European Journal of Cancer (1965)最新文献_第10页

Changes in SCM-responses of lymphocytes in mice after implantation with ehrlich ascites cells 植入埃利希腹水细胞后小鼠淋巴细胞scm反应的变化

European Journal of Cancer (1965) Pub Date : 1981-02-01 DOI: 10.1016/0014-2964(81)90032-3

L. Cercek, B. Cercek

引用次数: 4

Carcinoembryonic antigen levels in asymptomatic adolescents 无症状青少年的癌胚抗原水平

European Journal of Cancer (1965) Pub Date : 1981-02-01 DOI: 10.1016/0014-2964(81)90045-1

Edward Tabor , Robert J. Gerety , Charles F. Needy , Bennett L. Elisberg , A.R. Colon , Richard Jones

引用次数: 13

Pyrazofurin-resistant hepatoma cells deficient in adenosine kinase 吡唑呋喃耐药肝癌细胞缺乏腺苷激酶

European Journal of Cancer (1965) Pub Date : 1981-01-01 DOI: 10.1016/0014-2964(81)90210-3

D.Parker Suttle , Ronald J. Harkrader, Robert C. Jackson

{"title":"Pyrazofurin-resistant hepatoma cells deficient in adenosine kinase","authors":"D.Parker Suttle , Ronald J. Harkrader, Robert C. Jackson","doi":"10.1016/0014-2964(81)90210-3","DOIUrl":"10.1016/0014-2964(81)90210-3","url":null,"abstract":"<div>A pyrazofurin-resistant subline of the Morris rat hepatoma 3924A has been isolated in vitro. These cells, designated subline 3924A/1P39-3, were 100-fold resistant to pyrazofurin, and showed cross-resistance towards 6-methylmercaptopurine riboside and 6-chloropurine riboside, but not towards 6-azauridine or arabinosyladenine. Measurement of cellular enzyme activities indicated that the level of adenosine kinase in the mutant was decreased to 2% of the value in the parental cell line, but activities of uridine kinase, adenosine deaminase, deoxyadenosine kinase and orotidine 5′-monophosphate decarboxylase showed no significant change. Despite the extensive deletion of adenosine kinase, the sensitivity of the mutant to adenosine toxicity was not greatly different from that of the parental 3924A cell line. Incubation of the cells for 20 hr in presence of 300 μM adenosine caused an increase of 43% in the adenine nucleotide pool of the 1P39-3 cells, as compared with an increase of 93% in the parental 3924A cells. In both lines 300 μM adenosine caused significant depletion in uridine nucleotides and phosphoribosylpyrophosphate pools. Nevertheless, uridine (1 mM) did not reverse the adenosine toxicity in either case. These cells have provided direct evidence that the antipyrimidine agent, pyrazofurin, is activated by adenosine kinase in rat hepatoma cells. The results also show that loss of adenosine kinase does not affect adenosine toxicity in these cells, suggesting that the toxicity may be attributable to free adenosine rather than overproduction of adenine nucleotides.</div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 1","pages":"Pages 43-51"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90210-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17232277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Effect of an aromatic retinoic acid analog (Ro 10-9359) on growth of virus-induced papilloma (Shope) and related neoplasia of rabbits 芳香族维甲酸类似物(ro10 -9359)对兔病毒诱导乳头状瘤(Shope)及相关肿瘤生长的影响

European Journal of Cancer (1965) Pub Date : 1981-01-01 DOI: 10.1016/0014-2964(81)90209-7

Yohei Ito

引用次数: 25

Fellowships in pediatric hematology-oncology 儿科血液肿瘤学研究员

European Journal of Cancer (1965) Pub Date : 1981-01-01 DOI: 10.1016/0014-2964(81)90223-1

引用次数: 0

Characterization of tumor lines derived from spontaneous metastases of a transplanted murine sarcoma 小鼠移植肉瘤自发转移肿瘤系的特征

European Journal of Cancer (1965) Pub Date : 1981-01-01 DOI: 10.1016/0014-2964(81)90213-9

Alberto Mantovani, Raffaella Giavazzi, Giulio Alessandri, Federico Spreafico, Silvio Garattini

{"title":"Characterization of tumor lines derived from spontaneous metastases of a transplanted murine sarcoma","authors":"Alberto Mantovani, Raffaella Giavazzi, Giulio Alessandri, Federico Spreafico, Silvio Garattini","doi":"10.1016/0014-2964(81)90213-9","DOIUrl":"10.1016/0014-2964(81)90213-9","url":null,"abstract":"<div>Cell lines were obtained from nine individual spontaneous metastases of the murine mFS6 sarcoma by s.c. inoculation of lung deposits in syngeneic mice. When inoculated i.m., two lines (M4 and M7) from metastases had greater, and two (M8 and M9) had less metastasizing capacity than the primary mFS6 sarcoma. The remaining cell lines gave spontaneous metastases similar in incidence, number and weight to the primary mFS6 tumor. When inoculated i.v., M2 and M4 gave consistently more lung deposits than mFS6 cells, whereas cells from M1, M5, M6 and M8 produced fewer artificial metastases than the primary tumor. Eight individual lung metastases were disaggregated and tested for metastasizing capacity immediately after isolation from the lung parenchyma: spontaneous and artificial metastases from metastatic cells were similar to the primary tumor, except for one secondary which was less metastatic. The immunological characteristics of cell lines from metastases were studied by in vivo immunization and challenge. Seven lines from metastases and the primary tumor had weak cross-reacting transplantation antigens whereas two lines (M3 and M4) had no demonstrable antigenicity. Thus, cell lines from individual spontaneous metastases are heterogeneous in many respects, including metastasizing capacity. However in this model metastasis does not appear to be the expression of strong selection of variant cells with increased metastatic potential.</div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 1","pages":"Pages 71-76"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90213-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18276841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 61

Endogenous oestradiol-17β concentration in breast tumours determined by mass fragmentography and by radioimmunoassay: Relationship to receptor content 用质谱和放射免疫分析法测定乳腺肿瘤中内源性雌二醇-17β的浓度：与受体含量的关系

European Journal of Cancer (1965) Pub Date : 1981-01-01 DOI: 10.1016/0014-2964(81)90220-6

M. Edery , J. Goussard , L. Dehennin , R. Scholler , J. Reiffsteck , M.A. Drosdowsky

引用次数: 103

Editorial communication to contributors to the European journal of cancer 向《欧洲癌症杂志》撰稿人的编辑交流

European Journal of Cancer (1965) Pub Date : 1981-01-01 DOI: 10.1016/0014-2964(81)90205-X

引用次数: 0

The apparent lack of association of antibody activity to murine leukemia virus and lymphoma development in (AKR × CBA) F1 mice 小鼠白血病病毒抗体活性明显缺乏与（AKR×CBA）F1小鼠淋巴瘤发展的相关性

European Journal of Cancer (1965) Pub Date : 1981-01-01 DOI: 10.1016/0014-2964(81)90217-6

R.D. Barnes, Maureen Tuffrey, H.C. Holmes

{"title":"The apparent lack of association of antibody activity to murine leukemia virus and lymphoma development in (AKR × CBA) F1 mice","authors":"R.D. Barnes, Maureen Tuffrey, H.C. Holmes","doi":"10.1016/0014-2964(81)90217-6","DOIUrl":"https://doi.org/10.1016/0014-2964(81)90217-6","url":null,"abstract":"<div>We have in the past proposed the hypothesis that virus-associated lymphoma development in AKR mice might be in some way related to the occurrence of antibody activity to murine leukemia virus (MuLV). Here we have attempted to test this hypothesis using the 125I-protein A radioimmunoassay recently developed in this laboratory. Previous findings in naturally derived (AKR × CBA/H-T6Crc) F1 confirmed the presence of MuLV, moreover, at levels comparable to or indeed occasionally in excess of, the AKR. Despite this, tumours were uncommon during the first year of life and no antibody activity could be detected at this time. It was later noted that lymphomas did occur in the F1 but in the second year. To test our hypothesis that there may be a possible association between tumour resistance and antibody activity, these hybrids have been investigated further during this later period.In addition, we have examined other groups of mice in which we have attempted to prematurely induce antibody activity experimentally.In both these situations there was no apparent relationship between tumour development and the presence of anti-MuLV activity.</div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 1","pages":"Pages 93-98"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90217-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72072414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heterotransplantation of natural bovine lymphosarcoma to nude mice 天然牛淋巴肉瘤对裸鼠的异体移植

European Journal of Cancer (1965) Pub Date : 1981-01-01 DOI: 10.1016/0014-2964(81)90212-7

M. Onuma , K. Matsumoto , H. Kodama , Y. Fujimoto , R. Moriguchi , T. Mikami , H. Izawa

引用次数: 9