MedComm – Biomaterials and Applications最新文献

Self-Assembly of Therapeutic Peptides for Enhanced Cancer Therapy: Strategies, Therapeutic Performance, and Future Perspectives 用于增强癌症治疗的治疗肽的自组装：策略、治疗性能和未来展望

MedComm – Biomaterials and Applications Pub Date : 2026-10-26 DOI: 10.1002/mba2.70084

Yuelin Fang, Xue Wan, Shihe Wang, Honglan Dai, Huiling Zeng, Nan Chen, Xinxin Zhang

{"title":"Self-Assembly of Therapeutic Peptides for Enhanced Cancer Therapy: Strategies, Therapeutic Performance, and Future Perspectives","authors":"Yuelin Fang, Xue Wan, Shihe Wang, Honglan Dai, Huiling Zeng, Nan Chen, Xinxin Zhang","doi":"10.1002/mba2.70084","DOIUrl":"https://doi.org/10.1002/mba2.70084","url":null,"abstract":"Therapeutic peptides have attracted increasing attention for cancer therapy owing to their high biological activity, target specificity, and diverse mechanisms of action, but their clinical application is limited by poor stability and inefficient delivery. Peptide self-assembly has emerged as a promising peptide delivery strategy that enables therapeutic peptides to organize into well-defined supramolecular structures through non-covalent interactions, offering opportunities to improve their delivery performance. This review provides a comprehensive overview of peptide self‑assembly mechanisms, focusing on synergistic non‑covalent interactions and environmental modulation, and summarizes the major assembly strategies for antitumor peptides, including spontaneous self-assembly of monomers, co-assembly with functional components, and tumor microenvironment-responsive assembly. The application of self-assembly strategies in improving tumor accumulation, tumor retention, intracellular delivery, and antitumor efficacy of antitumor peptides was also discussed. Finally, we highlight the current challenges associated with structural stability, scalable manufacturing, and clinical translation, and propose potential strategies to facilitate clinical translation of self-assembling peptide therapeutics. Overall, this review provides a systematic framework for the rational design of self-assembling therapeutic peptides and offers perspectives for the development of next-generation peptide nanomedicines for cancer therapy.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"5 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70084","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149259268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application and Research Progress of Nucleic Acid-Based Drug Delivery Systems in the Treatment of Intracerebral Hemorrhage 核酸给药系统在脑出血治疗中的应用与研究进展

MedComm – Biomaterials and Applications Pub Date : 2026-10-25 DOI: 10.1002/mba2.70081

Jingyan Wang, Xuejiao Zeng, Pengyu Niu, Jinjin Shi, Wenyan Yu

{"title":"Application and Research Progress of Nucleic Acid-Based Drug Delivery Systems in the Treatment of Intracerebral Hemorrhage","authors":"Jingyan Wang, Xuejiao Zeng, Pengyu Niu, Jinjin Shi, Wenyan Yu","doi":"10.1002/mba2.70081","DOIUrl":"https://doi.org/10.1002/mba2.70081","url":null,"abstract":"Intracerebral hemorrhage (ICH) is a devastating stroke subtype associated with high mortality and neurological disability, yet effective treatment remains constrained by the complex mechanisms of secondary brain injury and limited blood–brain barrier (BBB) permeability. In this context, Nucleic Acid-Based Drug Delivery Systems (NADDS) offer a promising strategy by enabling precise gene regulation and targeted modulation of disease-associated pathways. However, a systematic framework linking nucleic acid modalities, carrier design, disease stage and translational feasibility in ICH remains lacking. This review first summarizes the therapeutic mechanisms and delivery requirements of representative nucleic acid drugs, including siRNA, miRNA, antisense oligonucleotides and mRNA, for modulating neuroinflammation, oxidative stress and neurological repair after ICH. It then focuses on three major NADDS—lipid nanoparticles, exosome-based delivery systems and DNA nanomaterial-based delivery systems—highlighting their structural characteristics, design principles, cargo loading strategies, delivery mechanisms, advantages, limitations and recent applications in ICH. The major challenges encountered during NADDS-based treatment of ICH, including dynamic BBB permeability, carrier selection, insufficient loading efficiency, biosafety concerns, manufacturing scalability and patient heterogeneity, are discussed. By integrating these advances, this review clarifies the therapeutic potential of these three platforms and provides a foundation for developing safer, more efficient, and clinically translatable nucleic acid therapies for ICH.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"5 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70081","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149258762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Applications of Scanning Ion Conductance Microscope in Biomedical Fields” 对“扫描离子电导显微镜在生物医学领域的应用”的更正

MedComm – Biomaterials and Applications Pub Date : 2026-10-20 DOI: 10.1002/mba2.70095

引用次数: 0

Correction to “Biomedical Applications and Prospects of Temperature-Orchestrated Photothermal Therapy” 对“温度调控光热疗法的生物医学应用和前景”的更正

MedComm – Biomaterials and Applications Pub Date : 2026-10-20 DOI: 10.1002/mba2.70094

引用次数: 0

Correction to “Recent Progress in 3D Printing Degradable Polylactic Acid-Based Bone Repair Scaffold for the Application of Cancellous Bone Defect” 更正“3D打印可降解聚乳酸骨修复支架在松质骨缺损中的应用研究进展”

MedComm – Biomaterials and Applications Pub Date : 2026-10-20 DOI: 10.1002/mba2.70093

{"title":"Correction to “Recent Progress in 3D Printing Degradable Polylactic Acid-Based Bone Repair Scaffold for the Application of Cancellous Bone Defect”","authors":"","doi":"10.1002/mba2.70093","DOIUrl":"https://doi.org/10.1002/mba2.70093","url":null,"abstract":"Hu X, Lin Z, He J, et al. Recent progress in 3D printing degradable polylactic acid-based bone repair scaffold for the application of cancellous bone defect. MedComm Biomat Appl. 2022; 1:e14.The reference 2 and 28 were identical, therefore reference 28 should be removed.The reference 50 and 137 were identical, therefore reference 137 should be removed.The reference 62 and 134 were identical, therefore reference 134 should be removed.The reference 79 and 116 were identical, therefore reference 116 should be removed.The reference 80 and 122 were identical, therefore reference 122 should be removed.The reference 81 and 121 were identical, therefore reference 121 should be removed.The reference 82 and 123 were identical, therefore reference 123 should be removed.The reference 83 and 127 were identical, therefore reference 127 should be removed.The reference 85 and 120 were identical, therefore reference 120 should be removed.The reference 86 and 117 were identical, therefore reference 117 should be removed.The reference 90 and 135 were identical, therefore reference 135 should be removed.The reference 94 and 141 were identical, therefore reference 141 should be removed.The reference 95 and 144 were identical, therefore reference 144 should be removed.We apologize for this error.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"5 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70093","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149258403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Nanotechnology-Based CRISPR/Cas9 Delivery System for Genome Editing in Cancer Treatment” 更正“基于纳米技术的CRISPR/Cas9基因编辑系统用于癌症治疗”

MedComm – Biomaterials and Applications Pub Date : 2026-10-15 DOI: 10.1002/mba2.70088

{"title":"Correction to “Nanotechnology-Based CRISPR/Cas9 Delivery System for Genome Editing in Cancer Treatment”","authors":"","doi":"10.1002/mba2.70088","DOIUrl":"https://doi.org/10.1002/mba2.70088","url":null,"abstract":"Zhou S, Li Y, Wu Q, Gong C. Nanotechnology based CRISPR/Cas9 delivery system for genome editing in cancer treatment. MedComm – Biomater Appl. 2024; 3:e70.The reference 27 and 30 were identical, therefore reference 30 should be removed.The reference 10 and 33 were identical, therefore reference 33 should be removed.The reference 58 and 60 were identical, therefore reference 60 should be removed.The reference 21 and 62 were identical, therefore reference 62 should be removed.The reference 20 and 72 were identical, therefore reference 72 should be removed.The reference 29 and 84 were identical, therefore reference 84 should be removed.The reference 28 and 86 were identical, therefore reference 86 should be removed.The reference 80 and 104 were identical, therefore reference 104 should be removed.The reference 108 and 110 were identical, therefore reference 110 should be removed.The reference 109 and 117 were identical, therefore reference 117 should be removed.The reference 225 and 249 were identical, therefore reference 249 should be removed.The reference 52 and 280 were identical, therefore reference 280 should be removed.The reference 105 and 307 were identical, therefore reference 307 should be removed.We apologize for this error.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"5 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70088","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149205821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Biogenic Silver Nanoparticles in Diabetes: In Vivo Mechanisms, Therapeutic Potential, and Future Perspectives: A Review” 对“生物源银纳米颗粒治疗糖尿病：体内机制、治疗潜力和未来展望：综述”的更正

MedComm – Biomaterials and Applications Pub Date : 2026-10-15 DOI: 10.1002/mba2.70091

引用次数: 0

Correction to “Mxene-Based Electrochemiluminescence (ECL) Biosensors: A Review on Analyte Detection and Diagnostic Applications” 更正“基于mxene的电化学发光（ECL）生物传感器：分析物检测和诊断应用综述”

MedComm – Biomaterials and Applications Pub Date : 2026-10-15 DOI: 10.1002/mba2.70089

引用次数: 0

Correction to “Targeting Delivery of Cyanidin-Loaded With Ti3C2 Nanosheets for Alleviating Vascular Calcification in Chronic Kidney Disease” 对“靶向递送负载Ti3C2纳米片的花青素减轻慢性肾脏疾病血管钙化”的更正

MedComm – Biomaterials and Applications Pub Date : 2026-10-15 DOI: 10.1002/mba2.70090

引用次数: 0

Correction to “Improving Proteolysis-Targeting Chimera Delivery by Targeting Key Biomarkers in Tumor Endocytosis Pathways” 更正“通过靶向肿瘤内吞途径中的关键生物标志物改善蛋白水解靶向嵌合体递送”

MedComm – Biomaterials and Applications Pub Date : 2026-10-15 DOI: 10.1002/mba2.70092

引用次数: 0