Colorimetric detection of SARS-CoV-2 variants with paper-based analytical devices

Qi Wang, Zhaowei Chen, Huanghao Yang
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引用次数: 0

Abstract

Given that the severe acute respiratory syndrome coronavirus 2 (SRAS-CoV-2) virus keeps mutating during the COVID-19 pandemic, there is an urgent need to develop a quick and convenient test method to detect real-life samples for mass on-site screening. Zhang et al. proposed a novel strategy for rapid detection and discrimination of SARS-CoV-2 and its variants at rather low cost utilizing a subtly designed DNA probe. By combining with a paper-based colorimetric amplification platform, the results could be analyzed by the naked eyes or a widely used smartphone.

Abstract Image

用纸质分析设备比色法检测严重急性呼吸系统综合征冠状病毒2型变异株
鉴于严重急性呼吸综合征冠状病毒2(SRAS-CoV-2)病毒在新冠肺炎大流行期间不断变异,迫切需要开发一种快速方便的检测方法来检测真实样本,以进行大规模现场筛查。张等人提出了一种利用巧妙设计的DNA探针以相当低的成本快速检测和区分严重急性呼吸系统综合征冠状病毒2型及其变体的新策略。通过与纸质比色放大平台相结合,可以通过肉眼或广泛使用的智能手机对结果进行分析。
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