MedComm – Biomaterials and Applications最新文献

Nanomedicine for Cranial Repair: Insights From Recent Advance in Nanomaterial-Based Cranioplasty 纳米医学用于颅骨修复：基于纳米材料的颅骨成形术的最新进展

MedComm – Biomaterials and Applications Pub Date : 2025-09-19 DOI: 10.1002/mba2.70026

Tingting Zhang, Tong Sun, Xiaoshuang Dai, Dingkun Zhang, Junwen Guan

{"title":"Nanomedicine for Cranial Repair: Insights From Recent Advance in Nanomaterial-Based Cranioplasty","authors":"Tingting Zhang, Tong Sun, Xiaoshuang Dai, Dingkun Zhang, Junwen Guan","doi":"10.1002/mba2.70026","DOIUrl":"https://doi.org/10.1002/mba2.70026","url":null,"abstract":"Cranial defect repair remains a major challenge in orthopedics and regenerative medicine. Traditional approaches like autologous bone grafts face some limitations, including donor site morbidity and infection risks. Recent advances in nanotechnology have enabled innovative nanomedicine-based strategies for cranial repair. This review highlights current progress, applications, and challenges of nanomedicines, focusing on 10 bioactive categories: Ca-, C-, Ti-, Mg-, Ag-, Mn-, Si-, Se-, bio-based, and carrier-based nanomaterials. Among these, Ca-based nanomedicines, particularly nano-hydroxyapatite, dominate due to their structural similarity to natural bone. C-, Mg-, and Ti-based nanomaterials also show promise, offering excellent mechanical strength, biodegradability, and osteogenic activity. Bio-based and carrier-based systems further enhance biocompatibility and enable controlled drug delivery for improved bone regeneration. Despite their potential, critical challenges remain, including nanotoxicity, degradation control, and long-term clinical safety. Future research should focus on optimizing material properties, enhancing bioactivity, and ensuring translational feasibility. By addressing these hurdles, nanomedicine-based therapies could revolutionize cranial defect repair, providing safer, more efficient alternatives to conventional treatments. This review discusses these advancements while outlining future directions to maximize clinical impact.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"4 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145101843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid-Based Nanoplatforms in Hepatology: From Rational Design to Clinical Translation Challenges 肝脏病学中基于脂质的纳米平台：从理性设计到临床翻译挑战

MedComm – Biomaterials and Applications Pub Date : 2025-09-11 DOI: 10.1002/mba2.70025

Jie Wang, Qian Zhang, Lin Yang, Zijian Cheng, Chunhong Wang, Runlin Song, Honglan Dai, Xinxin Zhang

{"title":"Lipid-Based Nanoplatforms in Hepatology: From Rational Design to Clinical Translation Challenges","authors":"Jie Wang, Qian Zhang, Lin Yang, Zijian Cheng, Chunhong Wang, Runlin Song, Honglan Dai, Xinxin Zhang","doi":"10.1002/mba2.70025","DOIUrl":"https://doi.org/10.1002/mba2.70025","url":null,"abstract":"Liver diseases—encompassing hepatitis, liver fibrosis, fatty liver, and hepatocellular carcinoma—constitute a formidable global health challenge. Existing treatments are often limited by several key issues, such as low drug accumulation, poor selectivity for target cells, and the toxic side effects of drugs. Lipid-based nanocarriers (LBNCs) have emerged as an up-and-coming platform, leveraging their biocompatibility, versatile drug-loading capacity, and tunable targeting capabilities to overcome these limitations. This comprehensive review critically examines recent advances in the rational design of LBNCs, including liposomes, micelles, nanoemulsions, solid lipid nanoparticles, lipid nanoparticles, biomimetic lipid nanocarriers, and smart responsive lipid nanocarriers, as well as their applications in lipid materials. Subsequently, we delve into their translational application, meticulously reviewing preclinical successes and current clinical progress (encompassing active clinical trials and FDA-approved LBNC formulations). Finally, by analyzing the challenges from rational design to clinical translation, we propose forward-looking perspectives and strategic recommendations to overcome these hurdles and accelerate the realization of LBNC-based therapies in clinical hepatology. This review aims to serve as a valuable reference for researchers, providing in-depth insights into the evolving field of LBNCs and their significant therapeutic potential in hepatology.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"4 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70025","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cu2+-Coordinated NLG919: A Drug Delivery Nanoplatform to Activate Antitumor Immunity via Inducing Immunogenic Cell Death and Inhibiting Indoleamine 2,3-Dioxygenase-1 Cu2+-协同NLG919：通过诱导免疫原性细胞死亡和抑制吲哚胺2,3-双加氧酶-1激活抗肿瘤免疫的药物递送纳米平台

MedComm – Biomaterials and Applications Pub Date : 2025-09-01 DOI: 10.1002/mba2.70024

Lin-Ping Zhao, Chu-Yu Huang, Rong-Rong Zheng, Hang-Yu Zhou, Guang-Miao Chen, Yun Ye, Ying-Ling Miao, Shi-Ying Li

{"title":"Cu2+-Coordinated NLG919: A Drug Delivery Nanoplatform to Activate Antitumor Immunity via Inducing Immunogenic Cell Death and Inhibiting Indoleamine 2,3-Dioxygenase-1","authors":"Lin-Ping Zhao, Chu-Yu Huang, Rong-Rong Zheng, Hang-Yu Zhou, Guang-Miao Chen, Yun Ye, Ying-Ling Miao, Shi-Ying Li","doi":"10.1002/mba2.70024","DOIUrl":"https://doi.org/10.1002/mba2.70024","url":null,"abstract":"Chemotherapeutic drug combination to activate systemic antitumor immunity is appealing to fight metastatic tumors. In this study, copper ion (Cu2+) is able to coordinate with NLG919, serving as a nanoplatform (designated as CuN) for drug delivery. Meanwhile, such a metal-coordinated nanomedicine can also activate systemic antitumor immunity through immunogenic cell death (ICD) induction and indoleamine 2,3-dioxygenase-1 (IDO1) inhibition. Some representing antitumor agents, including cinnamic acid, mitoxantrone, docetaxel, β-lapachone, tazemetostat and mocetinostat, can be encapsulated into CuN regardless of their different physicochemical characteristics. Taking β-lapachone for example, the drug-carrying CuN (designated as Lap@CuN) can catalyze the production of excessive reactive oxygen species (ROS) to suppress tumor cell proliferation and trigger a robust ICD to release damage associated molecular patterns (DAMPs). Consequently, Lap@CuN not only inhibits primary tumor growth through chemotherapy but also reactivates the immune cells to exert an abscopal effect. Benefiting from the immune modulatory effect, Lap@CuN reduces the lung metastasis while not causing obvious side effects on mice. This study presents a universal metal-coordinated nanoplatform for the delivery of chemotherapeutic combinations, offering new insights into the design of combination therapies that can potentiate immunotherapeutic responses.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"4 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144927359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transdermal Liposomal Delivery Systems: Advantages, Applications, Challenges, and Prospects 经皮脂质体给药系统：优势、应用、挑战和前景

MedComm – Biomaterials and Applications Pub Date : 2025-08-29 DOI: 10.1002/mba2.70023

Hui Xing, Ziyi Zhao, Xiaoxu Zhu, Zhi Zhang, Guowei Li, Dong Ma

{"title":"Transdermal Liposomal Delivery Systems: Advantages, Applications, Challenges, and Prospects","authors":"Hui Xing, Ziyi Zhao, Xiaoxu Zhu, Zhi Zhang, Guowei Li, Dong Ma","doi":"10.1002/mba2.70023","DOIUrl":"https://doi.org/10.1002/mba2.70023","url":null,"abstract":"Transdermal drug delivery systems (TDDS) offer a noninvasive route for delivering active compounds directly to lesion sites while bypassing hepatic first-pass metabolism, thereby reducing systemic side effects and improving patient compliance. As such, TDDS have gained significant attention in disease treatment. However, the stratum corneum presents a major barrier to drug permeation due to its “brick-and-mortar” structure, limiting the effectiveness of transdermal strategies. Developing safe and efficient enhancement methods remains a major challenge. Among various drug delivery platforms, liposomal systems have attracted increasing interest owing to their nanoscale size, biocompatibility, high drug-loading capacity, and ability to protect drugs from enzymatic degradation. These carriers also interact favorably with skin lipids, enhancing drug penetration. Advances in nanotechnology have led to the development of novel liposomal formulations such as ethosomes, transfersomes, niosomes, and pharmacosomes, each tailored to address specific therapeutic needs. This review summarizes recent progress in liposome-based TDDS for both skin and systemic diseases, highlighting their mechanisms of action, therapeutic benefits, and clinical translation potential. Additionally, it explores future directions and ongoing challenges, aiming to provide a reference for advancing liposomal technologies in transdermal drug delivery.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"4 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A New Paradigm for Precision Drug Delivery in Inflammatory Bowel Disease: Effective Transfer, Enhanced Retention, and Pathology-Targeting Treatment via Biomaterials and Engineered Platforms 炎症性肠病精准药物递送的新范式：通过生物材料和工程平台有效转移、增强保留和病理靶向治疗

MedComm – Biomaterials and Applications Pub Date : 2025-08-17 DOI: 10.1002/mba2.70022

Ruoyi Gan, Enqi Ni, Guanyue Li, Wei Chen

{"title":"A New Paradigm for Precision Drug Delivery in Inflammatory Bowel Disease: Effective Transfer, Enhanced Retention, and Pathology-Targeting Treatment via Biomaterials and Engineered Platforms","authors":"Ruoyi Gan, Enqi Ni, Guanyue Li, Wei Chen","doi":"10.1002/mba2.70022","DOIUrl":"https://doi.org/10.1002/mba2.70022","url":null,"abstract":"Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), is a chronic inflammatory disorder of the gastrointestinal (GI) tract with increasing global prevalence. Despite advancements in IBD management, current therapies suffer from limitations, such as premature drug degradation, insufficient retention at inflamed sites, and systemic off-target effects, resulting in suboptimal efficacy and increased adverse events. To address these challenges, this review presents a new paradigm for precision drug delivery in IBD, highlighting three critical strategies: (1) effective transfer—ensuring efficient drug transport to the intestinal region by overcoming complex GI physiological barriers; (2) enhanced retention—prolonging drug residence at inflamed lesions to maximize local therapeutic effects; and (3) pathology-targeting treatment—executing therapeutic interventions based on IBD-associated pathological features to achieve localized treatment and minimize systemic toxicity. We emphasize the integration of advanced biomaterials and engineered therapeutic platforms as enablers of these strategies and illustrate their interactions with IBD pathophysiology. By analyzing recent breakthroughs in drug delivery systems and bioresponsive materials, this review outlines the design principles and translational potential of next-generation IBD therapeutics, offering insights for the development of more effective and patient-centric treatment approaches.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"4 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144861693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Bench to Bedside: Hydrogel Platforms Bridging Anti-Adhesion Barriers, Tissue Regeneration, and Personalized Postoperative Recovery 从工作台到床边：水凝胶平台桥接抗粘连屏障，组织再生和个性化术后恢复

MedComm – Biomaterials and Applications Pub Date : 2025-08-04 DOI: 10.1002/mba2.70021

Ting Wang, Hanchao Zhou, Jiangchuan He, Yunhe Zheng, Jinpeng Wen, Yu Huang, Kailai Liu, Yuchen Zhang, Ke Wang

{"title":"From Bench to Bedside: Hydrogel Platforms Bridging Anti-Adhesion Barriers, Tissue Regeneration, and Personalized Postoperative Recovery","authors":"Ting Wang, Hanchao Zhou, Jiangchuan He, Yunhe Zheng, Jinpeng Wen, Yu Huang, Kailai Liu, Yuchen Zhang, Ke Wang","doi":"10.1002/mba2.70021","DOIUrl":"https://doi.org/10.1002/mba2.70021","url":null,"abstract":"Postoperative adhesions represent a prevalent complication following surgical interventions, commonly forming between soft tissue surfaces within body cavities. These adhesions can give rise to severe consequences, such as chronic pain, organ dysfunction, intestinal obstruction, and infertility. Notwithstanding substantial progress in the prevention of postoperative adhesions, their underlying formation mechanisms remain intricate, and there is currently no fully effective approach to preclude their development. Hydrogels, characterized by their highly hydrophilic three-dimensional network structure, tissue-mimetic mechanical properties, and porous architecture, have demonstrated considerable promise as anti-adhesion barriers and as controlled-release carriers for therapeutic agents. In recent years, hydrogel materials have emerged as a focal point in the prevention and treatment of postoperative adhesions, owing to their excellent biocompatibility, tunable degradability, and injectability. Hydrogels have exhibited remarkable anti-adhesive and tissue-regenerative effects through multiple mechanisms, including physical isolation, anti-inflammatory and anti-fibrotic actions, and controlled drug delivery. This review summarizes the key properties and recent advancements in hydrogel-based anti-adhesion materials, outlines the types and functional characteristics of hydrogels currently utilized for adhesion prevention, and discusses the challenges encountered in clinical translation. Additionally, we explore future directions for the development of multifunctional composite hydrogels, offering novel perspectives and potential strategies for the effective prevention of postoperative adhesions and promotion of tissue regeneration.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"4 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144773875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

State-of-the-Art Fabrication of Microneedle Patches: A Mini-Review on Emerging Techniques 微针贴片的最新制造技术：新兴技术综述

MedComm – Biomaterials and Applications Pub Date : 2025-07-27 DOI: 10.1002/mba2.70020

Syed Waqas Ali Shah, Xingxing Li, Hao Yuan, Huiling Shen, Guifang Pan, Hanhan Xie, Jundong Shao

{"title":"State-of-the-Art Fabrication of Microneedle Patches: A Mini-Review on Emerging Techniques","authors":"Syed Waqas Ali Shah, Xingxing Li, Hao Yuan, Huiling Shen, Guifang Pan, Hanhan Xie, Jundong Shao","doi":"10.1002/mba2.70020","DOIUrl":"https://doi.org/10.1002/mba2.70020","url":null,"abstract":"Microneedle (MN) patches are an emerging platform in transdermal drug delivery, offering a minimally invasive, pain-free alternative to conventional administration routes. Their performance, biocompatibility, and clinical potential are fundamentally influenced by the fabrication methods used. This mini-review provides a critical overview of current and emerging MN fabrication techniques. Conventional approaches including micro-molding (MM), microelectromechanical systems (MEMS) fabrication, laser micromachining, three-dimensional (3D) printing, coating methods, and hydrogel-forming technologies are discussed in detail. Additionally, innovative strategies such as electrospinning (Els) and bioprinting (BP) are examined for their ability to enable complex architectures and functional enhancements. Each technique is evaluated based on its operational principles, material compatibility, structural resolution, and scalability. Emphasis is placed on how these fabrication strategies affect mechanical strength, drug delivery efficiency, and clinical translation. The review also highlights the challenges in transitioning from laboratory-scale development to commercial production. By integrating current advancements with future perspectives, this study provides a scientific foundation for guiding the rational design and large-scale fabrication of MN systems. The manuscript aims to support innovation in biomedical, pharmaceutical, and cosmetic applications by offering a comprehensive assessment of the technological landscape.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"4 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144714782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced Responsive Hydrogels for Diabetic Wound Healing: Design Principles, Controlled Drug Delivery, Therapeutic Strategies, and Application Prospects 先进的反应性水凝胶用于糖尿病伤口愈合：设计原则，控制药物输送，治疗策略和应用前景

MedComm – Biomaterials and Applications Pub Date : 2025-07-14 DOI: 10.1002/mba2.70019

Jiyuan Du, Caihong Xian, Xiaodan Liang, Shirou Fan, Liying Wang, Jun Wu

{"title":"Advanced Responsive Hydrogels for Diabetic Wound Healing: Design Principles, Controlled Drug Delivery, Therapeutic Strategies, and Application Prospects","authors":"Jiyuan Du, Caihong Xian, Xiaodan Liang, Shirou Fan, Liying Wang, Jun Wu","doi":"10.1002/mba2.70019","DOIUrl":"https://doi.org/10.1002/mba2.70019","url":null,"abstract":"Diabetic wounds characterized by impaired healing and amputation risks, pose clinical challenge worldwide. Hydrogel dressings have emerged as a promising therapeutic strategy due to their ability to absorb exudate, prevent infections, and control therapeutic agents delivery, with over a dozen products clinically approved or in trials. However, these hydrogels rely on passive drug release mechanisms, which do not dynamically respond to the pathological microenvironment of diabetic wounds, such as high glucose, elevated ROS, acidic pH, and increased enzyme activity, resulting in mismatched release kinetics and suboptimal therapeutic outcomes. To address these challenges, researchers have developed smart responsive hydrogels that utilize the wound's endogenous pathological cues as triggers for on-demand, spatiotemporal drug delivery. This approach enables personalized therapy by precisely modulating drug release in response to real-time wound changes, offering a transformative solution for enhancing healing efficacy. Herein, we review the pathological features of diabetic wounds, and then explores the design principles and therapeutic strategies of smart responsive hydrogels. Importantly, the review evaluates the challenges associated with these technologies and outlines future engineering directions to optimize their clinical adoption. This review aims to contribute to the rational design and practical clinical application of smart hydrogels for chronic wound care.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"4 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144624314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances of Microneedles for Cancer Diagnosis and Therapy 微针在癌症诊断和治疗中的研究进展

MedComm – Biomaterials and Applications Pub Date : 2025-07-03 DOI: 10.1002/mba2.70018

Chunli Yang, Li Zhang, Siyi Wang, Angxi Zhou, Run Tian, Maya Xiang, Ya Ren, Yang Yu, Rong Li, Maling Gou

{"title":"Advances of Microneedles for Cancer Diagnosis and Therapy","authors":"Chunli Yang, Li Zhang, Siyi Wang, Angxi Zhou, Run Tian, Maya Xiang, Ya Ren, Yang Yu, Rong Li, Maling Gou","doi":"10.1002/mba2.70018","DOIUrl":"https://doi.org/10.1002/mba2.70018","url":null,"abstract":"As the global incidence of cancer continues to rise, the need for innovative and precisive alternatives to conventional diagnostic and therapeutic methods has become increasingly urgent. Microneedles (MNs), comprising arrays of micron-scale projections, have emerged as a platform that provides a painless and minimally invasive system for interstitial fluid analysis and transdermal drug delivery. This technology demonstrates potential in cancer diagnostics through continuous biomarker monitoring using integrated biosensors, while enabling controlled release of chemotherapeutics, photothermal/photodynamic, and immunotherapeutic agents. Over the past decades, significant advancements in technology, materials, and medical applications have been achieved in the MN field, which have attracted increasing attention of reseachers. Currently, several MN-based strategies registered on ClinicalTrials.gov are actively investigating their applications in medince, positioning them as a promising new tool for cancer treatment and diagnosis. This review offers a comprehensive summary of the classification, design, fabrication materials, and techniques of MNs, along with their medical applications in cancer diagnosis, therapy, and the management of cancer-associated pain and hair loss. Furthermore, this review summarized ongoing clinical trials in investigating MN-based therapies for cancer patients. And challenges, future perspectives of applying MNs in cancer theranostics are also presented.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"4 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144550935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging Trends in Injectable Stimuli-Responsive Hydrogel Microspheres: Design Strategies and Therapeutic Innovations 可注射刺激反应水凝胶微球的新趋势：设计策略和治疗创新

MedComm – Biomaterials and Applications Pub Date : 2025-06-19 DOI: 10.1002/mba2.70017

Jiacheng Liu, Chengcheng Du, Senrui Liu, Junyan Liu, Xuefeng Luo, Jingdi Zhan, Zhuolin Chen, Zhenglin Zhu, Liangbin Zhou, Zhong Alan Li, Wei Huang, Yiting Lei

{"title":"Emerging Trends in Injectable Stimuli-Responsive Hydrogel Microspheres: Design Strategies and Therapeutic Innovations","authors":"Jiacheng Liu, Chengcheng Du, Senrui Liu, Junyan Liu, Xuefeng Luo, Jingdi Zhan, Zhuolin Chen, Zhenglin Zhu, Liangbin Zhou, Zhong Alan Li, Wei Huang, Yiting Lei","doi":"10.1002/mba2.70017","DOIUrl":"https://doi.org/10.1002/mba2.70017","url":null,"abstract":"Hydrogels, as three-dimensional hydrophilic polymer networks, have been widely utilized in biomedical applications due to their excellent biocompatibility, high water content, and tunable physicochemical properties. However, traditional bulk hydrogels often suffer from limitations such as inadequate mechanical strength, slow response to external stimuli, and restricted diffusion efficiency, which hinder their performance in dynamic biological environments. To overcome these challenges, hydrogel microspheres (HMs) have emerged as a promising alternative, which offers advantages such as injectability, high surface-area-to-volume ratio, and tunable functionality. By integrating natural and synthetic materials with advanced fabrication techniques, including microfluidics and emulsification, researchers have achieved precise control over the morphology, size, and bioactivity of HMs. In recent years, stimuli-responsive HMs have attracted significant attention for their ability to respond intelligently to environmental cues such as pH, reactive oxygen species (ROS), enzymes, and temperature. This enables controlled drug release, enhanced therapeutic precision, and spatiotemporal regulation in biomedical applications. This review systematically summarizes the materials, fabrication strategies, and functional mechanisms of stimuli-responsive HMs, highlighting their applications in drug delivery, disease treatment, and tissue engineering. Furthermore, key challenges and future perspectives are discussed, which provides insights into how these intelligent HMs can advance personalized medicine and clinical translation.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"4 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144323422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0