Green Analytical Chemistry最新文献

{"title":"Exploring the molecular interactions of 4,4′-dichlorodiphenyldichloroethylene, imidacloprid, lambda-cyhalothrin, and malathion with antioxidant enzymes and their relevance to oxidative stress","authors":"Prem Rajak,&nbsp;Abhratanu Ganguly,&nbsp;Sayantani Nanda","doi":"10.1016/j.greeac.2025.100228","DOIUrl":"10.1016/j.greeac.2025.100228","url":null,"abstract":"<div><div>Oxidative stress is a detrimental condition that occurs when there is an imbalance between sub-cellular antioxidants and free radicals. Endogenous antioxidants actively scavenge free radicals and prevent oxidative stress. Pesticides can affect antioxidant activities. However, molecular interactions between the pesticides and endogenous antioxidants are not clear. Hence, objective of the present study is to dissect the intermolecular interactions between the widely-used pesticides (4,4′-dichlorodiphenyldichloroethylene, 4,4′-DDE; imidacloprid, IMD; lambda-cyhalothrin, CYH; malathion, MAL) and major antioxidant enzymes (Glutathione peroxidase-4, Glutathione S-Transferase, Catalase, Glutathione reductase, Superoxide dismutase-1) that might be responsible for altered enzyme activities and induction of oxidative stress. The binding affinity analysis using AutoDock vina and Discovery Studio Visualizer was conducted to unveil the potential intermolecular interactions between the pesticides and antioxidants. In the results, 4,4′-DDE, IMD, CYH, and MAL interacted with the antioxidants through stable hydrogen bonds, carbon-hydrogen bonds, van der Waals, and other hydrophobic interactions. Additionally, considerable binding affinities between the pesticides and enzymes were noted. ADME analyses have also revealed that the majority of pesticides can cross GI, exhibit low to high water solubility, and follow Lipinski's rule. Hence, results of the present study suggest that pesticides can potentially interact with antioxidants to modulate their catalytic activity and induce oxidative stress.</div></div>","PeriodicalId":100594,"journal":{"name":"Green Analytical Chemistry","volume":"12 ","pages":"Article 100228"},"PeriodicalIF":0.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano-LC with new neutral monolith for biomolecule separation","authors":"Cemil Aydoğan ,&nbsp;Sinan Bayındır ,&nbsp;Halise Avcil ,&nbsp;Bayram Yurt","doi":"10.1016/j.greeac.2025.100226","DOIUrl":"10.1016/j.greeac.2025.100226","url":null,"abstract":"<div><div>A new capillary monolith based on the co-polymerization of 2-napthylmethacrylate (NMM) as the functional monomer and trimethylolpropane trimethacrylate as the crosslinker was introduced for nano-LC. Porogenic solvent was composed of cyclohexanol and 1-dodecanol. The influence of both monomer and porogenic solvent on the monolithic structure was investigated. The characterization of NMM monolithic column was performed using scanning electron microscopy and chromatographic analyses. It was shown that the developed NMM monolith produced over than 43.280 plates/m. Homologous alkylbenzenes and polyaromatic hydrocarbons were chromatographed on the final NMM monolith, allowing promising hydrophobic and π-π interactions. Column-to column and run-to-run and reproducibility values were found as 2.4–3.2 % and &lt;2.47 %, respectively. The developed monolith was further applied for biomolecule separation. Three dipeptides (e.g. Ala-Tyr, Gly-Phe and <span>l</span>-carnosine) and five standard proteins, namely ribonuclease A, α-chymotrypsinogen, lysozyme, cytochrome C, Myoglobine were separated using the monolith in order to evaluate its potential. Both peptides and proteins were well separated using the NMM monolith in nano-LC, indicating promising alternative for sensitive chromatographic analyses.</div></div>","PeriodicalId":100594,"journal":{"name":"Green Analytical Chemistry","volume":"12 ","pages":"Article 100226"},"PeriodicalIF":0.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143419441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the removal of Polyfluoroalkyl Substances (PFAS) from water using destructive and non-destructive methods","authors":"Hafiz Nawaz Hussain ,&nbsp;Muhammad Idrees Jilani ,&nbsp;Faiza Imtiaz ,&nbsp;Toheed Ahmed ,&nbsp;Muhammad Bilal Arshad ,&nbsp;Muhammad Mudassar ,&nbsp;Muhammad Noman Sharif","doi":"10.1016/j.greeac.2025.100225","DOIUrl":"10.1016/j.greeac.2025.100225","url":null,"abstract":"<div><div>Per and polyfluoroalkyl substances (PFAS) are persistent synthetic chemicals with strong carbon-fluorine (C-F) bonds, making them resistant to environmental degradation. Their widespread presence in groundwater, surface water, and drinking water, particularly subtypes like PFOS and PFOA, highlights a critical need for effective removal methods. Current challenges include the durability of PFAS bonds and the environmental mobility of these substances. This study hypothesizes that adsorption offers a scalable and cost-effective approach for PFAS remediation. Using advanced adsorbent materials, the research evaluates the efficiency of adsorption technologies and their applicability to real-world scenarios. Results demonstrate the potential of novel adsorbents to achieve high PFAS removal rates while minimizing secondary contamination risks. The study concludes that aligning these solutions with evolving environmental regulations and assessing their cost and scalability are vital for tackling PFAS pollution effectively. This research contributes actionable insights to the development of sustainable PFAS management strategies, addressing critical gaps in large-scale applications.</div></div>","PeriodicalId":100594,"journal":{"name":"Green Analytical Chemistry","volume":"12 ","pages":"Article 100225"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive assessment of greenness of ICP-OES methods for determination of metals","authors":"Aesha Bhalodia,&nbsp;Sonal Desai","doi":"10.1016/j.greeac.2025.100222","DOIUrl":"10.1016/j.greeac.2025.100222","url":null,"abstract":"<div><div>This paper evaluates the greenness of Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES) methods for determination metal and metalloid. ICP-OES is a precise technique for multi-element quantification, making it vital for environmental monitoring by detecting trace levels of toxic elements like cadmium, lead, mercury, and arsenic. Using greenness assessment tools such as GAPI (Green Analytical Procedure Index), MoGAPI (Modified Green Analytical Procedure Index), AGREE (Analytical GREEnness Metric), AGREEprep (Analytical Greenness Metric for Sample Preparation), BAGI (Blue Applicability Grade Index) and ChlorTox (Chloroform oriented Toxicity Estimation Scale), 16 methods were evaluated for their environmental sustainability. These tools provide insights into the eco-friendliness of selected ICP-OES techniques, highlighting its benefits for greener and safer analytical processes.</div></div>","PeriodicalId":100594,"journal":{"name":"Green Analytical Chemistry","volume":"12 ","pages":"Article 100222"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a novel simultaneous equation and Q-absorbance ratio method for the quantitative estimation of atenolol and hydrochlorothiazide in combined tablet dosage forms: A green analytical chemistry approach","authors":"Ashok H. Akabari ,&nbsp;Divya K. Solanki ,&nbsp;Sagarkumar K. Patel ,&nbsp;Palak Desai ,&nbsp;Gamit Jainisha ,&nbsp;Bhavesh Patel ,&nbsp;Birenkumar N. Shah ,&nbsp;Ketan V. Shah","doi":"10.1016/j.greeac.2025.100224","DOIUrl":"10.1016/j.greeac.2025.100224","url":null,"abstract":"<div><div>This study aims to develop and validate novel UV spectrophotometric methods for the simultaneous estimation of atenolol and hydrochlorothiazide in pharmaceutical dosage forms and bulk. The proposed methods are Simultaneous Equation and Q-Absorbance Ratio methods offer a cost-effective, eco-friendly alternative to chromatographic techniques. The λ_max of atenolol and hydrochlorothiazide were identified at 224.00 nm and 234.00 nm, respectively, with an isoabsorptive point at 229.00 nm for the Q-Absorbance Ratio method. The validation followed ICH Q2 (R1) guidelines, demonstrating excellent linearity (R² &gt; 0.99 for both drugs), accuracy (98.5 %–101.2 %), precision (%RSD &lt; 2 %), and sensitivity (LOD: 1.61 µg/mL for atenolol, 0.78 µg/mL for hydrochlorothiazide). The developed methods were successfully applied to a marketed formulation, showing recovery rates within acceptable limits. The environmental sustainability of these methods was assessed using ComplexGAPI, AGREE, Analytical Eco-Scale, ChlorTox WHN, and CHEMS-1 tools. The AGREE score (0.71) and ComplexGAPI assessment (eight green attributes, two red) confirmed superior eco-friendliness over reported HPLC methods (AGREE: 0.62). ChlorTox scores further validated minimal toxicity risks. This research highlights an efficient, accurate, and environmentally benign alternative for atenolol and hydrochlorothiazide analysis, aligning with green analytical chemistry principles.</div></div>","PeriodicalId":100594,"journal":{"name":"Green Analytical Chemistry","volume":"12 ","pages":"Article 100224"},"PeriodicalIF":0.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143419442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paving the way towards green contaminant analysis: Strategies and considerations for sustainable analytical chemistry","authors":"Adrián Fuente-Ballesteros,&nbsp;Ana M. Ares,&nbsp;José Bernal","doi":"10.1016/j.greeac.2025.100221","DOIUrl":"10.1016/j.greeac.2025.100221","url":null,"abstract":"<div><div>Contaminant analysis is essential for protecting environmental integrity, ensuring food safety, and safeguarding public health. However, traditional analytical methodologies, while robust and precise, often rely on resource-intensive practices that pose significant environmental challenges. This review delves into strategies for transitioning towards greener contaminant analysis, focusing on the integration of sustainable practices without compromising analytical performance. It discusses the application of green chemistry principles and white analytical methods, emphasizing their role in addressing the growing need for eco-friendly approaches in analytical chemistry. Key strategies for greener contaminant analysis are explored in depth, including: (1) in situ measurements, (2) green solvents, (3) miniaturization and automation, (4) advanced materials, (5) greenness in chromatography, (6) energy consumption, and (7) waste management and circular economy. Additionally, recent case studies are highlighted to showcase the practical implementation of these strategies in real-world scenarios. As the emergence and study of contaminants continue to gain prominence in analytical chemistry, the shift towards more sustainable analytical techniques becomes increasingly critical. This review aims to provide a comprehensive overview of the current trends, strategies, and future perspectives driving the development of greener methodologies in contaminant analysis.</div></div>","PeriodicalId":100594,"journal":{"name":"Green Analytical Chemistry","volume":"12 ","pages":"Article 100221"},"PeriodicalIF":0.0,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143419440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eutectic solvent mixtures in environmental contaminants analysis: A review on current trends and future perspectives","authors":"Andrea Schincaglia ,&nbsp;Alberto Cavazzini ,&nbsp;Luisa Pasti ,&nbsp;Giorgia Purcaro ,&nbsp;Marco Beccaria","doi":"10.1016/j.greeac.2025.100220","DOIUrl":"10.1016/j.greeac.2025.100220","url":null,"abstract":"<div><div>This review provides an overview of recent advancements in applying eutectic solvents (ES) to extract and quantify a wide range of environmental contaminants, including pharmaceuticals, personal care products, plasticizers, metals, and emerging pollutants. The unique physicochemical properties of ES, such as low volatility, thermal stability, and tunable solvation capabilities, align with green analytical chemistry principles, making them attractive alternatives to conventional organic solvents. In particular, ES-based microextraction techniques have emerged as promising strategies to reduce hazardous solvent consumption and minimize waste. Despite these advantages, specific challenges persist, including insufficient toxicity and biodegradability data, incomplete understanding of their long-term environmental fate, and difficulties in meeting regulatory requirements when using ES as extraction media. By evaluating current practices and pinpointing areas that require further investigation, this review aims to provide a comprehensive overview of the state-of-the-art, guiding future research toward more informed applications of ES in environmental contaminant analysis and fostering the adoption of sustainable microextraction approaches.</div></div>","PeriodicalId":100594,"journal":{"name":"Green Analytical Chemistry","volume":"12 ","pages":"Article 100220"},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of neonicotinoids and other residues in orange pollen by micro-QuEChERS and UHPLC–MS/MS","authors":"Gabriela Brito Almeida ,&nbsp;Jordana Alves Ferreira ,&nbsp;Robson R.M. Barizon ,&nbsp;Sonia C.N. Queiroz ,&nbsp;Carla Beatriz Grespan Bottoli","doi":"10.1016/j.greeac.2025.100223","DOIUrl":"10.1016/j.greeac.2025.100223","url":null,"abstract":"<div><div>Producers of citrus crops use different types of insecticides, such as neonicotinoids, to combat pests and diseases of these cultures. Neonicotinoids are systemic insecticides and are translocated to the plant tissue, which may leave residues in pollen and cause adverse effects on bees. Pesticide contamination of pollen is also a food safety issue in human nutrition since the product is consumed as a food supplement. Therefore, the determination of these pesticides in pollen is important to help understand their effects on bees because pollen is their main nutrient source. In this work, we developed and validated a method using UHPLC–MS/MS to determine pesticide residues in orange pollen using micro-QuEChERS extraction, which uses low consumption of solvent, sample, and reagents. The analytical method demonstrated linearity over the range of 50 to 1000 μg kg⁻¹, with a correlation coefficient of ≥0.990. Trueness and precision were assessed using spiked samples, analyzed in quintuplicate at concentrations of 50, 100, and 200 μg kg⁻¹. Trueness values ranged between 81 and 115 %, while precision, expressed as relative standard deviation (RSD), was consistently below 20 %. The limit of quantification (LOQ) was established at 50 μg kg⁻¹, with acceptable precision and accuracy observed at this level. Experimental treatment samples showed high concentrations of clothianidin, imidacloprid, and thiamethoxam, while in commercial samples, the analytes were below the LOQ or not detected.</div></div>","PeriodicalId":100594,"journal":{"name":"Green Analytical Chemistry","volume":"12 ","pages":"Article 100223"},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143438054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonic-aided dispersive solid-phase microextraction employing magnetic halloysite nano clay for simultaneous preconcentration of lead (II) and cadmium (II)","authors":"Nyeleti Bridget Mabaso ,&nbsp;Mthokozisi Mnguni ,&nbsp;Philiswa Nosizo Nomngongo ,&nbsp;Luthando Nyaba","doi":"10.1016/j.greeac.2025.100219","DOIUrl":"10.1016/j.greeac.2025.100219","url":null,"abstract":"<div><div>Heavy metal poisoning of water by lead Pb(II) and cadmium Cd(II) is a severe environmental issue. A magnetic halloysite nano clay (Fe₃O₄@HNT) was synthesised for the simultaneous preconcentration of Cd(II) and Pb(II) using an ultrasound-assisted dispersive micro-solid phase extraction technique (US-DMSPE). Various characterisation techniques were employed to characterise the nanocomposite, confirming the nanostructure and chemical composition of Fe₃O₄@HNT. The transmission electron microscope (TEM) showed that the inner cavity of the tube was approximately 10–21 nm (with an average of 13.4 ± 3.4 nm), and the lengths are variable. In addition, the open-ended and inner cavity characteristics provided a passage and additional active sorption sites for the target analytes.</div><div>Brunauer–Emmett–Teller (BET) confirmed the mesoporosity of the adsorbent, which corresponds with the inner diameter as confirmed by TEM. The preconcentration parameters were optimised using fractional factorial design (FrFD) and central composite design (CCD). Under the optimised experimental conditions, the detection limits were 0.037 and 0.054 µg/L, and the dynamic range was 0.1–400 µg/L for cadmium and lead, respectively. The method had good precision with RSD (&lt;4.5 %) and R² (0.9987 for cadmium and 0.9975 for lead). This technique successfully determined lead and cadmium in water samples with excellent relative recovery in the 98.8 to 106 % range.</div></div>","PeriodicalId":100594,"journal":{"name":"Green Analytical Chemistry","volume":"12 ","pages":"Article 100219"},"PeriodicalIF":0.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143388126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green analysis of illicit drugs on banknote dust","authors":"Teresa Cecchi,&nbsp;Arianna Giuliani,&nbsp;Carlo Catini","doi":"10.1016/j.greeac.2025.100218","DOIUrl":"10.1016/j.greeac.2025.100218","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Purpose&lt;/h3&gt;&lt;div&gt;This study aims to develop and validate the first analytical method to assess the presence of common illicit drugs on banknote dust from counting machines via green preanalytical and analytical approaches. Banknote dust represents the most eligible sample to ascertain the circulation of drugs of abuse. Prevalence measures of sociological interest, provided by analysing their traces on banknote dust, are less affected by the variability of their concentrations in each bill because banknote dust represents an averaged sample of high statistical significance.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;A simple banknote dust (10.0 ± 0.1 mg) extraction made use of 10 ml of a green extractant, comprising 98 % water, 2 % ethanol, and 0.1 % formic acid. A UHPLC&lt;img&gt;HRMS system with ethanol as the organic modifier was used to develop and optimize the chromatographic method; a stable isotope labelled internal standard for each analyte was used to compensate matrix effects and possible losses. The Levene test, Mandel's test, and Shapiro-Wilk's test were used to obtain the best calibration model. The Green Analytical Procedure Index (GAPI), the Analytical GREEnness Metric Approach (AGREE), the and the Eco-scale were used to assess the greenness of the method.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Going green (AGREE score 0.83/1, Eco-Scale score 88/100) limits shortcomings due to the use of classical organic solvents in the extraction step and improves the chromatographic outcome. The linear weighted models gave limits of detections (LODs) ranging from 0.7 (3,4-Methylenedioxyamphetamine, MDA) to 3.9 ng/ml (Tetrahydrocannabinol, THC). For cocaine, they were lower than previously reported. For other analytes, no comparison can be provided because they were never analyzed in banknote dust. Intra-day and inter-day precision and accuracy were much better than those recommended by guidelines. The developed method was applied to 5 banknote dust samples from local banknote counter machines and 4 dust samples of different origins. No illicit drugs were found except cocaine in banknote dust. Its concentration ranged only one order of magnitude, from 2.76E+02 to 4.01E+03 mg of cocaine per gram of banknote dust, in agreement with previous results obtained with methanol as an extractant and organic modifier.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions and perspectives&lt;/h3&gt;&lt;div&gt;The greenness of the methods has many intrinsic merits for the environment, chromatographers and the chromatographic outcome. The way drug is consumed is more important than other ways of banknote contamination. To have an idea of drug circulation in a geographical area, the sampling of banknote dust can provide the police with reliable analytical evidence of high statistical value complementing results from anonymous questionnaires and drug seizures. Avoiding the processing of a large number of banknotes is an additional aim of Green Analytical Chemistry, since it entails waste prevention an","PeriodicalId":100594,"journal":{"name":"Green Analytical Chemistry","volume":"12 ","pages":"Article 100218"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}