nanogenerator (PENG) to characterize its electrochemical properties. Comparative voltage analysis of PDMS films made with weight percentages of (0%, 1%, 5%, 10%, 15% and 20%) zinc stannate sub-microcubes and nanowebs morphologies were done using an oscilloscope. These tests reveal an increased voltage output for the zinc stannate nanoweb morphology. The combination of these synthesis methods forming 3D zinc stannate nanoweb arrays could have far-reaching implications in producing other metal oxides when approaching the design of perovskite nanomaterials and piezoelectric energy harvesting systems in the coming decade.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"11 ","pages":"Article 100120"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144481486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “nano-HA and Gel Improves Mechanical Performance and Biomineralization of 3D-printed nano-HA/Gel/CMC Bone Scaffolds” [Nano Trends 9 (2025) 100097]","authors":"Şule Arıcı ,&nbsp;Alper Güven ,&nbsp;Hatice Kaya ,&nbsp;Fatih Erdem Baştan ,&nbsp;Duygu Ege","doi":"10.1016/j.nwnano.2025.100121","DOIUrl":"10.1016/j.nwnano.2025.100121","url":null,"abstract":"","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"10 ","pages":"Article 100121"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing Crataegus rosei “tejocote” for biogenic synthesis of copper nanoparticles and cytotoxicity in normal and cancer cells","authors":"Gilmer David Cab-Torres ,&nbsp;Lluvia López ,&nbsp;Daniela Salado-Leza ,&nbsp;Gabriela Navarro-Tovar","doi":"10.1016/j.nwnano.2025.100122","DOIUrl":"10.1016/j.nwnano.2025.100122","url":null,"abstract":"<div><div>The biogenic synthesis of metallic nanoparticles (MNPs) using plant extracts has been proposed as a facile and low-cost process that can enhance the antimicrobial and anticancer properties of those MNPs, suggesting that the plant extract capping can also improve biosafety. In this work, copper nanoparticles (CuNPs) (86 ± 46 nm) were synthesized using a <em>Crataegus rosei</em> “tejocote” extract (rich in polyphenols and flavonoids), and the obtained particles were evaluated in human keratinocytes HaCaT cells (healthy cells) and tumor prostate PC-3 cells to determine toxicity and antitumor activity, respectively. The plant extract showed non or slight cytotoxic effects in both HaCaT and PC-3 cells at the tested concentrations. On the other hand, CuNPs synthesized with <em>C. rosei</em> extract showed an IC₅₀ =120 ± 1.13 µg/mL in HaCaT cells, but in tumor PC-3 cells the IC₅₀ = 491 ± 1.06 µg/mL. It is showed that <em>C. rosei</em> capping is insufficient to tune the oxidative stress in healthy cells exposed to CuNPs at higher concentrations, and, that higher concentrations of CuNPs are required to reduce the cell viability in &lt;70 % in tumor PC-3 cells. Thus, a further study with different biogenic synthesized CuNPs particle size could determine different effects on the same models. It is also relevant to carry out <em>in vitro</em> analysis with other cancer cells and biomarkers.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"10 ","pages":"Article 100122"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144239555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One arrow two eagle: Multifunctional Nb5+-doped TiO2 nanoparticles for tumor photothermal-sonodynamic therapy","authors":"Wei Wang ,&nbsp;Wenquan Huang ,&nbsp;Yan Li ,&nbsp;Guangcan Xiang ,&nbsp;Yuting Zhang ,&nbsp;Haichuang Lan ,&nbsp;Peng Geng ,&nbsp;Shuzhang Xiao","doi":"10.1016/j.nwnano.2025.100124","DOIUrl":"10.1016/j.nwnano.2025.100124","url":null,"abstract":"<div><div>Titanium dioxide nanoparticles (TiO₂) have been widely used as biocompatible sonosensitizers, but their wide bandgap (3.0-3.2 eV) and rapid carrier recombination result in poor sonodynamic therapy efficacy. In order to expand the biological applications of nano-TiO₂, this work prepared Nb-doped TiO₂ nanoparticles (Nb:TiO₂) via a simple thermal decomposition method. The optical absorption of Nb:TiO₂ extended from the ultraviolet absorption edge (∼380 nm) of pure TiO₂ to near-infrared (NIR) absorption (&gt;1100 nm). Under 1064 nm light irradiation, Nb:TiO₂ nanoparticles efficiently convert NIR light energy into heat, with a photothermal conversion efficiency of 39.1 %, demonstrating their potential as excellent nano-photothermal agents. Under ultrasound excitation, the singlet oxygen (¹O₂) generation rate of Nb:TiO₂ was 1.51 times higher than that of undoped TiO₂, making it a more effective inorganic nano-sonosensitizer. Under combined light-ultrasound conditions, the cell survival rate was reduced to just 8.3 % after 8 min, indicating that the synergistic treatment of PTT-SDT effectively kills tumor cells. Therefore, this doping strategy provides new insights for expanding the biological applications of other TiO₂-based semiconductors.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"10 ","pages":"Article 100124"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging trends in nanotechnologies for vitamin delivery: Innovation and future prospects","authors":"Md. Sumon Miah ,&nbsp;Md. Waziur Rahman Chy ,&nbsp;Tanvir Ahmed ,&nbsp;Mahjabin Suchi ,&nbsp;Md. Awwal Muhtady ,&nbsp;Shah Nizam Uddin Ahmad ,&nbsp;Mohammad Afzal Hossain","doi":"10.1016/j.nwnano.2025.100126","DOIUrl":"10.1016/j.nwnano.2025.100126","url":null,"abstract":"<div><div>Nanotechnology has emerged as a cutting-edge approach to improving Vitamin Delivery systems, addressing critical challenges such as poor solubility, instability, and limited bioavailability. Conventional Vitamin Formulations are often challenged with rapid degradation and inefficient absorption, reducing their effectiveness. Integrating nanocarriers - including polymeric nanoparticles, lipid-based nanoparticles, metal-based systems, liposomes, and nano-emulsions - has demonstrated significant potential in enhancing vitamin stability and controlled release, optimizing nutrient uptake in the body. This review explores the diverse applications of nanotechnology in Vitamin Delivery, emphasizing the advantages of various nanocarrier systems. It discusses how nanoscale delivery platforms improve vitamin protection, solubility, and absorption, potentially leading to more effective supplementation strategies. Additionally, key challenges hindering the large-scale adoption of these technologies are examined, including concerns related to toxicity, regulatory uncertainties, and economic feasibility. The need for standardized safety assessments and well-defined regulatory frameworks remains a major hurdle in translating laboratory research into commercially viable products.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"10 ","pages":"Article 100126"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144239541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimicry at the nanoscale - a review of nanomaterials inspired by nature","authors":"Deepa Mundekkad,&nbsp;Anjali R Mallya","doi":"10.1016/j.nwnano.2025.100119","DOIUrl":"10.1016/j.nwnano.2025.100119","url":null,"abstract":"<div><div>Biomimetic nanomaterials and nanosystems leverage nature's designs and mechanisms to develop innovative solutions in various fields, including medicine, environmental science, and energy systems. This review explores the fundamental principles of biomimicry in nanotechnology, highlighting the rich diversity of bioinspired materials, such as nanocomposites and polymers. While examining their applications, ranging from targeted drug delivery and regenerative medicine to efficient environmental remediation and energy conversion., the review also focuses on the characterization methods that enable the understanding of these materials at the nanoscale. It also addresses the current challenges, such as scalability, biological compatibility, and safety. Finally, the review outlines future directions for research, emphasizing the integration of advanced computational techniques and interdisciplinary collaboration to enhance the design and application of biomimetic nanomaterials. By bridging biological intuition with technological innovation, biomimetic nanotechnology holds great promise for addressing complex global challenges.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"10 ","pages":"Article 100119"},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive review on biochar, with a particular focus on nano properties and applications","authors":"Irene Curcio ,&nbsp;Riccardo Gigli ,&nbsp;Francesca Mormile ,&nbsp;Cristina Mormile","doi":"10.1016/j.nwnano.2025.100117","DOIUrl":"10.1016/j.nwnano.2025.100117","url":null,"abstract":"<div><div>Biochar is a carbon-based material obtained from the thermal decomposition of a wide range of organic biomass. Its earliest uses date back to ancient agricultural practices across the world, where it was used to enrich the soil. However, it has recently become an area of interest due to its potential in environmental remediation and industrial applications. This article provides a description of the main production techniques and their advantages. It offers an overview of the physical and chemical properties, including surface area, porosity, and elemental composition, as well as the factors that influence them. It also reviews different activation methods used to enhance biochar's properties, depending on its intended use. It discusses the applications that are now in use, such as its role in environmental remediation, energy production, and as a catalyst, analysing the possible future applications as well. All of this is realized with a careful examination of nanobiochar, investigating how certain properties, such as surface area and porosity, differ at nanoscale. Materials with a size of less than one hundred nanometers are classified as \"nano\" and tend to behave differently due to the significant increase in surface-to-volume ratio, which leads to the observation of quantum confinement effects.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"10 ","pages":"Article 100117"},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}