MedComm – Biomaterials and Applications最新文献

{"title":"Recent advances in smart-responsive hydrogels for tissue repairing","authors":"Cheng Hu,&nbsp;Li Yang,&nbsp;Yunbing Wang","doi":"10.1002/mba2.23","DOIUrl":"https://doi.org/10.1002/mba2.23","url":null,"abstract":"<p>The rapid development of biomedical materials and tissue engineering technology has played an increasingly important role in the process of tissue repair in recent years. Smart-responsive hydrogels are three-dimensional network structures formed by cross-linking of hydrophilic polymers. In addition to having conventional hydrogels that approximate the natural extracellular matrix structure and serve as delivery vehicles for functional molecules (drugs and proteins). More importantly, smart-responsive hydrogels can achieve relevant changes in material morphology or properties under the conditions of changes in physical, chemical, and biological factors, thereby achieving controlled functional molecules release. It is more urgent to design and build smart-responsive hydrogels to achieve precise tissue repair with the introduction of the concept of precision medicine and drug delivery. In this review, we highlight different types of smart-responsive hydrogels and their mechanisms of response to different stimuli and discuss their potential for application in different types of tissue repair, such as chronic wound repair, damaged heart tissue repair, brain nerve tissue repair, and other fields. Finally, we present the prospects of smart-responsive hydrogels in tissue repair. In general, the current progress in the application of smart-responsive hydrogels in tissue repair lays the foundation for future applications in other diseases.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.23","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134804748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Near-infrared-II-activated photothermal nanotransducers for wireless neuronal stimulation","authors":"Xianzhe Tang,&nbsp;Zhaowei Chen,&nbsp;Huangyao Yang","doi":"10.1002/mba2.15","DOIUrl":"10.1002/mba2.15","url":null,"abstract":"<p>Recently, Wu et al.<span>¹</span> presented an interesting study using near-infrared II (NIR-II)-activated photothermal nanotransducers for remote deep-brain stimulation (DBS) in freely behaving animals in an efficient and safe fashion. This study provided a complementary method for state-of-the-art technologies utilized for DBS. DBS with superior spatial-temporal precision would hold great promise for clinical management of brain disorders and fundamental neuroscience and offer unique advantages compared to brain lesioning procedures regarding reversibility and adaptability.<span>²</span></p><p>Over the past decades, a host of strategies have been developed for the modulation of neurons deep in the brain.<span>³</span> To name a few, conventional electrical stimulation with implantable microelectrodes has been widely applied for DBS, which, however, suffers from coarse temporal resolution and chronic immune responses (e.g., gliosis) at the implantation site of brain tissues.<span>²</span> As a technology showing the revolutionary impact on neurobiology, optogenetics holds great potential in elucidation or manipulation of specific neurons and neural circuits with precise timings and locations.<span>⁴</span> In this paradigm, to minimize the scattering of light in the brain, invasive optical fibers must be inserted to deliver photons to the target neurons which are infected with opsin-expressing vectors. The implantation of optical fibers easily causes permanent damage to the brain tissues and physically perturbates animals' natural movement, confining conventional optogenetics to limited applications.<span>⁵</span> Recent advances in sonogenetics, sono-optogenetics, and magnetothermal genetics have allowed the dissection of neuron circuits via implant-free and tether-free stimulation strategies.<span>³</span> Nevertheless, limitation remains for these technologies because the activity sphere for animal behavior manipulation is spatially confined around a resonant coil or a focused ultrasound beam.<span>³</span></p><p>Alternatively, NIR (700–1700 nm in wavelength) light has emerged for tether-less deep-brain modulation with the assistance of upconversion and photothermal micro- and nanoparticles as the transducers.<span>^6-8</span> The 808 nm laser, a common NIR-I (700–900 nm) illumination source, has been leveraged for modulating neural activity with Nd-doped upconversion nanoparticles. Attributing to the low absorption coefficient of water at such a wavelength, the overheating side effect caused by NIR irradiation was mitigated, yet its limited penetration depth (1–2 mm) hindered its application for DBS. Meanwhile, although 980 nm NIR-II excited Yb-doped upconversion transducers have shown certain promises in modulating deep brain neurons, there are still concerns associated with nonspecific tissue heating. Therefore, further improvements are des","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.15","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80358420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering nanostructured pure cancer cell membrane-derived vesicles as a novel therapeutic cancer vaccine","authors":"Hongliang He,&nbsp;Chunqing Guo,&nbsp;Wenjie Liu,&nbsp;Shixian Chen,&nbsp;Xiang-Yang Wang,&nbsp;Hu Yang","doi":"10.1002/mba2.22","DOIUrl":"10.1002/mba2.22","url":null,"abstract":"<p>Extracted cancer cell membrane carries the antigens of the parent tumor cell. This autologous antigen repertoire presents cancer cell membrane-derived nanoparticles highly immunogenic to the body's immune system. Cancer cell membrane-derived nanoparticles antigenically recapitulate the parental cancer cells and can be exploited to induce immune response reactive with tumor-associated antigens (TAAs). The use of the cancer cell membrane-derived nanoparticles to deliver immunostimulatory adjuvants facilitates the cross-presentation of tumor antigens by antigen-presenting cells and their costimulation, triggering potent antigen-specific T responses to eliminate established tumors. These nanoparticles can be engineered to carry immunostimulatory signals to facilitate the cross-presentation of TAAs and the induction of potent antitumor immunity. In this study, cancer cell membrane-based vesicles (CCMVs) are prepared from B16 melanoma cells and engineered to deliver the immunological agent polyinosinic:polycytidylic acid (poly-IC). We show that CCMV is preferentially uptaken by bone marrow-derived dendritic cells (BMDCs) as compared to other cell types (macrophages, fibroblasts). The efficient delivery of poly-IC to BMDCs results in enhanced antigen cross-presenting capability of BMDCs and T-cell activation. Additionally, immunization of mice with poly-IC-carrying CCMV elicits a potent antitumor immune response. In conclusion, poly-IC-decorated tumor-derived CCMV may be used as a therapeutic vaccine to potentiate antitumor immunity.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.22","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84258464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomaterials to promote vascularization in tissue engineering organs and ischemic fibrotic diseases","authors":"Wenyan Zhao,&nbsp;Junpeng Zhu,&nbsp;Jiaxin Hang,&nbsp;Wen Zeng","doi":"10.1002/mba2.16","DOIUrl":"10.1002/mba2.16","url":null,"abstract":"<p>The formation of the complex and fully functional vascular networks in pivotal organs is a key challenge in tissue engineering research. Functional blood vessels not only maintain oxygen and nutrient delivery but also effectively get rid of waste. Recently, a deep understanding of the vascular tissue structure and tissue microenvironment helps to make several great progress in the construction of highly complex and biomimetic vascularized tissues and organs, using biomaterials such as hydrogels and biomaterial composites. In this review, we summarized the advantages and research progress of biomaterials used in constructing the vascularized tissue in tissue engineering regeneration, ischemic fibrosis, and so on. We also discussed the progression of vascularization in organs and organoids. First, we discuss the applications of biomaterial-based vascularized tissue in bone, skin, and other tissue regeneration. Secondly, we discussed biomaterials and their components in promoting vascularization of ischemic fibrosis organs such as cerebral infarction, myocardial infarction, and renal fibrosis. In addition, we also introduced the strategies and applications that biomaterials function as a biomimetic extracellular matrix performed to construct vascularized tissues or organs in vitro. Finally, coming opportunities and challenges are also discussed and commented on.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.16","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73299719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential for Manuka honey-inspired therapeutics to improve the host–biomaterial response","authors":"Evan N. Main,&nbsp;Gary L. Bowlin","doi":"10.1002/mba2.18","DOIUrl":"10.1002/mba2.18","url":null,"abstract":"<p>Honey has been used by a wide variety of cultures across the world and for thousands of years to prevent infection and improve wound healing. Recently, Manuka honey has been demonstrated to be a potent antibacterial and anti-inflammatory therapeutic and has been incorporated into an array of wound dressings, as well as being ingested for its anti-inflammatory and antioxidant effects. Burgeoning investigation into Manuka honey's potential as a biomaterial additive has shown promising results in reducing acute inflammatory behavior from neutrophils, the most abundant leukocyte in the body, and the potent drivers of the initial immune response to implanted biomaterials. This paper discusses the most abundant antioxidant chemicals found in Manuka honey and explains their contribution to the anti-inflammatory and prowound resolution effects seen by Manuka honey therapeutics. This paper also examines the benefits and drawbacks to current Manuka honey therapies and provides future potential uses for Manuka honey-inspired therapeutics that could greatly benefit host–biomaterial integration, reduce scar tissue development at the site of implantation, and lower discomfort to the patient caused by biomaterial implantation.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.18","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72903858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controllable protein network based on DNA-origami and biomedical applications","authors":"Xinwei Wang,&nbsp;Xiao Zhao","doi":"10.1002/mba2.17","DOIUrl":"10.1002/mba2.17","url":null,"abstract":"<p>As an important part of driving natural life systems, the function of protein networks is accurately controlled through many parameters, like distance, quantity, position, and orientation. Nevertheless, it would be very hard to control the physical arrangement of the multiple proteins to generate cellular signaling events or complex enzymatic cascades, for instance small molecule organic synthesis DNA nanotechnology provides matching nanoscale dimensions, the special programmability of DNA, and the capability and compatibility of many proteins and nucleic acids. DNA origami has precise addressing capabilities at the nanoscale, which ensures the accurate assembly of the protein networks. These characteristics indicate that the DNA origami is a highly addressable programmable nanomaterial, which can be applied for building artificial protein networks. Up to now, researchers have achieved significant progress in the establishment and application of the DNA origami-protein networks. In the current review, we introduce the superiorities of DNA origami-protein networks in detail, concluded their construction strategies, and their recent progression and applications in biomedicine and biophysics. In the end, we look into the future prospects of DNA origami-protein networks. Finally, we looked forward to the future perspective of DNA origami-protein networks.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.17","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"119477313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Nanotracker” for superior early disease diagnosis","authors":"Hanwen Wang,&nbsp;Jiahuan He,&nbsp;Guojun Chen","doi":"10.1002/mba2.12","DOIUrl":"10.1002/mba2.12","url":null,"abstract":"<p>Pu and coworkers developed a disease biomarker-activatable polyfluorophore nanosensor that comprises protease-reactive peptide brushes, self-immolative linkers, and renal clearance/tumor-targeting moiety-conjugated fluorophore units, for noninvasive near-infrared fluorescence imaging and urinalysis, enabling superior early disease diagnosis.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.12","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79753481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent progress in 3D printing degradable polylactic acid-based bone repair scaffold for the application of cancellous bone defect","authors":"Xulin Hu,&nbsp;Zhidong Lin,&nbsp;Jian He,&nbsp;Minchang Zhou,&nbsp;Shuhao Yang,&nbsp;Yao Wang,&nbsp;Kainan Li","doi":"10.1002/mba2.14","DOIUrl":"10.1002/mba2.14","url":null,"abstract":"<p>Large size bone defects have become a growing clinical challenge. Cancellous bone, which has the highest volume ratio, the fastest replacement rate, and interconnected porous structure, plays a major role in bone repairing. Considering the structure and composition of cancellous bone, building a bionic 3D scaffold via customized-3D printing technology is the key to solving the problem. As the earliest degradable medical polymer material approved by Food and Drug Administration, polylactic acid has been proved to have excellent biosafety and can be copolymerized or blended with other synthetic polymers, natural polymers, and inorganic materials to improve its performance to better meet clinical applications. A series of biodegradable bone repair scaffolds based on polylactic acid composites and 3D printing technology are developed to achieve large bone defects. Here, we review the composition and structure of cancellous bone, highlighting the relationship to the requirements of bone repair scaffolds. The different types of polylactic-acid-based materials applied in 3D printing technology are described, emphasizing the connection between materials, preparation methods, and applications.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.14","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73378344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in 3D printing hydrogel for topical drug delivery","authors":"Yue Zhang,&nbsp;Chao Wang","doi":"10.1002/mba2.11","DOIUrl":"10.1002/mba2.11","url":null,"abstract":"<p>Polymer hydrogel has been used as a drug delivery carrier for many decades. Recently, the emergence of three-dimensional (3D) printing technology has opened up a new area for applications of drug delivery based on polymer hydrogel. A series of drug delivery platforms based on 3D printing hydrogel are developed to achieve local delivery of small/large molecule drugs as well as therapeutic cells. Compared with other manufacturing technologies, 3D printing technology can achieve high-precision personalized manufacturing and complex spatial structure construction, which has a wide application prospect in the biomedical field. In this review, we summarized the recent advances in 3D printed polymer hydrogels as delivery platforms in drug and cell topical delivery. 3D printed drug delivery platform realizes drug delivery and controlled release locally. Meanwhile, precise control and manufacturing also provide conditions for customized drug delivery platforms. Besides this, a complex spatial structure constructed based on 3D printing technology is also conducive to cell proliferation and differentiation, providing a new carrier for tissue engineering and repair. Biomedical applications based on 3D printing technology promote the development of precision medicine and personalized medicine and provide a new direction for further research and application of 3D printing technology.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.11","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83692595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A nanovesicle platform to deliver neoantigens and immune checkpoint inhibitors: To ASPIRE for novel cancer vaccines","authors":"Hongwei Cheng,&nbsp;Hwan-Ching Tai","doi":"10.1002/mba2.4","DOIUrl":"10.1002/mba2.4","url":null,"abstract":"<p>Tumor immunotherapy has made a breakthrough in clinical application, and the combination of vaccine and immune checkpoint inhibitors (ICI) is a promising strategy in cancer management. However, the complete immune response is still unresolved. Liu et al.<span>¹</span> report a genetically engineered cell membrane nanovesicle, which integrates antigen self-presentation and immunosuppression reversal (ASPIRE) for boosting cancer immunotherapy (Figure 1). It is the comprehensive demonstration of a personalized vaccine formula that has the power to directly activate both naive T cells and exhausted T cells. Besides, this artificial nanovaccine has a nanoscale size, better stability, and an excellent homing effect, which could rapidly enrich the lymphatic system. This specific antigen self-presentation strategy is superior to conventional vaccines. Importantly, B7 codelivery is first introduced to the anti-PD1 therapy, which not only activates T lymphocyte immune response but also breaks immunosuppression.</p><p>In 1971, the US government declared a “war on cancer” through its National Cancer Act, which marked the beginning of modern cancer research. Half a century later, despite significant progress in many areas of cancer treatment, cancer remains a leading cause of death globally. Therefore, the quest to search for new and creative ways to cure cancer continues. A new strategy that has attracted much attention is to train or augment our own immune system to destroy cancer cells. The feasibility of this idea has been recently demonstrated through the clinical successes of ICI, such as anti-PD-1 or anti-PDL1 antibodies, and chimeric antigen receptor (CAR) T-cell therapies.<span>²</span></p><p>However, the clinical benefits of ICI and CAR T-cell therapies are still relatively limited compared to conventional chemotherapies or targeted therapies based on small-molecule drugs. Although our immune system has the capacity to target cancer cells, there are also various ways that cancer cells may evolve to escape such immune surveillance. After all, cancer cells originate from our own somatic cells, which have various ways to avoid being attacked by the immune system. There is a need for more efficient and more widely applicable methods to boost immune defenses against various types of cancers, and the idea of vaccination naturally comes to mind.</p><p>Even before we had any scientific understanding of the pathogens causing infectious diseases or the inner workings of immune systems, the first modern vaccine (against smallpox) was successfully developed by the end of the 18th century. A dozen vaccines were developed before the Second World War, before the breakthrough discoveries in molecular biology. Then, why not develop vaccines for certain types of cancer?</p><p>It turns out that we cannot vaccinate against tumors simply by the systematic administration of antigens found on cancer cells. Through recent research into the tumor mi","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78969056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}