Mechanobiology in Medicine最新文献_第9页

Probing the protrusions: lamellipodia and filopodia in cancer invasion and beyond 探究突起：癌症侵袭及其他过程中的片状和丝状突起

Mechanobiology in Medicine Pub Date : 2024-06-01 Epub Date: 2024-03-20 DOI: 10.1016/j.mbm.2024.100064

Laras Pratiwi, Elisa Elisa, Henry Sutanto

{"title":"Probing the protrusions: lamellipodia and filopodia in cancer invasion and beyond","authors":"Laras Pratiwi, Elisa Elisa, Henry Sutanto","doi":"10.1016/j.mbm.2024.100064","DOIUrl":"https://doi.org/10.1016/j.mbm.2024.100064","url":null,"abstract":"<div><p>The dynamic protrusions of lamellipodia and filopodia have emerged as crucial players in tumor progression and metastasis. These membrane structures, governed by intricate actin cytoskeletal rearrangements, facilitate cancer cell migration, invasion, and interaction with the tumor microenvironment. This review provides a comprehensive examination of the structural and functional attributes of lamellipodia and filopodia, shedding light on their pivotal roles in mediating cancer invasion. Navigating through the intricate landscape of cancer biology, the review illuminates the intricate signaling pathways and regulatory mechanisms orchestrating the formation and activity of these protrusions. The discussion extends to the clinical implications of lamellipodia and filopodia, exploring their potential as diagnostic and prognostic markers, and delving into therapeutic strategies that target these structures to impede cancer progression. As we delve into the future, the review outlines emerging technologies and unexplored facets that beckon further research, emphasizing the need for collaborative efforts to unravel the complexities of lamellipodia and filopodia in cancer, ultimately paving the way for innovative therapeutic interventions.</p></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"2 2","pages":"Article 100064"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949907024000275/pdfft?md5=5e8e0610146b04739a39d45afef98e3d&pid=1-s2.0-S2949907024000275-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140209064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanics of serotonin-producing human entero-endocrine cells 分泌羟色胺的人类肠内分泌细胞的机理

Mechanobiology in Medicine Pub Date : 2024-06-01 Epub Date: 2024-02-08 DOI: 10.1016/j.mbm.2024.100044

Tom M.J. Evers , Joep Beumer , Hans Clevers , Alireza Mashaghi

引用次数: 0

Mechanotransduction in subchondral bone microenvironment and targeted interventions for osteoarthritis 软骨下骨微环境中的机制传导和骨关节炎的靶向干预措施

Mechanobiology in Medicine Pub Date : 2024-06-01 Epub Date: 2024-02-05 DOI: 10.1016/j.mbm.2024.100043

Rui Feng , Wenhui Hu , Yuheng Li , Xuan Yao , Jianmei Li , Xiaoming Li , Jing Zhang , Yu Wu , Fei Kang , Shiwu Dong

{"title":"Mechanotransduction in subchondral bone microenvironment and targeted interventions for osteoarthritis","authors":"Rui Feng , Wenhui Hu , Yuheng Li , Xuan Yao , Jianmei Li , Xiaoming Li , Jing Zhang , Yu Wu , Fei Kang , Shiwu Dong","doi":"10.1016/j.mbm.2024.100043","DOIUrl":"10.1016/j.mbm.2024.100043","url":null,"abstract":"<div><p>Osteoarthritis (OA) is a progressive degenerative joint sickness related with mechanics, obesity, ageing, <em>etc</em>., mainly characterized by cartilage degeneration, subchondral bone damage and synovium inflammation. Coordinated mechanical absorption and conduction of the joint play significant roles in the prevalence and development of OA. Subchondral bone is generally considered a load-burdening tissue where mechanosensitive cells are resident, including osteocytes, osteoblast lineage cells, and osteoclast lineage cells (especially less concerned in mechanical studies). Mechano-signaling imbalances affect complicated cellular events and disorders of subchondral bone homeostasis. This paper will focus on the significance of mechanical force as the pathogenesis, involvement of various mechanical force patterns in mechanosensitive cells, and mechanobiology research of loading devices <em>in vitro</em> and <em>in vivo</em>, which are further discussed. Additionally, various mechanosensing structures (<em>e.g</em>., transient receptor potential channels, gap junctions, primary cilia, podosome-associated complexes, extracellular vesicles) and mechanotransduction signaling pathways (<em>e.g</em>., Ca<sup>2+</sup> signaling, Wnt/β-catenin, RhoA GTPase, focal adhesion kinase, cotranscriptional activators YAP/TAZ) in mechanosensitive bone cells. Finally, we highlight potential targets for improving mechanoprotection in the treatment of OA. These advances furnish an integration of mechanical regulation of subchondral bone homeostasis, as well as OA therapeutic approaches by modulating mechanical homeostasis.</p></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"2 2","pages":"Article 100043"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949907024000068/pdfft?md5=2456e3a7b55c2a6f548d64379791d3e8&pid=1-s2.0-S2949907024000068-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139817437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of matrix stiffness on immune cells in bone biology 骨生物学中基质硬度对免疫细胞的影响

Mechanobiology in Medicine Pub Date : 2024-06-01 Epub Date: 2024-02-22 DOI: 10.1016/j.mbm.2024.100046

Ting Jiang , Meng-Ting Zheng , Ruo-Mei Li , Ning-Juan Ouyang

{"title":"The effects of matrix stiffness on immune cells in bone biology","authors":"Ting Jiang , Meng-Ting Zheng , Ruo-Mei Li , Ning-Juan Ouyang","doi":"10.1016/j.mbm.2024.100046","DOIUrl":"10.1016/j.mbm.2024.100046","url":null,"abstract":"<div><p>Bone and immune cells typically inhabit the same microenvironment and engage in mutual interactions to collectively execute the functions of the “osteoimmune system.” Establishing a harmonized and enduring osteoimmune system significantly enhances bone regeneration, necessitating the maintenance of bone and immune homeostasis. Recently, mechanobiology has garnered increasing interest in bone tissue engineering, with matrix stiffness emerging as a crucial parameter that has been extensively investigated. The effect of matrix stiffness on bone homeostasis remains relatively clear. Soft substrates tend to significantly affect the chondrogenic differentiation of bone marrow mesenchymal stem cells, whereas increasing matrix stiffness is advantageous for osteogenic differentiation. Increased stiffness increases osteoclast differentiation and activity. Additionally, there is increasing emphasis on immune homeostasis, which necessitates dynamic communication between immune cells. Immune cells are crucial in initiating bone regeneration and driving early inflammatory responses. Functional changes induced by matrix stiffness are pivotal for determining the outcomes of engineered tissue mimics. However, inconsistent and incomparable findings regarding the responses of different immune cells to matrix stiffness can be perplexing owing to variations in the stiffness range, measurement methods, and other factors. Therefore, this study aimed to provide a comprehensive review of the specific effects of matrix stiffness on diverse immune cells, with a particular focus on its implications for bone regeneration, which would offer theoretical insights into the treatment of large segmental bony defects and assist in the clinical development of new engineering strategies.</p></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"2 2","pages":"Article 100046"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949907024000093/pdfft?md5=32830fd5ccb0440aa455483d1f52a402&pid=1-s2.0-S2949907024000093-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140465958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rescuing SERCA2 pump deficiency: A novel approach to improve bone mechano-responsiveness in type 2 diabetes 挽救 SERCA2 泵缺陷：改善 2 型糖尿病患者骨骼机械反应性的新方法

Mechanobiology in Medicine Pub Date : 2024-06-01 Epub Date: 2024-02-24 DOI: 10.1016/j.mbm.2024.100047

Zhifeng Yu , X. Edward Guo

{"title":"Rescuing SERCA2 pump deficiency: A novel approach to improve bone mechano-responsiveness in type 2 diabetes","authors":"Zhifeng Yu , X. Edward Guo","doi":"10.1016/j.mbm.2024.100047","DOIUrl":"https://doi.org/10.1016/j.mbm.2024.100047","url":null,"abstract":"<div><p>A recent study published in <em>Nature Communications</em> demonstrated that restoring SERCA2 pump deficiency can enhance bone mechano-responsiveness in type 2 diabetes (T2D) by modulating osteocyte calcium dynamics. The findings revealed that in T2D mice, the ability of the bone to respond to mechanical stress is compromised, primarily due to attenuated calcium oscillatory dynamics within osteocytes rather than in osteoblasts or osteoclasts. The underlying mechanism of this reduction in bone mechano-responsiveness in T2D was identified as a specific decrease in osteocytic SERCA2 expression mediated by PPARα. Additionally, mice overexpressing SERCA2 in osteocytes exhibited reduced deterioration of bone mechano-responsiveness induced by T2D. Collectively, this study provides mechanistic insights into T2D-induced deterioration in bone mechano-responsiveness and identifies a promising therapeutic approach to counteract T2D-associated fragility fractures.</p></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"2 2","pages":"Article 100047"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S294990702400010X/pdfft?md5=673fabd07f7fc63f32f1485c817369bc&pid=1-s2.0-S294990702400010X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140112983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The roles of extracellular vesicles released by mechanically stimulated osteocytes in regulating osteoblast and osteoclast functions 机械刺激骨细胞释放的细胞外小泡在调控成骨细胞和破骨细胞功能中的作用

Mechanobiology in Medicine Pub Date : 2024-06-01 Epub Date: 2024-03-27 DOI: 10.1016/j.mbm.2024.100065

Yumei Chen , Runze Zhao , Li Yang , X. Edward Guo

{"title":"The roles of extracellular vesicles released by mechanically stimulated osteocytes in regulating osteoblast and osteoclast functions","authors":"Yumei Chen , Runze Zhao , Li Yang , X. Edward Guo","doi":"10.1016/j.mbm.2024.100065","DOIUrl":"10.1016/j.mbm.2024.100065","url":null,"abstract":"<div><p>Bone adapts to mechanical loading by changing its shape and mass. Osteocytes, as major mechanosensors, are critical for bone modeling/remodeling in response to mechanical stimuli. Intracellular calcium oscillation is one of the early responses in osteocytes, and this further facilitates bone cell communication through released biochemical signals. Our previous study has found that mechanically induced calcium oscillations in osteocytes enhance the release of extracellular vesicles (EVs), and those released EVs can elevate bone formation activity. However, the mechanism of mechanically stimulated EVs’ regulation of bone formation and resorption is still unclear. Here, using <em>in vitro</em> studies, we exposed OCY454 cells, with relatively high sclerostin expression, to steady fluid flow (SFF) and characterized the functions of rapidly released EVs in osteoblast and osteoclast regulation. Our study demonstrates that SFF stimulates intracellular calcium response in OCY454 cells and further induces sclerostin, osteoprotegerin (OPG), receptor activator of NF-κB ligand (RANKL) inside or outside EVs to regulate osteoblast and osteoclast activities. This load-induced protein and EVs release is load-duration dependent. Moreover, stimulated osteocytes rapidly regulate osteoclast maturation through EVs capsulated RANKL. In contrast, other regulating proteins, OPG, and sclerostin, are mainly released directly into the medium without EV capsulation.</p></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"2 2","pages":"Article 100065"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949907024000287/pdfft?md5=e2faf11abd74c6b1e6ba230c7caae064&pid=1-s2.0-S2949907024000287-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140400797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular matrix stiffness modulates the mechanophenotypes and focal adhesions of colon cancer cells leading to their invasions via YAP1 细胞外基质硬度通过 YAP1 调节结肠癌细胞的机械表型和病灶粘附，从而导致其侵袭

Mechanobiology in Medicine Pub Date : 2024-06-01 Epub Date: 2024-03-19 DOI: 10.1016/j.mbm.2024.100062

Kaide Xia , Wenhui Hu , Yun Wang , Jin Chen , Zuquan Hu , Chenyi An , Pu Xu , Lijing Teng , Jieheng Wu , Lina Liu , Sichao Zhang , Jinhua Long , Zhu Zeng

{"title":"Extracellular matrix stiffness modulates the mechanophenotypes and focal adhesions of colon cancer cells leading to their invasions via YAP1","authors":"Kaide Xia , Wenhui Hu , Yun Wang , Jin Chen , Zuquan Hu , Chenyi An , Pu Xu , Lijing Teng , Jieheng Wu , Lina Liu , Sichao Zhang , Jinhua Long , Zhu Zeng","doi":"10.1016/j.mbm.2024.100062","DOIUrl":"10.1016/j.mbm.2024.100062","url":null,"abstract":"<div><p>Distal metastasis is the main cause of clinical treatment failure in patients with colon cancer. It is now known that the invasion and metastasis of cancer cells is precisely regulated by chemical and physical factors <em>in vivo</em>. However, the role of extracellular matrix (ECM) stiffness in colon cancer cell (CCCs) invasion and metastasis remains unclear. Here, bioinformatical analysis suggested that a high expression level of yes associated protein 1 (YAP1) was significantly associated with metastasis and poor prognosis in colon cancer patients. We further investigated the effects of polyacrylamide hydrogels with different stiffnesses (3, 20, and 38 kPa), which were simulated as ECM, on the mechanophenotype (F-actin cytoskeleton organization, electrophoretic rate, membrane fluidity, and Young's modulus) of CCCs. The results showed that a stiffer ECM could induce the maturation of focal adhesions and formation of stress fibers in CCCs, regulate their mechanophenotypes, and promote cell motility. We also demonstrated that the expression levels of YAP1 and paxillin were positively correlated in patients with colon cancer. YAP1 knockdown reduces paxillin clustering and cell motility and alters the cellular mechanophenotypes of CCCs. This is of great significance for an in-depth understanding of the invasion and metastatic mechanisms of colon cancer and for the optimization of clinical therapy from the perspective of mechanobiology.</p></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"2 2","pages":"Article 100062"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949907024000251/pdfft?md5=8225712552eb8e5633ae7b59efe64ce1&pid=1-s2.0-S2949907024000251-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140280551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulatory role of interfacial adhesion and mechanical microenvironments in microbe-host interactions 界面粘附和机械微环境在微生物-宿主相互作用中的调节作用

Mechanobiology in Medicine Pub Date : 2024-06-01 Epub Date: 2024-03-01 DOI: 10.1016/j.mbm.2024.100060

Yuting Feng, Jianyong Huang

{"title":"Regulatory role of interfacial adhesion and mechanical microenvironments in microbe-host interactions","authors":"Yuting Feng, Jianyong Huang","doi":"10.1016/j.mbm.2024.100060","DOIUrl":"10.1016/j.mbm.2024.100060","url":null,"abstract":"<div><p>A recent study published in <em>Nature Communications</em> showed that essential modulatory roles of interfacial adhesion and mechanical microenvironments such as geometric constraints and extracellular matrix stiffness, in microbe-host cell interactions. This study utilized single-cell force spectroscopy and RNA sequencing to gain insight into the intrinsic mechanisms by which the mechanical microenvironment regulates bacterial-host interactions and therefore reveal potential interventions against bacterial invasion. Meanwhile, the adhesion forces involved in the bacterial–host interactions were recognized as a new indicator for assessing the extent of bacterial infection. Taken together, these findings demonstrate that interfacial adhesion forces and mechanical microenvironments play a dominant role in modulating functions and behaviors of microorganisms and host cells, which also provide a mechanobiology-inspired idea for the development of subsequent drug-resistant antimicrobials and broad-spectrum antiviral drugs.</p></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"2 2","pages":"Article 100060"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949907024000238/pdfft?md5=5a9dc4292dc1bffe61407088d51445eb&pid=1-s2.0-S2949907024000238-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140084375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical constraints in tumor guide emergent spatial patterns of glioblastoma cancer stem cells 肿瘤的机械约束引导胶质母细胞瘤肿瘤干细胞涌现的空间模式

Mechanobiology in Medicine Pub Date : 2024-03-01 Epub Date: 2023-10-29 DOI: 10.1016/j.mbm.2023.100027

Ngoc Luu , Shuhao Zhang , Raymond H.W. Lam , Weiqiang Chen

{"title":"Mechanical constraints in tumor guide emergent spatial patterns of glioblastoma cancer stem cells","authors":"Ngoc Luu , Shuhao Zhang , Raymond H.W. Lam , Weiqiang Chen","doi":"10.1016/j.mbm.2023.100027","DOIUrl":"10.1016/j.mbm.2023.100027","url":null,"abstract":"<div><p>The mechanical constraints in the overcrowding glioblastoma (GBM) microenvironment have been implicated in the regulation of tumor heterogeneity and disease progression. Especially, such mechanical cues can alter cellular DNA transcription and give rise to a subpopulation of tumor cells called cancer stem cells (CSCs). These CSCs with stem-like properties are critical drivers of tumorigenesis, metastasis, and treatment resistance. Yet, the biophysical and molecular machinery underlying the emergence of CSCs in tumor remained unexplored. This work employed a two-dimensional micropatterned multicellular model to examine the impact of mechanical constraints arisen from geometric confinement on the emergence and spatial patterning of CSCs in GBM tumor. Our study identified distinct spatial distributions of GBM CSCs in different geometric patterns, where CSCs mostly emerged in the peripheral regions. The spatial pattern of CSCs was found to correspond to the gradients of mechanical stresses resulted from the interplay between the cell-ECM and cell–cell interactions within the confined environment. Further mechanistic study highlighted a Piezo1-RhoA-focal adhesion signaling axis in regulating GBM cell mechanosensing and the subsequent CSC phenotypic transformation. These findings provide new insights into the biophysical origin of the unique spatial pattern of CSCs in GBM tumor and offer potential avenues for targeted therapeutic interventions.</p></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"2 1","pages":"Article 100027"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S294990702300027X/pdfft?md5=8cb1fdcefd8d046399822b671fd596bc&pid=1-s2.0-S294990702300027X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136127636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differentiation potential of periodontal Col1+ cells under orthodontic force 正畸力作用下牙周Col1+细胞的分化潜能

Mechanobiology in Medicine Pub Date : 2024-03-01 Epub Date: 2023-10-29 DOI: 10.1016/j.mbm.2023.100026

Xinyu Wang , Xiangru Huang , Xin Gao , Hongyuan Xu , Anting Jin , Xijun Wang , Siyuan Sun , Yuanqi Liu , Yanfei Zhu , Jingyi Liu , Tingwei Lu , Qinggang Dai , Lingyong Jiang

{"title":"Differentiation potential of periodontal Col1+ cells under orthodontic force","authors":"Xinyu Wang , Xiangru Huang , Xin Gao , Hongyuan Xu , Anting Jin , Xijun Wang , Siyuan Sun , Yuanqi Liu , Yanfei Zhu , Jingyi Liu , Tingwei Lu , Qinggang Dai , Lingyong Jiang","doi":"10.1016/j.mbm.2023.100026","DOIUrl":"10.1016/j.mbm.2023.100026","url":null,"abstract":"<div><p>Mechanical force often has clear effects on tissue niche remodeling. However, the changes in stem cells and their roles in clinical treatment remain unclear. Orthodontic tooth movement (OTM), the primary approach to treating dental-maxillofacial malformations, involves reconstruction of periodontal tissue. Herein, lineage tracing revealed that Col1<sup>+</sup> cells are distributed in the periodontal ligament and are sensitive to mechanical forces during OTM. Immunofluorescence analysis confirms that Col1<sup>+</sup> cells can differentiate into osteoblasts and fibroblasts under orthodontic force. Moreover, Col1<sup>+</sup> cells may be involved in angiogenesis. These findings suggest that Col1<sup>+</sup> cells play a crucial role in the mechanical remodeling of periodontal tissue during OTM and may serve as a valuable tool for studying the mechanism of OTM.</p></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"2 1","pages":"Article 100026"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949907023000268/pdfft?md5=a787cc765ac64da96728b3ec8e94edbf&pid=1-s2.0-S2949907023000268-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136154022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0