MedComm – Biomaterials and Applications最新文献_第9页

Oral hard tissue defect models for evaluating the regenerative efficacy of implant materials 口腔硬组织缺损模型用于评估植入材料的再生效果

MedComm – Biomaterials and Applications Pub Date : 2023-05-15 DOI: 10.1002/mba2.38

Xiaowen Sun, Boon Chin Heng, Xuehui Zhang

{"title":"Oral hard tissue defect models for evaluating the regenerative efficacy of implant materials","authors":"Xiaowen Sun, Boon Chin Heng, Xuehui Zhang","doi":"10.1002/mba2.38","DOIUrl":"https://doi.org/10.1002/mba2.38","url":null,"abstract":"Oral hard tissue defects are common concomitant symptoms of oral diseases, which have poor prognosis and often exert detrimental effects on the physical and mental health of patients. Implant materials can accelerate the regeneration of oral hard tissue defects (such as periodontal defects, alveolar bone defects, maxilla bone defects, mandible bone defects, alveolar ridge expansion, and site preservation), but their regenerative efficacy and biocompatibility need to be preclinically validated in vivo with animal-based oral hard tissue defect models. The choice of oral hard tissue defect model depends on the regenerative effect and intended application of the tested implant material. At the same time, factors that need to be considered include techniques for constructing the particular defect model, the scaffold/graft material used, the availability of animal model evaluation techniques and instrumentation, as well as costs and time constraints. In this article, we summarize the common oral hard tissue defect models in various animal species (such as periodontal model, jaw defect model, and implantation defect model) that can be used to evaluate the regenerative efficacy and biocompatibility of implant materials.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.38","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50133707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

DNA origami technology for biomedical applications: Challenges and opportunities 用于生物医学应用的DNA折纸技术：挑战与机遇

MedComm – Biomaterials and Applications Pub Date : 2023-05-04 DOI: 10.1002/mba2.37

Ling Li, Shihong Nie, Ting Du, Jiaxuan Zhao, Xiaoyuan Chen

{"title":"DNA origami technology for biomedical applications: Challenges and opportunities","authors":"Ling Li, Shihong Nie, Ting Du, Jiaxuan Zhao, Xiaoyuan Chen","doi":"10.1002/mba2.37","DOIUrl":"https://doi.org/10.1002/mba2.37","url":null,"abstract":"DNA origami, a promising branch of structural DNA technology, refers to the technique of folding a single-stranded DNA scaffold into well-defined nanostructures. In recent years, DNA origami nanostructures have shown considerable promise in a variety of biomedical applications, owing to their biodegradability, unique programmability, and addressability. Despite their popularity, the biomedical application of DNA origami techniques, which exploits their unique programmability and addressability, is rare in previous studies. Most recently, mounting evidence has demonstrated the robustness of DNA origami nanostructures in the spatial organization of functional components at the nanoscale in the biomedical field. These examples provide typical paradigms to fully realize the potential of DNA origami techniques by taking advantage of their unique programmability and addressability. This minireview summarizes the recent advancements of DNA origami techniques in biosensing, biocatalysis, and drug delivery, and the representative examples using DNA origami nanostructures for the spatial organization of functional molecules with nanometric precision are highlighted. We further discuss the possible limitations and challenges for in vivo applications, including stability issues and potential immunogenicity, and finally, propose some strategies to overcome these obstacles to fully realize the potential of DNA origami techniques in biomedical applications.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.37","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50121163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and intraocular evaluation of cetirizine hydrochloride ophthalmic liposomes and a liposome in situ gel 盐酸西替利嗪眼用脂质体及脂质体原位凝胶的制备及眼内评价

MedComm – Biomaterials and Applications Pub Date : 2023-04-19 DOI: 10.1002/mba2.39

Jing Zhang, Lan Wang, Jianghong Li, Yuhong Guo, Jinxin Chen, Xudong Li, Man Cheng, Bo Feng, Ying Zhang

{"title":"Preparation and intraocular evaluation of cetirizine hydrochloride ophthalmic liposomes and a liposome in situ gel","authors":"Jing Zhang, Lan Wang, Jianghong Li, Yuhong Guo, Jinxin Chen, Xudong Li, Man Cheng, Bo Feng, Ying Zhang","doi":"10.1002/mba2.39","DOIUrl":"https://doi.org/10.1002/mba2.39","url":null,"abstract":"Cetirizine hydrochloride (CTZ), an antiallergic drug, is a new-generation H1 receptor antagonist and a second-generation H1 antihistamine. We aimed to prepare cetirizine hydrochloride liposomes, based on which cetirizine hydrochloride liposomal (CTZL) in situ gel (ISG) was prepared, to improve the retention time in the eye. CTZL were prepared by the ethanol injection method combined with the ammonium sulfate gradient method. A CTZ liposomal temperature-sensitive gel was prepared using the cold dissolution method. Large-eared white rabbits were used in retention and irritation experiments. The liposomes were small single-chambered liposomes, spherical or sphere-like, with a vesicle size of 187.03 ± 6.20 nm, an encapsulation efficiency of 70.39 ± 1.13%, and a drug loading capacity of 4.63 ± 0.06%. The gelling temperatures before and after dilution by simulated tear fluid were 26.1 ± 0.2°C and 34.2 ± 0.2°C, the vesicle size was 184.94 ± 7.28 nm, and the liposomes were spherical or sphere-like in the gel matrix. The in vitro dissolution and release experiments indicate that the gel was released upon dissolution and exhibited a zero-level release pattern. Preparation into liposomes and liposomal gels prolonged the ocular retention time of the formulation without ocular irritation.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.39","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50137455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanotechnology connecting copper metabolism and tumor therapy 连接铜代谢和肿瘤治疗的纳米技术

MedComm – Biomaterials and Applications Pub Date : 2023-04-14 DOI: 10.1002/mba2.36

Yongjuan Li, Ya Dong, Xinyao Zhou, Kelong Fan

{"title":"Nanotechnology connecting copper metabolism and tumor therapy","authors":"Yongjuan Li, Ya Dong, Xinyao Zhou, Kelong Fan","doi":"10.1002/mba2.36","DOIUrl":"https://doi.org/10.1002/mba2.36","url":null,"abstract":"Copper (Cu) is an essential trace element in the human body that is involved in the formation of several natural enzymes, such as superoxide dismutase and cyclooxygenase. Due to the high density of the outer electron cloud of Cu, which allows the transfer of multiple electrons, Cu is often used as the catalytic center in various metabolic enzymes. However, both deficiency and excessive accumulation of Cu can result in irreversible damage to cells. Therefore, strategies to regulate Cu metabolism, such as Cu exhaustion and Cu supplementation, have emerged as attractive approaches in anticancer therapy, due to the potential damages caused by Cu metabolism disorders. Notably, recent advancements in nanotechnology have enabled the development of nanomaterials that can regulate Cu metabolism, making this therapy applicable in vivo. In this review, we provide a systematic discussion of the physical and chemical properties of Cu and summarize the applications of nanotechnology in Cu metabolism-based antitumor therapy. Finally, we outline the future directions and challenges of nano-Cu therapy, emphasizing the scientific problems and technical bottlenecks that need to be addressed for successful clinical translation.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.36","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50132089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent progress in orodispersible films-mediated therapeutic applications: A review 口腔分散膜介导的治疗应用进展

MedComm – Biomaterials and Applications Pub Date : 2023-04-04 DOI: 10.1002/mba2.34

Yu Tian, Jiangtao Lin, Hongshu Jing, Quan Wang, Zhihua Wu, Yourong Duan

{"title":"Recent progress in orodispersible films-mediated therapeutic applications: A review","authors":"Yu Tian, Jiangtao Lin, Hongshu Jing, Quan Wang, Zhihua Wu, Yourong Duan","doi":"10.1002/mba2.34","DOIUrl":"https://doi.org/10.1002/mba2.34","url":null,"abstract":"Orodispersible films (ODFs) as a relatively novel delivery platform have increasingly attracted enormous attention owing to their various advantages compared to conventional oral dosage forms, including fast disintegration, ease of administration without consumption of water, and rapid absorption of incorporated drug, high patient compliance for pediatrics, geriatrics and patients with swallowing difficulties. This review aims to summarize the developments and possibilities that ODFs as the potential carrier for chemical drugs, vaccine, probiotics, and herbal extracts. Especially, with the outbreak of coronavirus disease 2019 (COVID-19), the advantages of ODFs related to ease of transporation and distribution without cold-chain as well as low-cost manufacturing make ODFs a promising carrier for vaccines against COVID-19. Subsequently, the current therapeutic applications of ODFs delivered either locally or systemically for potential patients suffering from various diseases are discussed, including oral inflammation, cardiovascular diseases, pain disorders, nausea and vomiting, mood or mental disorders, erectile dysfunction and pulmonary diseases. Finally, this review provides overview of the novel inkjet printing and three-dimensional printing techniques, and the possibility of extemporaneous preparation for ODFs in hospital pharmacies via printing techniques are discussed as well.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.34","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50126374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Colorimetric detection of SARS-CoV-2 variants with paper-based analytical devices 用纸质分析设备比色法检测严重急性呼吸系统综合征冠状病毒2型变异株

MedComm – Biomaterials and Applications Pub Date : 2023-03-18 DOI: 10.1002/mba2.35

Qi Wang, Zhaowei Chen, Huanghao Yang

引用次数: 0

Nanobiotechnology-mediated radioimmunotherapy treatment for triple-negative breast cancer 纳米生物技术介导的放射性免疫疗法治疗癌症三阴性

MedComm – Biomaterials and Applications Pub Date : 2023-03-14 DOI: 10.1002/mba2.32

Mei Zhu, Xi Yang, Jia You, Lingnan Zheng, Cheng Yi, Ying Huang

{"title":"Nanobiotechnology-mediated radioimmunotherapy treatment for triple-negative breast cancer","authors":"Mei Zhu, Xi Yang, Jia You, Lingnan Zheng, Cheng Yi, Ying Huang","doi":"10.1002/mba2.32","DOIUrl":"https://doi.org/10.1002/mba2.32","url":null,"abstract":"Breast cancer has become the most common and greatest threat to women's health in the world. As the most dangerous subtype of breast cancer, triple-negative breast cancer (TNBC) can lead develop drug resistance, resulting in poor therapeutic effects. The synergistic effect of radiotherapy and immunotherapy can not only improve the therapeutic effect of in situ TNBC but also induce the strong abscopal effect of radiotherapy to remove the tumor cells from the metastatic tumor and prevent tumor recurrence. However, many preclinical studies have pointed out that the application of radioimmunotherapy still has such problems as large toxic and side effects of drugs and asynchronous administration scheme. With the increasing popularity of nanobiotechnology in tumor therapy, there are more and more research results related to nanoparticles, such as inorganic nanoparticles, organic nanoparticles, and nanoparticle–hydrogel complexes in radioimmunotherapy. In this review, we briefly summarize the related clinical treatment methods of TNBC and review the related nanobiotechnology used in the preclinical studies of TNBC radioimmunotherapy. It is mainly characterized by the controlled release of drugs locally, enhanced radiosensitization, and avoidance of systemic toxicity. However, further studies are needed to improve the convenience and effectiveness, so as to explore new options for the clinical treatment of TNBC.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.32","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50150818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomimetic photosynthetic system: Shedding light on the restoration of cell metabolism 仿生光合系统：揭示细胞代谢的恢复

MedComm – Biomaterials and Applications Pub Date : 2023-03-04 DOI: 10.1002/mba2.33

Jiayi Hu, Fangman Chen, Dan Shao

引用次数: 0

Dendrimer and dendrimer gel-derived drug delivery systems: Breaking bottlenecks of topical administration of glaucoma medications 树枝状聚合物和树枝状聚合物凝胶衍生的药物递送系统：打破青光眼药物局部给药的瓶颈

MedComm – Biomaterials and Applications Pub Date : 2023-02-20 DOI: 10.1002/mba2.30

Juan Wang, Boxuan Li, Uday B. Kompella, Hu Yang

{"title":"Dendrimer and dendrimer gel-derived drug delivery systems: Breaking bottlenecks of topical administration of glaucoma medications","authors":"Juan Wang, Boxuan Li, Uday B. Kompella, Hu Yang","doi":"10.1002/mba2.30","DOIUrl":"https://doi.org/10.1002/mba2.30","url":null,"abstract":"Due to high structural flexibility, multidrug carrying capability, and tunable size, dendrimers have been used as suitable carriers for ophthalmic drug delivery. Drug molecules can be either encapsulated or chemically coupled to dendrimers. The nanoscopic size, spheroidal shape, and cationic surface of polyamidoamine (PAMAM) dendrimers promote their interaction with the cornea and result in prolonged precorneal retention. Dendrimers could be further cross-linked to produce three-dimensional hydrogel networks or dendrimer hydrogels (DH). The properties of the DH can be readily adjusted to maintain both fluidity and adhesiveness, making them suitable for developing topical ocular drug formulations. Micro-/nano- sized DHs, that is, dendrimer micro-/nano- gels, have unique properties such as ease of administration, large specific surface area for adhesion, and drug targeting functionalities, making them attractive for ophthalmic drug delivery. This perspective reports advances in PAMAM dendrimer based drug delivery systems including drug conjugates and micro- and nano- gels to enhance and sustain the delivery of multiple anti-glaucoma drugs, Dendrimer and dendrimer gel-derived drug delivery systems hold great potential as multifunctional topical drug delivery systems for the eye.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.30","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50138568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Amphiphilic photosensitizer polymer as a nanocarrier of cytotoxic molecule for carrier-free combination therapy 两亲性光敏剂聚合物作为细胞毒性分子的纳米载体用于无载体联合治疗

MedComm – Biomaterials and Applications Pub Date : 2023-02-09 DOI: 10.1002/mba2.28

Jingqi Xin, Caiting Deng, Meichen Zheng, Feifei An

引用次数: 0