MedComm – Biomaterials and Applications最新文献

{"title":"Pseudomonas lipopeptide: An excellent biomedical agent","authors":"Vivek Chauhan,&nbsp;Shreya Mazumdar,&nbsp;Akash Pandey,&nbsp;Shamsher S. Kanwar","doi":"10.1002/mba2.27","DOIUrl":"https://doi.org/10.1002/mba2.27","url":null,"abstract":"<p>Lipopeptides are surface active molecules with hydrophilic and hydrophobic regions and are kenned to be engendered by different species of <i>Bacillus</i> and <i>Pseudomonas</i>. These lipopeptides can be applied in different domains because of their remarkable properties like antibacterial, antifungal, anticorrosion, antitumor, and antiviral. They act by engendering pores in the cell membrane to perforate and conclusively disrupt them. This property of lipopeptide is valuable as an antimicrobial agent. In 2003, lipopeptides were approved as an antibiotic drug in the United States by the USA Food and Drug Administration (FDA) for the purpose of skin and blood infections caused by bacterial species. The biosynthetic genes for these lipopeptides are regulated by the nonribosomal peptide synthetase system. Amphisin, Tolaasin, Viscosin, and Syringomycin are the four main types of lipopeptides produced by <i>Pseudomonas</i> species. Since these lipopeptides are nontoxic, biodegradable, and environmentally cordial, they can abbreviate undesirable ecological perturbances. They can be considered a multifarious weapon for their application in different domains such as biocontrol agents in plants, emulsifiers in cosmetic and food industries, anticorrosion agents in petroleum industries, and antimicrobial agents in pharmaceutical and biomedical industries.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.27","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50128972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applications of scanning ion conductance microscope in biomedical fields","authors":"Xinrui Gong,&nbsp;Xinyuan Fan,&nbsp;Yiming Huang,&nbsp;Yuqi Du,&nbsp;Xiaoyu Wang,&nbsp;Xiaoyu Liu,&nbsp;Zhiyao He","doi":"10.1002/mba2.26","DOIUrl":"https://doi.org/10.1002/mba2.26","url":null,"abstract":"<p>Scanning ion conductance microscopy (SICM) is a scanning probe technique to reflect the surface morphology of the sample with the probe's motion trajectory through measuring the current between the probe and the surface of the sample. Since the surface of the sample can be scanned noncontact and the morphological characteristics of the living cell can be obtained under physiological conditions, SICM is particularly important in the field of biomedicine. SICM has strong potentials in various applications, such as the real-time and high-resolution imaging of living cells, monitoring the volume and movements of living cells. In addition, SICM combines with various technologies such as patch clamp and nanopipette to study the physical properties of cells. Furthermore, using SICM to observe cell and tissue structure provides more directions for studying the mechanism of disease. This review briefly introduces the principles and imaging modes of SICM and outlines the recent applications and development of SICM in biomedical research. We also introduce the limitations of the existing SICM technology and make a perspective on its future development.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.26","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50119157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomedical applications and prospects of temperature-orchestrated photothermal therapy","authors":"Nuo Xu,&nbsp;Xu Zhang,&nbsp;Tingting Qi,&nbsp;Yongzhi Wu,&nbsp;Xi Xie,&nbsp;Fangman Chen,&nbsp;Dan Shao,&nbsp;Jinfeng Liao","doi":"10.1002/mba2.25","DOIUrl":"10.1002/mba2.25","url":null,"abstract":"<p>Photothermal therapy (PTT) has been regarded as a promising strategy considering its advantages of high inherent specificity and a lower invasive burden. Since the photothermal killing of cells/bacteria showed different patterns of death depending on the varying temperature in PTT, the temperature change of PTT is vital to cell/tissue response in scientific research and clinical application. On one hand, mild PTT has received substantial attention in the treatment of cancer and soft/hard tissue repair. On the other hand, the high temperature induced by PTT is capable of antibacterial capacity, which is better than conventional antibiotic therapy with drug resistance. Herein, we summarize the recent developments in the application of temperature-dependent photothermal biomaterials, mainly covering the temperature ranges of 40–42°C, 43–50°C, and over 50°C. We highlight the biological mechanism of PTT and the latest progress in the treatment of different diseases. Finally, we conclude by discussing the challenges and perspectives of biomaterials in addressing temperature-orchestrated PTT. Given a deep understanding of the interaction between temperature and biology, rationally designed biomaterials with sophisticated photothermal responsiveness will benefit the outcomes of personalized PTT toward various diseases.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.25","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88246011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD3-T-cell-engager (TCE) therapies to overcome solid tumors: Beyond BiTEs","authors":"Jiali Zhang,&nbsp;Qianqian Guo,&nbsp;Quan Wang,&nbsp;Yourong Duan","doi":"10.1002/mba2.20","DOIUrl":"10.1002/mba2.20","url":null,"abstract":"<p>CD3-T-cell-engager (TCE) therapies, such as bispecific T-cell engagers (BiTEs), have achieved extraordinary success in treating hematological malignancies and have shown therapeutic effects comparable with those of chimeric antigen receptor (CAR)-T therapies. However, solid tumors are challenging to treat with TCE therapies due to tumor heterogeneity, limited tumor enrichment, an immunosuppressive tumor microenvironment (TME), a lack of pre-existing tumor-infiltrating lymphocytes (TILs), serious on-target off-tumor toxicity, and so forth. Thanks to the increased understanding of resistance mechanisms and novel technologies, the next generation of TCE therapies for solid tumors is emerging. We focus on summarizing the latest progress in CD3-based TCE therapies and discussing the future perspective of TCE therapeutic strategies against solid tumors. This perspective highlighted novel multitarget TCE therapies that integrated multiple functionalities to enhance antitumor efficacy while minimizing off-target toxicity. Furthermore, TCE therapies also could be rationally combined with other antitumor therapeutics, including oncolytic viruses, CAR-T cells, and immune checkpoint blockade. Moreover, TCEs should not be limited to redirecting polyclone T cells to tumor cells. The development of novel TCEs to bridge T cells and other cells in the TME is also promising. This perspective motivates the development of the new TCE therapies strategy to broaden the armamentarium of CD3-TCE therapies and overcome solid tumors.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.20","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79376336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tissue origin matters: Maintenance of tenogenic phenotype on the tendon and not skin collagen-derived devices","authors":"Anna Sorushanova,&nbsp;Dimitrios Tsiapalis,&nbsp;Ioannis Skoufos,&nbsp;Athina Tzora,&nbsp;Una FitzGerald,&nbsp;Anne M. Mullen,&nbsp;Dimitrios I. Zeugolis","doi":"10.1002/mba2.24","DOIUrl":"10.1002/mba2.24","url":null,"abstract":"<p>Recent data suggest that collagen retains the memory of the tissue that it derives from. With this in mind, collagen (from bovine skin and tendon) sponges were fabricated with different crosslinking densities, and their physicochemical and biological properties were assessed. As the crosslinking density was increased, the resistance to collagenase digestion, denaturation temperature, compressive stress, and compressive modulus was significantly increased and the free amine content, % swelling, and human dermal fibroblast cytocompatibility were significantly reduced. The tendon-collagen-derived scaffolds exhibited significantly higher compressive stress and compressive modulus values and induced significantly higher human tenocyte DNA concentration and metabolic activity than the skin-collagen-derived scaffolds. In human tenocyte cultures on day 14, the 1 mM 4-arm polyethylene-glycol succinimidyl glutarate tendon-collagen-derived collagen sponges induced significantly higher collagen type III synthesis (as expected at early stages of physiological tendon healing) and downregulated actin alpha 2 (associated with myofibroblast differentiation) and the skin-collagen-derived collagen sponges induced significantly higher collagen type IV synthesis (found primarily at the dermal-epidermal junction) and upregulated prolyl 4-hydroxylase subunit alpha-1 (associated with collagen biosynthesis and constitutes a target for antifibrotic compounds). Our data indicate that the tissue from which collagen is extracted should be considered in the development of medical devices.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.24","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79544734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smart intraoral systems for advanced drug delivery","authors":"Yuan Liu,&nbsp;Honglian Guo,&nbsp;Rengui Xu,&nbsp;Wei Chen","doi":"10.1002/mba2.19","DOIUrl":"10.1002/mba2.19","url":null,"abstract":"<p>Drug administration through the oral cavity is considered to be a convenient, effective, and time-saving strategy in the clinic with high safety and quick onset, especially for patients with needle fear and swallowing difficulties. Without the degradation in gastrointestinal tract and first-pass metabolism, the intraoral drug delivery system turns out to be an attractive option for macromolecule absorption, which will provide a promising platform for the successful delivery of protein, peptide, nucleic acid, and polysaccharide. Nevertheless, limited bioavailability, short retention time, and poor reproducibility pose a major hurdle to the further application of conventional intraoral drug delivery systems. Recent advances in chemical, material, and engineering techniques bring great opportunities to improve intraoral system fabrication and applications, owing to the high biocompatibility and functional diversity. In this review, we systematically summarize the recent development of smart intraoral drug delivery systems, including fast dissolving oral films, medicinal chewing gum systems, intraoral mucoadhesive systems, physical assisted systems, intelligent intraoral device, and chemically assisted systems. Moreover, the challenges and prospects for clinical and industrial applications of current strategies are well discussed. It is believed that the smart intraoral system would serve as a promising candidate to improve human life in the near future.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.19","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72555433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspectives in the vaccine development against Opisthorchis viverrini liver fluke","authors":"Ahmed O. Shalash,&nbsp;Mariusz Skwarczynski,&nbsp;Istvan Toth","doi":"10.1002/mba2.21","DOIUrl":"10.1002/mba2.21","url":null,"abstract":"<p>Liver flukes, <i>Opisthorchis viverrini</i>, infect around 10 million individuals in Southeast Asia, alone, and cause 26,000 deaths in the region per year. Despite being classified as a Group 1 carcinogen, and presenting one of the leading causes of cholangiocarcinoma in epidemic areas, <i>O. viverrini</i> infection is a neglected tropical disease. Control measures were implemented in epidemic areas to limit the outspread of infection; however, prophylactic vaccines are urgently needed to protect against future reinfections. This holds especially true due to the limited curative efficacy of the approved anthelmintic drug. In this article, we have briefly summarized the recently reported information regarding hepatobiliary cancer pathogenesis, approved treatment, and control measures against infection. Further, we highlighted the progress in the identification of protective antigens against <i>Opisthorchiasis</i> and proposed the investigation of additional promising antigens relying on vaccine progress against related infectious parasites. We highlighted the relative efficacies of the developed preclinical vaccines, suggested alternative vaccine designs and combinations, and commented on the required immunological responses. Moreover, we also reviewed biomaterials used in vaccine delivery against <i>O. viverrini</i> infections, summarized all the reported vaccine design approaches against the disease, and provided future perspectives regarding vaccine development, the utilization of biomaterials, and the discovery of highly protective antigens.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.21","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91095528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in smart-responsive hydrogels for tissue repairing","authors":"Cheng Hu,&nbsp;Li Yang,&nbsp;Yunbing Wang","doi":"10.1002/mba2.23","DOIUrl":"https://doi.org/10.1002/mba2.23","url":null,"abstract":"<p>The rapid development of biomedical materials and tissue engineering technology has played an increasingly important role in the process of tissue repair in recent years. Smart-responsive hydrogels are three-dimensional network structures formed by cross-linking of hydrophilic polymers. In addition to having conventional hydrogels that approximate the natural extracellular matrix structure and serve as delivery vehicles for functional molecules (drugs and proteins). More importantly, smart-responsive hydrogels can achieve relevant changes in material morphology or properties under the conditions of changes in physical, chemical, and biological factors, thereby achieving controlled functional molecules release. It is more urgent to design and build smart-responsive hydrogels to achieve precise tissue repair with the introduction of the concept of precision medicine and drug delivery. In this review, we highlight different types of smart-responsive hydrogels and their mechanisms of response to different stimuli and discuss their potential for application in different types of tissue repair, such as chronic wound repair, damaged heart tissue repair, brain nerve tissue repair, and other fields. Finally, we present the prospects of smart-responsive hydrogels in tissue repair. In general, the current progress in the application of smart-responsive hydrogels in tissue repair lays the foundation for future applications in other diseases.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.23","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134804748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Near-infrared-II-activated photothermal nanotransducers for wireless neuronal stimulation","authors":"Xianzhe Tang,&nbsp;Zhaowei Chen,&nbsp;Huangyao Yang","doi":"10.1002/mba2.15","DOIUrl":"10.1002/mba2.15","url":null,"abstract":"<p>Recently, Wu et al.<span>¹</span> presented an interesting study using near-infrared II (NIR-II)-activated photothermal nanotransducers for remote deep-brain stimulation (DBS) in freely behaving animals in an efficient and safe fashion. This study provided a complementary method for state-of-the-art technologies utilized for DBS. DBS with superior spatial-temporal precision would hold great promise for clinical management of brain disorders and fundamental neuroscience and offer unique advantages compared to brain lesioning procedures regarding reversibility and adaptability.<span>²</span></p><p>Over the past decades, a host of strategies have been developed for the modulation of neurons deep in the brain.<span>³</span> To name a few, conventional electrical stimulation with implantable microelectrodes has been widely applied for DBS, which, however, suffers from coarse temporal resolution and chronic immune responses (e.g., gliosis) at the implantation site of brain tissues.<span>²</span> As a technology showing the revolutionary impact on neurobiology, optogenetics holds great potential in elucidation or manipulation of specific neurons and neural circuits with precise timings and locations.<span>⁴</span> In this paradigm, to minimize the scattering of light in the brain, invasive optical fibers must be inserted to deliver photons to the target neurons which are infected with opsin-expressing vectors. The implantation of optical fibers easily causes permanent damage to the brain tissues and physically perturbates animals' natural movement, confining conventional optogenetics to limited applications.<span>⁵</span> Recent advances in sonogenetics, sono-optogenetics, and magnetothermal genetics have allowed the dissection of neuron circuits via implant-free and tether-free stimulation strategies.<span>³</span> Nevertheless, limitation remains for these technologies because the activity sphere for animal behavior manipulation is spatially confined around a resonant coil or a focused ultrasound beam.<span>³</span></p><p>Alternatively, NIR (700–1700 nm in wavelength) light has emerged for tether-less deep-brain modulation with the assistance of upconversion and photothermal micro- and nanoparticles as the transducers.<span>^6-8</span> The 808 nm laser, a common NIR-I (700–900 nm) illumination source, has been leveraged for modulating neural activity with Nd-doped upconversion nanoparticles. Attributing to the low absorption coefficient of water at such a wavelength, the overheating side effect caused by NIR irradiation was mitigated, yet its limited penetration depth (1–2 mm) hindered its application for DBS. Meanwhile, although 980 nm NIR-II excited Yb-doped upconversion transducers have shown certain promises in modulating deep brain neurons, there are still concerns associated with nonspecific tissue heating. Therefore, further improvements are des","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.15","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80358420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering nanostructured pure cancer cell membrane-derived vesicles as a novel therapeutic cancer vaccine","authors":"Hongliang He,&nbsp;Chunqing Guo,&nbsp;Wenjie Liu,&nbsp;Shixian Chen,&nbsp;Xiang-Yang Wang,&nbsp;Hu Yang","doi":"10.1002/mba2.22","DOIUrl":"10.1002/mba2.22","url":null,"abstract":"<p>Extracted cancer cell membrane carries the antigens of the parent tumor cell. This autologous antigen repertoire presents cancer cell membrane-derived nanoparticles highly immunogenic to the body's immune system. Cancer cell membrane-derived nanoparticles antigenically recapitulate the parental cancer cells and can be exploited to induce immune response reactive with tumor-associated antigens (TAAs). The use of the cancer cell membrane-derived nanoparticles to deliver immunostimulatory adjuvants facilitates the cross-presentation of tumor antigens by antigen-presenting cells and their costimulation, triggering potent antigen-specific T responses to eliminate established tumors. These nanoparticles can be engineered to carry immunostimulatory signals to facilitate the cross-presentation of TAAs and the induction of potent antitumor immunity. In this study, cancer cell membrane-based vesicles (CCMVs) are prepared from B16 melanoma cells and engineered to deliver the immunological agent polyinosinic:polycytidylic acid (poly-IC). We show that CCMV is preferentially uptaken by bone marrow-derived dendritic cells (BMDCs) as compared to other cell types (macrophages, fibroblasts). The efficient delivery of poly-IC to BMDCs results in enhanced antigen cross-presenting capability of BMDCs and T-cell activation. Additionally, immunization of mice with poly-IC-carrying CCMV elicits a potent antitumor immune response. In conclusion, poly-IC-decorated tumor-derived CCMV may be used as a therapeutic vaccine to potentiate antitumor immunity.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.22","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84258464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}