{"title":"小鼠白血病病毒抗体活性明显缺乏与（AKR×CBA）F1小鼠淋巴瘤发展的相关性","authors":"R.D. Barnes, Maureen Tuffrey, H.C. Holmes","doi":"10.1016/0014-2964(81)90217-6","DOIUrl":null,"url":null,"abstract":"<div><p>We have in the past proposed the hypothesis that virus-associated lymphoma development in AKR mice might be in some way related to the occurrence of antibody activity to murine leukemia virus (MuLV). Here we have attempted to test this hypothesis using the <sup>125</sup><em>I</em>-protein A radioimmunoassay recently developed in this laboratory. Previous findings in naturally derived (AKR × CBA/H-T6Crc) F<sub><em>1</em></sub> confirmed the presence of MuLV, moreover, at levels comparable to or indeed occasionally in excess of, the AKR. Despite this, tumours were uncommon during the first year of life and no antibody activity could be detected at this time. It was later noted that lymphomas did occur in the F<sub><em>1</em></sub> but in the second year. To test our hypothesis that there may be a possible association between tumour resistance and antibody activity, these hybrids have been investigated further during this later period.</p><p>In addition, we have examined other groups of mice in which we have attempted to prematurely induce antibody activity experimentally.</p><p>In both these situations there was no apparent relationship between tumour development and the presence of anti-MuLV activity.</p></div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 1","pages":"Pages 93-98"},"PeriodicalIF":0.0000,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90217-6","citationCount":"0","resultStr":"{\"title\":\"The apparent lack of association of antibody activity to murine leukemia virus and lymphoma development in (AKR × CBA) F1 mice\",\"authors\":\"R.D. Barnes, Maureen Tuffrey, H.C. Holmes\",\"doi\":\"10.1016/0014-2964(81)90217-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>We have in the past proposed the hypothesis that virus-associated lymphoma development in AKR mice might be in some way related to the occurrence of antibody activity to murine leukemia virus (MuLV). Here we have attempted to test this hypothesis using the <sup>125</sup><em>I</em>-protein A radioimmunoassay recently developed in this laboratory. Previous findings in naturally derived (AKR × CBA/H-T6Crc) F<sub><em>1</em></sub> confirmed the presence of MuLV, moreover, at levels comparable to or indeed occasionally in excess of, the AKR. Despite this, tumours were uncommon during the first year of life and no antibody activity could be detected at this time. It was later noted that lymphomas did occur in the F<sub><em>1</em></sub> but in the second year. To test our hypothesis that there may be a possible association between tumour resistance and antibody activity, these hybrids have been investigated further during this later period.</p><p>In addition, we have examined other groups of mice in which we have attempted to prematurely induce antibody activity experimentally.</p><p>In both these situations there was no apparent relationship between tumour development and the presence of anti-MuLV activity.</p></div>\",\"PeriodicalId\":100497,\"journal\":{\"name\":\"European Journal of Cancer (1965)\",\"volume\":\"17 1\",\"pages\":\"Pages 93-98\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1981-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0014-2964(81)90217-6\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Cancer (1965)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0014296481902176\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Cancer (1965)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0014296481902176","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The apparent lack of association of antibody activity to murine leukemia virus and lymphoma development in (AKR × CBA) F1 mice
We have in the past proposed the hypothesis that virus-associated lymphoma development in AKR mice might be in some way related to the occurrence of antibody activity to murine leukemia virus (MuLV). Here we have attempted to test this hypothesis using the 125I-protein A radioimmunoassay recently developed in this laboratory. Previous findings in naturally derived (AKR × CBA/H-T6Crc) F1 confirmed the presence of MuLV, moreover, at levels comparable to or indeed occasionally in excess of, the AKR. Despite this, tumours were uncommon during the first year of life and no antibody activity could be detected at this time. It was later noted that lymphomas did occur in the F1 but in the second year. To test our hypothesis that there may be a possible association between tumour resistance and antibody activity, these hybrids have been investigated further during this later period.
In addition, we have examined other groups of mice in which we have attempted to prematurely induce antibody activity experimentally.
In both these situations there was no apparent relationship between tumour development and the presence of anti-MuLV activity.
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