MedComm – Biomaterials and Applications最新文献

{"title":"Development and Optimization of a Nanophytosomes-Based Thermogel as a Topical Anti-Psoriatic for Increased Solubility and Bioavailability","authors":"Ananda Kumar Chettupalli,&nbsp;Thatipally Rajeshwar,&nbsp;Sarad Pawar Naik Bukke","doi":"10.1002/mba2.70050","DOIUrl":"10.1002/mba2.70050","url":null,"abstract":"<p>Herbal extracts often demonstrate promising in vitro activity but limited in vivo efficacy due to poor solubility, permeability, and stability. Phytosomal delivery systems offer a strategy to increase the transdermal delivery and bioavailability. This study aimed to develop and optimize a <i>Leucas aspera</i> phytosomal thermogel for improved topical treatment of psoriasis. Phytosomes were-prepared from phospholipid complexes and optimized via a Box–Behnken design. The optimized formulation was evaluated for vesicle size, zeta potential, entrapment efficiency (EE), in vitro drug release, and skin deposition. Anti-psoriatic efficacy was assessed in an imiquimod induced psoriasis mouse model through PASI scoring, ear thickness measurement, organ index analysis, transepidermal water loss and hydration studies, and histopathology. The optimized PHY gel exhibited a particle size of 92.23 ± 9.1 nm, zeta potential of −32.45 ± 0.43 mV, EE of 89.1 ± 4.6%, and cumulative drug release of 94.5 ± 1.3%. Skin deposition was significantly greater (82.61 ± 1.86%) than that of the unmodified extract gel. In vivo, the phytosome gel reduced imiquimod induced psoriasis severity, demonstrating efficacy comparable to that of the reference formulation. Overall, the <i>Leucas aspera</i> phytosome gel significantly improved dermal delivery and therapeutic efficacy, highlighting phytosomal systems as a promising platform for topical psoriasis therapy.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70050","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147668481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stimuli-Responsive Poly(Disulfide)s: A Versatile Platform for Intelligent Drug Delivery Systems","authors":"Yuechen He,&nbsp;Qiuhong Ouyang,&nbsp;Xinglv Chen,&nbsp;Qian Zhong,&nbsp;Xunhuan Song,&nbsp;Yujie Sun,&nbsp;Bingran Yu,&nbsp;Meng Qin","doi":"10.1002/mba2.70046","DOIUrl":"10.1002/mba2.70046","url":null,"abstract":"<p>Poly(disulfide)s represent a class of dynamic polymers whose synthesis is facilitated by the reversible exchange and recombination of disulfide bonds. This unique polymerization mechanism, combined with the structural flexibility of cyclic disulfide monomers and the diversity of ring-opening polymerization (ROP) methods, enables precise control over polymer architecture and functionality. The resulting materials exhibit remarkable characteristics including reversible redox-responsiveness, tunable degradation kinetics, self-healing capabilities, and enhanced cellular uptake efficiency. This review systematically examines the fundamental aspects of poly(disulfide)s, beginning with the design principles of monomer structures and progressing through various ROP strategies such as thermal, photo-initiated, and catalyst-mediated approaches. We critically analyze how these synthetic parameters influence key polymer properties including molecular weight distribution, stimulus responsiveness, and biocompatibility. The application potential of poly(disulfide)s in drug delivery is comprehensively explored, with particular focus on their performance in nucleic acid delivery systems for gene therapy, protein and peptide delivery for biotherapeutic applications, and small molecule drug carriers for enhanced therapeutic efficacy. By integrating recent advances in polymer chemistry with biomedical engineering perspectives, this review aims to provide valuable insights for the rational design of poly(disulfide)-based delivery platforms and their translation into clinical applications.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147669012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translational Pathways for Smart and Bioactive Dental Biomaterials: Biocompatibility Standards, Sterilisation, Sustainability and Regulation","authors":"Katarzyna Chojnacka,&nbsp;Marcin Mikulewicz","doi":"10.1002/mba2.70047","DOIUrl":"https://doi.org/10.1002/mba2.70047","url":null,"abstract":"<p>Smart and bioactive dental biomaterials aim to deliver functional and therapeutic effects in the oral cavity; clinical uptake requires translation from laboratory performance to safe, durable and regulated use. This review synthesises translational requirements for advanced dental and craniofacial biomaterials, focusing on risk-based biocompatibility planning and reporting aligned with ISO 10993 and dentistry-specific ISO 7405. Oral constraints include long-term exposure to saliva and the oral microbiota, cyclic loading and release of active species or degradation products. The review summarises design and evaluation priorities for antibacterial and bioactive implant interfaces, including microbiome-aware assessment informed by metagenomic signatures of peri-implant dysbiosis and clinically relevant endpoints beyond standard in vitro screens. Implementation constraints include validating low-temperature sterilisation for thermolabile polymers, functional coatings and additively manufactured parts, and substantiating sustainability claims using life-cycle assessment consistent with ISO 14040/14044 and explicit system boundaries. The review also outlines regulatory, standardisation and economic factors shaping claim credibility, combination-product classification, evidence generation and post-market learning, alongside ageing-related host variability. These elements provide a practical roadmap for developing dental biomaterials that remain verifiable, safe and functional across the device life cycle.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147566896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular Vesicles-Functionalized Biomaterials for Oral Disease Theragnostics","authors":"Zhe Zhao,&nbsp;Yiyu Zeng,&nbsp;Rui Liu,&nbsp;Xuemei Qiu","doi":"10.1002/mba2.70048","DOIUrl":"https://doi.org/10.1002/mba2.70048","url":null,"abstract":"<p>Oral diseases impair oral function and are closely linked to various systemic conditions. Current clinical diagnosis and treatment modalities remain constrained by inherent limitations, necessitating innovative therapeutic strategies. Extracellular vesicles (EVs) have emerged as promising tools due to their natural biocompatibility, low immunogenicity, and intrinsic drug delivery capabilities. Concurrently, advances in biomaterials have provided versatile platforms for stable EVs delivery and spatiotemporally controlled release. This review systematically summarizes the biological characteristics and functions of EVs, comparing the influence of cellular sources and isolation methods on their properties. We further discuss strategies for EVs functionalization and examine the design principles of biomaterial-based delivery systems incorporating engineered EVs. Additionally, we highlight recent progress in functionalized EV-loaded biomaterials for integrated diagnosis and treatment of periodontal disease, dental caries, oral mucosal diseases, and oral cancer. The advantages of this integrated theragnostic approach and current translational challenges are critically analyzed. Finally, future directions involving personalized medicine and intelligent biomaterials are proposed to advance precision oral healthcare.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70048","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147564818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Efficacy of Mesenchymal Stem Cell Allograft Materials in Foot and Ankle Surgery: A Systematic Review","authors":"Mark A. Plantz,&nbsp;Michael P. Foy,&nbsp;Joseph G. Lyons,&nbsp;Sara Shah,&nbsp;Anish R. Kadakia","doi":"10.1002/mba2.70045","DOIUrl":"https://doi.org/10.1002/mba2.70045","url":null,"abstract":"&lt;p&gt;Nonunion after foot and ankle procedures is a challenging and expensive complication, often requiring additional medical care, including revision surgery [&lt;span&gt;1-10&lt;/span&gt;]. However, augmentation with bone grafting can be used to help facilitate bone healing. There has been significant interest in developing bone graft substitutes for bony fusions [&lt;span&gt;1-10&lt;/span&gt;]. More recently, there has been growing interest in stem cell products [&lt;span&gt;1-10&lt;/span&gt;]. Mesenchymal stem cell allografts (MSCAs) are allogenic bone grafts that contain live mesenchymal stem cells [&lt;span&gt;1-10&lt;/span&gt;]. The purpose of this systematic review is to summarize recent literature regarding the efficacy and safety of MSCA materials in foot and ankle fusion.&lt;/p&gt;&lt;p&gt;In November 2025, a query of PubMed and Embase was undertaken to identify all studies evaluating the use of cellular bone allograft materials in foot and ankle fusion procedures. ClinicalTrials.gov was also queried for ongoing clinical trials. The exact search criteria are summarized in the Supporting Information. Studies published between January 1, 2000, and November 15, 2025, were included in the query. Identified studies were screened by two independent reviewers in a double-blinded manner.&lt;/p&gt;&lt;p&gt;To be included in the final review, a minimum follow-up of at least 6 months was required. Studies that evaluated the use of MSCA as an independent graft material for any fusion procedures of the ankle, hindfoot, and midfoot were included. Studies that assessed other procedures were included if data pertaining to foot and ankle fusion procedures were reported separately. Studies that assessed other graft materials were included if data pertaining to the use of MSCA were reported separately. Revision or salvage procedures were included in the analysis and were identified as such.&lt;/p&gt;&lt;p&gt;The following data were extracted from each study: study title, author names and affiliations, year of publication, type of study design, experimental and control groups, the date range of the procedures performed, age and sex of patients, stem cell formulations, follow-up intervals, comorbid conditions, the type of procedure, fusion scoring, and complications. The main outcome measures were the overall fusion rate and the rate of complications. Outcomes for specific graft materials and fusion procedures were included, if reported. Fusion rates were determined by plain radiographs alone, computed tomography (CT), or a combination of radiographs and CT. Our statistical analysis is summarized within the Supporting Information. The grading of each study is summarized in the Supporting Information.&lt;/p&gt;&lt;p&gt;A total of 11 studies met the final inclusion criteria [&lt;span&gt;1-11&lt;/span&gt;]. The PRISMA flow diagram for all phases of the literature review is provided in the Supporting Information. The level of evidence varied—one study reached Level 1 criteria, two studies reached Level 2, three studies reached Level 3, and five studies reached Level 4","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147563195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myogenic Differentiation on 3D-Printed Interpenetrating Bioactive Hydrogel of Decellularised Human Placenta With Fish Scale Gelatin","authors":"Asmita Biswas,&nbsp;Ragavi Rajasekaran,&nbsp;Pravin Vasudeo Vaidya,&nbsp;Atul Kumar Ojha,&nbsp;Suman Mishra,&nbsp;Sayan Mukherjee,&nbsp;Saikat Biswas,&nbsp;Nantu Dogra,&nbsp;Padmavati Manchikanti,&nbsp;Santanu Dhara","doi":"10.1002/mba2.70044","DOIUrl":"https://doi.org/10.1002/mba2.70044","url":null,"abstract":"<p>Tissue-specific templates are essential for muscle differentiation as they enhance cell alignment and regeneration. Advancements in extrusion 3D printing with biomaterial inks enable customizable designs and tailored spatial arrangements. Key growth factors and extracellular matrix (ECM) constituents are crucial for muscle differentiation from stem cells, with the placenta being a significant resource. This study explores human placenta ECM-fish gelatin-based hydrogels as a cost-effective alternative. ECM was obtained via ultrasonication-assisted decellularisation, which preserved its structure while removing cellular content. The research focused on placenta-gelatin ink formulations for scaffold printing, forming an interpenetrating network hydrogel. Rheological analysis indicated that placenta-fish gelatin biomaterial ink exhibited a higher storage modulus compared to only fish gelatin formulations. Analytical techniques such as FESEM, FTIR, and the Ninhydrin assay confirmed that the placenta hydrogels exhibit shape fidelity and achieved approximately 75 ± 7% crosslinking density. Hydrogels supported cellular proliferation and aligned growth. Myogenic differentiation involving C2C12 cells and human amniotic membrane stem cells (HAMSCs) demonstrated organized myoblasts and aligned myotubes, respectively. CAM assay revealed enhanced angiogenesis and microvascular growth with negligible hemolysis. This research offers biowaste-derived ECM hydrogels for skeletal muscle engineering, eliminating the need for sacrificial templates or synthetic crosslinkers.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147568650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chlorine-Functionalized Nano-Hydroxyapatite Coatings Enhance Osseointegration in Immediate Implantation by Modulating Host–Bacteria Competition","authors":"Zhiqiang Qi,&nbsp;Xueya Wang,&nbsp;Zhongxi Sun,&nbsp;Xiaoqi Su,&nbsp;Feng Chen,&nbsp;Haiyan Li,&nbsp;Xuehan Li,&nbsp;Baodong Zhao,&nbsp;Yong Sun,&nbsp;Guowei Wang,&nbsp;Xiaojing Wang","doi":"10.1002/mba2.70043","DOIUrl":"https://doi.org/10.1002/mba2.70043","url":null,"abstract":"<p>Immediate implantation integrates three surgical procedures into one and shortens the treatment cycle, showing great clinical value. However, in patients with periodontitis, the high risk of infection remains a major challenge. A critical failure factor lies in the first 24 h after implantation, when host cells and pathogenic bacteria compete for occupancy on the implant surface, yet effective strategies to regulate this process are still lacking. To address this issue, we developed a nano-hydroxyapatite/chloride ion composite coating (MAO(Ti)-nHA-Cl) using combined micro-arc oxidation and anodization. The Ti–Cl structure within the coating sustainably generates low-dose hypochlorous acid (HClO), which disrupts bacterial cell walls and effectively inhibits adhesion and proliferation of pathogenic bacteria. This design allows timely intervention in the cell–bacteria competitive adhesion process during the early postoperative window. Our results showed that MAO(Ti)-nHA-Cl significantly suppressed common oral pathogens, while enhancing MC3T3-E1 cell adhesion, upregulation of osteogenic genes, and mineralized differentiation. In a rat femoral infection model, the coating reduced inflammatory responses and promoted new bone formation. Collectively, this study provides a strategy to regulate host–bacteria competition at the implant interface, offering theoretical support for early osseointegration in immediate implantation for periodontitis patients and suggesting a new direction for functionalized implant surface design.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147315459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and Biological Properties of Estradiol-Cyclodextrin-Polydopamine Functional Coating on Polypropylene Mesh Surface","authors":"Xia Yu,&nbsp;Shilei Li,&nbsp;Lu Yang,&nbsp;Li He,&nbsp;Yan Liu,&nbsp;Yuxin Hu,&nbsp;Jianhong Liu,&nbsp;Yan Wang,&nbsp;Hongyuan Fan,&nbsp;Xiaoqin Jiang,&nbsp;Yonghong Lin,&nbsp;Changchun Zhou","doi":"10.1002/mba2.70042","DOIUrl":"https://doi.org/10.1002/mba2.70042","url":null,"abstract":"<p>Polypropylene (PP) biological meshes are the most widely used implantable materials for the clinical treatment of pelvic organ prolapse (POP). To address the inflammation and impaired tissue repair associated with mesh implantation, as well as to compensate for estrogen deficiency in postmenopausal women (a high-risk group for POP), this study designed and optimized a biofunctional coating for PP mesh. Using polydopamine (PDA) as a mediator, estradiol (E2, a natural estrogen) was loaded onto the mesh surface to construct a composite functional coating. The fabrication process involved three key steps: first, the PP mesh surface was activated via oxygen plasma treatment at 0.3–0.4 mBar for 3 min to achieve thorough cleaning and surface activation. Second, a uniform PDA coating was deposited under light-protected conditions using a 4 mg/mL dopamine solution at pH 8.5. Finally, a gel solution containing E2 and randomly methylated β-cyclodextrin (RAMEB) at a 1:2 molar ratio was loaded onto the PDA layer to form the E2-loaded composite coating. Material characterization was performed using micro-Fourier transform infrared spectroscopy (Micro-FTIR) and scanning electron microscopy/energy-dispersive spectroscopy (SEM/EDS) to analyze the coating's composition and morphology. The biological performance was evaluated through hydrophilicity testing and in vitro co-culture with L929 fibroblasts. Results demonstrated that the PDA-mediated E2-loaded coating exhibited excellent cytocompatibility, significantly promoting cell adhesion, spreading, and proliferation.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70042","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147315509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellulose-Based Nanocomposites in Drug Delivery and Antimicrobial Therapies: Emerging Innovations and Translational Outlook","authors":"Suraj Kumar,&nbsp;Rishabha Malviya,&nbsp;Sathvik Belagodu Sridhar,&nbsp;Tarun Wadhwa,&nbsp;Javedh Shareef","doi":"10.1002/mba2.70040","DOIUrl":"https://doi.org/10.1002/mba2.70040","url":null,"abstract":"<p>Cellulose-based nanocomposites have emerged as sustainable and versatile biomaterials with promising applications in drug delivery and antimicrobial therapy. Nanocellulose, derived from plant, algal, or bacterial sources, possesses unique features such as biocompatibility, biodegradability, mechanical robustness, and low cytotoxicity. The primary forms of cellulose nanocrystals (CNCs), cellulose nanofibrils (CNFs), and bacterial nanocellulose (BNC) exhibit distinct structural and functional advantages suitable for biomedical applications. Despite these advances, a comprehensive synthesis of their fabrication strategies, functional modifications, and biomedical performance is lacking. This review discusses recent innovations in the design and development of cellulose-based nanocomposites, highlighting advanced fabrication techniques including electrospinning, enzymatic functionalization, self-assembly, and surface modification. We discussed their high surface-to-volume ratio, tunable degradation kinetics, and extracellular matrix-mimicking architecture, which enhance their performance as scaffolds for tissue engineering and carriers for controlled and targeted drug delivery. Additionally, their intrinsic antibacterial activity, coupled with biocompatibility, positions them as safer alternatives to metallic nanoparticles. Emerging applications in wound healing, bone and cartilage regeneration, 3D-printed biomaterials, and medical implants are critically evaluated. By integrating material design, functionalization, and therapeutic applications, this review provides valuable insights into the potential of cellulose-based nanocomposites as multifunctional platforms for sustained drug delivery, infection control, and next-generation biomedical interventions.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146197006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Key Role of Nanotechnology on Intratumoral Microbiome Modulation for Cancer Immunotherapy","authors":"Yumei Gan,&nbsp;Yan Zhang,&nbsp;Xia Dong,&nbsp;Feng Lv","doi":"10.1002/mba2.70038","DOIUrl":"https://doi.org/10.1002/mba2.70038","url":null,"abstract":"<p>The intratumoral microbiome has emerged as a critical component of the tumor microenvironment (TME), playing a significant role in tumorigenesis, pathological classification, metastasis, and prognosis. The nutrient-rich, hypoxic, acidic, and immunosuppressive nature of the TME facilitates the establishment of diverse intratumoral microbiome communities. In turn, the intratumoral microbiome further contributes to the formation of cold TME through mechanisms such as genetic and epigenetic alterations, pro-inflammatory responses, immune modulation, tumor metastasis, and enhanced drug resistance. Targeting and eliminating the intratumoral microbiome using nanotechnology presents a unique therapeutic strategy for overcoming chemotherapy resistance and improving the immunosuppressive TME. This review summarizes the microbial characteristics of various tumors and microbiome-mediated oncogenic mechanisms, with particular emphasis on recent advancements in nanotechnology aimed at eliminating the intratumoral microbiome and reprogramming the cold TME, thereby enhancing the efficacy of tumor immunotherapy. Our aim is to provide valuable insights to strengthen the effectiveness of tumor immunotherapy.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146001993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}