Nano Trends最新文献

Removal of rhodamine 6G from aqueous solution in a continuous mode using nano-micro composite membranes

Nano Trends Pub Date : 2025-03-01 DOI: 10.1016/j.nwnano.2025.100096

Chris Ademola Bode-Aluko , Omoniyi Pereao , Alechine E. Ameh , Emmanuel Omoniyi , Alexander Nechaev , Leslie Petrik

{"title":"Removal of rhodamine 6G from aqueous solution in a continuous mode using nano-micro composite membranes","authors":"Chris Ademola Bode-Aluko , Omoniyi Pereao , Alechine E. Ameh , Emmanuel Omoniyi , Alexander Nechaev , Leslie Petrik","doi":"10.1016/j.nwnano.2025.100096","DOIUrl":"10.1016/j.nwnano.2025.100096","url":null,"abstract":"<div><div>This research presents the production of nanofibers, track-etched membrane, and nanofiber/track-etched composite membranes and their dye rejection studies. Polyamide 6 nanofibers (PA6-nfs) and polyacrylonitrile nanofibers (PAN-nfs) were fabricated using an electrospinning technique. Their respective composites with the metalized track-etched polyethylene terephthalate film (PET-TM), PET-TMPA6, and PET-TMPAN were also fabricated via electrospinning. The membranes were characterized using HRSEM, TEM, BET, and TGA techniques. The rejection experiments were studied with respect to the pH and the concentration of rhodamine 6G (RD), as well as the flow rate of the system. The pH is the most significant parameter in the filtration system at higher dye concentrations. At pH 10, the rejection percentages of 10 mg/L RD were 91.27% for PET-TMPAN and 70.66% for PET-TMPA6 at a flow rate of 1 mL/min. Also, PAN-nfs, PA6-nfs, and PET-TM gave 65.97%, 36.80%, and 24.53%, respectively. The composite membranes have higher rejection capabilities in comparison to their respective nanofibers. The performance of PET-TMPAN at a lower flow rate of 0.5 mL/min showed that the RD rejection by PET-TMPAN increased by ≈5 percent (91.27 to 96.01). At a lower concentration of 2 mg/L (to simulate higher dilution in river water) and pH (5.6), PET-TMPAN had a 99.59% RD rejection. All the membranes were regenerated and reused. The composite membrane PET-TMPAN has the capability to remove RD at both higher (96.01%) and lower concentrations (99.59%) of RD at lower flow rate, thereby making the system applicable and easy to use in river water purification.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"9 ","pages":"Article 100096"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143518856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of the bio-interaction of nitrogen-doped graphene quantum dots with human serum albumin aiming a quantification method

Nano Trends Pub Date : 2025-03-01 DOI: 10.1016/j.nwnano.2025.100099

Rocio Soto-Chochocca , Renan Lira de Farias , Luis Miguel Gutierrez-Beleño , Sonia Letichevsky , Fernando Lázaro Freire-Jr , York E. Serge-Correales , Rogéria R. Gonçalves , Marlin Pedrozo-Peñafiel , Ricardo Q. Aucelio

{"title":"Study of the bio-interaction of nitrogen-doped graphene quantum dots with human serum albumin aiming a quantification method","authors":"Rocio Soto-Chochocca , Renan Lira de Farias , Luis Miguel Gutierrez-Beleño , Sonia Letichevsky , Fernando Lázaro Freire-Jr , York E. Serge-Correales , Rogéria R. Gonçalves , Marlin Pedrozo-Peñafiel , Ricardo Q. Aucelio","doi":"10.1016/j.nwnano.2025.100099","DOIUrl":"10.1016/j.nwnano.2025.100099","url":null,"abstract":"<div><div>In recent years, carbon-based nanomaterials, such as graphene quantum dots (GQDs), have garnered significant attention due to their remarkable physicochemical and biological properties. This work presents a study evaluating the interaction between N-doped GQDs, produced from a mixture of citric acid and urea (referred here as GQDs-U), with human serum albumin (HSA). The GQDs-U were characterized using spectroscopic techniques, and their concentration was expressed in terms of total carbon content in aqueous dispersion. They present average diameter of about 8 nm, with average hydrodynamic diameter of around 12 nm, and a surface charge of -7 mV at pH 7.4. Assays revealed that a progressive increase in GQDs-U concentration led to the quenching of HSA fluorescence with quenching directly correlated with temperature, also indicating a mixed quenching mechanism with a predominance of the dynamic type, suggesting mutual conformational rearrangements of HSA/GQDs-U before reaching thermodynamic equilibrium. Additionally, it was shown that GQDs-U could be used as a probe to quantify HAS with the increase in photoluminescence of GQDs-U upon the addition of HSA demonstrating effective energy transfer, as GQDs-U were found to promote quenching in HSA photoluminescence. This study indicated sound evidence of stability of the nanomaterial, in aqueous dispersions, in terms of optical and morphological properties. The stability over time suggests the viability of GQDs-U as analytical probes for HSA even after a long period (30 days) of GQDs-U aging. The work also enhanced the understanding of the complex time-structure-activity relationship in this biomolecule/nanomaterial system.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"9 ","pages":"Article 100099"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143576763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A nano-enabled structural GFRP composite for self-powered multi-sensing applications

Nano Trends Pub Date : 2025-03-01 DOI: 10.1016/j.nwnano.2025.100101

Lampros Koutsotolis, Angelos Voudouris Itskaras, George Karalis, Alkiviadis S. Paipetis

{"title":"A nano-enabled structural GFRP composite for self-powered multi-sensing applications","authors":"Lampros Koutsotolis, Angelos Voudouris Itskaras, George Karalis, Alkiviadis S. Paipetis","doi":"10.1016/j.nwnano.2025.100101","DOIUrl":"10.1016/j.nwnano.2025.100101","url":null,"abstract":"<div><div>Composites are the most widely used structural material in fields where weight reduction is crucial, since they capitalize on high strength and stiffness together with low density. With growing concerns around sustainability and energy consumption, the next generation of advanced composites needs to incorporate additional functionalities. Hence, multifunctional composites emerge as a promising technological area, enabling the design of structures that are lighter, more efficient, and capable of performing multiple roles. This study introduces a nano-enabled structural glass fiber-reinforced polymer (GFRP) composite that exhibits self-powered multi-sensing capabilities, utilizing the Seebeck effect. The Thermoelectric Generator (TEG)-enabled laminate was designed with the scope of achieving specific output characteristics. The composite functioned as a power supply for the Structural Health Monitoring (SHM) of composite coupons with various electrical resistances, showcasing the dependency of the sensitivity on the TEG output characteristics. Additionally, it was able to respond to environmental stimuli, including temperature changes, infrared (IR), and ultraviolet (UV) radiation, making it a versatile tool for various sensing applications. Since the response was a generated electrical signal, the sensing process was inherently self-powered. The amalgamation of functionalities marks the first time where a single structural element simultaneously exhibits all those capabilities. This approach reveals enticing aspects for the development of smart composite structures.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"9 ","pages":"Article 100101"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143576760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stoichiometric dependent MoS2 with tuned edge sulfur as excellent anode material for Li-ion batteries

Nano Trends Pub Date : 2025-03-01 DOI: 10.1016/j.nwnano.2025.100095

Sanket N. Yadav , Praveen Kumar , K.K. Sharma , R.S. Kalubarme , Vinayak G. Parale , Varsha D. Phadtare , L.D. Jadhav

{"title":"Stoichiometric dependent MoS2 with tuned edge sulfur as excellent anode material for Li-ion batteries","authors":"Sanket N. Yadav , Praveen Kumar , K.K. Sharma , R.S. Kalubarme , Vinayak G. Parale , Varsha D. Phadtare , L.D. Jadhav","doi":"10.1016/j.nwnano.2025.100095","DOIUrl":"10.1016/j.nwnano.2025.100095","url":null,"abstract":"<div><div>Molybdenum disulfide (MoS<sub>2</sub>) has emerged as a promising negative electrode due to its excellent capacity in Li-ion- battery applications. The optoelectronic and electrochemical properties of hydrothermally grown MoS<sub>2</sub> micro-flower (flakes) have been intensively investigated. Still, the influence of stoichiometric ratio on the electrochemical and optical properties has been largely ignored, especially in Li-ion battery applications. Here, in this context, we systematically vary the stoichiometric ratio of sulfur precursor (Thiourea) in three distinct synthesized MoS<sub>2</sub> samples, A1, A2, and A3, via controlled hydrothermal reaction and investigate the associated changes in the electrochemical properties of synthesized MoS<sub>2</sub>. X-ray photoelectron spectroscopy was employed to measure relative variations in stoichiometry and the existence of MoS<sub>2</sub> species. Sample A1 possesses the lowest sulfur content, and it shows a higher specific capacity (2185 mAhg<sup>−1</sup>) and coulombic efficiency (88.11 %) as an anode material in Li-ion battery application.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"9 ","pages":"Article 100095"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143526711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

nano-HA and Gel improves mechanical performance and biomineralization of 3D-printed nano-HA/Gel/CMC bone scaffolds

Nano Trends Pub Date : 2025-03-01 DOI: 10.1016/j.nwnano.2025.100097

Şule Arıcı , Alper Güven , Hatice Kaya , Fatih Erdem Baştan , Duygu Ege

{"title":"nano-HA and Gel improves mechanical performance and biomineralization of 3D-printed nano-HA/Gel/CMC bone scaffolds","authors":"Şule Arıcı , Alper Güven , Hatice Kaya , Fatih Erdem Baştan , Duygu Ege","doi":"10.1016/j.nwnano.2025.100097","DOIUrl":"10.1016/j.nwnano.2025.100097","url":null,"abstract":"<div><div>In 3D printing scaffolds for bone tissue engineering applications, obtaining high degree of printability and shape fidelity while maintaining sufficient mechanical support are important obstacles. To address this issue, in this study, carboxymethyl cellulose (CMC) is used as a viscosity enhancer to improve shape fidelity of 3D-printed hydroxyapatite (nano-HA)/ gelatin (Gel) constructs. nano-HA/Gel/CMC hydrogels were 3D printed with varying compositions, gelatin ratios of 7.5 % and 15 %, a constant CMC ratio of 7.5 %, and HA ratios of 10 % and 20 %. After the EDC/NHS (100 mM:20 mM) crosslinking procedure, the effects of nano-HA and Gel concentrations were investigated by Fourier Transform Infrared (FTIR) analysis, printability studies, mechanical analysis, water contact angle, % water uptake, % weigh loss and pH studies. Additionally, bioactivity, cell culture and biomineralization studies were conducted. The printability was reduced when 20 % HA was added due to swelling with addition of nano-HA. The results indicated that nano-HA addition and 15 % Gel highly improves the mechanical properties and the highest compressive strength reached 2.6 MPa for HA10/G15/C7.5. MC3T3-E1 pre-osteoblasts were attached and proliferated on all study groups. Alizarin red staining and SBF studies showed high bioactivity of the samples. According to the experimental results, 3D-printed nano-HA/Gel/CMC scaffolds show potential for bone tissue engineering.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"9 ","pages":"Article 100097"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of annealing conditions on the resistive switching behavior of solution processed formamidinium lead bromide FaPbBr3 devices

Nano Trends Pub Date : 2025-03-01 DOI: 10.1016/j.nwnano.2025.100100

Amrita Singh, Saumya Paliwal, Aditi Upadhyaya, Saral Kumar Gupta, C.M.S. Negi

{"title":"Role of annealing conditions on the resistive switching behavior of solution processed formamidinium lead bromide FaPbBr3 devices","authors":"Amrita Singh, Saumya Paliwal, Aditi Upadhyaya, Saral Kumar Gupta, C.M.S. Negi","doi":"10.1016/j.nwnano.2025.100100","DOIUrl":"10.1016/j.nwnano.2025.100100","url":null,"abstract":"<div><div>Hybrid organic-inorganic halide perovskites (OIHPs) are emerging as strong contenders for next-generation flexible nonvolatile memory systems due to their fascinating properties, including mixed ionic-electronic transport, high abundance, and cost-effective fabrication processes. This study investigates the impact of annealing the active layer on the resistive switching (RS) performance of FTO/formamidinium lead bromide (FAPbBr<sub>3</sub>)/Al devices. Devices were fabricated with the FAPbBr<sub>3</sub> layer annealed under different conditions: 50 °C for 10 min (Device D1), 60 °C for 20 min (Device D2), and 100 °C for 30 min (Device D3). Each device displayed distinct bipolar hysteresis in current-voltage (I-V) characteristics, with Device D2 displaying the most prominent hysteresis loop. X-ray diffraction (XRD) analysis identified that the FAPbBr<sub>3</sub> layer in Device D2 predominantly contained the FABr–PbBr<sub>2</sub>–DMF intermediate complex, resulting in a higher density of native defects. This increased defect density likely enhanced bromide ion migration, facilitating greater ionic accumulation at the interface, which contributed to the pronounced hysteresis loop. A model combining ionic transport and energy band modulation is proposed to elucidate the resistive switching (RS) mechanism in these devices. Capacitance-frequency (C–f) analysis further corroborated the highest interfacial charge accumulation for Device D2, reflected by its maximum accumulation capacitance. Additionally, the Device D2 exhibited the highest ionic conductivity, driving enhanced ion migration and accumulation at the interface, thereby enhancing the RS behavior. This work highlights the critical role of annealing in optimizing the RS performance, offering valuable insights for advancing perovskite-based RS device technologies.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"9 ","pages":"Article 100100"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143576761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biogas production using zirconium and zinc-based nanocatalysts and evaluation using a predictive modeling approach

Nano Trends Pub Date : 2025-03-01 DOI: 10.1016/j.nwnano.2025.100098

Abbas A. Abdullahi , Mustapha D. Garba , Tawfik A. Saleh

{"title":"Biogas production using zirconium and zinc-based nanocatalysts and evaluation using a predictive modeling approach","authors":"Abbas A. Abdullahi , Mustapha D. Garba , Tawfik A. Saleh","doi":"10.1016/j.nwnano.2025.100098","DOIUrl":"10.1016/j.nwnano.2025.100098","url":null,"abstract":"<div><div>Anaerobic digestion (AD), a method of converting waste into energy, is commonly used in processing various organic wastes. It has been studied and recognized for its effectiveness. This study aimed to quantify the biogas yield from the catalytic co-digestion of rumen contents, and distilled water blended cow dung. This was achieved by fabricating biodigesters for the digestion of the contents. The study was carried out using nine identical digesters. For the biodigester without the catalyst (NC), that is control, the cumulative volume of gas produced during the study was 13,320 mL for 1:3. When 5 % w/w ZrO<sub>2</sub>, ZnO was added to the mixtures, the volume of gas increased drastically to 36,537 mL, and 21,944 mL respectively. The experimental dataset obtained after 33 days of the study was used in building the machine learning models. The best-performing model achieved during the training had a correlation coefficient between 0.9795 and 1 for the control, ZnO, and ZrO<sub>2</sub> catalytic loading, and the test correlation coefficient of the test datasets was between 0.9782 and 1. However, the Multilayer perceptron (MLP) model performed best in both the training and testing throughout the whole study having a Pearson correlation coefficient of 1. However, the study relied on a small test dataset of 11 entries. This study has opened possibilities to utilize anaerobic co-digestion technology not only for biogas generation but also to employ machine learning modeling for modeling and understanding anaerobic digestion from cow dung and rumen contents. Furthermore, it contributes to the sustainable development goals by offering an alternative energy source.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"9 ","pages":"Article 100098"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143594081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering PAMAM dendrimers for optimized drug delivery

Nano Trends Pub Date : 2025-02-16 DOI: 10.1016/j.nwnano.2025.100094

Amin Aleebrahim Dehkordi , Shirin Mollazadeh , Amirreza Talaie , Mostafa Yazdimamaghani

{"title":"Engineering PAMAM dendrimers for optimized drug delivery","authors":"Amin Aleebrahim Dehkordi , Shirin Mollazadeh , Amirreza Talaie , Mostafa Yazdimamaghani","doi":"10.1016/j.nwnano.2025.100094","DOIUrl":"10.1016/j.nwnano.2025.100094","url":null,"abstract":"<div><div>Dendrimers, first introduced by Fritz Vögtle in 1978, have emerged as promising nanocarriers for drug delivery due to their unique branched architecture, large internal cavities, and numerous surface amine groups. These dendrimers efficiently load various drugs through electrostatic interactions, covalent bonding, or encapsulation, owing to their high density of terminal amine groups. However, the inherent cationic nature of PAMAM dendrimers can lead to cytotoxicity and limited systemic circulation due to interactions with negatively charged biomolecules. To address these limitations, surface modification strategies have been developed to enhance targeting, trigger controlled drug release, and decrease cytotoxicity. This review critically examines recent advancements in engineering PAMAM dendrimers for improved drug delivery, focusing on strategies to increase drug loading capacity, achieve tissue-specific targeting, reduce toxicity, and enable stimuli-responsive release. Furthermore, this review evaluates the challenges and future prospects of engineered PAMAM dendrimer-based drug delivery systems to provide a comprehensive roadmap for advancing these platforms in nanomedicine and targeted therapeutics.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"9 ","pages":"Article 100094"},"PeriodicalIF":0.0,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing coolant performance using carbon nanoparticles as additives

Nano Trends Pub Date : 2025-02-16 DOI: 10.1016/j.nwnano.2025.100093

Kailash Arole , Anubhav Sarmah , Joseph V. Kosmoski , Evan C. Johnson , Micah J. Green , Hong Liang

{"title":"Enhancing coolant performance using carbon nanoparticles as additives","authors":"Kailash Arole , Anubhav Sarmah , Joseph V. Kosmoski , Evan C. Johnson , Micah J. Green , Hong Liang","doi":"10.1016/j.nwnano.2025.100093","DOIUrl":"10.1016/j.nwnano.2025.100093","url":null,"abstract":"<div><div>The mixture of water and ethylene glycol (EG) as conventional coolants has been widely used in automobile radiators for decades. However, these heat-transfer fluids have low thermal conductivity and fail to fulfill the needs of upcoming high-speed and compact vehicles. Nanomaterial additives offer an opportunity to develop new coolants with improved thermal and physical performance. The feasibility of a new class of carbon-based nanomaterial as an additive for coolant is investigated in this work. Experiments were conducted to measure the effect of carbon nanoplatelets on the thermal conductivity, thermal diffusivity, specific heat, and viscosity of ethylene glycol-based coolants. The addition of carbon nanoplatelets into EG:water at a loading of 0.5 wt.% increased thermal conductivity and diffusivity by 15.7 % and 45.9 %, respectively. The addition of 0.5 wt.% of carbon nanoplatelets showed a viscosity drop of 16.6 %. This reduction in viscosity creates a smaller boundary layer, resulting in enhanced heat transfer and better performance. Thus, the improved thermophysical properties offered by this new class of carbon nanoparticles show promise for their use as an additive in coolants.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"9 ","pages":"Article 100093"},"PeriodicalIF":0.0,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143471295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Defining acceptance criteria for silver nanoparticles: correlating synthesis quality with biological outcomes in an In Vitro Lung Cancer Model

Nano Trends Pub Date : 2025-02-14 DOI: 10.1016/j.nwnano.2025.100090

Bárbara Gomes , Marjorie Dardis Murucci , Wanderson de Souza , Beatriz Kopke Dal-Cheri , Ana Resende , Natália Yoshihara , Luths Geaquinto , José Mauro Granjeiro , Celso Sant'Anna , Leonardo Boldrini

{"title":"Defining acceptance criteria for silver nanoparticles: correlating synthesis quality with biological outcomes in an In Vitro Lung Cancer Model","authors":"Bárbara Gomes , Marjorie Dardis Murucci , Wanderson de Souza , Beatriz Kopke Dal-Cheri , Ana Resende , Natália Yoshihara , Luths Geaquinto , José Mauro Granjeiro , Celso Sant'Anna , Leonardo Boldrini","doi":"10.1016/j.nwnano.2025.100090","DOIUrl":"10.1016/j.nwnano.2025.100090","url":null,"abstract":"<div><div>Lung cancer remains a leading cause of cancer-related mortality worldwide, underscoring the need for innovative therapeutic strategies. This study explores the development and evaluation of silver nanoparticles (AgNPs) synthesized under optimized heating and cooling protocols to refine their physicochemical properties for antitumor applications. The AgNPs were synthesized using chemical synthesis using a reduction and bottom-up strategy. Eight synthesis protocols were optimized, and key parameters, such as particle size, morphology, and stability, were systematically characterized using UV–visible spectroscopy, dynamic light scattering, nanoparticle tracking analysis, and electron microscopy. Selected nanoparticles were evaluated for their cytotoxic effects on A549 lung adenocarcinoma cells, demonstrating dose- and time-dependent reductions in cell viability. Mechanistic insights revealed early apoptosis, assessed using flow cytometry by detecting phosphatidylserine externalization with Annexin V staining, propidium iodide uptake for membrane integrity, and lactate dehydrogenase release for cell damage. Surface coatings played a pivotal role, with citrate-stabilized AgNPs exhibiting rapid cytotoxicity and PVA-stabilized AgNPs showing sustained effects. This study underscores the importance of tailoring synthesis conditions to achieve reproducible and biologically effective AgNPs, providing a foundation for advancing nanotechnology-based cancer therapies.</div></div>","PeriodicalId":100942,"journal":{"name":"Nano Trends","volume":"9 ","pages":"Article 100090"},"PeriodicalIF":0.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0