Nano Trends最新文献

{"title":"The apparent and hidden variables for optimizing and functionalizing non-alternant nanographenes: A comprehensive study","authors":"Aristides D. Zdetsis","doi":"10.1016/j.nwnano.2025.100131","DOIUrl":"10.1016/j.nwnano.2025.100131","url":null,"abstract":"<div><div>Atomically precise non-alternant isomers of short armchair graphene nanoribbons (AGNRs) with <em>A</em> = 2 armchair and <em>Z</em> = 3, 4 zigzag rings have been recently synthesized by introducing Stone-Wales (SW) moieties, pursuing open shell magnetic states for spintronic applications. Hereby, to support the synthesis of new SW-AGNRs, we develop new and efficient principles and rules, based on the fundamental but largely misunderstood concept of (anti)aromaticity. We find that the driving force is increasing global aromaticity (rather than decreasing local antiaromaticity) through preserving the original aromaticity pattern (AP) of the parent alternant AGNR. The resulting APs are practically identical for both open-singlet and triplet states, leading to nearly isoenergetic open shell magnetic states. We uncover that the optimum arrangement of the SW moieties, involving minimum energy cost, is their closer proximity to the “inert” empty rings in the parent AP, which is found identical to the daughter AP, both determined by Z through the generalized rule: <em>Z</em> = 3n, 3n±1 (<em>n</em> = 1, 2…). As proof of concept, we study in detail the SW3×4 and SW4×4, which have similar spintronic, but distinct optoelectronic and structural characteristics. SW4×4, is a better candidate for optoelectronic, in addition to spintronic applications. For the <em>Z</em> = 2 SW2×3AGNRs, which are special cases with mixed and incomplete APs, our current preliminary results suggest possible applications as three-stage magnetic switches (diamagnetic, antiferromagnetic, and ferromagnetic). These results, obtained using aromaticity as a simple and efficient tool rather than a fuzzy concept, apply also to the already synthesized SW-AGNRs, validating our earlier and present results and predictions.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"11 ","pages":"Article 100131"},"PeriodicalIF":0.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High precision correlative analysis of dielectric behavior evolution and anisotropy in graphene oxide thin film as a function of thermal annealing parameters","authors":"Hesam Amiri ,&nbsp;Aidin Nikookhesal ,&nbsp;Divagar Murugan ,&nbsp;Stefan Scholz ,&nbsp;Michael Frentzen ,&nbsp;Yuan Cao ,&nbsp;Philip Nickl ,&nbsp;Jörg Radnik ,&nbsp;Jörg M. Stockmann ,&nbsp;Xuan-Thang Vu ,&nbsp;Madaboosi S. Narayanan ,&nbsp;Joachim Knoch ,&nbsp;Sven Ingebrandt ,&nbsp;Mohsen Adeli ,&nbsp;Vivek Pachauri","doi":"10.1016/j.nwnano.2025.100130","DOIUrl":"10.1016/j.nwnano.2025.100130","url":null,"abstract":"<div><div>Graphene oxide (GO) and reduced graphene oxide (rGO) attract keen interest from different science and technology sectors owing to their tunable material characteristics dependent on C/O ratio. Thermal annealing in different gaseous environments serves as an effective approach to manipulate the C/O ratio in graphitic lattice, making it suitable for various electronic, optical and composites applications. Despite regular use of thermal annealing, systematic studies on dielectric properties evolution in GO against different annealing parameters remain elusive. This work reports on a reliable approach that adopts a joint Raman Spectroscopy, Mueller Matrix Spectroscopic Ellipsometry (MMSE) and high-precision electrical impedance spectroscopy (HP-EIS) framework for studying the evolution of dielectric behavior and anisotropies in GO. The experimental platform involved lithography-defined GO patterns connected to metal microelectrodes and glass passivation for protection from gaseous environments during annealing and measurements using Raman, MMSE and HP-EIS. The presented study delineates the effects of annealing parameters such as temperature, heating rate, and gaseous environment on GO permittivity. Novel findings include the discovery of a direct relationship between heating rate and dielectric properties, as well as determination of vertical limitation of MMSE for permittivity distribution characterization in GO, for the first time, to be around 8 nm.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"11 ","pages":"Article 100130"},"PeriodicalIF":0.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outer membrane vesicles (OMVs) and their therapeutic potential as anti-infectious agents","authors":"Mariana Ottaiano Gonçalves ,&nbsp;Paula Maria Pincela Lins ,&nbsp;Giulia Kassab ,&nbsp;Vanderlei Bagnato ,&nbsp;Valtencir Zucolotto","doi":"10.1016/j.nwnano.2025.100129","DOIUrl":"10.1016/j.nwnano.2025.100129","url":null,"abstract":"<div><div>Outer membrane vesicles (OMVs) derived from Gram-negative bacteria have emerged as promising therapeutic agents for combating infectious diseases. These small, spherical structures carry diverse cargo molecules, including virulence factors, antigens, and immunomodulatory molecules. OMVs derived from pathogenic bacteria can be engineered to deliver antimicrobial peptides, antibiotics, or specific antigens, eliciting targeted immune responses against bacterial pathogens. Similarly, OMVs can deliver viral antigens, facilitating immune recognition and clearance of viral infections. Furthermore, OMVs can be engineered to encapsulate antifungal agents or fungal antigens, enabling targeted delivery and immune activation against fungal pathogens. The cargo-carrying capacity and immunostimulatory properties of OMVs make them valuable tools for developing effective treatments against infectious diseases. This review also discusses the challenges and future directions in applying OMVs as therapeutic agents, highlighting the need for further research and development to harness their full potential in clinical applications. Overall, OMVs represent a promising avenue for developing novel therapeutic strategies against infectious diseases, offering targeted and immunomodulatory strategies for combating bacterial, viral, and fungal infections.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"11 ","pages":"Article 100129"},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoparticles engineering strategies for lymph-node targeted cancer immunotherapy","authors":"Hitesh Harsukhbhai Chandpa ,&nbsp;Anuradha Gupta ,&nbsp;Shovan Naskar ,&nbsp;Jairam Meena","doi":"10.1016/j.nwnano.2025.100128","DOIUrl":"10.1016/j.nwnano.2025.100128","url":null,"abstract":"<div><div>Recent advancements in understanding the immune system's role in cancer have shifted focus towards immunomodulatory drugs targeting specific immune cells. Lymph nodes (LNs), as key sites for immune response initiation, present a promising target for cancer immunotherapy. This review explores the use of nanotechnology to achieve lymph node-targeted delivery of immunotherapeutics. Various biomaterial-based delivery systems including polymeric nanoparticles, inorganic nanoparticles, lipid-based, peptide/RNA-based, and virus-based systems, have been discussed to enhance the effectiveness and safety profile of cancer immunotherapy. The review also delves into the lymphatic architecture, barriers for nanoparticle delivery and strategies for targeting lymph nodes to improve antigen cross-presentation and adaptive immune responses.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"11 ","pages":"Article 100128"},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144702933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomaterials for biomedical applications: Addressing regulatory hurdles and strategic solutions","authors":"Sunil Gujjar ,&nbsp;Samiksha Kukal ,&nbsp;Prakash Jayabal ,&nbsp;Neha Balaji ,&nbsp;Saloni Sainger ,&nbsp;Srabaita Roy ,&nbsp;Suneel Rallapalli ,&nbsp;Ravikiran Mahadevappa ,&nbsp;Shilpi Minocha ,&nbsp;Saran Kumar ,&nbsp;Santosh Mathapati","doi":"10.1016/j.nwnano.2025.100127","DOIUrl":"10.1016/j.nwnano.2025.100127","url":null,"abstract":"<div><div>Nanotechnology has revolutionized modern healthcare by providing innovative solutions for the diagnosis, treatment, and monitoring of various medical conditions. The unique biological, chemical, and mechanical attributes of nanomaterials have favoured their use for various medical applications, including drug delivery, tissue engineering, implantable devices, bio-molecular detection, and diagnostics. However, potential risks associated with nanomaterial usage on health and environment raised concerns regarding their safety and regulatory oversight. Focusing exclusively on nanomaterial design with less attention towards nano-bio interaction has become a significant bottleneck to their clinical translation. This review aims to provide a concise overview of the characteristics of nanomaterials which find exciting applications in biological and biomedical fields. More importantly, we put forth the current regulation status of these advanced materials, highlighting the potential challenges and uncertainties in the regulatory assessment, and discussing potential strategies for effective regulation. A robust regulatory framework will allow a smooth clinical translation of such materials without compromising patient safety.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"11 ","pages":"Article 100127"},"PeriodicalIF":0.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144338759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoparticle-encapsulated metal-organic frameworks: innovative design strategies and biomedical applications","authors":"Pranita Rananaware ,&nbsp;Parimal Pandit ,&nbsp;Mahesh Narayan ,&nbsp;Varsha Brahmkhatri","doi":"10.1016/j.nwnano.2025.100125","DOIUrl":"10.1016/j.nwnano.2025.100125","url":null,"abstract":"<div><div>Extremely porous compounds containing metal ions connected by organic ligands are referred to as metal-organic frameworks or MOFs, with special features including distinct crystal structure, huge surface area, high pore volume, adjustable pore architecture, and remarkable drug loading capacity. The limitations of individual components are overcome by a unique combination of MOFs with diverse materials, such as polymers, nanoparticles, and enzymes, to build sophisticated functional composites. The most useful are MOF composites encased in nanoparticles (NPs), which incorporate NP characteristics into MOFs for improved applications. Bioimaging, magnetic resonance imaging, photothermal treatment, and luminescence, is made possible by encapsulating magnetic (iron oxide), plasmonic (AuNPs, AgNPs), and optically active quantum dots in MOFs respectively. With an emphasis on design strategies, synthesis techniques, and their effectiveness in imaging, targeted drug delivery, and therapy, this review is focusing on nanoparticle-encapsulated MOF composites for cancer drug delivery, diagnosis, and therapy.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"11 ","pages":"Article 100125"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved triboelectric nanogenerator by as-prepared lithium niobate for energy harvesting and sensing applications","authors":"Jahid Inam Chowdhury ,&nbsp;Md. Wasikur Rahman ,&nbsp;Md Arafat Hossain ,&nbsp;Nicholas Dimakis ,&nbsp;Mohammed Jasim Uddin","doi":"10.1016/j.nwnano.2025.100123","DOIUrl":"10.1016/j.nwnano.2025.100123","url":null,"abstract":"<div><div>Triboelectric nanogenerators (TENGs) have garnered significant research interest due to their ability to harvest mechanical energy efficiently. In this study, we report a TENG composed of polydimethylsiloxane (PDMS) and polyvinyl alcohol (PVA) as triboelectric layers. To enhance charge generation in the PDMS composite polymer, we incorporated lithium niobate (LiNbO₃) nanoparticles, leveraging their piezoelectric and ferroelectric properties. The LiNbO₃ nanoparticles were synthesized using a solid-state reaction method, resulting in two distinct phases: triclinic LiNbO₃ and monoclinic LiNb₃O₈. Various weight percentages of LiNbO₃ and LiNb₃O₈ nanoparticles were added to the PDMS matrix to optimize power generation. The maximum open-circuit voltage (V_OC) and short-circuit current (I_sc) were achieved with 7 wt% LiNbO₃ and LiNb₃O₈ added to the PDMS. The corresponding values were approximately 2.54 V and 10.24 V, and 170 nA and 2 μA, respectively. Furthermore, the fabricated TENG was employed to harvest energy from raindrops and human body movement. Using tap water as a raindrop source, the maximum V_OC was found to be approximately 2.25 V at a water pressure of 8 N/cm². The TENG also demonstrated remarkable capability in sensing human physiological motions, such as during regular walking, running, and jumping.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"11 ","pages":"Article 100123"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanostructured zinc stannate perovskite films synthesized via molten salt modified-solvothermal method for enhanced piezoelectric properties","authors":"Christopher Munoz ,&nbsp;Alyssah Fuentes ,&nbsp;Cristian Alaniz ,&nbsp;Tarik Dickens ,&nbsp;Mohammed Jasim Uddin","doi":"10.1016/j.nwnano.2025.100120","DOIUrl":"10.1016/j.nwnano.2025.100120","url":null,"abstract":"<div><div>Three dimensional (3D) piezoelectric zinc stannate (ZnSnO₃) nanoweb arrays are synthesized using a molten salt modified solvothermal method and deposited in PDMS films for electrochemical analysis of its piezoelectric response. This work is a preliminary assessment of comparative piezoelectric efficacy influenced by changes in synthesis, effecting dimension and particle size. Advantages of hydrothermal, molten salt, and solvothermal synthesis methods were leveraged to facilitate several chemical and surface engineering techniques to enhance piezoelectric properties by increasing the surface area of zinc stannate nanoparticles. The combination of these treatments reduce the size of zinc stannate to approximately ∼40nm-80nm weblike networks. Scanning electron microscopy (SEM) and X-Ray Diffraction (XRD) analysis reveal a mesoporous protonated tristannate (H₂Sn₃O₇) nanoweb template with connecting wirelike strands having diameters ranging from 12-27nm across and pores up to 50nm in diameter. Subsequent solvothermal treatment produces the perovskite nanoweb in a mixed solvent solution of critical dielectric conditions found to be 80% ethanol and 20% water for maximum Zn²⁺ deposition. ZnSnO₃ nanowebs (NW) were deposited in PDMS thin films and used as a piezoelectric nanogenerator (PENG) to characterize its electrochemical properties. Comparative voltage analysis of PDMS films made with weight percentages of (0%, 1%, 5%, 10%, 15% and 20%) zinc stannate sub-microcubes and nanowebs morphologies were done using an oscilloscope. These tests reveal an increased voltage output for the zinc stannate nanoweb morphology. The combination of these synthesis methods forming 3D zinc stannate nanoweb arrays could have far-reaching implications in producing other metal oxides when approaching the design of perovskite nanomaterials and piezoelectric energy harvesting systems in the coming decade.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"11 ","pages":"Article 100120"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144481486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “nano-HA and Gel Improves Mechanical Performance and Biomineralization of 3D-printed nano-HA/Gel/CMC Bone Scaffolds” [Nano Trends 9 (2025) 100097]","authors":"Şule Arıcı ,&nbsp;Alper Güven ,&nbsp;Hatice Kaya ,&nbsp;Fatih Erdem Baştan ,&nbsp;Duygu Ege","doi":"10.1016/j.nwnano.2025.100121","DOIUrl":"10.1016/j.nwnano.2025.100121","url":null,"abstract":"","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"10 ","pages":"Article 100121"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing Crataegus rosei “tejocote” for biogenic synthesis of copper nanoparticles and cytotoxicity in normal and cancer cells","authors":"Gilmer David Cab-Torres ,&nbsp;Lluvia López ,&nbsp;Daniela Salado-Leza ,&nbsp;Gabriela Navarro-Tovar","doi":"10.1016/j.nwnano.2025.100122","DOIUrl":"10.1016/j.nwnano.2025.100122","url":null,"abstract":"<div><div>The biogenic synthesis of metallic nanoparticles (MNPs) using plant extracts has been proposed as a facile and low-cost process that can enhance the antimicrobial and anticancer properties of those MNPs, suggesting that the plant extract capping can also improve biosafety. In this work, copper nanoparticles (CuNPs) (86 ± 46 nm) were synthesized using a <em>Crataegus rosei</em> “tejocote” extract (rich in polyphenols and flavonoids), and the obtained particles were evaluated in human keratinocytes HaCaT cells (healthy cells) and tumor prostate PC-3 cells to determine toxicity and antitumor activity, respectively. The plant extract showed non or slight cytotoxic effects in both HaCaT and PC-3 cells at the tested concentrations. On the other hand, CuNPs synthesized with <em>C. rosei</em> extract showed an IC₅₀ =120 ± 1.13 µg/mL in HaCaT cells, but in tumor PC-3 cells the IC₅₀ = 491 ± 1.06 µg/mL. It is showed that <em>C. rosei</em> capping is insufficient to tune the oxidative stress in healthy cells exposed to CuNPs at higher concentrations, and, that higher concentrations of CuNPs are required to reduce the cell viability in &lt;70 % in tumor PC-3 cells. Thus, a further study with different biogenic synthesized CuNPs particle size could determine different effects on the same models. It is also relevant to carry out <em>in vitro</em> analysis with other cancer cells and biomarkers.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"10 ","pages":"Article 100122"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144239555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}