Role and potential therapeutic strategies of matrix mechanics for optimizing tumor radiotherapy

Mechanobiology in Medicine Pub Date : 2023-12-19 DOI:10.1016/j.mbm.2023.100037

Yaxin Deng , Guobao Chen , Jiali Xiao , Hong Deng

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Abstract

Radiation therapy is one of the most effective therapeutic modalities for tumors. The changes in matrix stiffness of tumors and associated tissues are important consequences of side effects after radiotherapy. They are documented to induce the radio-resistance of cancer cells and promote the recurrence and metastasis of tumors, resulting in poor patient prognosis. Identifying the relationship between radiation and matrix stiffness is beneficial to optimize clinical treatment schemes and ultimately improve the patient prognosis. Herein, this review includes knowledge regarding the specific cellular, molecular processes and relevant clinical factors of the changes in matrix stiffness of tumors or associated tissues induced by radiation. The effects of altered matrix stiffness on the behaviors of cancer cells and associated normal cells are further detailed. It also reviews literatures to elucidate the mechanical signal transduction mechanism in radiotherapy and proposes some strategies to enhance the efficacy of radiotherapy based on matrix mechanics.

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基质力学对优化肿瘤放疗的作用和潜在治疗策略

放射治疗是治疗肿瘤最有效的方法之一。肿瘤及相关组织基质硬度的变化是放疗副作用的重要后果。有资料表明，基质硬度的变化会诱导癌细胞产生放射抗性，促进肿瘤的复发和转移，从而导致患者预后不良。明确辐射与基质僵化之间的关系有利于优化临床治疗方案，最终改善患者预后。在此，本综述包括有关辐射诱导肿瘤或相关组织基质硬度变化的特定细胞、分子过程和相关临床因素的知识。基质硬度的改变对癌细胞和相关正常细胞行为的影响也被进一步详细阐述。报告还回顾了阐明放疗中机械信号转导机制的文献，并提出了一些基于基质力学提高放疗疗效的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Mechanobiology in Medicine

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