{"title":"仿生光合系统：揭示细胞代谢的恢复","authors":"Jiayi Hu, Fangman Chen, Dan Shao","doi":"10.1002/mba2.33","DOIUrl":null,"url":null,"abstract":"<p>Specific mature cell membrane camouflaging facilitated the internalization of nanothylakoids through homologous targeting and membrane fusion. Under red light irradiation, the biomimetic nanothylakoids (cell membrane-camouflaged nanoparticulate thylakoids, CM-NTUs) would provide sufficient ATP and increase nicotinamide adenine dinucleotide phosphate (NADPH) to correct energy imbalance to improve metabolic homeostasis through enhancing anabolism in degenerated cells. Consequently, CM-NTUs promoted cartilage homeostasis and remarkedly ameliorated osteoarthritis progression in animals, offering therapeutic avenues for various degenerative diseases.\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"2 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.33","citationCount":"0","resultStr":"{\"title\":\"Biomimetic photosynthetic system: Shedding light on the restoration of cell metabolism\",\"authors\":\"Jiayi Hu, Fangman Chen, Dan Shao\",\"doi\":\"10.1002/mba2.33\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Specific mature cell membrane camouflaging facilitated the internalization of nanothylakoids through homologous targeting and membrane fusion. Under red light irradiation, the biomimetic nanothylakoids (cell membrane-camouflaged nanoparticulate thylakoids, CM-NTUs) would provide sufficient ATP and increase nicotinamide adenine dinucleotide phosphate (NADPH) to correct energy imbalance to improve metabolic homeostasis through enhancing anabolism in degenerated cells. Consequently, CM-NTUs promoted cartilage homeostasis and remarkedly ameliorated osteoarthritis progression in animals, offering therapeutic avenues for various degenerative diseases.\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure></p>\",\"PeriodicalId\":100901,\"journal\":{\"name\":\"MedComm – Biomaterials and Applications\",\"volume\":\"2 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-03-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.33\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"MedComm – Biomaterials and Applications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/mba2.33\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"MedComm – Biomaterials and Applications","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/mba2.33","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Biomimetic photosynthetic system: Shedding light on the restoration of cell metabolism
Specific mature cell membrane camouflaging facilitated the internalization of nanothylakoids through homologous targeting and membrane fusion. Under red light irradiation, the biomimetic nanothylakoids (cell membrane-camouflaged nanoparticulate thylakoids, CM-NTUs) would provide sufficient ATP and increase nicotinamide adenine dinucleotide phosphate (NADPH) to correct energy imbalance to improve metabolic homeostasis through enhancing anabolism in degenerated cells. Consequently, CM-NTUs promoted cartilage homeostasis and remarkedly ameliorated osteoarthritis progression in animals, offering therapeutic avenues for various degenerative diseases.
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