MedComm – Biomaterials and Applications最新文献

{"title":"CD3-T-cell-engager (TCE) therapies to overcome solid tumors: Beyond BiTEs","authors":"Jiali Zhang,&nbsp;Qianqian Guo,&nbsp;Quan Wang,&nbsp;Yourong Duan","doi":"10.1002/mba2.20","DOIUrl":"10.1002/mba2.20","url":null,"abstract":"<p>CD3-T-cell-engager (TCE) therapies, such as bispecific T-cell engagers (BiTEs), have achieved extraordinary success in treating hematological malignancies and have shown therapeutic effects comparable with those of chimeric antigen receptor (CAR)-T therapies. However, solid tumors are challenging to treat with TCE therapies due to tumor heterogeneity, limited tumor enrichment, an immunosuppressive tumor microenvironment (TME), a lack of pre-existing tumor-infiltrating lymphocytes (TILs), serious on-target off-tumor toxicity, and so forth. Thanks to the increased understanding of resistance mechanisms and novel technologies, the next generation of TCE therapies for solid tumors is emerging. We focus on summarizing the latest progress in CD3-based TCE therapies and discussing the future perspective of TCE therapeutic strategies against solid tumors. This perspective highlighted novel multitarget TCE therapies that integrated multiple functionalities to enhance antitumor efficacy while minimizing off-target toxicity. Furthermore, TCE therapies also could be rationally combined with other antitumor therapeutics, including oncolytic viruses, CAR-T cells, and immune checkpoint blockade. Moreover, TCEs should not be limited to redirecting polyclone T cells to tumor cells. The development of novel TCEs to bridge T cells and other cells in the TME is also promising. This perspective motivates the development of the new TCE therapies strategy to broaden the armamentarium of CD3-TCE therapies and overcome solid tumors.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.20","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79376336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tissue origin matters: Maintenance of tenogenic phenotype on the tendon and not skin collagen-derived devices","authors":"Anna Sorushanova,&nbsp;Dimitrios Tsiapalis,&nbsp;Ioannis Skoufos,&nbsp;Athina Tzora,&nbsp;Una FitzGerald,&nbsp;Anne M. Mullen,&nbsp;Dimitrios I. Zeugolis","doi":"10.1002/mba2.24","DOIUrl":"10.1002/mba2.24","url":null,"abstract":"<p>Recent data suggest that collagen retains the memory of the tissue that it derives from. With this in mind, collagen (from bovine skin and tendon) sponges were fabricated with different crosslinking densities, and their physicochemical and biological properties were assessed. As the crosslinking density was increased, the resistance to collagenase digestion, denaturation temperature, compressive stress, and compressive modulus was significantly increased and the free amine content, % swelling, and human dermal fibroblast cytocompatibility were significantly reduced. The tendon-collagen-derived scaffolds exhibited significantly higher compressive stress and compressive modulus values and induced significantly higher human tenocyte DNA concentration and metabolic activity than the skin-collagen-derived scaffolds. In human tenocyte cultures on day 14, the 1 mM 4-arm polyethylene-glycol succinimidyl glutarate tendon-collagen-derived collagen sponges induced significantly higher collagen type III synthesis (as expected at early stages of physiological tendon healing) and downregulated actin alpha 2 (associated with myofibroblast differentiation) and the skin-collagen-derived collagen sponges induced significantly higher collagen type IV synthesis (found primarily at the dermal-epidermal junction) and upregulated prolyl 4-hydroxylase subunit alpha-1 (associated with collagen biosynthesis and constitutes a target for antifibrotic compounds). Our data indicate that the tissue from which collagen is extracted should be considered in the development of medical devices.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.24","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79544734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smart intraoral systems for advanced drug delivery","authors":"Yuan Liu,&nbsp;Honglian Guo,&nbsp;Rengui Xu,&nbsp;Wei Chen","doi":"10.1002/mba2.19","DOIUrl":"10.1002/mba2.19","url":null,"abstract":"<p>Drug administration through the oral cavity is considered to be a convenient, effective, and time-saving strategy in the clinic with high safety and quick onset, especially for patients with needle fear and swallowing difficulties. Without the degradation in gastrointestinal tract and first-pass metabolism, the intraoral drug delivery system turns out to be an attractive option for macromolecule absorption, which will provide a promising platform for the successful delivery of protein, peptide, nucleic acid, and polysaccharide. Nevertheless, limited bioavailability, short retention time, and poor reproducibility pose a major hurdle to the further application of conventional intraoral drug delivery systems. Recent advances in chemical, material, and engineering techniques bring great opportunities to improve intraoral system fabrication and applications, owing to the high biocompatibility and functional diversity. In this review, we systematically summarize the recent development of smart intraoral drug delivery systems, including fast dissolving oral films, medicinal chewing gum systems, intraoral mucoadhesive systems, physical assisted systems, intelligent intraoral device, and chemically assisted systems. Moreover, the challenges and prospects for clinical and industrial applications of current strategies are well discussed. It is believed that the smart intraoral system would serve as a promising candidate to improve human life in the near future.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.19","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72555433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspectives in the vaccine development against Opisthorchis viverrini liver fluke","authors":"Ahmed O. Shalash,&nbsp;Mariusz Skwarczynski,&nbsp;Istvan Toth","doi":"10.1002/mba2.21","DOIUrl":"10.1002/mba2.21","url":null,"abstract":"<p>Liver flukes, <i>Opisthorchis viverrini</i>, infect around 10 million individuals in Southeast Asia, alone, and cause 26,000 deaths in the region per year. Despite being classified as a Group 1 carcinogen, and presenting one of the leading causes of cholangiocarcinoma in epidemic areas, <i>O. viverrini</i> infection is a neglected tropical disease. Control measures were implemented in epidemic areas to limit the outspread of infection; however, prophylactic vaccines are urgently needed to protect against future reinfections. This holds especially true due to the limited curative efficacy of the approved anthelmintic drug. In this article, we have briefly summarized the recently reported information regarding hepatobiliary cancer pathogenesis, approved treatment, and control measures against infection. Further, we highlighted the progress in the identification of protective antigens against <i>Opisthorchiasis</i> and proposed the investigation of additional promising antigens relying on vaccine progress against related infectious parasites. We highlighted the relative efficacies of the developed preclinical vaccines, suggested alternative vaccine designs and combinations, and commented on the required immunological responses. Moreover, we also reviewed biomaterials used in vaccine delivery against <i>O. viverrini</i> infections, summarized all the reported vaccine design approaches against the disease, and provided future perspectives regarding vaccine development, the utilization of biomaterials, and the discovery of highly protective antigens.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.21","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91095528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in smart-responsive hydrogels for tissue repairing","authors":"Cheng Hu,&nbsp;Li Yang,&nbsp;Yunbing Wang","doi":"10.1002/mba2.23","DOIUrl":"https://doi.org/10.1002/mba2.23","url":null,"abstract":"<p>The rapid development of biomedical materials and tissue engineering technology has played an increasingly important role in the process of tissue repair in recent years. Smart-responsive hydrogels are three-dimensional network structures formed by cross-linking of hydrophilic polymers. In addition to having conventional hydrogels that approximate the natural extracellular matrix structure and serve as delivery vehicles for functional molecules (drugs and proteins). More importantly, smart-responsive hydrogels can achieve relevant changes in material morphology or properties under the conditions of changes in physical, chemical, and biological factors, thereby achieving controlled functional molecules release. It is more urgent to design and build smart-responsive hydrogels to achieve precise tissue repair with the introduction of the concept of precision medicine and drug delivery. In this review, we highlight different types of smart-responsive hydrogels and their mechanisms of response to different stimuli and discuss their potential for application in different types of tissue repair, such as chronic wound repair, damaged heart tissue repair, brain nerve tissue repair, and other fields. Finally, we present the prospects of smart-responsive hydrogels in tissue repair. In general, the current progress in the application of smart-responsive hydrogels in tissue repair lays the foundation for future applications in other diseases.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.23","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134804748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Near-infrared-II-activated photothermal nanotransducers for wireless neuronal stimulation","authors":"Xianzhe Tang,&nbsp;Zhaowei Chen,&nbsp;Huangyao Yang","doi":"10.1002/mba2.15","DOIUrl":"10.1002/mba2.15","url":null,"abstract":"<p>Recently, Wu et al.<span>¹</span> presented an interesting study using near-infrared II (NIR-II)-activated photothermal nanotransducers for remote deep-brain stimulation (DBS) in freely behaving animals in an efficient and safe fashion. This study provided a complementary method for state-of-the-art technologies utilized for DBS. DBS with superior spatial-temporal precision would hold great promise for clinical management of brain disorders and fundamental neuroscience and offer unique advantages compared to brain lesioning procedures regarding reversibility and adaptability.<span>²</span></p><p>Over the past decades, a host of strategies have been developed for the modulation of neurons deep in the brain.<span>³</span> To name a few, conventional electrical stimulation with implantable microelectrodes has been widely applied for DBS, which, however, suffers from coarse temporal resolution and chronic immune responses (e.g., gliosis) at the implantation site of brain tissues.<span>²</span> As a technology showing the revolutionary impact on neurobiology, optogenetics holds great potential in elucidation or manipulation of specific neurons and neural circuits with precise timings and locations.<span>⁴</span> In this paradigm, to minimize the scattering of light in the brain, invasive optical fibers must be inserted to deliver photons to the target neurons which are infected with opsin-expressing vectors. The implantation of optical fibers easily causes permanent damage to the brain tissues and physically perturbates animals' natural movement, confining conventional optogenetics to limited applications.<span>⁵</span> Recent advances in sonogenetics, sono-optogenetics, and magnetothermal genetics have allowed the dissection of neuron circuits via implant-free and tether-free stimulation strategies.<span>³</span> Nevertheless, limitation remains for these technologies because the activity sphere for animal behavior manipulation is spatially confined around a resonant coil or a focused ultrasound beam.<span>³</span></p><p>Alternatively, NIR (700–1700 nm in wavelength) light has emerged for tether-less deep-brain modulation with the assistance of upconversion and photothermal micro- and nanoparticles as the transducers.<span>^6-8</span> The 808 nm laser, a common NIR-I (700–900 nm) illumination source, has been leveraged for modulating neural activity with Nd-doped upconversion nanoparticles. Attributing to the low absorption coefficient of water at such a wavelength, the overheating side effect caused by NIR irradiation was mitigated, yet its limited penetration depth (1–2 mm) hindered its application for DBS. Meanwhile, although 980 nm NIR-II excited Yb-doped upconversion transducers have shown certain promises in modulating deep brain neurons, there are still concerns associated with nonspecific tissue heating. Therefore, further improvements are des","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.15","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80358420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering nanostructured pure cancer cell membrane-derived vesicles as a novel therapeutic cancer vaccine","authors":"Hongliang He,&nbsp;Chunqing Guo,&nbsp;Wenjie Liu,&nbsp;Shixian Chen,&nbsp;Xiang-Yang Wang,&nbsp;Hu Yang","doi":"10.1002/mba2.22","DOIUrl":"10.1002/mba2.22","url":null,"abstract":"<p>Extracted cancer cell membrane carries the antigens of the parent tumor cell. This autologous antigen repertoire presents cancer cell membrane-derived nanoparticles highly immunogenic to the body's immune system. Cancer cell membrane-derived nanoparticles antigenically recapitulate the parental cancer cells and can be exploited to induce immune response reactive with tumor-associated antigens (TAAs). The use of the cancer cell membrane-derived nanoparticles to deliver immunostimulatory adjuvants facilitates the cross-presentation of tumor antigens by antigen-presenting cells and their costimulation, triggering potent antigen-specific T responses to eliminate established tumors. These nanoparticles can be engineered to carry immunostimulatory signals to facilitate the cross-presentation of TAAs and the induction of potent antitumor immunity. In this study, cancer cell membrane-based vesicles (CCMVs) are prepared from B16 melanoma cells and engineered to deliver the immunological agent polyinosinic:polycytidylic acid (poly-IC). We show that CCMV is preferentially uptaken by bone marrow-derived dendritic cells (BMDCs) as compared to other cell types (macrophages, fibroblasts). The efficient delivery of poly-IC to BMDCs results in enhanced antigen cross-presenting capability of BMDCs and T-cell activation. Additionally, immunization of mice with poly-IC-carrying CCMV elicits a potent antitumor immune response. In conclusion, poly-IC-decorated tumor-derived CCMV may be used as a therapeutic vaccine to potentiate antitumor immunity.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.22","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84258464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomaterials to promote vascularization in tissue engineering organs and ischemic fibrotic diseases","authors":"Wenyan Zhao,&nbsp;Junpeng Zhu,&nbsp;Jiaxin Hang,&nbsp;Wen Zeng","doi":"10.1002/mba2.16","DOIUrl":"10.1002/mba2.16","url":null,"abstract":"<p>The formation of the complex and fully functional vascular networks in pivotal organs is a key challenge in tissue engineering research. Functional blood vessels not only maintain oxygen and nutrient delivery but also effectively get rid of waste. Recently, a deep understanding of the vascular tissue structure and tissue microenvironment helps to make several great progress in the construction of highly complex and biomimetic vascularized tissues and organs, using biomaterials such as hydrogels and biomaterial composites. In this review, we summarized the advantages and research progress of biomaterials used in constructing the vascularized tissue in tissue engineering regeneration, ischemic fibrosis, and so on. We also discussed the progression of vascularization in organs and organoids. First, we discuss the applications of biomaterial-based vascularized tissue in bone, skin, and other tissue regeneration. Secondly, we discussed biomaterials and their components in promoting vascularization of ischemic fibrosis organs such as cerebral infarction, myocardial infarction, and renal fibrosis. In addition, we also introduced the strategies and applications that biomaterials function as a biomimetic extracellular matrix performed to construct vascularized tissues or organs in vitro. Finally, coming opportunities and challenges are also discussed and commented on.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.16","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73299719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential for Manuka honey-inspired therapeutics to improve the host–biomaterial response","authors":"Evan N. Main,&nbsp;Gary L. Bowlin","doi":"10.1002/mba2.18","DOIUrl":"10.1002/mba2.18","url":null,"abstract":"<p>Honey has been used by a wide variety of cultures across the world and for thousands of years to prevent infection and improve wound healing. Recently, Manuka honey has been demonstrated to be a potent antibacterial and anti-inflammatory therapeutic and has been incorporated into an array of wound dressings, as well as being ingested for its anti-inflammatory and antioxidant effects. Burgeoning investigation into Manuka honey's potential as a biomaterial additive has shown promising results in reducing acute inflammatory behavior from neutrophils, the most abundant leukocyte in the body, and the potent drivers of the initial immune response to implanted biomaterials. This paper discusses the most abundant antioxidant chemicals found in Manuka honey and explains their contribution to the anti-inflammatory and prowound resolution effects seen by Manuka honey therapeutics. This paper also examines the benefits and drawbacks to current Manuka honey therapies and provides future potential uses for Manuka honey-inspired therapeutics that could greatly benefit host–biomaterial integration, reduce scar tissue development at the site of implantation, and lower discomfort to the patient caused by biomaterial implantation.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.18","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72903858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controllable protein network based on DNA-origami and biomedical applications","authors":"Xinwei Wang,&nbsp;Xiao Zhao","doi":"10.1002/mba2.17","DOIUrl":"10.1002/mba2.17","url":null,"abstract":"<p>As an important part of driving natural life systems, the function of protein networks is accurately controlled through many parameters, like distance, quantity, position, and orientation. Nevertheless, it would be very hard to control the physical arrangement of the multiple proteins to generate cellular signaling events or complex enzymatic cascades, for instance small molecule organic synthesis DNA nanotechnology provides matching nanoscale dimensions, the special programmability of DNA, and the capability and compatibility of many proteins and nucleic acids. DNA origami has precise addressing capabilities at the nanoscale, which ensures the accurate assembly of the protein networks. These characteristics indicate that the DNA origami is a highly addressable programmable nanomaterial, which can be applied for building artificial protein networks. Up to now, researchers have achieved significant progress in the establishment and application of the DNA origami-protein networks. In the current review, we introduce the superiorities of DNA origami-protein networks in detail, concluded their construction strategies, and their recent progression and applications in biomedicine and biophysics. In the end, we look into the future prospects of DNA origami-protein networks. Finally, we looked forward to the future perspective of DNA origami-protein networks.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.17","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"119477313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}