Force-dependent rapid immunoassay of high specificity and sensitivity

Mechanobiology in Medicine Pub Date : 2024-03-21 DOI:10.1016/j.mbm.2024.100061

Xiaodan Zhao , Yanqige Jiang , Yu Zhou , Jie Yan

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Abstract

The significance of early detection and isolation of infected individuals, along with the quantitative assessment of antibodies against the virus, has gained widespread recognition during the ongoing covid-19 pandemic. This necessitates the development of cost-effective, user-friendly, decentralized testing methods characterized by both high sensitivity and specificity. In this article, we present a comprehensive review of an innovative, low-cost rapid decentralized immunoassay technology, applicable across various diagnostic and quantitative testing scenarios. Distinguishing itself from conventional immunoassay technologies, this method is featured with mechanically enhanced specificity without compromising sensitivity. We delve into the basic principle of the technology and a comparative analysis of this technology in relation to other immunodiagnostic methods, highlighting its potential applications in a wide spectrum of diagnostic tests.

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高特异性和高灵敏度的力依赖性快速免疫分析法

在科维-19 病毒大流行期间，早期检测和隔离感染者以及定量评估病毒抗体的重要性得到了广泛认可。因此，有必要开发具有高灵敏度和高特异性的成本效益高、使用方便的分散式检测方法。在本文中，我们对一种创新的、低成本的分散式快速免疫测定技术进行了全面评述，该技术适用于各种诊断和定量检测方案。区别于传统的免疫测定技术，这种方法的特点是在不影响灵敏度的情况下，机械地提高了特异性。我们深入探讨了该技术的基本原理，并对该技术与其他免疫诊断方法进行了比较分析，强调了它在各种诊断检测中的潜在应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Mechanobiology in Medicine

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