MedComm – Biomaterials and Applications最新文献

{"title":"Amphiphilic photosensitizer polymer as a nanocarrier of cytotoxic molecule for carrier-free combination therapy","authors":"Jingqi Xin,&nbsp;Caiting Deng,&nbsp;Meichen Zheng,&nbsp;Feifei An","doi":"10.1002/mba2.28","DOIUrl":"https://doi.org/10.1002/mba2.28","url":null,"abstract":"<p>Various nanocarriers have been explored to deliver drugs for combination therapy. However, most nanocarriers are composed of inert materials without contribution for improving the cancer therapeutic effect. Herein, a hydrophobic photosensitizer is conjugated to poly (ethylene glycol) to form an amphiphilic polymer, which further self-assembles into nanomicelle. The generated nanomicelle can act as a nanocarrier to encapsulate a cytotoxic molecule, IR-775, for combination therapy. The yielded nanodrug is totally composed of pharmacologically active ingredients to avoid any possible toxicity resulted from carrier materials. The nanodrug performs enhanced therapeutic effect compared with any monotherapy and exhibits negligible hemolysis, indicating good biocompatibility for further in vivo applications.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.28","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50126151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting staphylococcal bone infections","authors":"Zhang Xiangchun,&nbsp;Xulin Hu,&nbsp;Hongping Chen","doi":"10.1002/mba2.31","DOIUrl":"https://doi.org/10.1002/mba2.31","url":null,"abstract":"<p>A novel quinolone antibiotic was developed by Shiladitya Sengupta and colleagues using molecular-docking simulation, and one lead compound, VCD-077, was selected based on this strategy.<span>¹</span> Antimicrobial resistance is increasing, driven by widespread antibiotic overuse in medical and agricultural settings.<span>²</span> Paradoxically, despite the urgent need to develop a new generation of antibiotics, their marketability is suppressed, partly because the new antibacterial drug may quickly develop new resistance and the development of new antibiotics is sluggish.<span>^{3, 4}</span> The ideal next-generation antibiotic should demonstrate excellent activity against drug-resistant bacteria, good biosafety, flexible drug delivery, and the ability to retard the development of resistance. In this regard, recently researchers have focused on developing novel antibiotics by improving drug performance, availability, targeted enrichment, and reducing systemic toxicity.</p><p>Reporting in Nature Biomedical Engineering, Shiladitya Sengupta and colleagues now show that VCD-077 screened by molecular-docking simulations exhibits excellent activity against drug-resistant bacteria and its biofilms, reduces the development of bacterial resistance and is compatible with bone cement for local delivery and treatment of staphylococcal bone infections in rats (Figure 1).<span>¹</span></p><p>Bone infections are rising rapidly due to accidental fractures and the global aging population.<span>⁵</span> Sengupta and co-authors designed a series of quinolone antibiotics using molecular-docking simulation. They selected VCD-077 from 17 candidate antibiotics, which can effectively against clinical drug-resistant staphylococcal and retard the development of resistance. The minimal inhibitory concentration (MIC) of ciprofloxacin, <i>Staphylococcus aureus</i> sensitive antibiotics, increased stepwise to 64.0 μg/ml by the 20th passage to <i>S. aureus</i>. While <i>S. aureus</i> were still sensitive to VCD-077 even at the 28th passage. Specifically, VCD-077 is potent against <i>S. aureus</i> and <i>Staphylococcus epidermidis</i> biofilms because it is a weak acid with a single pKa of 5.8, that is, it still maintains antibacterial activity at pH 5.5–7.4. In contrast, gentamicin lost part of its activity at acid pH 5.5. Therefore, VCD-077 has a unique advantage in the prevailing weakly acidic infected bone environment. Notably, VCD-077 is physicochemically compatible with polymethylmethacrylate bone cement, exhibits desired pharmacokinetics without loss of mechanical properties of bone cement. VCD-077-impregnated bone cement showed more powerful anti-infective activity compared with either FDA-approved rifampin or gentamicin-impregnated bone cement. Overall, the authors show that VCD-077-impregnated bone cement could be used as rational next-generation drugs or coatings to treat bone infections.</p><p>The high efficacy ","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.31","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50121311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2-Hydroxy-1,4-naphthoquinone [Lawsone] integrated rare-earth hybrid materials as biocompatible UV/IR filter agents","authors":"Sheemol V. Narayanan,&nbsp;Muthusundar Kumar,&nbsp;Valan R. Gnanaraj,&nbsp;Sruthi C. Rajan,&nbsp;Viji Selvaraj,&nbsp;Solaiappan Ananthakumar","doi":"10.1002/mba2.29","DOIUrl":"https://doi.org/10.1002/mba2.29","url":null,"abstract":"<p>UV filter agents are essential ingredients in cosmetics and fabrics for rendering the property of protection from harmful UV radiation. The focus of this research was on the development of biocompatible hybrid UV/IR filter agents through sol–gel processing of nano-sized lanthanum titanate, zirconate, and phosphate-based rare-earth materials. 2-Hydroxy-1,4-naphthoquinone (Lawsone) is an ideal candidate, owing to its biocompatibility, for treating the sol of the rare-earth systems to produce inorganic-organic hybrids with classical orange shades. The rare-earth hybrids were characterized by X-Ray diffraction, dynamic light scattering, fourier transform infrared spectroscopy, scanning electron microscopy, UV-Vis, photo-luminescence, and Near Infrared (NIR) spectroscopy. The results of characterization indicated that the hybrids offer &gt;90% of NIR reflectance in the wavelength region from 700 to 1100 nm. They also exhibited excellent shielding in UV-A and UV-B regions, thus qualifying them as cool colors with useful optical as well as heat management characteristics. The sun protection factor calculated by optical density measurements showed that the synthesized hybrids have potential applications as UV filter agents in sunscreen lotions. The cell viability analyzed by the MTT (4,5-dimethylthiazol-2-yl)−2,5-diphenyltetrazolium bromide) assay affirmed the biocompatibility of the hybrids as none of the systems was found cytotoxic. This study was devoted to exploring the beneficial properties of rare-earth-based hybrid systems in pharmacological applications.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.29","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50145418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudomonas lipopeptide: An excellent biomedical agent","authors":"Vivek Chauhan,&nbsp;Shreya Mazumdar,&nbsp;Akash Pandey,&nbsp;Shamsher S. Kanwar","doi":"10.1002/mba2.27","DOIUrl":"https://doi.org/10.1002/mba2.27","url":null,"abstract":"<p>Lipopeptides are surface active molecules with hydrophilic and hydrophobic regions and are kenned to be engendered by different species of <i>Bacillus</i> and <i>Pseudomonas</i>. These lipopeptides can be applied in different domains because of their remarkable properties like antibacterial, antifungal, anticorrosion, antitumor, and antiviral. They act by engendering pores in the cell membrane to perforate and conclusively disrupt them. This property of lipopeptide is valuable as an antimicrobial agent. In 2003, lipopeptides were approved as an antibiotic drug in the United States by the USA Food and Drug Administration (FDA) for the purpose of skin and blood infections caused by bacterial species. The biosynthetic genes for these lipopeptides are regulated by the nonribosomal peptide synthetase system. Amphisin, Tolaasin, Viscosin, and Syringomycin are the four main types of lipopeptides produced by <i>Pseudomonas</i> species. Since these lipopeptides are nontoxic, biodegradable, and environmentally cordial, they can abbreviate undesirable ecological perturbances. They can be considered a multifarious weapon for their application in different domains such as biocontrol agents in plants, emulsifiers in cosmetic and food industries, anticorrosion agents in petroleum industries, and antimicrobial agents in pharmaceutical and biomedical industries.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.27","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50128972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applications of scanning ion conductance microscope in biomedical fields","authors":"Xinrui Gong,&nbsp;Xinyuan Fan,&nbsp;Yiming Huang,&nbsp;Yuqi Du,&nbsp;Xiaoyu Wang,&nbsp;Xiaoyu Liu,&nbsp;Zhiyao He","doi":"10.1002/mba2.26","DOIUrl":"https://doi.org/10.1002/mba2.26","url":null,"abstract":"<p>Scanning ion conductance microscopy (SICM) is a scanning probe technique to reflect the surface morphology of the sample with the probe's motion trajectory through measuring the current between the probe and the surface of the sample. Since the surface of the sample can be scanned noncontact and the morphological characteristics of the living cell can be obtained under physiological conditions, SICM is particularly important in the field of biomedicine. SICM has strong potentials in various applications, such as the real-time and high-resolution imaging of living cells, monitoring the volume and movements of living cells. In addition, SICM combines with various technologies such as patch clamp and nanopipette to study the physical properties of cells. Furthermore, using SICM to observe cell and tissue structure provides more directions for studying the mechanism of disease. This review briefly introduces the principles and imaging modes of SICM and outlines the recent applications and development of SICM in biomedical research. We also introduce the limitations of the existing SICM technology and make a perspective on its future development.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.26","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50119157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomedical applications and prospects of temperature-orchestrated photothermal therapy","authors":"Nuo Xu,&nbsp;Xu Zhang,&nbsp;Tingting Qi,&nbsp;Yongzhi Wu,&nbsp;Xi Xie,&nbsp;Fangman Chen,&nbsp;Dan Shao,&nbsp;Jinfeng Liao","doi":"10.1002/mba2.25","DOIUrl":"10.1002/mba2.25","url":null,"abstract":"<p>Photothermal therapy (PTT) has been regarded as a promising strategy considering its advantages of high inherent specificity and a lower invasive burden. Since the photothermal killing of cells/bacteria showed different patterns of death depending on the varying temperature in PTT, the temperature change of PTT is vital to cell/tissue response in scientific research and clinical application. On one hand, mild PTT has received substantial attention in the treatment of cancer and soft/hard tissue repair. On the other hand, the high temperature induced by PTT is capable of antibacterial capacity, which is better than conventional antibiotic therapy with drug resistance. Herein, we summarize the recent developments in the application of temperature-dependent photothermal biomaterials, mainly covering the temperature ranges of 40–42°C, 43–50°C, and over 50°C. We highlight the biological mechanism of PTT and the latest progress in the treatment of different diseases. Finally, we conclude by discussing the challenges and perspectives of biomaterials in addressing temperature-orchestrated PTT. Given a deep understanding of the interaction between temperature and biology, rationally designed biomaterials with sophisticated photothermal responsiveness will benefit the outcomes of personalized PTT toward various diseases.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.25","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88246011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD3-T-cell-engager (TCE) therapies to overcome solid tumors: Beyond BiTEs","authors":"Jiali Zhang,&nbsp;Qianqian Guo,&nbsp;Quan Wang,&nbsp;Yourong Duan","doi":"10.1002/mba2.20","DOIUrl":"10.1002/mba2.20","url":null,"abstract":"<p>CD3-T-cell-engager (TCE) therapies, such as bispecific T-cell engagers (BiTEs), have achieved extraordinary success in treating hematological malignancies and have shown therapeutic effects comparable with those of chimeric antigen receptor (CAR)-T therapies. However, solid tumors are challenging to treat with TCE therapies due to tumor heterogeneity, limited tumor enrichment, an immunosuppressive tumor microenvironment (TME), a lack of pre-existing tumor-infiltrating lymphocytes (TILs), serious on-target off-tumor toxicity, and so forth. Thanks to the increased understanding of resistance mechanisms and novel technologies, the next generation of TCE therapies for solid tumors is emerging. We focus on summarizing the latest progress in CD3-based TCE therapies and discussing the future perspective of TCE therapeutic strategies against solid tumors. This perspective highlighted novel multitarget TCE therapies that integrated multiple functionalities to enhance antitumor efficacy while minimizing off-target toxicity. Furthermore, TCE therapies also could be rationally combined with other antitumor therapeutics, including oncolytic viruses, CAR-T cells, and immune checkpoint blockade. Moreover, TCEs should not be limited to redirecting polyclone T cells to tumor cells. The development of novel TCEs to bridge T cells and other cells in the TME is also promising. This perspective motivates the development of the new TCE therapies strategy to broaden the armamentarium of CD3-TCE therapies and overcome solid tumors.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.20","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79376336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tissue origin matters: Maintenance of tenogenic phenotype on the tendon and not skin collagen-derived devices","authors":"Anna Sorushanova,&nbsp;Dimitrios Tsiapalis,&nbsp;Ioannis Skoufos,&nbsp;Athina Tzora,&nbsp;Una FitzGerald,&nbsp;Anne M. Mullen,&nbsp;Dimitrios I. Zeugolis","doi":"10.1002/mba2.24","DOIUrl":"10.1002/mba2.24","url":null,"abstract":"<p>Recent data suggest that collagen retains the memory of the tissue that it derives from. With this in mind, collagen (from bovine skin and tendon) sponges were fabricated with different crosslinking densities, and their physicochemical and biological properties were assessed. As the crosslinking density was increased, the resistance to collagenase digestion, denaturation temperature, compressive stress, and compressive modulus was significantly increased and the free amine content, % swelling, and human dermal fibroblast cytocompatibility were significantly reduced. The tendon-collagen-derived scaffolds exhibited significantly higher compressive stress and compressive modulus values and induced significantly higher human tenocyte DNA concentration and metabolic activity than the skin-collagen-derived scaffolds. In human tenocyte cultures on day 14, the 1 mM 4-arm polyethylene-glycol succinimidyl glutarate tendon-collagen-derived collagen sponges induced significantly higher collagen type III synthesis (as expected at early stages of physiological tendon healing) and downregulated actin alpha 2 (associated with myofibroblast differentiation) and the skin-collagen-derived collagen sponges induced significantly higher collagen type IV synthesis (found primarily at the dermal-epidermal junction) and upregulated prolyl 4-hydroxylase subunit alpha-1 (associated with collagen biosynthesis and constitutes a target for antifibrotic compounds). Our data indicate that the tissue from which collagen is extracted should be considered in the development of medical devices.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.24","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79544734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smart intraoral systems for advanced drug delivery","authors":"Yuan Liu,&nbsp;Honglian Guo,&nbsp;Rengui Xu,&nbsp;Wei Chen","doi":"10.1002/mba2.19","DOIUrl":"10.1002/mba2.19","url":null,"abstract":"<p>Drug administration through the oral cavity is considered to be a convenient, effective, and time-saving strategy in the clinic with high safety and quick onset, especially for patients with needle fear and swallowing difficulties. Without the degradation in gastrointestinal tract and first-pass metabolism, the intraoral drug delivery system turns out to be an attractive option for macromolecule absorption, which will provide a promising platform for the successful delivery of protein, peptide, nucleic acid, and polysaccharide. Nevertheless, limited bioavailability, short retention time, and poor reproducibility pose a major hurdle to the further application of conventional intraoral drug delivery systems. Recent advances in chemical, material, and engineering techniques bring great opportunities to improve intraoral system fabrication and applications, owing to the high biocompatibility and functional diversity. In this review, we systematically summarize the recent development of smart intraoral drug delivery systems, including fast dissolving oral films, medicinal chewing gum systems, intraoral mucoadhesive systems, physical assisted systems, intelligent intraoral device, and chemically assisted systems. Moreover, the challenges and prospects for clinical and industrial applications of current strategies are well discussed. It is believed that the smart intraoral system would serve as a promising candidate to improve human life in the near future.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.19","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72555433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspectives in the vaccine development against Opisthorchis viverrini liver fluke","authors":"Ahmed O. Shalash,&nbsp;Mariusz Skwarczynski,&nbsp;Istvan Toth","doi":"10.1002/mba2.21","DOIUrl":"10.1002/mba2.21","url":null,"abstract":"<p>Liver flukes, <i>Opisthorchis viverrini</i>, infect around 10 million individuals in Southeast Asia, alone, and cause 26,000 deaths in the region per year. Despite being classified as a Group 1 carcinogen, and presenting one of the leading causes of cholangiocarcinoma in epidemic areas, <i>O. viverrini</i> infection is a neglected tropical disease. Control measures were implemented in epidemic areas to limit the outspread of infection; however, prophylactic vaccines are urgently needed to protect against future reinfections. This holds especially true due to the limited curative efficacy of the approved anthelmintic drug. In this article, we have briefly summarized the recently reported information regarding hepatobiliary cancer pathogenesis, approved treatment, and control measures against infection. Further, we highlighted the progress in the identification of protective antigens against <i>Opisthorchiasis</i> and proposed the investigation of additional promising antigens relying on vaccine progress against related infectious parasites. We highlighted the relative efficacies of the developed preclinical vaccines, suggested alternative vaccine designs and combinations, and commented on the required immunological responses. Moreover, we also reviewed biomaterials used in vaccine delivery against <i>O. viverrini</i> infections, summarized all the reported vaccine design approaches against the disease, and provided future perspectives regarding vaccine development, the utilization of biomaterials, and the discovery of highly protective antigens.</p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.21","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91095528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}