Mechanobiology in Medicine最新文献_第8页

Role and potential therapeutic strategies of matrix mechanics for optimizing tumor radiotherapy 基质力学对优化肿瘤放疗的作用和潜在治疗策略

Mechanobiology in Medicine Pub Date : 2023-12-19 DOI: 10.1016/j.mbm.2023.100037

Yaxin Deng , Guobao Chen , Jiali Xiao , Hong Deng

{"title":"Role and potential therapeutic strategies of matrix mechanics for optimizing tumor radiotherapy","authors":"Yaxin Deng , Guobao Chen , Jiali Xiao , Hong Deng","doi":"10.1016/j.mbm.2023.100037","DOIUrl":"10.1016/j.mbm.2023.100037","url":null,"abstract":"<div><p>Radiation therapy is one of the most effective therapeutic modalities for tumors. The changes in matrix stiffness of tumors and associated tissues are important consequences of side effects after radiotherapy. They are documented to induce the radio-resistance of cancer cells and promote the recurrence and metastasis of tumors, resulting in poor patient prognosis. Identifying the relationship between radiation and matrix stiffness is beneficial to optimize clinical treatment schemes and ultimately improve the patient prognosis. Herein, this review includes knowledge regarding the specific cellular, molecular processes and relevant clinical factors of the changes in matrix stiffness of tumors or associated tissues induced by radiation. The effects of altered matrix stiffness on the behaviors of cancer cells and associated normal cells are further detailed. It also reviews literatures to elucidate the mechanical signal transduction mechanism in radiotherapy and proposes some strategies to enhance the efficacy of radiotherapy based on matrix mechanics.</p></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"2 1","pages":"Article 100037"},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949907023000372/pdfft?md5=a7bfabed7a16a217dbd63f6b782d4d68&pid=1-s2.0-S2949907023000372-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139019662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Osteoinductive intramedullary implant as an adjunctive therapy for bone transport: A promising approach to accelerate bone defect healing 骨诱导髓内种植体作为骨运输的辅助治疗:一种有希望的加速骨缺损愈合的方法

Mechanobiology in Medicine Pub Date : 2023-11-04 DOI: 10.1016/j.mbm.2023.100030

Yuejun Lin , Jiaming Yang , Gang Li

引用次数: 0

Cell mechanics in early vertebrate development: Yap mechanotransduction controls notochord formation and neural tube patterning 早期脊椎动物发育中的细胞力学:Yap机械转导控制脊索形成和神经管模式

Mechanobiology in Medicine Pub Date : 2023-11-01 DOI: 10.1016/j.mbm.2023.100029

Zheng Guo, Jing Du

引用次数: 0

Topographical cues of biomaterials and fibroblast activation: Are they related? 生物材料的地形线索和成纤维细胞的激活:它们是否相关?

Mechanobiology in Medicine Pub Date : 2023-10-31 DOI: 10.1016/j.mbm.2023.100028

Zuhan Chen, Huanjing Bi, Xiaoming Ding

引用次数: 0

Mechanical constraints in tumor guide emergent spatial patterns of glioblastoma cancer stem cells 肿瘤的机械约束引导胶质母细胞瘤肿瘤干细胞涌现的空间模式

Mechanobiology in Medicine Pub Date : 2023-10-29 DOI: 10.1016/j.mbm.2023.100027

Ngoc Luu , Shuhao Zhang , Raymond H.W. Lam , Weiqiang Chen

{"title":"Mechanical constraints in tumor guide emergent spatial patterns of glioblastoma cancer stem cells","authors":"Ngoc Luu , Shuhao Zhang , Raymond H.W. Lam , Weiqiang Chen","doi":"10.1016/j.mbm.2023.100027","DOIUrl":"10.1016/j.mbm.2023.100027","url":null,"abstract":"<div><p>The mechanical constraints in the overcrowding glioblastoma (GBM) microenvironment have been implicated in the regulation of tumor heterogeneity and disease progression. Especially, such mechanical cues can alter cellular DNA transcription and give rise to a subpopulation of tumor cells called cancer stem cells (CSCs). These CSCs with stem-like properties are critical drivers of tumorigenesis, metastasis, and treatment resistance. Yet, the biophysical and molecular machinery underlying the emergence of CSCs in tumor remained unexplored. This work employed a two-dimensional micropatterned multicellular model to examine the impact of mechanical constraints arisen from geometric confinement on the emergence and spatial patterning of CSCs in GBM tumor. Our study identified distinct spatial distributions of GBM CSCs in different geometric patterns, where CSCs mostly emerged in the peripheral regions. The spatial pattern of CSCs was found to correspond to the gradients of mechanical stresses resulted from the interplay between the cell-ECM and cell–cell interactions within the confined environment. Further mechanistic study highlighted a Piezo1-RhoA-focal adhesion signaling axis in regulating GBM cell mechanosensing and the subsequent CSC phenotypic transformation. These findings provide new insights into the biophysical origin of the unique spatial pattern of CSCs in GBM tumor and offer potential avenues for targeted therapeutic interventions.</p></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"2 1","pages":"Article 100027"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S294990702300027X/pdfft?md5=8cb1fdcefd8d046399822b671fd596bc&pid=1-s2.0-S294990702300027X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136127636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differentiation potential of periodontal Col1+ cells under orthodontic force 正畸力作用下牙周Col1+细胞的分化潜能

Mechanobiology in Medicine Pub Date : 2023-10-29 DOI: 10.1016/j.mbm.2023.100026

Xinyu Wang , Xiangru Huang , Xin Gao , Hongyuan Xu , Anting Jin , Xijun Wang , Siyuan Sun , Yuanqi Liu , Yanfei Zhu , Jingyi Liu , Tingwei Lu , Qinggang Dai , Lingyong Jiang

{"title":"Differentiation potential of periodontal Col1+ cells under orthodontic force","authors":"Xinyu Wang , Xiangru Huang , Xin Gao , Hongyuan Xu , Anting Jin , Xijun Wang , Siyuan Sun , Yuanqi Liu , Yanfei Zhu , Jingyi Liu , Tingwei Lu , Qinggang Dai , Lingyong Jiang","doi":"10.1016/j.mbm.2023.100026","DOIUrl":"10.1016/j.mbm.2023.100026","url":null,"abstract":"<div><p>Mechanical force often has clear effects on tissue niche remodeling. However, the changes in stem cells and their roles in clinical treatment remain unclear. Orthodontic tooth movement (OTM), the primary approach to treating dental-maxillofacial malformations, involves reconstruction of periodontal tissue. Herein, lineage tracing revealed that Col1<sup>+</sup> cells are distributed in the periodontal ligament and are sensitive to mechanical forces during OTM. Immunofluorescence analysis confirms that Col1<sup>+</sup> cells can differentiate into osteoblasts and fibroblasts under orthodontic force. Moreover, Col1<sup>+</sup> cells may be involved in angiogenesis. These findings suggest that Col1<sup>+</sup> cells play a crucial role in the mechanical remodeling of periodontal tissue during OTM and may serve as a valuable tool for studying the mechanism of OTM.</p></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"2 1","pages":"Article 100026"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949907023000268/pdfft?md5=a787cc765ac64da96728b3ec8e94edbf&pid=1-s2.0-S2949907023000268-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136154022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insight to motor clutch model for sensing of ECM residual strain 电机离合器模型在电解加工残余应变检测中的应用

Mechanobiology in Medicine Pub Date : 2023-10-12 DOI: 10.1016/j.mbm.2023.100025

Valeria Panzetta , Claudia De Clemente , Michele Russo , Sabato Fusco , Paolo A. Netti

{"title":"Insight to motor clutch model for sensing of ECM residual strain","authors":"Valeria Panzetta , Claudia De Clemente , Michele Russo , Sabato Fusco , Paolo A. Netti","doi":"10.1016/j.mbm.2023.100025","DOIUrl":"https://doi.org/10.1016/j.mbm.2023.100025","url":null,"abstract":"<div><p>The mechanical microenvironment strongly affects cell state and decisions. Cell mechanosensing has been described by a <em>molecular clutch</em> which gets progressively engaged depending upon the stiffness of the extracellular material. Through the actuation of pulling forces exerted by actin fibres on the mechanosensitive talin-integrin molecular complex, cells sense and react to the stiffness of their surroundings. However, whether the truly cell mechanosensing is regulated by the pure elastic stiffness or by the strain energy density of the ECM is still debated. Here we report that the cell response to change of strain energy density out of loading induced deformation (purely elastic) can be accounted for by including, within the same frame of the molecular clutch model, the residual strain/stress to which the ECM could be subjected before establishing any interaction with the molecular clutches. To include the contribution of residual stresses, an additional spring orthogonal to the ones already present in the original clutch model has been introduced; this spring takes memory of the ECM strain energy when axially deformed before any interaction with cell molecular clutches can occur. To evaluate the influence of strain on the optimum number of clutches, the model has been implemented with different levels of strain. Results suggest that cells undergo a reinforcement process, stiffening the cytoskeleton in response to the ECM stress/strain energy.</p></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"1 2","pages":"Article 100025"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49890625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Covalent organic framework-based nanoplatforms with tunable mechanical properties for drug delivery and cancer therapy 基于共价有机框架的纳米平台，具有可调的机械性能，用于药物传递和癌症治疗

Mechanobiology in Medicine Pub Date : 2023-09-28 DOI: 10.1016/j.mbm.2023.100024

Liefeng Hu , Yonggang Lv

引用次数: 0

Stiffness matters: A soft bone marrow organoid rejuvenates hematopoietic stem cells 硬度很重要:柔软的骨髓类器官可以使造血干细胞恢复活力

Mechanobiology in Medicine Pub Date : 2023-09-01 DOI: 10.1016/j.mbm.2023.100009

Xiaoying Zhang, Rui Yue

引用次数: 0

Platelet-derived microvesicles drive vascular smooth muscle cell migration via forming podosomes and promoting matrix metalloproteinase-9 activity 血小板来源的微泡通过形成足质体和促进基质金属蛋白酶-9活性来驱动血管平滑肌细胞迁移

Mechanobiology in Medicine Pub Date : 2023-09-01 DOI: 10.1016/j.mbm.2023.100003

He Ren , Jiahe Chen , Kai Huang , Ying-Xin Qi

{"title":"Platelet-derived microvesicles drive vascular smooth muscle cell migration via forming podosomes and promoting matrix metalloproteinase-9 activity","authors":"He Ren , Jiahe Chen , Kai Huang , Ying-Xin Qi","doi":"10.1016/j.mbm.2023.100003","DOIUrl":"https://doi.org/10.1016/j.mbm.2023.100003","url":null,"abstract":"<div><p>We have shown that platelet-derived microvesicles (PMVs) induce abnormal proliferation, migration, and energy metabolism of vascular smooth muscle cells (VSMCs) after vascular intimal injury. Here, we examined a novel role of podosome in mediating matrix metalloproteinase-9 (MMP-9) dependent VSMC migration induced by platelet-derived microvesicles (PMVs). VSMCs were isolated from the thoracic aortas of male Sprague Dawley (SD) rats and identified with immunofluorescent staining. Blood samples were collected from SD Rats, the platelets were isolated with density gradient centrifugation from the blood samples and activated by collagen I. Intriguingly, proteins expressed in platelets were found to participate in the positive regulation of podosome assembly using GO analysis by DAVID, and most of the proteins were found in extracellular exosomes. Of note, activated platelets indirectly induced VSMC migration via releasing PMVs which was verified using platelets and VSMCs transwell co-culture system. Besides, podosome, an invasive protrusion to mediate extracellular matrix (ECM) remodeling, was formed in VSMCs to induce cell migration. Furthermore, MMP-9 activity detected by gelatin zymography was used to verify the function of the podosome in ECM remodeling. The result indicated that MMP-9 activity was robustly activated in VSMCs to implement the function of the podosome. In addition, gelatin degradation was detected in intact VSMCs using a gelatin degradation assay after co-culture with platelets. Taken together, our data reveal a novel mechanism that PMVs promote VSMC migration via forming podosomes and inducing MMP-9 activity.</p></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"1 1","pages":"Article 100003"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49880730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0