MedComm – Biomaterials and Applications最新文献_第3页

Smart Design: Integrating Artificial Intelligence and Gene Editing for Advanced mRNA Therapeutics 智能设计：整合人工智能和基因编辑用于先进的mRNA治疗

MedComm – Biomaterials and Applications Pub Date : 2026-08-02 DOI: 10.1002/mba2.70062

Haixing Shi, Shengbin Liu, Danni Dai, Shanhui Jiang, Tingchen Tian, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Fang Liu, Xue Tang, Xin Jiang, Xiangrong Song

{"title":"Smart Design: Integrating Artificial Intelligence and Gene Editing for Advanced mRNA Therapeutics","authors":"Haixing Shi, Shengbin Liu, Danni Dai, Shanhui Jiang, Tingchen Tian, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Fang Liu, Xue Tang, Xin Jiang, Xiangrong Song","doi":"10.1002/mba2.70062","DOIUrl":"https://doi.org/10.1002/mba2.70062","url":null,"abstract":"Artificial intelligence (AI) and gene editing are increasingly being applied to the design and evaluation of mRNA therapeutics. Although mRNA-based medicines have achieved clear clinical impact in vaccination, broader applications remain limited by mRNA instability, delivery barriers, tissue selectivity, and unwanted immunogenicity. This review examines how AI and gene editing can be combined to address these constraints. AI-based models support predictive optimization of untranslated regions, codon usage, secondary structure, and lipid nanoparticle (LNP) formulations, thereby improving the efficiency of sequence and delivery-system design. In parallel, CRISPR-Cas (clustered regularly interspaced short palindromic repeats-associated proteins) systems, base editors, and emerging RNA-editing tools provide platforms for disease modeling, target validation, and functional testing of mRNA-based interventions. We emphasize that the value of this convergence lies in iterative workflows: gene-editing screens generate quantitative datasets for model training, whereas AI helps prioritize editing strategies, guide sequence refinement, and improve delivery design. We also summarize representative applications, translational limitations, and prospects for closed-loop AI-gene editing platforms. Overall, the integration of computational prediction with programmable genome and RNA engineering may support more precise, adaptable, and clinically translatable mRNA therapeutics.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148752462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-Drug-Loaded Liposomes: Design Strategies, Mechanistic Insights, and Therapeutic Applications in Cancer 双重药物负载脂质体：设计策略、机制洞察和癌症治疗应用

MedComm – Biomaterials and Applications Pub Date : 2026-07-21 DOI: 10.1002/mba2.70060

Neelam Sinha, Rohan Chand Sahu, Rohit Patil, Dinesh Kumar, Ashish Kumar Agrawal

{"title":"Dual-Drug-Loaded Liposomes: Design Strategies, Mechanistic Insights, and Therapeutic Applications in Cancer","authors":"Neelam Sinha, Rohan Chand Sahu, Rohit Patil, Dinesh Kumar, Ashish Kumar Agrawal","doi":"10.1002/mba2.70060","DOIUrl":"https://doi.org/10.1002/mba2.70060","url":null,"abstract":"Liposomal nanocarriers are clinically established platforms for targeted drug delivery due to their biocompatibility and ability to encapsulate both hydrophilic and hydrophobic agents. However, conventional single-drug liposomes are limited by suboptimal efficacy, systemic toxicity, and multidrug resistance. Dual-drug-loaded liposomes (DDLs) address these limitations by enabling co-delivery of synergistic agents within a single nanocarrier. This review provides an integrated analysis of DDL systems, focusing on formulation design, drug loading strategies, and key physicochemical parameters governing encapsulation efficiency and controlled release. Mechanistic insights into therapeutic enhancement are highlighted, including modulation of efflux transporters, reversal of epithelial–mesenchymal transition, and synchronized intracellular delivery. The impact of ligand-mediated functionalization on tumor targeting and cellular uptake is also critically evaluated. Unlike existing reviews, this work provides a unified framework integrating formulation design, mechanistic insights into drug synergy, and translational challenges specific to DDLs, addressing a critical gap in the existing literature. Preclinical and clinical evidence, including approved formulations such as Vyxeos, is discussed. Remaining barriers include scale-up, reproducibility, immune interactions, and regulatory complexity. Future directions emphasize personalized and stimulus-responsive nanomedicine for improved cancer therapy.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70060","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148615595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sustained Release and Therapeutic Evaluation of Simvastatin-Loaded Bioglass–Chitosan Gel Formulation for Skin Regeneration and Wound Healing Potential 辛伐他汀负载生物玻璃壳聚糖凝胶制剂对皮肤再生和伤口愈合潜力的缓释和疗效评价

MedComm – Biomaterials and Applications Pub Date : 2026-07-17 DOI: 10.1002/mba2.70063

Durgesh Kumar, Suhela Tyeb, Baby Shruit Shukla, Vivek Verma, Nitesh Kumar

{"title":"Sustained Release and Therapeutic Evaluation of Simvastatin-Loaded Bioglass–Chitosan Gel Formulation for Skin Regeneration and Wound Healing Potential","authors":"Durgesh Kumar, Suhela Tyeb, Baby Shruit Shukla, Vivek Verma, Nitesh Kumar","doi":"10.1002/mba2.70063","DOIUrl":"https://doi.org/10.1002/mba2.70063","url":null,"abstract":"Chronic wounds pose a major clinical challenge due to a complex pathophysiological condition. It is characterized by persistent inflammation, excessive oxidative stress, and a high risk of bacterial infection, which hinders tissue repair. To address this, a multifunctional hydrogel dressing based on gallic acid conjugated chitosan (G-CHI) and integrated with simvastatin and heparin-functionalized Ag/Zn-doped bioactive glass (HBG). The incorporation of gallic acid improved the structural integrity and viscoelastic behavior of the hydrogel. The release kinetics study demonstrated controlled liberation of Ag+ and Zn2+ ions within biologically safe limits over 24 h, while simvastatin exhibited diffusion-controlled release behavior. The hydrogel also exhibited desirable adhesive properties, indicating its suitability as a wound dressing material. In vitro biofunctional assays showed enhanced antioxidant activity (~75% free radical scavenging), hemocompatibility (< 5% hemolysis), and effectiveness against both Staphylococcus aureus and Escherichia coli (> 90% efficacy in time kill assay). Further, synergistic release of simvastatin and bioglass showed enhanced proliferation of fibroblast (NIH 3T3), keratinocyte (HaCaT), and endothelial cells (SVEC), accompanied by increased collagen deposition compared to control groups. These findings suggest that the synthesized hydrogel (BSG-CHI) provides a favorable microenvironment for tissue regeneration and wound management applications.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148467434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Targeting Delivery of Cyanidin-Loaded With Ti3C2 Nanosheets for Alleviating Vascular Calcification in Chronic Kidney Disease” 对“靶向递送负载Ti3C2纳米片的花青素减轻慢性肾脏疾病血管钙化”的更正

MedComm – Biomaterials and Applications Pub Date : 2026-07-17 DOI: 10.1002/mba2.70072

引用次数: 0

Correction to “Biomedical Applications and Prospects of Temperature-Orchestrated Photothermal Therapy” 对“温度调控光热疗法的生物医学应用和前景”的更正

MedComm – Biomaterials and Applications Pub Date : 2026-07-17 DOI: 10.1002/mba2.70068

引用次数: 0

Correction to “Recent Advances and Perspectives of Multifunctional Nanogels in Biomedical Applications” 更正“多功能纳米凝胶在生物医学应用中的最新进展和展望”

MedComm – Biomaterials and Applications Pub Date : 2026-07-17 DOI: 10.1002/mba2.70069

引用次数: 0

Correction to “Nonviral Vector System for Cancer Immunogene Therapy” 对“用于癌症免疫基因治疗的非病毒载体系统”的更正

MedComm – Biomaterials and Applications Pub Date : 2026-07-17 DOI: 10.1002/mba2.70066

引用次数: 0

Correction to “Recent Progress in 3D Printing Degradable Polylactic Acid-Based Bone Repair Scaffold for the Application of Cancellous Bone Defect” 更正“3D打印可降解聚乳酸骨修复支架在松质骨缺损中的应用研究进展”

MedComm – Biomaterials and Applications Pub Date : 2026-07-17 DOI: 10.1002/mba2.70067

引用次数: 0

Correction to “The Potency of Aloe Emodin-Loaded Nanoparticles in Conjunction With IFN-γ for the Pretreatment of Mesenchymal Stem Cells With Class II Transactivator Silence to Alleviate Severe Acute Pancreatitis” 更正“芦荟大黄素纳米颗粒联合IFN-γ预处理II类反激活因子沉默的间充质干细胞以减轻严重急性胰腺炎的效力”

MedComm – Biomaterials and Applications Pub Date : 2026-07-17 DOI: 10.1002/mba2.70070

{"title":"Correction to “The Potency of Aloe Emodin-Loaded Nanoparticles in Conjunction With IFN-γ for the Pretreatment of Mesenchymal Stem Cells With Class II Transactivator Silence to Alleviate Severe Acute Pancreatitis”","authors":"","doi":"10.1002/mba2.70070","DOIUrl":"https://doi.org/10.1002/mba2.70070","url":null,"abstract":"Y. Zou, Q. Qin, X. Song, et al., “The Potency of Aloe Emodin-Loaded Nanoparticles in Conjunction With IFN-γ for the Pretreatment of Mesenchymal Stem Cells With Class II Transactivator Silence to Alleviate Severe Acute Pancreatitis,” MedComm – Biomaterials and Applications 4 (2025): e70001.In the original version of this article, the “Author Contributions” section was incomplete and failed to include all authors listed in the manuscript's roster. Specifically, the contribution of author Ailing Jiang was omitted.“This should have read”:Author Contributions:Yu Zou: data curation, writing – original draft. Qin Qin: investigation, validation. Xiaoshuang Song: writing – review and editing. Yuchuan Deng: methodology. Simeng Liu: methodology. Huimin Liu: methodology. Ailing Jiang: methodology, investigation. Mao Wang: formal analysis. Yiran Song: formal analysis. Dujiang Yang: writing – original draft. Huimin Lu: writing – original draft. Kun Jiang: writing – original draft, supervision. Qian Yao: writing – original draft, funding acquisition. Yu Zheng: conceptualization, funding acquisition, supervision. All authors have read and approved the final manuscript.”We apologize for this error.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70070","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148467115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Antimicrobial Copper Ion-Graphene Oxide Composite to Inhibit Pseudomonas aeruginosa Keratitis in Rabbits” 对“抗菌铜离子-氧化石墨烯复合材料抑制兔铜绿假单胞菌角膜炎”的更正

MedComm – Biomaterials and Applications Pub Date : 2026-07-17 DOI: 10.1002/mba2.70073

引用次数: 0