MedComm – Biomaterials and Applications最新文献

{"title":"Synergistic Regulation of Biomaterials and Macrophages: A Novel Paradigm in Immunotherapy","authors":"Jiayu Zhang,&nbsp;Songhang Xing,&nbsp;Shanshan Zhang,&nbsp;Yuan Hao,&nbsp;Xiaojie Qu,&nbsp;Wurihan Bao,&nbsp;Manwei Hao,&nbsp;Han Sun,&nbsp;Mingyuan Dong,&nbsp;Huiling Zhang,&nbsp;Dan Huang,&nbsp;Yiqi Wang,&nbsp;Xuanjie Jiang,&nbsp;Xiaoyu Pu,&nbsp;Yanyan Chi,&nbsp;Xingtong Wang,&nbsp;Xuefeng Li","doi":"10.1002/mba2.70079","DOIUrl":"https://doi.org/10.1002/mba2.70079","url":null,"abstract":"<p>Macrophages have emerged as central regulators of tissue homeostasis, inflammation, and regeneration, yet their remarkable phenotypic plasticity and functional heterogeneity pose substantial challenges for therapeutic modulation. This review provides a comprehensive synthesis of macrophage immunobiology and its translation into bioengineered material strategies for cancer immunotherapy, anti-infective/inflammatory therapy, and tissue regeneration. We first delineate the ontogeny and functional specialization of tissue-resident and tumor-associated macrophage populations, the marker-defined subpopulations revealed by single-cell technologies, and the signaling networks that govern macrophage polarization. We further examine the complex crosstalk between macrophages and the microenvironment, encompassing interactions with tumor cells, fibroblasts, neutrophils, and T cells, as well as metabolic regulation by lactate, cAMP, exosomes, and trained immunity. Building on this mechanistic foundation, we systematically review bioengineered delivery platforms spanning nanoscale carriers, cell membrane-coated biomimetic systems, surface-functionalized particles, and macroscale hydrogels and scaffolds, emphasizing the bidirectional macrophage–material feedback that dictates therapeutic outcomes. Despite notable progress, challenges in macrophage heterogeneity, manufacturing scalability, and long-term safety remain. We highlight emerging directions, including single-cell and spatial transcriptomics-guided design, trained immunity-based strategies, and artificial intelligence-driven material development, which together promise to accelerate the translation of macrophage-targeting biomaterials from bench to bedside.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"5 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70079","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149145932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-Printed Biomedical Materials for Personalized Medicine: Materials, Manufacturing Strategies, Translational Applications, and Future Perspectives","authors":"Qingbing Wang,&nbsp;Ningning Liang,&nbsp;Fengping Zhu,&nbsp;Tao Sun","doi":"10.1002/mba2.70076","DOIUrl":"https://doi.org/10.1002/mba2.70076","url":null,"abstract":"<p>Personalized medical treatment aims to tailor diagnosis and treatment plans to individual patients, accounting for differences in anatomical structure, gene expression, and lesion microenvironment. Traditional mold-based manufacturing methods can hardly produce implants that perfectly match unique patient lesions. Three-dimensional (3D) bioprinting has grown from simple shape replication to microscale biomimetic manufacturing and active therapeutic devices, supported by continuous progress in smart biomaterials, high-precision printing equipment, and cell-compatible bioinks. This review systematically compares traditional manufacturing with 3D bioprinting, summarizes the design principles of patient-matched repair scaffolds, and outlines the major application directions, including patient-derived disease models and real-time sensing therapeutic devices. It also examines the key obstacles restricting clinical translation, including insufficient vascularization of large tissue grafts, uncertain long-term material safety, and inconsistent global medical device approval standards. Furthermore, an artificial intelligence (AI)–multi-omics integrated design framework is proposed to guide future biomaterial development. By connecting basic materials research with clinical needs, this review aims to provide clear technical pathways toward next-generation individualized precision repair technologies.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70076","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148994314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rational Synthesis of MOF-Derived Selenium Vacancy-Rich Hollow CoNiSe2-x Triangular Nanosheet Arrays on Carbon Cloth for Non-Enzymatic Glucose Sensing","authors":"Fangjun Chen,&nbsp;Yi Duan,&nbsp;Jiangtao Lin,&nbsp;Yan Zhu,&nbsp;Wanxin Cao,&nbsp;Yourong Duan,&nbsp;Yuanyuan Li","doi":"10.1002/mba2.70080","DOIUrl":"https://doi.org/10.1002/mba2.70080","url":null,"abstract":"<p>Rational structural and defect engineering of self-supporting electrodes is highly desirable for developing high-performance non-enzymatic glucose sensors. Herein, selenium vacancy-rich hollow CoNiSe_2-<i>x</i> triangular nanosheet arrays were directly constructed on carbon cloth through a MOF-derived ion-exchange strategy followed by solvothermal selenization and controlled NaBH₄ reduction. Compared with previously reported Co/Ni-based selenide glucose sensors, CoNiSe_2-x/CC combines hollow triangular nanosheets and selenium-vacancy engineering in a binder-free carbon-cloth electrode. The hollow structure improves electrolyte access and exposes more electroactive surface, while selenium vacancies provide additional active sites for glucose oxidation. Benefiting from these synergistic advantages, the CoNiSe_2-<i>x</i>/CC electrode exhibits excellent electrocatalytic activity toward glucose, delivering an ultrawide linear range of 0.5–10,000 µM, a high sensitivity of 4919 µA mM^–1 cm^–2, and a low detection limit of 0.34 µM. Moreover, the sensor demonstrates good selectivity, long-term stability, repeatability, and reproducibility. Practical analysis in human serum further confirms its reliable applicability for real-sample glucose detection. This work provides a facile strategy for designing vacancy-rich hollow bimetallic selenide electrodes and highlights the potential of CoNiSe_2-<i>x</i>/CC for flexible non-enzymatic glucose sensing.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70080","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148994315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravitreal Delivery of Cationic DMP Micelles Suppresses Choroidal Neovascularization","authors":"Yingying Chen,&nbsp;Jieping Wu,&nbsp;Ke Men,&nbsp;Jiamei Yang,&nbsp;Mohan Liu,&nbsp;Meixia Zhang","doi":"10.1002/mba2.70082","DOIUrl":"https://doi.org/10.1002/mba2.70082","url":null,"abstract":"&lt;p&gt;Neovascular age-related macular degeneration (AMD) is characterized by choroidal neovascularization (CNV), which remains a major cause of irreversible vision loss worldwide [&lt;span&gt;1&lt;/span&gt;]. Although intravitreal anti-vascular endothelial growth factor (VEGF) therapy has improved clinical outcomes, repeated injections, incomplete responsiveness, and long-term treatment burden remain important limitations [&lt;span&gt;2&lt;/span&gt;]. Nanomaterial-based ocular delivery systems have attracted increasing interest because of their favorable biocompatibility and sustained delivery potential. However, whether cationic micelles possess intrinsic therapeutic activity independent of drug loading remains largely unexplored.&lt;/p&gt;&lt;p&gt;Here, we investigated DMP, a cationic micelle assembled from 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) and methoxy poly(ethylene glycol)-block-poly(ε-caprolactone) (mPEG-PCL), as a stand-alone therapeutic strategy for CNV (Figure 1A). DMP micelles were prepared by thin-film hydration and had a mean hydrodynamic diameter of 86.48 ± 3.78 nm, a polydispersity index of 0.101, and a zeta potential of +46.40 ± 3.87 mV. Transmission electron microscopy confirmed their spherical morphology (Figure 1A).&lt;/p&gt;&lt;p&gt;We evaluated DMP uptake and cytocompatibility in rat Müller rMC-1 cells, consistent with the species used for the in vivo experiments. Rhodamine-labeled DMP was readily taken up by rMC-1 cells. MTT assays showed that cell viability remained above 80% at DMP concentrations up to 600 μg/mL and decreased at 800 μg/mL, while remaining substantially higher than that following PEI25K treatment (Figure 1B). Among the inhibitors tested, M-β-CD significantly reduced DMP uptake, whereas CPZ and filipin III had no significant effects. Latrunculin A increased DMP-associated fluorescence, which may reflect altered cortical actin constraints or vesicular trafficking rather than actin-dependent uptake. These findings support a cholesterol-sensitive component of DMP uptake but do not establish a single internalization pathway (Figure 1B). Following intravitreal injection, rhodamine-labeled DMP was detected across multiple retinal layers, supporting its distribution within the retina (Figure 1C).&lt;/p&gt;&lt;p&gt;To evaluate the anti-neovascular effect of DMP, a laser-induced CNV model was established in Brown Norway rats, followed by intravitreal administration of DMP 1 day after laser photocoagulation. Fundus fluorescein angiography (FFA) on Day 7 showed lower CNV leakage grades in DMP-treated eyes than in saline-treated controls (&lt;i&gt;p&lt;/i&gt; &lt; 0.0001; Figure 1D). IB4 staining on Day 14 likewise showed a smaller CNV area after DMP treatment (79,700 ± 18,083 vs. 169,537 ± 23,220 μm&lt;sup&gt;2&lt;/sup&gt;; &lt;i&gt;p&lt;/i&gt; = 0.0140; Figure 1D).&lt;/p&gt;&lt;p&gt;To preliminarily explore biological pathways associated with DMP treatment, we performed RNA-seq analysis on retinal tissues after intravitreal administration. Transcriptomic analysis revealed upregulation of immune- and antigen present","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70082","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148994018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Organic Aggregates for Biomedical Phototheranostics","authors":"Bowen Fu,&nbsp;Yayun Peng,&nbsp;Ting Cai","doi":"10.1002/mba2.70077","DOIUrl":"https://doi.org/10.1002/mba2.70077","url":null,"abstract":"<p>Organic aggregates are emerging as versatile platforms for biomedical phototheranostics, as aggregation provides a direct means to regulate excited-state behavior beyond the limits of isolated chromophores. Whereas conventional organic dyes often undergo aggregation-caused quenching, uncontrolled packing, and rapid nonradiative deactivation, rationally engineered aggregates can enhance fluorescence, stabilize triplet excitons, promote reactive oxygen species generation, or channel absorbed energy into heat and photoacoustic signals. This review summarizes recent progress in the design and biomedical application of organic aggregates, with particular emphasis on the relationships among molecular structure, aggregate organization, excited-state energy dissipation, optical output, and biological function. We discuss key aggregate-state photophysical mechanisms, including aggregation-induced emission, restriction of intramolecular motion, excitonic coupling, charge-transfer interactions, and triplet-state stabilization, and examine how these principles are implemented through molecular packing, crystallinity, supramolecular confinement, and nanostructure engineering. Representative applications in fluorescence and room-temperature phosphorescence imaging, photoacoustic and photothermal imaging, photodynamic and photothermal therapy, and multimodal image-guided treatment are highlighted. Finally, we outline major challenges related to structural heterogeneity, in vivo stability, biodistribution, biodegradation, biosafety, reproducible manufacturing, and clinical translation, and identify design priorities for next-generation organic aggregate phototheranostic systems.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70077","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148942639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Situ Chimeric Antigen Receptor Macrophage Programming: Engineered Zeolitic Imidazolate Framework-8 Nanocarriers for Improved Immunotherapy in Prostate Cancer","authors":"Ziwei Xu,&nbsp;Di Wu,&nbsp;Qi Zhang","doi":"10.1002/mba2.70078","DOIUrl":"https://doi.org/10.1002/mba2.70078","url":null,"abstract":"&lt;p&gt;In the latest publication in ACS Nano, Liang et al. [&lt;span&gt;1&lt;/span&gt;] designed PZAML nanocarriers with a hierarchical structure of pDNA@ZIF-8@Au cluster@mannose@lipid layer that enabled spatially specific co-delivery of interferon-gamma (IFN-γ) and chimeric antigen receptor (CAR) genes, thereby enabling in situ construction of CAR-macrophage (CAR-M), as well as specific tumor-killing and adaptive immunity activation, representing a promising approach for immunotherapy of prostate cancer through systematic in vivo editing of CAR-Ms.&lt;/p&gt;&lt;p&gt;Prostate cancer has a high incidence and is the fifth leading cause of cancer-related deaths, with traditional treatments prone to recurrence. Owing to prostate-specific membrane antigen (PSMA) expression, anti-PSMA CAR-T-cell immunotherapy (CAR-T) has enhanced targeting to prostate cancer cells. As a “cold tumor”, prostate cancer restricts T cell infiltration and CAR-T efficacy. However, solid tumors have high tumor-associated macrophage (TAM) infiltration, providing a research direction for “cold tumor” treatment. Nevertheless, TAM infiltration is consistently associated with poor prognosis across multiple solid tumors, including prostate, breast, and ovarian cancers. Compared with CAR-natural killer (CAR-NK) cell, CAR-M exhibits the capacity to infiltrate solid tumors, remodel the immune microenvironment, and activate adaptive immunity [&lt;span&gt;2&lt;/span&gt;]. Nevertheless, the clinical translation of CAR-M therapy is currently hampered by complex &lt;i&gt;ex vivo&lt;/i&gt; manufacturing processes, limited &lt;i&gt;in vivo&lt;/i&gt; persistence, and safety concerns associated with viral vectors [&lt;span&gt;3&lt;/span&gt;]. In recent years, Zeolitic Imidazolate Framework-8 (ZIF-8) serves as the core component of the PZAML nanocarrier, enabling efficient encapsulation and intracellular delivery of nucleic acid drugs through its high specific surface area, pH-responsive release properties, and proton-sponge effect. However, due to its positively charged surface, non-specific uptake by liver limits the delivery efficiency of ZIF-8. Therefore, it is urgent to develop a safe and straightforward in vivo in situ editing delivery system to overcome the current technical limitations.&lt;/p&gt;&lt;p&gt;To solve the aforementioned issue, Liang's group constructed PZAML nanocarriers for in situ CAR-M programming of M2-type macrophages in solid tumor (Figure 1). Using ZIF-8 to encapsulate the CAR plasmid, gold clusters and mannose were successively modified on its surface, and a pH-responsive lipid layer was coated. In the acidic tumor microenvironment, the mannose ligands exposed upon lipid layer dissociation exhibit preferential binding affinity for CD206 on M2-type macrophages. The PZAML system achieves precise tumor targeting owing to the accumulation of M2-type macrophages and high surface expression of CD206, which enables preferential binding and efficient internalization of the mannose ligands. After endocytosis, ZIF-8 releases the plasmid via the “proton sponge effe","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70078","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148942745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Proteolysis-Targeting Chimera Delivery by Targeting Key Biomarkers in Tumor Endocytosis Pathways","authors":"Huahua Chen,&nbsp;Jiayan Jiao,&nbsp;Huiling Yang,&nbsp;Tao He","doi":"10.1002/mba2.70065","DOIUrl":"https://doi.org/10.1002/mba2.70065","url":null,"abstract":"<p>Proteolysis-targeting chimeras (PROTACs) are promising therapeutic agents for targeted protein degradation via the ubiquitin-proteasome system; however, their clinical application is severely constrained by poor membrane permeability due to high molecular weight and polar surface area, limiting passive diffusion. Emerging evidence suggests that receptor-mediated endocytosis within tumor microenvironments provides an alternative and potentially generalizable entry route for PROTAC delivery independent of classical diffusion. This review proposes a systematic framework for tumor endocytosis-guided PROTAC delivery, centered on the identification and exploitation of endocytic biomarkers. A three-tiered screening strategy is established based on tumor-selective expression, validated internalization capacity, and functional relevance to tumor dependency. Using this framework, nine representative biomarkers are evaluated with respect to endocytic pathways, intracellular trafficking fate, and delivery suitability. Furthermore, we present a unified PROTAC engineering strategy matrix integrating ligand design, cleavable linker chemistry, and endosomal escape modules to align with receptor-specific trafficking behaviors. A multiscale validation pipeline covering binding, internalization, intracellular release, and in vivo pharmacodynamics is also outlined. Collectively, this review establishes tumor endocytic pathways as programmable delivery interfaces, providing a rational roadmap for next-generation PROTAC design with improved efficiency and translational potential.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70065","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148783659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barnacle-Inspired Water-Displacing Injectable Adhesive for Rapid Hemostasis and Antibacterial Sealing in Wet Environments","authors":"Jiaxian Zhou,&nbsp;Hang Li","doi":"10.1002/mba2.70064","DOIUrl":"https://doi.org/10.1002/mba2.70064","url":null,"abstract":"<p>Uncontrolled bleeding in wet or actively hemorrhaging environments remains a major clinical challenge in trauma management and surgical procedures. Conventional hemostatic agents and tissue adhesives often exhibit insufficient adhesion strength and delayed coagulation upon contact with blood or moisture at the tissue interface. Inspired by the underwater adhesion mechanism of barnacle cement, we developed an injectable, multifunctional hemostatic adhesive that achieves rapid coagulation, strong adhesion to wet tissues, and inherent antibacterial properties. The adhesive integrates a silicone oil-assisted water-displacement phase with a bioadhesive polymer network composed of carboxymethyl chitosan, hyaluronic acid, and quaternized chitosan. In vitro tests revealed a markedly reduced blood clotting index (9.0% ± 0.6%) and shorter clotting time (2.6 ± 0.5 min), surpassing the performance of commercial gelatin sponges. Enhanced red blood cell adsorption and superior wet tissue adhesion strength (27.3 kPa on porcine skin) compared to fibrin glue further confirm its hemostatic efficacy. The adhesive also demonstrated excellent cytocompatibility and significant antibacterial activity. Overall, this barnacle-inspired injectable adhesive offers a promising approach for achieving rapid hemostasis and infection-resistant wound sealing in moist clinical settings.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “MXene-Based Electrochemiluminescence (ECL) Biosensors: A Review on Analyte Detection and Diagnostic Applications”","authors":"","doi":"10.1002/mba2.70075","DOIUrl":"https://doi.org/10.1002/mba2.70075","url":null,"abstract":"<p>Zhang, K. (2025), MXene-Based Electrochemiluminescence (ECL) Biosensors: A Review on Analyte Detection and Diagnostic Applications. MedComm – Biomaterials and Applications, 4: e70027.</p><p>Missing keywords in articles published online</p><p>We apologize for this error.</p><p>Keywords should be added as follows:</p><p>Keywords: MXene; Electrochemiluminescence (ECL); Biosensor; Diagnostic applications</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70075","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148752841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Sustained Release and Therapeutic Evaluation of Simvastatin-Loaded Bioglass–Chitosan Gel Formulation for Skin Regeneration and Wound Healing Potential”","authors":"","doi":"10.1002/mba2.70074","DOIUrl":"https://doi.org/10.1002/mba2.70074","url":null,"abstract":"<p>D. Kumar, S. Tyeb, B. S. Shukla, V. Verma, and N. Kumar, “Sustained Release and Therapeutic Evaluation of Simvastatin-Loaded Bioglass–Chitosan Gel Formulation for Skin Regeneration and Wound Healing Potential,” <i>MedComm – Biomaterials and Applications</i> 5 (2026): e70063.</p><p>The live/dead cell images of the SVEC endothelial cells in Figure 4d were unintentionally omitted during the revision process.</p><p>The omission was purely inadvertent and does not affect the experimental results, data interpretation, or the scientific conclusions of the manuscript.</p><p>We apologize for this error.</p><p>Revised Figure 4 to be added is attached below.</p><p>No change in Figure 4 captions of published manuscript.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70074","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148752884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}