Mechanobiology in Medicine最新文献_第6页

Mechanobiology of Type 1 hypersensitivity: Elucidating the impacts of mechanical forces in allergic reactions 1 型超敏反应的机械生物学：阐明过敏反应中机械力的影响

Mechanobiology in Medicine Pub Date : 2024-02-01 DOI: 10.1016/j.mbm.2024.100041

Henry Sutanto

{"title":"Mechanobiology of Type 1 hypersensitivity: Elucidating the impacts of mechanical forces in allergic reactions","authors":"Henry Sutanto","doi":"10.1016/j.mbm.2024.100041","DOIUrl":"https://doi.org/10.1016/j.mbm.2024.100041","url":null,"abstract":"<div><p>Type 1 hypersensitivity involves an exaggerated immune reaction triggered by allergen exposure, leading to rapid release of inflammatory mediators. Meanwhile, mechanobiology explores how physical forces influence cellular processes, and recent research underscores its relevance in allergic reactions. This review provides a concise overview of Type 1 hypersensitivity, highlighting the pivotal role of mast cells and immunoglobulin E (IgE) antibodies in orchestrating allergic reactions. Recognizing the dynamic nature of cellular responses in allergies, this study subsequently delves into the emerging field of mechanobiology and its significance in understanding the mechanical forces governing immune cell behavior. Furthermore, molecular forces during mast cell activation and degranulation are explored, elucidating the mechanical aspects of IgE binding and cytoskeletal rearrangements. Next, we discuss the intricate interplay between immune cells and the extracellular matrix, emphasizing the impact of matrix stiffness on cellular responses. Additionally, we examine key mechanosensitive signaling pathways, including the mitogen-activated protein kinase (MAPK) pathway, Rho guanosine triphosphatase (GTPase) and integrin-mediated focal adhesion signaling, shedding light on their contributions to hypersensitivity reactions. This interplay of mechanobiology and Type 1 hypersensitivity provides insights into potential therapeutic targets and biomarkers, paving the way for better clinical management of Type 1 hypersensitivity reactions.</p></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"2 1","pages":"Article 100041"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949907024000044/pdfft?md5=adfe1fafbdc05ac9316b2a18d7522f69&pid=1-s2.0-S2949907024000044-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139682632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in modeling cellular mechanical perceptions and responses via the membrane-cytoskeleton-nucleus machinery 通过膜-细胞骨架-细胞核机制建立细胞机械感知和响应模型的研究进展

Mechanobiology in Medicine Pub Date : 2024-01-26 DOI: 10.1016/j.mbm.2024.100040

Hongyuan Zhu , Run Miao , Jin Wang , Min Lin

{"title":"Advances in modeling cellular mechanical perceptions and responses via the membrane-cytoskeleton-nucleus machinery","authors":"Hongyuan Zhu , Run Miao , Jin Wang , Min Lin","doi":"10.1016/j.mbm.2024.100040","DOIUrl":"10.1016/j.mbm.2024.100040","url":null,"abstract":"<div><p>Mechanical models offer a quantitative framework for understanding scientific problems, predicting novel phenomena, and guiding experimental designs. Over the past few decades, the emerging field of cellular mechanobiology has greatly benefited from the substantial contributions of new theoretical tools grounded in mechanical models. Within the expansive realm of mechanobiology, the investigation of how cells sense and respond to their microenvironment has become a prominent research focus. There is a growing acknowledgment that cells mechanically interact with their external surroundings through an integrated machinery encompassing the cell membrane, cytoskeleton, and nucleus. This review provides a comprehensive overview of mechanical models addressing three pivotal components crucial for force transmission within cells, extending from mechanosensitive receptors on the cell membrane to the actomyosin cytoskeleton and ultimately to the nucleus. We present the existing numerical relationships that form the basis for understanding the structures, mechanical properties, and functions of these components. Additionally, we underscore the significance of developing mechanical models in advancing cellular mechanobiology and propose potential directions for the evolution of these models.</p></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"2 1","pages":"Article 100040"},"PeriodicalIF":0.0,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949907024000032/pdfft?md5=9cc9bc2134b458ce7ef7620179555ecf&pid=1-s2.0-S2949907024000032-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139639812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Substrate topography affects PC12 cell differentiation through mechanotransduction mechanisms 基底形貌通过机械传导机制影响 PC12 细胞分化

Mechanobiology in Medicine Pub Date : 2024-01-24 DOI: 10.1016/j.mbm.2024.100039

Lina Papadimitriou , Anna Karagiannaki , Emmanuel Stratakis , Anthi Ranella

{"title":"Substrate topography affects PC12 cell differentiation through mechanotransduction mechanisms","authors":"Lina Papadimitriou , Anna Karagiannaki , Emmanuel Stratakis , Anthi Ranella","doi":"10.1016/j.mbm.2024.100039","DOIUrl":"10.1016/j.mbm.2024.100039","url":null,"abstract":"<div><p>Neural stem cells <em>in vivo</em> receive information from biochemical and biophysical cues of their microenvironment that affect their survival, proliferation and differentiation toward specific lineages. Recapitulation of these conditions <em>in vitro</em> is better achieved in 3D cell cultures. Especially the cells that grow in scaffold-dependent 3D cultures establish more complex cell–cell and cell–material interactions enabling the study of the various signaling pathways. The biochemical signaling from growth factors and hormones has been extensively studied over the years. More recently cumulative evidence demonstrates that cell sensing and response to mechanical stimuli is mediated through mechanotransduction pathways. Although individual signaling pathways activated by biochemical or mechanical cues in cells are well-studied, synergistic or antagonistic effects among them need further research to be fully understood. The understanding of the alteration of the cell behavior due to a microenvironmental cues would be greatly enhanced by the study of key elements that lie in the convergence of biochemical and mechanical pathways. Here we analyzed the effect of the substrate topography on the nerve growth factor (NGF) induced differentiation of PC12 cells. Our results showed that the topography interferes with NGF-induced neuronal differentiation and this is reflected in the reduced activation of the integrin-mediated mechanotransduction.</p></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"2 1","pages":"Article 100039"},"PeriodicalIF":0.0,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949907024000020/pdfft?md5=be7ebdbcd5a269d3f2d18d7fc317d4a6&pid=1-s2.0-S2949907024000020-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139632810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomechanical modeling of cell chirality and symmetry breaking of biological systems 细胞手性和生物系统对称性破坏的生物力学建模

Mechanobiology in Medicine Pub Date : 2024-01-05 DOI: 10.1016/j.mbm.2024.100038

Tasnif Rahman , Frank D. Peters , Leo Q. Wan

{"title":"Biomechanical modeling of cell chirality and symmetry breaking of biological systems","authors":"Tasnif Rahman , Frank D. Peters , Leo Q. Wan","doi":"10.1016/j.mbm.2024.100038","DOIUrl":"10.1016/j.mbm.2024.100038","url":null,"abstract":"<div><p>Accumulating evidence strongly suggests that cell chirality plays a pivotal role in driving left-right (LR) symmetry breaking, a widespread phenomenon in living organisms. Whole embryos and excised organs have historically been employed to investigate LR symmetry breaking and have yielded exciting findings. In recent years, <em>in vitro</em> engineered platforms have emerged as powerful tools to reveal cellular chiral biases and led to uncovering molecular and biophysical insights into chiral morphogenesis, including the significant role of the actin cytoskeleton. Establishing a link between observed <em>in vivo</em> tissue chiral morphogenesis and the determined chiral bias of cells <em>in vitro</em> has become increasingly important. In this regard, computational mathematical models hold immense value as they can explain and predict tissue morphogenic behavior based on the chiral biases of individual cells. Here, we present the formulations and discoveries achieved using various computational models spanning different biological scales, from the molecular and cellular levels to tissue and organ levels. Furthermore, we offer insights into future directions and the role of such models in advancing the study of asymmetric cellular mechanobiology.</p></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"2 1","pages":"Article 100038"},"PeriodicalIF":0.0,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949907024000019/pdfft?md5=f838dfd35608eeaeb7fe4453dd63f3b3&pid=1-s2.0-S2949907024000019-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139393664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role and potential therapeutic strategies of matrix mechanics for optimizing tumor radiotherapy 基质力学对优化肿瘤放疗的作用和潜在治疗策略

Mechanobiology in Medicine Pub Date : 2023-12-19 DOI: 10.1016/j.mbm.2023.100037

Yaxin Deng , Guobao Chen , Jiali Xiao , Hong Deng

{"title":"Role and potential therapeutic strategies of matrix mechanics for optimizing tumor radiotherapy","authors":"Yaxin Deng , Guobao Chen , Jiali Xiao , Hong Deng","doi":"10.1016/j.mbm.2023.100037","DOIUrl":"10.1016/j.mbm.2023.100037","url":null,"abstract":"<div><p>Radiation therapy is one of the most effective therapeutic modalities for tumors. The changes in matrix stiffness of tumors and associated tissues are important consequences of side effects after radiotherapy. They are documented to induce the radio-resistance of cancer cells and promote the recurrence and metastasis of tumors, resulting in poor patient prognosis. Identifying the relationship between radiation and matrix stiffness is beneficial to optimize clinical treatment schemes and ultimately improve the patient prognosis. Herein, this review includes knowledge regarding the specific cellular, molecular processes and relevant clinical factors of the changes in matrix stiffness of tumors or associated tissues induced by radiation. The effects of altered matrix stiffness on the behaviors of cancer cells and associated normal cells are further detailed. It also reviews literatures to elucidate the mechanical signal transduction mechanism in radiotherapy and proposes some strategies to enhance the efficacy of radiotherapy based on matrix mechanics.</p></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"2 1","pages":"Article 100037"},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949907023000372/pdfft?md5=a7bfabed7a16a217dbd63f6b782d4d68&pid=1-s2.0-S2949907023000372-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139019662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Osteoinductive intramedullary implant as an adjunctive therapy for bone transport: A promising approach to accelerate bone defect healing 骨诱导髓内种植体作为骨运输的辅助治疗:一种有希望的加速骨缺损愈合的方法

Mechanobiology in Medicine Pub Date : 2023-11-04 DOI: 10.1016/j.mbm.2023.100030

Yuejun Lin , Jiaming Yang , Gang Li

引用次数: 0

Cell mechanics in early vertebrate development: Yap mechanotransduction controls notochord formation and neural tube patterning 早期脊椎动物发育中的细胞力学:Yap机械转导控制脊索形成和神经管模式

Mechanobiology in Medicine Pub Date : 2023-11-01 DOI: 10.1016/j.mbm.2023.100029

Zheng Guo, Jing Du

引用次数: 0

Topographical cues of biomaterials and fibroblast activation: Are they related? 生物材料的地形线索和成纤维细胞的激活:它们是否相关?

Mechanobiology in Medicine Pub Date : 2023-10-31 DOI: 10.1016/j.mbm.2023.100028

Zuhan Chen, Huanjing Bi, Xiaoming Ding

引用次数: 0

Mechanical constraints in tumor guide emergent spatial patterns of glioblastoma cancer stem cells 肿瘤的机械约束引导胶质母细胞瘤肿瘤干细胞涌现的空间模式

Mechanobiology in Medicine Pub Date : 2023-10-29 DOI: 10.1016/j.mbm.2023.100027

Ngoc Luu , Shuhao Zhang , Raymond H.W. Lam , Weiqiang Chen

{"title":"Mechanical constraints in tumor guide emergent spatial patterns of glioblastoma cancer stem cells","authors":"Ngoc Luu , Shuhao Zhang , Raymond H.W. Lam , Weiqiang Chen","doi":"10.1016/j.mbm.2023.100027","DOIUrl":"10.1016/j.mbm.2023.100027","url":null,"abstract":"<div><p>The mechanical constraints in the overcrowding glioblastoma (GBM) microenvironment have been implicated in the regulation of tumor heterogeneity and disease progression. Especially, such mechanical cues can alter cellular DNA transcription and give rise to a subpopulation of tumor cells called cancer stem cells (CSCs). These CSCs with stem-like properties are critical drivers of tumorigenesis, metastasis, and treatment resistance. Yet, the biophysical and molecular machinery underlying the emergence of CSCs in tumor remained unexplored. This work employed a two-dimensional micropatterned multicellular model to examine the impact of mechanical constraints arisen from geometric confinement on the emergence and spatial patterning of CSCs in GBM tumor. Our study identified distinct spatial distributions of GBM CSCs in different geometric patterns, where CSCs mostly emerged in the peripheral regions. The spatial pattern of CSCs was found to correspond to the gradients of mechanical stresses resulted from the interplay between the cell-ECM and cell–cell interactions within the confined environment. Further mechanistic study highlighted a Piezo1-RhoA-focal adhesion signaling axis in regulating GBM cell mechanosensing and the subsequent CSC phenotypic transformation. These findings provide new insights into the biophysical origin of the unique spatial pattern of CSCs in GBM tumor and offer potential avenues for targeted therapeutic interventions.</p></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"2 1","pages":"Article 100027"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S294990702300027X/pdfft?md5=8cb1fdcefd8d046399822b671fd596bc&pid=1-s2.0-S294990702300027X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136127636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differentiation potential of periodontal Col1+ cells under orthodontic force 正畸力作用下牙周Col1+细胞的分化潜能

Mechanobiology in Medicine Pub Date : 2023-10-29 DOI: 10.1016/j.mbm.2023.100026

Xinyu Wang , Xiangru Huang , Xin Gao , Hongyuan Xu , Anting Jin , Xijun Wang , Siyuan Sun , Yuanqi Liu , Yanfei Zhu , Jingyi Liu , Tingwei Lu , Qinggang Dai , Lingyong Jiang

{"title":"Differentiation potential of periodontal Col1+ cells under orthodontic force","authors":"Xinyu Wang , Xiangru Huang , Xin Gao , Hongyuan Xu , Anting Jin , Xijun Wang , Siyuan Sun , Yuanqi Liu , Yanfei Zhu , Jingyi Liu , Tingwei Lu , Qinggang Dai , Lingyong Jiang","doi":"10.1016/j.mbm.2023.100026","DOIUrl":"10.1016/j.mbm.2023.100026","url":null,"abstract":"<div><p>Mechanical force often has clear effects on tissue niche remodeling. However, the changes in stem cells and their roles in clinical treatment remain unclear. Orthodontic tooth movement (OTM), the primary approach to treating dental-maxillofacial malformations, involves reconstruction of periodontal tissue. Herein, lineage tracing revealed that Col1<sup>+</sup> cells are distributed in the periodontal ligament and are sensitive to mechanical forces during OTM. Immunofluorescence analysis confirms that Col1<sup>+</sup> cells can differentiate into osteoblasts and fibroblasts under orthodontic force. Moreover, Col1<sup>+</sup> cells may be involved in angiogenesis. These findings suggest that Col1<sup>+</sup> cells play a crucial role in the mechanical remodeling of periodontal tissue during OTM and may serve as a valuable tool for studying the mechanism of OTM.</p></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"2 1","pages":"Article 100026"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949907023000268/pdfft?md5=a787cc765ac64da96728b3ec8e94edbf&pid=1-s2.0-S2949907023000268-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136154022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0