{"title":"Biomimetic photosynthetic system: Shedding light on the restoration of cell metabolism","authors":"Jiayi Hu, Fangman Chen, Dan Shao","doi":"10.1002/mba2.33","DOIUrl":null,"url":null,"abstract":"<p>Specific mature cell membrane camouflaging facilitated the internalization of nanothylakoids through homologous targeting and membrane fusion. Under red light irradiation, the biomimetic nanothylakoids (cell membrane-camouflaged nanoparticulate thylakoids, CM-NTUs) would provide sufficient ATP and increase nicotinamide adenine dinucleotide phosphate (NADPH) to correct energy imbalance to improve metabolic homeostasis through enhancing anabolism in degenerated cells. Consequently, CM-NTUs promoted cartilage homeostasis and remarkedly ameliorated osteoarthritis progression in animals, offering therapeutic avenues for various degenerative diseases.\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"2 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.33","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"MedComm – Biomaterials and Applications","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/mba2.33","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Specific mature cell membrane camouflaging facilitated the internalization of nanothylakoids through homologous targeting and membrane fusion. Under red light irradiation, the biomimetic nanothylakoids (cell membrane-camouflaged nanoparticulate thylakoids, CM-NTUs) would provide sufficient ATP and increase nicotinamide adenine dinucleotide phosphate (NADPH) to correct energy imbalance to improve metabolic homeostasis through enhancing anabolism in degenerated cells. Consequently, CM-NTUs promoted cartilage homeostasis and remarkedly ameliorated osteoarthritis progression in animals, offering therapeutic avenues for various degenerative diseases.
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